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Heart Failure

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845 papers 100 to 500 followers
By Elvis Amao Internal Medicine , Cardiology and infectious diseases
https://www.readbyqxmd.com/read/28435003/the-hemodynamic-effects-of-aortic-insufficiency-in-patients-supported-with-continuous-flow-left-ventricular-assist-devices
#1
Gabriel Sayer, Nitasha Sarswat, Gene H Kim, Sirtaz Adatya, Diego Medvedofsky, Daniel Rodgers, Eric Kruse, Takeyoshi Ota, Valluvan Jeevanandam, Roberto Lang, Nir Uriel
BACKGROUND: The impact of aortic insufficiency (AI) on the morbidity and mortality of left ventricular assist device (LVAD) patients remains controversial. This study's aim is to assess the hemodynamics of LVAD patients with at least mild AI, at baseline and in response to device speed changes. METHODS: Asymptomatic LVAD patients were prospectively enrolled and underwent a hemodynamic and echocardiographic ramp study. Hemodynamics at rest and in response to device speed changes were compared between patients with at least mild AI at their baseline speed and patients without AI...
April 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28396040/risk-assessment-and-comparative-effectiveness-of-left-ventricular-assist-device-and-medical-management-in-ambulatory-heart-failure-patients-the-roadmap-study-2-year-results
#2
Randall C Starling, Jerry D Estep, Douglas A Horstmanshof, Carmelo A Milano, Josef Stehlik, Keyur B Shah, Brian A Bruckner, Sangjin Lee, James W Long, Craig H Selzman, Vigneshwar Kasirajan, Donald C Haas, Andrew J Boyle, Joyce Chuang, David J Farrar, Joseph G Rogers
OBJECTIVES: The authors sought to provide the pre-specified primary endpoint of the ROADMAP (Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients) trial at 2 years. BACKGROUND: The ROADMAP trial was a prospective nonrandomized observational study of 200 patients (97 with a left ventricular assist device [LVAD], 103 on optimal medical management [OMM]) that showed that survival with improved functional status at 1 year was better with LVADs compared with OMM in a patient population of ambulatory New York Heart Association functional class IIIb/IV patients...
March 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28400028/predicting-clinical-and-echocardiographic-response-after-cardiac-resynchronization-therapy-with-a-score-combining-clinical-electrocardiographic-and-echocardiographic-parameters
#3
Anne Bernard, Aymeric Menet, Sylvestre Marechaux, Maxime Fournet, Frederic Schnell, Yves Guyomar, Christophe Leclercq, Philippe Mabo, Laurent Fauchier, Erwan Donal
The L2ANDS2 score was previously found to be able to assess the probability of left ventricular (LV) remodeling. We sought to evaluate this score in terms of clinical outcomes: 275 patients with heart failure, from 2 centers, implanted with a cardiac resynchronization therapy (CRT) device were followed at least 2 years after implantation. Baseline clinical, electrocardiographic, and echocardiographic characteristics including left bundle branch block, age >70 years, nonischemic etiology, LV end-diastolic diameter <40 mm/m(2), and septal flash by echocardiography were integrated in 4 scoring systems...
March 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28408022/left-ventricular-assist-device-as-a-bridge%C3%A2-to-recovery-for-patients-with-advanced-heart-failure
#4
Djordje G Jakovljevic, Magdi H Yacoub, Stephan Schueler, Guy A MacGowan, Lazar Velicki, Petar M Seferovic, Sandeep Hothi, Bing-Hsiean Tzeng, David A Brodie, Emma Birks, Lip-Bun Tan
BACKGROUND: Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation, as destination therapy, or in some patients, as a bridge to recovery. OBJECTIVES: This study evaluated whether patients undergoing an LVAD bridge-to-recovery protocol can achieve cardiac and physical functional capacities equivalent to those of healthy controls. METHODS: Fifty-eight male patients-18 implanted with a continuous-flow LVAD, 16 patients with LVAD explanted (recovered patients), and 24 heart transplant candidates (HTx)-and 97 healthy controls performed a maximal graded cardiopulmonary exercise test with continuous measurements of respiratory gas exchange and noninvasive (rebreathing) hemodynamic data...
