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Carbapenemase

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93 papers 25 to 100 followers Carbapenemase enterobacteria
https://www.readbyqxmd.com/read/29456043/colistin-alone-versus-colistin-plus-meropenem-for-treatment-of-severe-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-an-open-label-randomised-controlled-trial
#1
Mical Paul, George L Daikos, Emanuele Durante-Mangoni, Dafna Yahav, Yehuda Carmeli, Yael Dishon Benattar, Anna Skiada, Roberto Andini, Noa Eliakim-Raz, Amir Nutman, Oren Zusman, Anastasia Antoniadou, Pia Clara Pafundi, Amos Adler, Yaakov Dickstein, Ioannis Pavleas, Rosa Zampino, Vered Daitch, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Inbar Levi, Tanya Babich, Lena E Friberg, Johan W Mouton, Ursula Theuretzbacher, Leonard Leibovici
BACKGROUND: Colistin-carbapenem combinations are synergistic in vitro against carbapenem-resistant Gram-negative bacteria. We aimed to test whether combination therapy improves clinical outcomes for adults with infections caused by carbapenem-resistant or carbapenemase-producing Gram-negative bacteria. METHODS: A randomised controlled superiority trial was done in six hospitals in Israel, Greece, and Italy. We included adults with bacteraemia, ventilator-associated pneumonia, hospital-acquired pneumonia, or urosepsis caused by carbapenem-non-susceptible Gram-negative bacteria...
February 15, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29444952/treatment-of-infections-caused-by-extended-spectrum-beta-lactamase-ampc-and-carbapenemase-producing-enterobacteriaceae
#2
REVIEW
Jesús Rodríguez-Baño, Belén Gutiérrez-Gutiérrez, Isabel Machuca, Alvaro Pascual
Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is challenging, and some of the few active drugs are not available in many countries. For extended-spectrum β-lactamase and AmpC producers, carbapenems are the drugs of choice, but alternatives are needed because the rate of carbapenem resistance is rising. Potential active drugs include classic and newer β-lactam-β-lactamase inhibitor combinations, cephamycins, temocillin, aminoglycosides, tigecycline, fosfomycin, and, rarely, fluoroquinolones or trimethoprim-sulfamethoxazole...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29371104/activity-of-ceftazidime-avibactam-against-carbapenemase-producing-enterobacteriaceae-from-urine-samples-obtained-during-the-infection-carbapenem-resistance-evaluation-surveillance-trial-icrest-in-spain
#3
María García-Castillo, Sergio García-Fernández, Rosa Gómez-Gil, Cristina Pitart, Marina Oviaño, Irene Gracia-Ahufinger, Jazmín Díaz-Regañón, Marta Tato, Rafael Cantón
The increasing rates of carbapenemase-producing Enterobacteriaceae (CPE) represent an important threat to health care systems and make treatment of CPE infections a challenge. The aim of the infection-carbapenem resistance evaluation surveillance trial (iCREST) was to determinate the prevalence of CPE in urine specimens in Spain and to evaluate the in vitro activity of ceftazidime-avibactam. Urine specimens (n=11,826) were included and activity of ceftazidime-avibactam and comparators were investigated by broth microdilution in CPE...
January 22, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29379644/update-on-new-research-in-gram-negative-infections-european-congress-of-clinical-microbiology-and-infectious-diseases-2017-22-25-april-vienna-austria
#4
Matteo Bassetti, Susan Mayor
European Congress of Clinical Microbiology and Infectious Diseases 2017 (22-25 April, Vienna, Austria). Collaborative studies between hospitals in Europe and across the USA provided new insights into assessing susceptibility patterns and optimizing antimicrobial therapy in patients with infections caused by Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae (CPE) and Pseudomonas aeruginosa.
February 2018: Future Science OA
https://www.readbyqxmd.com/read/29267233/carbapenem-resistance-a-review
#5
REVIEW
Francis S Codjoe, Eric S Donkor
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by transferable carbapenemase-encoding genes. This type of resistance genes are already widespread in certain parts of the world, particularly Europe, Asia and South America, while the situation in other places such as sub-Saharan Africa is not well documented. In this paper, we provide an in-depth review of carbapenem resistance providing up-to-date information on the subject...
December 21, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29274802/susceptibility-testing-and-detection-of-%C3%AE-lactam-resistance-mechanisms-in-enterobacteriaceae-a-multicentre-national-proficiency-study
#6
María Díez-Aguilar, María-Carmen Conejo, María-Isabel Morosini, Núria Tormo Palop, Concepción Gimeno, Rafael Cantón, Álvaro Pascual
A nationwide study was developed to evaluate the ability of 60 Spanish clinical microbiology laboratories to predict the underlying β-lactam resistance mechanisms of 12 Enterobacteriaceae strains (CCS01-CCS12). Results obtained by two reference laboratories were compared with those reported by the participants that used their own routine susceptibility testing methodology. CLSI interpretive criteria were used in 53.3% of the centres, while 46.7% used EUCAST. The overall categorical agreement (CA) was 85.5%...
