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Heart Failure

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1028 papers 100 to 500 followers
By Elvis Amao Internal Medicine , Cardiology and infectious diseases
https://www.readbyqxmd.com/read/29234860/impact-of-right-ventricular-distensibility-on-congestive-heart-failure-with-preserved-left-ventricular-ejection-fraction-in-the-elderly
#1
Daisuke Harada, Hidetsugu Aasanoi, Ryuichi Ushijima, Takahisa Noto, Junya Takagawa, Hisanari Ishise, Hiroshi Inoue
To elucidate involvement of age-related impairments of right ventricular (RV) distensibility in the elderly congestive heart failure (CHF), we examined the prevalence of less-distensible right ventricle in patients with preserved left ventricular ejection fraction (LVEF) over a wide range of ages. In 893 patients aged from 40 to 102 years, we simultaneously recorded electrocardiogram, phonocardiogram, and jugular venous pulse wave. Using signal-processing techniques, the prominent 'Y' descent of jugular pulse waveform was detected as a hemodynamic sign of a less-distensible right ventricle...
December 13, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29235399/reviewing-the-use-of-ventricular-assist-devices-in-the-elderly-where-do-we-stand-today
#2
Nandini Nair, Enrique Gongora
Implantation of left ventricular assist devices (LVADS) in older patients appears to be an attractive option in the wake of donor shortage and increasing incidence and prevalence of end stage heart failure. Since the inception of the artificial heart program half a century ago tremendous progress in research and development has led to utilization of more sophisticated devices. VADs have therefore emerged as a successful therapy for extending life with meaningful quality. Areas covered: This review will address the use of LVADS as a bridge to transplantation, destination therapy and comparison of LVAD therapy with alternate list heart transplantation in the elderly population...
December 13, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29192360/hyperglycemia-induced-cardiac-contractile-dysfunction-in-the-diabetic-heart
#3
REVIEW
Raphael M Singh, Tahreem Waqar, Frank C Howarth, Ernest Adeghate, Keshore Bidasee, Jaipaul Singh
The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in ryanodine receptor, reduced activity of the sarcoplasmic reticulum calcium pump (SERCA) and, along with reduced activity of the sodium-calcium exchanger (NCX) and alterations in myofilament, collectively cause a calcium imbalance within the diabetic cardiomyocytes...
December 1, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#4
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29154416/left-ventricular-global-longitudinal-strain-in-patients-with-heart-failure-with-preserved-ejection-fraction-outcomes-following-an-acute-heart-failure-hospitalization
#5
Jonathan Buggey, Fawaz Alenezi, Hyun Ju Yoon, Matthew Phelan, Adam D DeVore, Michel G Khouri, Phillip J Schulte, Eric J Velazquez
AIMS: While abnormal resting LV GLS has been described in patients with chronic heart failure with preserved ejection fraction (HFpEF), its prognostic significance when measured during an acute heart failure hospitalization remains unclear. We assessed the association between left ventricular global longitudinal strain (LV GLS) and outcomes in patients hospitalized with acute HFpEF. METHODS AND RESULTS: We studied patients discharged alive for acute HFpEF from Duke University Medical Center between 2007 and 2010...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154431/association-between-electrocardiographic-and-echocardiographic-markers-of-stage-b-heart-failure-and-cardiovascular-outcome
#6
Hong Yang, Thomas H Marwick, Ying Wang, Mark Nolan, Kazuaki Negishi, Faisal Khan, Peter M Okin
AIMS: The detection of non-ischaemic (mainly hypertension, diabetes, and obesity) stage B heart failure (SBHF) may facilitate the recognition of those at risk of progression to overt HF and HF prevention. We sought the relationship of specific electrocardiographic (ECG) markers of SBHF to echocardiographic features of SBHF and their prognostic value for development of HF. The ECG markers were Cornell product (Cornell-P), P-wave terminal force in lead V1 (PTFV1), ST depression in lead V5 V6 (minSTmV5V6), and increased heart rate...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29124524/high-comorbidity-measured-by-the-charlson-comorbidity-index-associates-with-higher-1-year-mortality-risks-in-elderly-patients-experiencing-a-first-acute-heart-failure-hospitalization
#7
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Jonathan Franco, Abelardo Montero, Xavier Corbella
BACKGROUND: Comorbidity is related to poor health results in chronic heart failure (HF). AIMS: The purpose of the study was to assess whether a high Charlson Comorbidity Index score (CCI) relates to 1 year mortality after a first hospitalization for acute HF (AHF). METHODS: We reviewed the medical records of 897 patients > 65 years of age admitted within a two-year period because of a first episode of AHF. We analyzed two groups: low (CCI ≤ 2) and high (CCI > 2) comorbidity...