April 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28408037/reduced-anxiety-and-depression-in-patients-with-advanced-heart-failure-after-left-ventricular-assist-device-implantation
#5
Gardner Yost, Geetha Bhat, Edward Mahoney, Antone Tatooles
BACKGROUND: Despite the high prevalence of depression and anxiety in patients with advanced heart failure, the effects of left ventricular assist device (LVAD) implantation on these critically important aspects of mental health are not well understood. OBJECTIVE: We sought to assess changes in depression and anxiety following LVAD implantation. METHODS: The Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) were administered to 54 patients by a clinical psychologist at a mean of 12 days before LVAD implantation and 251 days after implantation...
February 12, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28380632/evaluation-of-right-ventricular-function-using-liver-stiffness-in-patients-with-left-ventricular-assist-device%C3%A2
#6
Noriyuki Kashiyama, Koichi Toda, Teruya Nakamura, Shigeru Miyagawa, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Daisuke Yoshioka, Yoshiki Sawa
OBJECTIVES: Although right ventricular failure (RVF) is a major concern after left ventricular assist device (LVAD) implantation, methodologies to evaluate RV function remain limited. Liver stiffness (LS), which is closely related to right-sided filling pressure and may indicate RVF severity, could be non-invasively and repeatedly assessed using transient elastography. Here we investigated the suitability of LS as a parameter of RV function in pre- and post-LVAD periods. METHODS: The study included 55 patients with LVAD implantation as a bridge to transplantation between 2011 and 2015 whose LS was assessed using transient elastography...
April 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28385314/management-of-ventricular-arrhythmias-in%C3%A2-patients-with-advanced-heart-failure
#7
REVIEW
Pasquale Santangeli, J Eduardo Rame, Edo Y Birati, Francis E Marchlinski
Advanced heart failure (A-HF) is characterized by progressive symptoms of heart failure despite optimal therapy. In patients with A-HF, ventricular arrhythmias (VAs) are common. Clinical studies evaluating different therapies to prevent VAs had very limited representation of patients with A-HF. Among antiarrhythmic drugs, only amiodarone reduces VAs, although its use may be associated with increased mortality. Catheter ablation with substrate modification is effective to achieve VA suppression in patients with A-HF, including those with left ventricular assist devices...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28367848/tnf-receptor-1-2-predict-heart-failure-risk-in-type-2-diabetes-mellitus-patients
#8
Zhang Ping, Ma Aiqun, Li Jiwu, Shao Liang
Inflammation plays an important role in heart failure and diabetes mellitus. Traditional serum markers have limited predictive value in heart failure and diabetes. TNFR1 and TNFR2 (TNFR1/2) have been proven to be strongly associated with heart failure and diabetes complications. This study aimed to assess the association of sTNFR1 and sTNFR2 levels and incidental HF risk in diabetes patients.We detected the mRNA, protein, and serum expression of TNFR1/2, their downstream signaling pathway protein NF-kB, and JNK expression and some traditional serum inflammatory markers in a heart failure group without diabetes mellitus or abnormal glucose tolerance (n = 84), a diabetes mellitus group without heart failure (n = 86), and a heart failure with diabetes mellitus group (n = 86)...
April 6, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28382468/role-of-hyperkalemia-in-heart-failure-and-the-therapeutic-use-of-potassium-binders
#9
Chaudhry M S Sarwar, Aditi A Bhagat, Stefan D Anker, Javed Butler
Hyperkalemia can be a life-threatening disorder, especially for at-risk patients with heart failure, chronic kidney disease, with diabetes, and patients on certain drugs like renin-angiotensin-aldosterone system antagonists and mineralocorticoid receptor antagonists. There are limited therapeutic options available for hyperkalemia, and they have narrow effectiveness because of their unfavorable side effects profile in long-term and high cost utilization requiring inpatient care. Patiromersorbitex calcium and sodium zirconium cyclosilicate are novel potassium-lowering compounds for the treatment and prevention of hyperkalemia in at-risk population...
