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AA and physiologic changes

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6 papers 25 to 100 followers
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://www.readbyqxmd.com/read/29225566/cdk5-is-essential-for-amphetamine-to-increase-dendritic-spine-density-in-hippocampal-pyramidal-neurons
#1
Soledad Ferreras, Guillermo Fernández, Víctor Danelon, María V Pisano, Luján Masseroni, Christopher A Chapleau, Favio A Krapacher, Estela C Mlewski, Daniel H Mascó, Carlos Arias, Lucas Pozzo-Miller, María G Paglini
Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with learning and memory. Recent reports suggest that Cdk5 plays an important role in drug addiction, but its role in psychostimulant's effects on dendritic spines in hippocampus remain unknown. We used in vivo and in vitro approaches to demonstrate that amphetamine increases dendritic spine density in pyramidal neurons of the hippocampus...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29179227/-on-the-risk-of-dependence-on-gabapentinoids
#2
Udo Bonnet, Norbert Scherbaum
In the last ten years, the prescriptions of the gabapentinoids gabapentin and pregabalin increased largely also in Germany. Since several national and international pharmacovigilance-databases have warned for abuse liabilities and overdose fatalities in association with both gabapentinoids, which moreover, became to be sold on internet and black-markets, their addictive power has been subject to an ongoing clinical debate. As pre- and post-approval clinical trials did not reveal significant signs of dependence on gabapentin or pregabalin, we systematically searched in PubMed and Scopus for clinical studies and case reports being associated with abuse of and dependence on these drugs...
November 27, 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27617300/coupling-neurogenetics-gars%C3%A2-and-a-nutrigenomic-based-dopaminergic-agonist-to-treat-reward-deficiency-syndrome-rds-targeting-polymorphic-reward-genes-for-carbohydrate-addiction-algorithms
#3
Kenneth Blum, Thomas Simpatico, Rajendra D Badgaiyan, Zsolt Demetrovics, James Fratantonio, Gozde Agan, Marcelo Febo, Mark S Gold
Earlier work from our laboratory, showing anti-addiction activity of a nutraceutical consisting of amino-acid precursors and enkephalinase inhibition properties and our discovery of the first polymorphic gene (Dopamine D2 Receptor Gene [DRD2]) to associate with severe alcoholism serves as a blue-print for the development of "Personalized Medicine" in addiction. Prior to the later genetic finding, we developed the concept of Brain Reward Cascade, which continues to act as an important component for stratification of addiction risk through neurogenetics...
2015: Journal of Reward Deficiency Syndrome
https://www.readbyqxmd.com/read/24227768/a-double-blind-within-subject-comparison-of-spontaneous-opioid-withdrawal-from-buprenorphine-versus-morphine
#4
RANDOMIZED CONTROLLED TRIAL
D Andrew Tompkins, Michael T Smith, Miriam Z Mintzer, Claudia M Campbell, Eric C Strain
Preliminary evidence suggests that there is minimal withdrawal after the cessation of chronically administered buprenorphine and that opioid withdrawal symptoms are delayed compared with those of other opioids. The present study compared the time course and magnitude of buprenorphine withdrawal with a prototypical μ-opioid agonist, morphine. Healthy, out-of-treatment opioid-dependent residential volunteers (N = 7) were stabilized on either buprenorphine (32 mg/day i.m.) or morphine (120 mg/day i.m.) administered in four divided doses for 9 days...
February 2014: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/25469651/possible-evidence-for-re-regulation-of-hpa-axis-and-brain-reward-systems-over-time-in-treatment-in-prescription-opioid-dependent-patients
#5
Scott C Bunce, Jonathan D Harris, Edward O Bixler, Megan Taylor, Emilie Muelly, Erin Deneke, Kenneth W Thompson, Roger E Meyer
OBJECTIVES: There is growing evidence for a neuroadaptive model underlying vulnerability to relapse in opioid dependence. The purpose of this study was to evaluate clinical measures hypothesized to mirror elements of allostatic dysregulation in patients dependent on prescription opioids at 2 time points after withdrawal, compared with healthy control participants. METHODS: Recently withdrawn (n = 7) prescription opioid-dependent patients were compared with the patients in supervised residential care for 2 to 3 months (extended care; n = 7) and healthy controls (n = 7) using drug cue reactivity, affect-modulated startle response tasks, salivary cortisol, and 8 days of sleep actigraphy...
January 2015: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/24724889/alcoholics-anonymous-and-twelve-step-recovery-a-model-based-on-social-and-cognitive-neuroscience
#6
Marc Galanter
BACKGROUND: In the course of achieving abstinence from alcohol, longstanding members of Alcoholics Anonymous (AA) typically experience a change in their addiction-related attitudes and behaviors. These changes are reflective of physiologically grounded mechanisms which can be investigated within the disciplines of social and cognitive neuroscience. OBJECTIVE: This article is designed to examine recent findings associated with these disciplines that may shed light on the mechanisms underlying this change...
May 2014: American Journal on Addictions
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