November 9, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29124734/evolution-of-a-geriatric-syndrome-pathophysiology-and-treatment-of-heart-failure-with-preserved-ejection-fraction
#8
REVIEW
Bharathi Upadhya, Barbara Pisani, Dalane W Kitzman
The majority of older adults who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). The prevalence of this syndrome is increasing, and the prognosis is not improving, unlike that of HF with reduced ejection fraction (HFrEF). Individuals with HFpEF have severe symptoms of effort intolerance, poor quality of life, frequent hospitalizations, and greater likelihood of death. Despite the importance of HFpEF, there are numerous major gaps in our understanding of its pathophysiology and management...
November 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29041005/cardiogenic-shock-during-first-infusion-of-anthracycline-chemotherapy-in-a-patient-with-hodgkin-lymphoma-an-unusual-event
#9
Giulio Binaghi, Damiana Congia, Stefano Cossa, Stefania Massidda, Daniele Pasqualucci, Federica Pilo, Emanuela Serra, Emanuele Angelucci, Maurizio Porcu
INTRODUCTION: Hodgkin lymphoma (HL) is one of the most common types of cancers of the lymphatic system. The currently available therapies enable a cure in approximately 80-85% of treated patients. However, the cardiotoxicity of HL treatment has become a major cause of morbidity and mortality in survivors mainly related to the use of anthracycline. CASE REPORT: An HL, staged IIIB, was diagnosed in a 60-year-old man with no cardiovascular disease. During the first cycle of ABVD chemotherapy (Adriamycin; bleomycin; vinblastine; dacarbazine), near the end of the dacarbazine infusion, the patient presented a sudden cardiogenic shock characterized by a severe left ventricular systolic dysfunction...
October 18, 2017: Cardiology
https://www.readbyqxmd.com/read/29135484/update-on-revascularization-in-patients-with-heart-failure-and-coronary-artery-disease
#10
Fadi Hage, Ali Hage, Haissam Haddad, Bob Kiaii
PURPOSE OF REVIEW: The review explores the recent findings surrounding the evaluation and the treatment of patients with heart failure and coronary artery disease. It also shed the light on the gaps in this area. RECENT FINDINGS: Surgical revascularization in patients with ischemic cardiomyopathy has the potential to offer symptomatic and survival benefits. SUMMARY: Patients with heart failure and coronary artery disease should be considered candidates for revascularization on the basis of their symptoms, extent of the disease, and comorbidities...
November 14, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29135524/a-palliative-approach-for-heart-failure-end-of-life-care
#11
Jane Maciver, Heather J Ross
PURPOSE OF REVIEW: The current review discusses the integration of guideline and evidence-based palliative care into heart failure end-of-life (EOL) care. RECENT FINDINGS: North American and European heart failure societies recommend the integration of palliative care into heart failure programs. Advance care planning, shared decision-making, routine measurement of symptoms and quality of life and specialist palliative care at heart failure EOL are identified as key components to an effective heart failure palliative care program...
November 10, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29113705/recent-advances-in-diagnosis-and-treatment-of-cardiac-amyloidosis
#12
REVIEW
Yasuhiro Izumiya, Seiji Takashio, Seitaro Oda, Yasuyuki Yamashita, Kenichi Tsujita
Cardiac amyloidosis (CA) has been believed to be a rare disease for a long time, but recent sophisticated diagnostic modalities demonstrate that a considerable number of CA patients are hidden among those diagnosed with heart failure. Prognosis of CA was poor, but recent developments in therapeutic interventions have improved survival in these patients. Therefore, early detection and precise diagnosis is clinically important. In this review article, we overview recent progress in diagnosis and treatment for CA...
November 4, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29115016/pulmonary-hypertension-in-stiff-left-atrial-syndrome-pathogenesis-and-treatment-in-one
#13
Micha T Maeder, Reto Nägele, Philipp Rohner, Daniel Weilenmann
We present the rare case of a patient with pulmonary hypertension in the context of the stiff left atrial syndrome after extensive catheter ablation, a unique constellation characterized by high pulmonary artery and pulmonary artery wedge pressures due to left atrial dysfunction but normal left ventricular end-diastolic pressure, normal mitral valve, and absence pulmonary vein stenosis. This patient was surprisingly oligosymptomatic, however, which may have been due to a persistent post-puncture atrial septal defect, which may have allowed for controlled left atrial decompression, which is in line with the novel concept of the catheter-based creation of an intracardiac shunt as a treatment for heart failure...