December 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29146039/clinical-features-and-outcomes-of-bacteraemia-due-to-oxa-48-like-carbapenemase-producing-klebsiella-pneumoniae-in-a-tertiary-hospital
#7
Ana Madueño, Jonathan González-García, María Del Mar Alonso Socas, María Antonia Miguel Gómez, María Lecuona
INTRODUCTION: Limited therapeutic options and high mortality make the management of OXA-48-like carbapenemase-producing Klebsiella pneumoniae (KPOXA-48) bacteraemia complicated. The aim of the study was to describe the clinical characteristics of KPOXA-48 bacteraemia between October 2013 and December 2016. MATERIAL AND METHODS: The variables to analyse were retrospectively collected from medical records. Carbapenemase production was confirmed by phenotypic and molecular methods...
November 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29115369/useful-independent-factors-for-distinguish-infection-and-colonization-in-patients-with-urinary-carbapenemase-producing-enterobacteriaceae-isolation
#8
L López-González, F J Candel, J M Viñuela-Prieto, J González-Del Castillo, A B García, I Pena, I Rodríguez-Avial
OBJECTIVE: The aim of this study is to know epidemiologic and clinical differences among those patients colonized or infected by carbapenemase-producing Enterobacteriaceae (CPE) and develop a predictive model to facilitate the clinical approach concerning to start antimicrobial therapy. METHODS: Observational retrospective cohort study was performed involving all patients with Urine carbapenemase-producing Enterobacteriaceae isolation (UCPEI) between November 2013 and July 2015...
November 7, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29126110/risks-of-infection-and-mortality-among-patients-colonized-with-kpc-producing-klebsiella-pneumoniae-validation-of-scores-and-proposal-for-management
#9
Angela Cano, Belén Gutiérrez-Gutiérrez, Isabel Machuca, Irene Gracia-Ahufinger, Elena Pérez-Nadales, Manuel Causse, Juan José Castón, Julia Guzman-Puche, Julian Torre-Giménez, Lara Kindelán, Luis Martínez-Martinez, Jesús Rodriguez-Baño, Julian Torre-Cisneros
Background: The management and indication of empirical treatment in Klebsiella pneumoniae-carbapenemase producing K. pneumoniae (KPC-Kp) colonized patients should be improved. Methods: A prospective cohort of 94 patients colonized by KPC-Kp was followed for 90 days to validate: (i) the Giannella risk score (GRS) to predict the development of any type of KPC-Kp infection and (ii) the INCREMENT-CPE score (ICS) to predict 30-day mortality in patients with infection...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28961793/covert-dissemination-of-carbapenemase-producing-klebsiella-pneumoniae-kpc-in-a-successfully-controlled-outbreak-long-and-short-read-whole-genome-sequencing-demonstrate-multiple-genetic-modes-of-transmission
#10
Jessica Martin, Hang T T Phan, Jacqueline Findlay, Nicole Stoesser, Louise Pankhurst, Indre Navickaite, Nicola De Maio, David W Eyre, Giles Toogood, Nicolas M Orsi, Andrew Kirby, Nicola Young, Jane F Turton, Robert L R Hill, Katie L Hopkins, Neil Woodford, Tim E A Peto, A Sarah Walker, Derrick W Crook, Mark H Wilcox
Background: Carbapenemase-producing Enterobacteriaceae (CPE), including KPC-producing Klebsiella pneumoniae (KPC-Kpn), are an increasing threat to patient safety. Objectives: To use WGS to investigate the extent and complexity of carbapenemase gene dissemination in a controlled KPC outbreak. Materials and methods: Enterobacteriaceae with reduced ertapenem susceptibility recovered from rectal screening swabs/clinical samples, during a 3 month KPC outbreak (2013-14), were investigated for carbapenemase production, antimicrobial susceptibility, variable-number-tandem-repeat profile and WGS [short-read (Illumina), long-read (MinION)]...
November 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28990132/oxa-48-like-carbapenemases-producing-enterobacteriaceae-in-different-niches
#11
REVIEW
Assia Mairi, Alix Pantel, Albert Sotto, Jean-Philippe Lavigne, Aziz Touati
The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences. To date, 11 OXA-48-like variants have been identified, with classical OXA-48 being the most widespread. These enzymes show high-level hydrolytic activity against penicillins and low-level hydrolysis towards carbapenems. Since the first description of the OXA-48 carbapenemase in Turkey, bacterial strains producing the enzyme have been extensively reported in nosocomial and community outbreaks in many parts of the word, particularly in the Mediterranean area and European countries...
