Luciano Gattinoni, Francesco Vasques, Luigi Camporota, Jennifer Meessen, Federica Romitti, Iacopo Pasticci, Eleonora Duscio, Francesco Vassalli, Lui G Forni, Didier Payen, Massimo Cressoni, Alberto Zanella, Roberto Latini, Michael Quintel, John J Marini
Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen use. Discriminating between these two mechanisms may be relevant for the early fluid resuscitation strategy. Objectives: To understand the relationship among central venous oxygen saturation (ScvO2 ), lactate, and base excess to better determine the origin of lactate. Methods: This was a post hoc analysis of baseline variables of 1,741 patients with sepsis enrolled in the multicenter trial ALBIOS (Albumin Italian Outcome Sepsis)...
September 1, 2019: American Journal of Respiratory and Critical Care Medicine