November 8, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29116107/micrornas-regulating-superoxide-dismutase-2-are-new-circulating-biomarkers-of-heart-failure
#14
Emilie Dubois-Deruy, Marie Cuvelliez, Jan Fiedler, Henri Charrier, Paul Mulder, Eleonore Hebbar, Angelika Pfanne, Olivia Beseme, Maggy Chwastyniak, Philippe Amouyel, Vincent Richard, Christophe Bauters, Thomas Thum, Florence Pinet
Although several risk factors such as infarct size have been identified, the progression of heart failure (HF) remains difficult to predict in clinical practice. Using an experimental rat model of post-myocardial infarction (MI), we previously identified 45 proteins differentially modulated during HF by proteomic analysis. This study sought to identify microRNAs (miRNAs) able to regulate these proteins and to test their relevance as biomarkers for HF. In silico bioinformatical analysis selected 13 miRNAs related to the 45 proteins previously identified...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118769/clinical-usefulness-of-urinary-liver-fatty-acid-binding-protein-excretion-for-predicting-acute-kidney-injury-during-the-first-7-days-and-the-short-term-prognosis-in-acute-heart-failure-patients-with-non-chronic-kidney-disease
#15
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
Background: The clinical significance of urinary liver fatty acid-binding protein (u-LFABP) in acute heart failure (AHF) patients remains unclear. Methods and Results: The u-LFABP levels on admission of 293 AHF patients were analyzed. The patients were divided into 2 groups according to the u-LFABP quartiles (Q1, Q2, and Q3 = low u-LFABP [L] group vs. Q4 = high u-LFABP [H] group). We evaluated the diagnostic and prognostic value of u-LFABP and compared the findings between the chronic kidney disease (CKD; n = 165) and non-CKD patients (n = 128)...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29119731/development-and-current-clinical-application-of-ventricular-assist-devices-in-china
#16
Yue Wu, Liang-Fan Zhu, Yun Luo
Heart failure has become one of the biggest threats to human health. Transplantation remains the most effective therapy for heart failure, but because of the shortage of donors, it cannot meet the demand. Ventricular assist devices (VADs) were developed to treat heart failure, and have now been clinically applied worldwide. As the country with the largest population, China is also facing the threat of heart failure. However, the development of VADs in China is very slow and is seldom discussed. This paper first talks about the background for VAD development in China...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29120543/-right-heart-failure-important-forold-and-young-patientsa-challenge-from-the-acute-to-the-chronic
#17
Latifa Jedday, Véronique Trombert, Philippe Meyer, Georg Ehret, Jean-Luc Reny, Clémence Cuvelier
The prevalence of the right heart failure (RHF) is poorly known. However, RHF is often a consequence of left heart failure due to an interdependance between both ventricles. RHF should be indentified because of prognostic relevance. RHF is defined by the inability to maintain adequate cardiac output through the lung circulation. It can result from volume overload, pressure overload, or a disorder of systolic function. Adaptive mechanisms such as dilation or hyper-trophy will maintain adequate hemodynamics. Once these mechanisms become insufficient, congestive signs and hemodynamic consequences will appear...
November 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29121731/normal-findings-on-noninvasive-cardiac-assessment-and-the-prediction-of-heart-failure-the-multi-ethnic-study-of-atherosclerosis-mesa
#18
Stephen T Broughton, Wesley T O'Neal, Mouaz Al-Mallah, David A Bluemke, Susan R Heckbert, Joao A C Lima, Elsayed Z Soliman
BACKGROUND: It is unknown if normal findings on noninvasive cardiac assessment are able to identify individuals who are low risk for developing heart failure (HF). METHODS: We examined if normal findings on the routine electrocardiogram (ECG) and cardiac magnetic resonance imaging (MRI) were able to identify individuals who are low risk for developing HF in 4986 (mean age=62±10years; 52% women; 39% White; 13% Chinese-American; 26% Black; 22% Hispanic) participants from the Multi-Ethnic Study of Atherosclerosis who were free of clinically apparent HF at baseline...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29094264/treating-disease-mechanisms-in-patients-with-heart-failure-and-diabetes-mellitus
#19
REVIEW
Amanda Trang, David Aguilar
PURPOSE OF REVIEW: Diabetes and heart failure commonly coexist and portend worsened prognosis than either disease alone. We explore mechanisms that may serve as potential treatment targets and review the effects of various contemporary glucose-lowering agents on heart failure outcomes. RECENT FINDINGS: Promising data has emerged on sodium-glucose cotransporter 2 (SLGT2) inhibitors as the first class of agents to improve cardiovascular mortality and heart failure outcomes in diabetic individuals both with and without established heart failure...
December 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29099931/clinical-fractures-among-older-men-with-diabetes-are-mediated-by-diabetic-complications
#20
Richard H Lee, Richard Sloane, Carl Pieper, Kenneth W Lyles, Robert A Adler, Courtney Van Houtven, Joanne LaFleur, Cathleen Colón-Emeric
Introduction: Type 2 diabetes mellitus among older women has been associated with increased bone mineral density, but paradoxically increased fracture risk. Findings among older men have varied, and potential mechanisms have not been fully elucidated. Methods: Retrospective study of male Veterans 65-99 years of age who received primary care in the Veterans Health Administration (VHA) from 2000 to 2010, using administrative data from all 146 VHA medical centers linked to Centers for Medicare and Medicaid Services (CMS) Medicare fee-for-service data...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
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