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Carbapenemase

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54 papers 0 to 25 followers Carbapenemase enterobacteria
https://www.readbyqxmd.com/read/27687074/carbapenemase-producing-enterobacteriaceae-in-the-uk-a-national-study-euscape-uk-on-prevalence-incidence-laboratory-detection-methods-and-infection-control-measures
#1
Pascale Trepanier, Kim Mallard, Danièle Meunier, Rachel Pike, Derek Brown, Janet P Ashby, Hugo Donaldson, F Mustafa Awad-El-Kariem, Indran Balakrishnan, Marc Cubbon, Paul R Chadwick, Michael Doughton, Rachael Doughton, Fiona Hardiman, Graham Harvey, Carolyne Horner, John Lee, Jonathan Lewis, Anne Loughrey, Rohini Manuel, Helena Parsons, John D Perry, Gemma Vanstone, Graham White, Nandini Shetty, John Coia, Camilla Wiuff, Katie L Hopkins, Neil Woodford
OBJECTIVES: To estimate UK prevalence and incidence of clinically significant carbapenemase-producing Enterobacteriaceae (CPE), and to determine epidemiological characteristics, laboratory methods and infection prevention and control (IPC) measures in acute care facilities. METHODS: A 6 month survey was undertaken in November 2013-April 2014 in 21 sentinel UK laboratories as part of the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) project...
September 29, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27593176/the-global-epidemiology-of-carbapenemase-producing-enterobacteriaceae
#2
David van Duin, Yohei Doi
Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases)...
August 11, 2016: Virulence
https://www.readbyqxmd.com/read/27597392/risk-factors-associated-with-carbapenemase-producing-klebsiella-pneumoniae-fecal-carriage-a-case-control-study-in-a-spanish-tertiary-care-hospital
#3
Ana Madueño, Jonathan González García, Maria José Ramos, Yanet Pedroso, Zaida Díaz, Jesus Oteo, María Lecuona
Asymptomatic colonization of the gastrointestinal tract by carbapenemase-producing Enterobacteriaceae is an important reservoir for transmission that may precede infection. This prospective, observational, case-control study was designed to identify risk factors for carbapenemase-producing Klebsiella pneumoniae (CPKP) fecal carriage. This study included 87 cases and 200 controls. Multivariate analysis identified length of stay (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.01-1.03; P = .03), previous hospitalization (OR, 5...
September 2, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27608310/-approach-to-directed-therapy-after-knowledge-of-the-isolate-carbapenemase-producing-enterobacteriaceae-multidrug-resistant-pseudomonas-aeruginosa-and-carbapenem-resistant-acinetobacter-baumannii
#4
REVIEW
J A Martínez
Directed treatment of infections due to multidrug-resistant Gram-negative bacilli is a difficult task, since it requires the use of a limited number of antibiotics that are often more toxic and possibly less efficacious than β-lactams and fluoroquinolones. Furthermore, there are very few controlled trials informing on the relative efficacy of different therapeutic strategies. As a general rule, it is recommended to use at least two active drugs or a combination with proven synergistic activity in vitro, because several observational studies have associated this practice with better outcomes and as a measure to potentially curb the emergence of further resistance...
September 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27608312/-old-and-new-antibiotics-for-therapy-of-multidrug-resistant-bacteria
#5
REVIEW
V Pintado
The lack of new antibiotics for multidrug-resistant bacteria is a matter of concern in microorganisms such as Pseudomonas aeruginosa, ESBL- and carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, methicillin-resistant Staphylococcous aureus and vancomycin-resistant Enterococcus faecium. This situation has conditioned the reuse of "old" antibiotics (colistin, fosfomycin), the use of more recent antibiotics with new indications or dosage regimens (tigecycline, meropenem) and the introduction of "new" antibiotics (β-lactams, lipoglycopeptides, oxazolidinones) that are the subject of this review...
September 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27608313/-monotherapy-vs-combined-therapy-in-the-treatment-of-multi-drug-resistance-gramnegative-bacteria
#6
REVIEW
F Martínez-Sagasti, M A González-Gallego, A Moneo-González
The increasing number of multidrug resistant gram negative bacteria, particularly in patients with risk factors, but in those who suffer community infections as well, is doing more and more difficult to choose the appropriate treatment. The most challenging cases are due to the production of extended-spectrum-β-lactamases (ESBL) and carbapenemases. This mini-review will discuss the adequacy of administering carbapenems when suspecting infections due to ESBL that could be modified after knowing the MIC of the isolated bacteria and the combined therapy in cases of carbapenemases, being particularly important to include a carbapenem and/or colistine at high dosages in this combination...