April 6, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28351486/potential-usefulness-of-diastolic-parameters-measured-by-strain-imaging-echocardiography-in-the-early-prediction-of-chemotherapy-induced-cardiotoxicity
#10
Dagmar F Hernandez-Suarez, Angel López-Candales
Over the past decades, chemotherapy has significantly increased the overall prognosis and survival of several patients diagnosed with cancer. However, the usefulness of some chemotherapeutic agents has been hindered by a collateral dose-dependent cardiotoxicity. To date, although extensive efforts have been directed to the early detection of subclinical toxicity in patients treated with these drugs, it remains unclear which approach would be best in order to prevent chemotherapy-induced cardiotoxicity (CIC)...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28367768/rates-and-predictive-factors-of-return-to-the-emergency-department-following-an-initial-release-by-the-emergency-department-for-acute-heart-failure
#11
Pierre-Géraud Claret, Lisa A Calder, Ian G Stiell, Justin W Yan, Catherine M Clement, Bjug Borgundvaag, Alan J Forster, Jeffrey J Perry, Brian H Rowe
OBJECTIVES: Following release by emergency department (ED) for acute heart failure (AHF), returns to ED represent important adverse health outcomes. The objective of this study was to document relapse events and factors associated with return to ED in the 14-day period following release by ED for patients with AHF. METHODS: The primary outcome was the number of return to ED for patients who were release by ED after the initial visit, for any related medical problem within 14 days of this initial ED visit...
April 3, 2017: CJEM
https://www.readbyqxmd.com/read/28377383/risk-of-stroke-in-patients-with-heart-failure-a-population-based-30-year-cohort-study
#12
Kasper Adelborg, Szimonetta Szépligeti, Jens Sundbøll, Erzsébet Horváth-Puhó, Victor W Henderson, Anne Ording, Lars Pedersen, Henrik Toft Sørensen
BACKGROUND AND PURPOSE: The long-term risk of specific stroke subtypes among heart failure patients is largely unknown. We examined short-term and long-term risk of ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in heart failure patients and in a general population comparison cohort. METHODS: In this nationwide cohort study (1980-2012), we used Danish population-based medical registries to identify and follow (1) all patients hospitalized for the first time with heart failure and (2) a birth year-, sex-, and calendar year-matched general population comparison cohort...
April 4, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28377439/association-between-use-of-long-acting-nitrates-and-outcomes-in-heart-failure-with-preserved-ejection-fraction
#13
Shir Lynn Lim, Lina Benson, Ulf Dahlström, Carolyn S P Lam, Lars H Lund
BACKGROUND: Nitrates may be beneficial in heart failure with preserved ejection fraction (HFpEF) by enhancing cGMP signaling and improving hemodynamics, but real-world data on potential efficacy are lacking. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with International Classification of Diseases, Tenth Revision comorbidity diagnoses and demographic and socioeconomic data. In HFpEF, defined as left ventricular ejection fraction ≥40%, we derived propensity scores for nitrate use using 52 baseline variables...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28380304/cardiopulmonary-exercise-testing-in-heart-failure-patients-with-specific-comorbidities
#14
Massimo F Piepoli, Ugo Corrà, Piergiuseppe Agostoni
Exercise capacity is one of the most powerful predicting factors of life expectancy, both in patients with and without cardiac disease. Cardiopulmonary exercise testing provides a global assessment of the integrative exercise responses involving the pulmonary, cardiovascular, hematopoietic, neuropsychological, and skeletal muscle systems, which are not adequately reflected through the measurement of individual organ system function. This relatively noninvasive, dynamic, physiologic overview allows the evaluation of both submaximal and peak exercise responses, providing the physician with relevant information for clinical decision making...
April 5, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28382470/comorbidities-in-heart-failure
#15
Haye H van der Wal, Vincent M van Deursen, Peter van der Meer, Adriaan A Voors
Comorbidities frequently accompany chronic heart failure (HF), contributing to increased morbidity and mortality, and an impaired quality of life. We describe the prevalence of several high-impact comorbidities in chronic HF patients and their impact on morbidity and mortality. Furthermore, we try to explain the underlying pathophysiological processes and the complex interaction between chronic HF and specific comorbidities. Although common risk factors are likely to contribute, it is reasonable to believe that factors associated with HF might cause other comorbidities and vice versa...