October 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29020404/colistin-vs-ceftazidime-avibactam-in-the-treatment-of-infections-due-to-carbapenem-resistant-enterobacteriaceae
#12
David van Duin, Judith J Lok, Michelle Earley, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Yohei Doi, Keith S Kaye, Vance G Fowler, David L Paterson, Robert A Bonomo, Scott Evans
Background: The efficacy of ceftazidime-avibactam - a cephalosporin-β-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase (KPC)-producing carbapenem-resistant Enterobacteriaceae (CRE) - as compared to colistin remains unknown. Methods: Patients initially treated with either ceftazidime-avibactam or colistin for CRE infections were selected from the Consortium on resistance against carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), a prospective, multicenter, observational study...
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29029114/carbapenem-resistant-citrobacter-spp-isolated-in-spain-from-2013-to-2015-produced-a-variety-of-carbapenemases-including-vim-1-oxa-48-kpc-2-ndm-1-and-vim-2
#13
David M Arana, Adriana Ortega, Eva González-Barberá, Noelia Lara, Verónica Bautista, Dolores Gómez-Ruíz, David Sáez, Sara Fernández-Romero, Belén Aracil, María Pérez-Vázquez, José Campos, Jesús Oteo
Objectives: There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013-15). Methods: In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE...
September 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28893689/management-of-kpc-producing-klebsiella-pneumoniae-infections
#14
REVIEW
M Bassetti, D R Giacobbe, H Giamarellou, C Viscoli, G L Daikos, G Dimopoulos, F G De Rosa, E J Giamarellos-Bourboulis, G M Rossolini, E Righi, I Karaiskos, M Tumbarello, D P Nicolau, P L Viale, G Poulakou
BACKGROUND: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas. AIMS: To provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions. SOURCES: PubMed search for relevant publications related to the management of KPC-KP infections. CONTENTS: A panel of experts developed a list of 12 questions to be addressed...
September 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28901793/intravenous-fosfomycin-for-the-treatment-of-hospitalized-patients-with-serious-infections
#15
Andrew F Shorr, Jason M Pogue, John F Mohr
With the worldwide increase in the rates of antimicrobial resistance, antimicrobials with novel mechanisms of action are needed to fill a void in the antimicrobial armamentarium. Areas covered: Intravenous fosfomycin has been studied extensively in a wide variety of infections including cUTI, lower respiratory tract infection, bone and joint infections, endocarditis, meningitis, and bacteremia outside of the United States. This paper reviews the in vitro activity, pharmacokinetic properties, and clinical experience of intravenous fosfomycin in hospitalized patients with serious infections...
October 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28865742/review-molecular-detection-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-enterobacteriaceae-in-a-clinical-setting
#16
REVIEW
Ineke G H Rood, Qingge Li
Enterobacteriaceae are a common source of both community- and hospital-acquired infections. The resistance of Enterobacteriaceae to β-lactam antibiotics is a major public health problem and rapid detection is essential for the proper management of infections. Not only for the initiation of the proper antimicrobial regimen but also to stop the spread of multi-resistant bacteria. In this review, molecular methods that detect extended-spectrum-β-lactamase-harboring and carbapenem-resistant Enterobacteriaceae were discussed...
November 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28847258/-formulation-of-neomycin-and-streptomycin-for-the-digestive-decontamination-of-carbapenemases-producing-klebsiella-pneumoniae
#17
Julia López-Santamaría Donoso, Isabel Viguera Guerra
No abstract text is available yet for this article.
September 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28712369/a-hospital-based-matched-case-control-study-to-identify-risk-factors-for-clinical-infection-with-oxa-48-producing-klebsiella-pneumoniae-in-rectal-carriers
#18
A Madueño, J Gonzalez Garcia, A Aguirre-Jaime, M Lecuona
Asymptomatic colonisation of the gastrointestinal tract by carbapenemase-producing Enterobacteriaceae is an important reservoir for transmission, which may precede infection. This retrospective observational case-control study was designed to identify risk factors for developing clinical infection with OXA-48-producing Klebsiella pneumoniae in rectal carriers during hospitalisation. Case patients (n = 76) had carbapenemase-producing K. pneumoniae (CPKP) infection and positive rectal culture for CPKP. Control patients (n = 174) were those with rectal colonisation with CPKP but without CPKP infection...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28637265/importance-of-carbapenemase-production-detection-in-carbapenem-resistant-enterobacteriaceae-looking-beyond-epidemiological-purposes
#19
Adriana Jimenez, Lilian Abbo, Merhawi T Gebrezgi
No abstract text is available yet for this article.
October 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28507112/mcr-1-and-oxa-48-in-vivo-acquisition-in-kpc-producing-escherichia-coli-after-colistin-treatment
#20
Racha Beyrouthy, Frederic Robin, Aude Lessene, Igor Lacombat, Laurent Dortet, Thierry Naas, Valérie Ponties, Richard Bonnet
The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France...
August 2017: Antimicrobial Agents and Chemotherapy
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