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Simone L Vernez, Zhamshid Okhunov, Jamie Wikenheiser, Cyrus Khoyilar, Rahul Dutta, Kathryn Osann, Kamaljot Kaler, Thomas K Lee, Ralph V Clayman, Jaime Landman
PURPOSE: We sought to characterize and three-dimensionally reconstruct the distribution of the autonomic innervation of the human ureter. MATERIALS AND METHODS: Three male and three female pairs of ureters were evaluated at 2 mm serial transverse sections along the entire length of the ureter. The location of nerve tissue was immunohistochemically identified using the neuronal marker, S100 protein, and ImageJ software was used to calculate nerve count and density in the adventitia and smooth muscle...
September 14, 2016: Journal of Urology
Marcel Drlík, Hana Flogelová, Kubát Martin, Tomášek Jan, Zerhau Pavel, Šmakal Oldřich, Novák Ivo, Komarc Martin, Kočvara Radim
INTRODUCTION: Low initial differential renal function (DRF) in patients with primary non-refluxing megaureter (PNRM) is considered an indication for surgery as are an increase of dilatation and symptoms. OBJECTIVE: We hypothesized that low DRF is not necessarily a result of obstruction, but may be due to impaired development of the upper urinary tract. Thus, in the absence of symptoms, there is a low risk for further loss of renal function. This study aimed to assess whether initially low DRF is a reliable indicator of obstruction...
August 2016: Journal of Pediatric Urology
Marie-Klaire Farrugia, Rowena Hitchcock, Anna Radford, Tariq Burki, Andrew Robb, Feilim Murphy
INTRODUCTION: It is well-known that the majority of congenital megaureters may be managed conservatively, but the indications and surgical options in patients requiring intervention are less well defined. Hence this topic was selected for discussion at the 2012 consensus meeting of the British Association of Paediatric Urologists (BAPU). Our aim was to establish current UK practice and derive a consensus management strategy. METHODS: An evidence-based literature review on a predefined set of questions on the management of the primary congenital megaureter was presented to a panel of 56 Consultant Surgeon members of the British Association of Paediatric Urologists (BAPU), and current opinion and practice established...
February 2014: Journal of Pediatric Urology
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