September 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27584588/reducing-the-impact-of-carbapenem-resistant-enterobacteriaceae-on-vulnerable-patient-groups-what-can-be-done
#7
Gökhan Metan, Murat Akova
PURPOSE OF REVIEW: Carbapenem-resistant Enterobacteriaceae (CRE) is a worldwide challenge and associated with a high mortality rate in critically ill patients. This review focused on rapid diagnosis, optimization of antimicrobial therapy, and implication of effective infection control precautions to reduce impact of CRE on vulnerable patients. RECENT FINDINGS: Several new diagnostic assays have recently been described for the early diagnosis of CRE. Retrospective studies are supportive for colistin plus meropenem combination for the treatment of CRE infections; however, solid evidence is still lacking...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27530752/the-spread-of-kpc-producing-enterobacteriaceae-in-spain-wgs-analysis-of-the-emerging-high-risk-clones-of-klebsiella-pneumoniae-st11-kpc-2-st101-kpc-2-and-st512-kpc-3
#8
Jesús Oteo, María Pérez-Vázquez, Verónica Bautista, Adriana Ortega, Pilar Zamarrón, David Saez, Sara Fernández-Romero, Noelia Lara, Raquel Ramiro, Belén Aracil, José Campos
OBJECTIVES: We analysed the microbiological traits and population structure of KPC-producing Enterobacteriaceae isolates collected in Spain between 2012 and 2014. We also performed a comparative WGS analysis of the three major KPC-producing Klebsiella pneumoniae clones detected. METHODS: Carbapenemase and ESBL genes were sequenced. The Institut Pasteur MLST scheme was used. WGS data were used to construct phylogenetic trees, to identify the determinants of resistance and to de novo assemble the genome of one representative isolate of each of the three major K...
August 15, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27441063/epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-infections-in-mediterranean-countries
#9
REVIEW
Corrado Girmenia, Alessandra Serrao, Martina Canichella
Infections by Carbapenem-Resistant Enterobacteriaceae (CRE), in particular, carbapenem-resistant Klebsiella pneumoniae (CRKp), are a significant public health challenge worldwide. Resistance to carbapenems in enterobacteriaceae is linked to different mechanisms, including the production of the various types of enzymes like KPC, VIM, IMP, NDM, and OXA-48. Despite several attempts to control the spread of these infections at the local and national level, the epidemiological situation for CRKp had worsened in the last years in the Mediterranean area...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27379038/global-dissemination-of-carbapenemase-producing-klebsiella-pneumoniae-epidemiology-genetic-context-treatment-options-and-detection-methods
#10
REVIEW
Chang-Ro Lee, Jung Hun Lee, Kwang Seung Park, Young Bae Kim, Byeong Chul Jeong, Sang Hee Lee
The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniae is a major source of concern. K. pneumoniae carbapenemases (KPCs) and carbapenemases of the oxacillinase-48 (OXA-48) type have been reported worldwide. New Delhi metallo-β-lactamase (NDM) carbapenemases were originally identified in Sweden in 2008 and have spread worldwide rapidly. In this review, we summarize the epidemiology of K...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27328762/performance-evaluation-of-three-automated-identification-systems-in-detecting-carbapenem-resistant-enterobacteriaceae
#11
Qingwen He, Weiyuan Chen, Liya Huang, Qili Lin, Jingling Zhang, Rui Liu, Bin Li
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) is prevalent around the world. Rapid and accurate detection of CRE is urgently needed to provide effective treatment. Automated identification systems have been widely used in clinical microbiology laboratories for rapid and high-efficient identification of pathogenic bacteria. However, critical evaluation and comparison are needed to determine the specificity and accuracy of different systems. The aim of this study was to evaluate the performance of three commonly used automated identification systems on the detection of CRE...
June 21, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27329263/comparison-of-the-modified-hodge-test-carba-np-test-and-carbapenem-inactivation-method-as-screening-methods-for-carbapenemase-producing-enterobacteriaceae
#12
Kageto Yamada, Machiko Kashiwa, Katsumi Arai, Noriyuki Nagano, Ryoichi Saito
We compared three screening methods for carbapenemase-producing Enterobacteriaceae. While the Modified-Hodge test and Carba NP test produced false-negative results for OXA-48-like and mucoid NDM producers, the carbapenem inactivation method (CIM) showed positive results for these isolates. Although the CIM required cultivation time, it is well suited for general clinical laboratories.