April 6, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28379039/elevated-serum-il-39-in-patients-with-st-segment-elevation-myocardial-infarction-was-related-with-left-ventricular-systolic-dysfunction
#16
Yu Luo, Feng Liu, Huadong Liu, Hongdan Chen, Wenfei Cheng, Shaohong Dong, Wei Xiong
AIM: To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS). PATIENTS & METHODS: Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated. RESULTS: The serum levels of IL-39 in ACS patients were significantly increased...
April 5, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28377186/reliability-construct-validity-and-determinants-of-6-minute-walk-test-performance-in-patients-with-chronic-heart-failure
#17
Nicole H M K Uszko-Lencer, Rafael Mesquita, Eefje Janssen, Christ Werter, Hans-Peter Brunner-La Rocca, Fabio Pitta, Emiel F M Wouters, Martijn A Spruit
BACKGROUND: In-depth analyses of the measurement properties of the 6-minute walk test (6MWT) in patients with chronic heart failure (CHF) are lacking. We investigated the reliability, construct validity, and determinants of the distance covered in the 6MWT (6MWD) in CHF patients. METHODS: 337 patients were studied (median age 65years, 70% male, ejection fraction 35%). Participants performed two 6MWTs on subsequent days. Demographics, anthropometrics, clinical data, ejection fraction, maximal exercise capacity, body composition, lung function, and symptoms of anxiety and depression were also assessed...
February 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28378600/addition-of-non-invasive-ventilatory-support-to-combined-aerobic-and-resistance-training-improves-dyspnea-and-quality-of-life-in-heart-failure-patients-a-randomized-controlled-trial
#18
Hugo Souza Bittencourt, Cristiano Gonçalves Cruz, Bruno Costa David, Erenaldo Rodrigues, Camille Magalhães Abade, Roque Aras Junior, Vitor Oliveira Carvalho, Francisco Borges Faria Dos Reis, Mansueto Gomes Neto
OBJECTIVE: To test the hypothesis that combined aerobic and resistance training and non-invasive ventilatory support result in additional benefits compared with combined aerobic and resistance training alone in heart failure patients. DESIGN: A randomized, single-blind, controlled study. SETTING: Cardiac rehabilitation center. PARTICIPANTS: A total of 46 patients with New York Heart Association class II/III heart failure were randomly assigned to a 10-week program of combined aerobic and resistance training, plus non-invasive ventilatory support ( n = 23) or combined aerobic and resistance training alone ( n = 23)...
April 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28353308/prognostic-value-of-red-blood-cell-distribution-width-in-patients-with-left-ventricular-systolic-dysfunction-insights-from-the-commit-hf-registry
#19
Jarosław Wasilewski, Łukasz Pyka, Michał Hawranek, Mateusz Tajstra, Michał Skrzypek, Michał Wasiak, Kamil Suliga, Kamil Bujak, Mariusz Gąsior
BACKGROUND: Previous studies have reported that in patients with heart failure, an increased value of red cell distribution width (RDW) is associated with adverse outcomes. Nonetheless, data regarding the association between RDW values and long-term mortality in patients with left ventricular systolic dysfunction (LVSD) are lacking. The aim of this investigation was to examine the relationship between mortality and RDW in patients with ischemic and non-ischemic LVSD. METHODS: Under analysis was 1734 patients with a left ventricular ejection fraction (LVEF) ≤ 35% of whom were hospitalized between 2009 and 2013...
March 29, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28356281/sex-and-race-related-differences-in-characteristics-and-outcomes-of-hospitalizations-for-heart-failure-with-preserved-ejection-fraction
#20
Parag Goyal, Tracy Paul, Zaid I Almarzooq, Janey C Peterson, Udhay Krishnan, Rajesh V Swaminathan, Dmitriy N Feldman, Martin T Wells, Maria G Karas, Irina Sobol, Mathew S Maurer, Evelyn M Horn, Luke K Kim
BACKGROUND: Sex and race have emerged as important contributors to the phenotypic heterogeneity of heart failure with preserved ejection fraction (HFpEF). However, there remains a need to identify important sex- and race-related differences in characteristics and outcomes using a nationally representative cohort. METHODS AND RESULTS: Data were obtained from the Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project-Nationwide Inpatient Sample files between 2008 and 2012...
March 29, 2017: Journal of the American Heart Association
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