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AA and physiologic changes

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4 papers 0 to 25 followers
By Christopher Cook Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's, 60000 beds referral base
https://www.readbyqxmd.com/read/27617300/coupling-neurogenetics-gars%C3%A2-and-a-nutrigenomic-based-dopaminergic-agonist-to-treat-reward-deficiency-syndrome-rds-targeting-polymorphic-reward-genes-for-carbohydrate-addiction-algorithms
#1
Kenneth Blum, Thomas Simpatico, Rajendra D Badgaiyan, Zsolt Demetrovics, James Fratantonio, Gozde Agan, Marcelo Febo, Mark S Gold
Earlier work from our laboratory, showing anti-addiction activity of a nutraceutical consisting of amino-acid precursors and enkephalinase inhibition properties and our discovery of the first polymorphic gene (Dopamine D2 Receptor Gene [DRD2]) to associate with severe alcoholism serves as a blue-print for the development of "Personalized Medicine" in addiction. Prior to the later genetic finding, we developed the concept of Brain Reward Cascade, which continues to act as an important component for stratification of addiction risk through neurogenetics...
2015: Journal of Reward Deficiency Syndrome
https://www.readbyqxmd.com/read/24227768/a-double-blind-within-subject-comparison-of-spontaneous-opioid-withdrawal-from-buprenorphine-versus-morphine
#2
RANDOMIZED CONTROLLED TRIAL
D Andrew Tompkins, Michael T Smith, Miriam Z Mintzer, Claudia M Campbell, Eric C Strain
Preliminary evidence suggests that there is minimal withdrawal after the cessation of chronically administered buprenorphine and that opioid withdrawal symptoms are delayed compared with those of other opioids. The present study compared the time course and magnitude of buprenorphine withdrawal with a prototypical μ-opioid agonist, morphine. Healthy, out-of-treatment opioid-dependent residential volunteers (N = 7) were stabilized on either buprenorphine (32 mg/day i.m.) or morphine (120 mg/day i.m.) administered in four divided doses for 9 days...
February 2014: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/25469651/possible-evidence-for-re-regulation-of-hpa-axis-and-brain-reward-systems-over-time-in-treatment-in-prescription-opioid-dependent-patients
#3
Scott C Bunce, Jonathan D Harris, Edward O Bixler, Megan Taylor, Emilie Muelly, Erin Deneke, Kenneth W Thompson, Roger E Meyer
OBJECTIVES: There is growing evidence for a neuroadaptive model underlying vulnerability to relapse in opioid dependence. The purpose of this study was to evaluate clinical measures hypothesized to mirror elements of allostatic dysregulation in patients dependent on prescription opioids at 2 time points after withdrawal, compared with healthy control participants. METHODS: Recently withdrawn (n = 7) prescription opioid-dependent patients were compared with the patients in supervised residential care for 2 to 3 months (extended care; n = 7) and healthy controls (n = 7) using drug cue reactivity, affect-modulated startle response tasks, salivary cortisol, and 8 days of sleep actigraphy...
January 2015: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/24724889/alcoholics-anonymous-and-twelve-step-recovery-a-model-based-on-social-and-cognitive-neuroscience
#4
Marc Galanter
BACKGROUND: In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. OBJECTIVE: This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change...
May 2014: American Journal on Addictions
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