September 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27337454/mobilization-of-carbapenemase-mediated-resistance-in-enterobacteriaceae
#13
Amy Mathers
There has been a dramatic increase in the last decade in the number of carbapenem-resistant Enterobacteriaceae, often leaving patients and their providers with few treatment options and resultant poor outcomes when an infection develops. The majority of the carbapenem resistance is mediated by bacterial acquisition of one of three carbapenemases (Klebsiella pneumoniae carbapenemase [KPC], oxacillinase-48-like [OXA-48], and the New Delhi metallo-β-lactamase [NDM]). Each of these enzymes has a unique global epidemiology and microbiology...
June 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27053674/evaluation-of-multiple-methods-for-detection-of-gastrointestinal-colonization-of-carbapenem-resistant-organisms-from-rectal-swabs
#14
Patricia J Simner, Isabella Martin, Belita Opene, Pranita D Tamma, Karen C Carroll, Aaron M Milstone
Rectal swabs from high-risk patients were screened for carbapenem-resistant organisms (CROs) using several methods. The direct MacConkey plate method was the most sensitive for CROs (95%), while chromID CARBA and the Check-Direct CPE screen assay were the most sensitive for the detection of carbapenemase-producing organisms (CPOs) (100%; all blaKPC). All methods had a specificity of >90% for CROs, and for CPOs, the specificity ranged from 85 to 98%. Broth enrichment methods performed poorly compared to direct inoculation methods, negating the need for the broth enrichment step...
June 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27042955/recent-advances-in-the-laboratory-detection-of-carbapenemase-producing-enterobacteriaceae
#15
Yasufumi Matsumura, Johann D Pitout
Carbapenemase-producing Enterobacteriaceae (CPE), mainly Klebsiella pneumoniae and Escherichia coli, have been increasing rapidly on a global scale and are considered to be significant health threats. The most common carbapenemases are KPCs, NDMs, OXA-48-like, IMPs and VIMs but their distribution and prevalence differs between countries. The accurate, simple, cost effective and rapid detection of carbapenemases in clinical laboratories is an important initial step to control the spread of CPE within institutions...
July 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27013887/insights-into-newer-antimicrobial-agents-against-gram-negative-bacteria
#16
REVIEW
Neelam Taneja, Harsimran Kaur
Currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. There are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have been revived from the past to tackle the menace of superbugs, including members of Enterobacteriaceae, Acinetobacter species, and Pseudomonas species. Very few newer antibiotics have been added to the pool of existing drugs...
2016: Microbiology Insights
https://www.readbyqxmd.com/read/26869070/-microbiological-methods-for-surveillance-of-carrier-status-of-multiresistant-bacteria
#17
Jesús Oteo, Germán Bou, Fernando Chaves, Antonio Oliver
The presence of colonised patients is one of the main routes for the spread of multiresistant bacteria, and its containment is a clinical and public health priority. Surveillance studies are essential for early detection of colonisation by these bacteria. This article discusses the different microbiological methods, both based on culturing and molecular methods, for detection of carriers of multiresistant bacteria. Those species with a high clinical/epidemiological impact or generating therapeutic difficulties are included: Methicillin-resistant Staphylococcus aureus, Enterococcus spp...
February 8, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/26862399/carbapenem-resistance-overview-of-the-problem-and-future-perspectives
#18
REVIEW
Georgios Meletis
Carbapenem resistance, mainly among Gram-negative pathogens, is an ongoing public-health problem of global dimensions. This type of antimicrobial resistance, especially when mediated by transferable carbapenemase-encoding genes, is spreading rapidly causing serious outbreaks and dramatically limiting treatment options. In this article, important key points related to carbapenem resistance are reviewed and future perspectives are discussed.
February 2016: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/26739152/the-problem-of-carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-detection
#19
REVIEW
Joseph D Lutgring, Brandi M Limbago
The emergence and spread of carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) are a significant clinical and public health concern. Reliable detection of CP-CRE is the first step in combating this problem. There are both phenotypic and molecular methods available for CP-CRE detection. There is no single detection method that is ideal for all situations.
March 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26675038/carbapenemase-producing-enterobacteriaceae-in-europe-assessment-by-national-experts-from-38-countries-may-2015
#20
Barbara Albiger, Corinna Glasner, Marc J Struelens, Hajo Grundmann, Dominique L Monnet
In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the 'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)' project to gain insights into the occurrence and epidemiology of carbapenemase-producing Enterobacteriaceae (CPE), to increase the awareness of the spread of CPE, and to build and enhance the laboratory capacity for diagnosis and surveillance of CPE in Europe. Data collected through a post-EuSCAPE feedback questionnaire in May 2015 documented improvement compared with 2013 in capacity and ability to detect CPE and identify the different carbapenemases genes in the 38 participating countries, thus contributing to their awareness of and knowledge about the spread of CPE...
2015: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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