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Clostridium difficile infection (CDI)

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60 papers 0 to 25 followers Clostridium difficile infection
https://www.readbyqxmd.com/read/28029471/treatment-of-clostridium-difficile-infection-a-national-survey-of-clinician-recommendations-and-the-use-of-faecal-microbiota-transplantation
#1
A R Prior, D Kevans, L McDowell, S Cudmore, F Fitzpatrick
Adherence to Clostridium difficile infection treatment guidelines is associated with lower recurrence rates and mortality as well as cost savings. This survey of Irish clinicians indicates that patients are managed using a variety of approaches. Faecal microbiota transplantation is potentially underused despite its recommendation in national and European guidelines.
October 14, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28065332/clostridium-difficile-contamination-of-health-care-workers-hands-and-its-potential-contribution-to-the-spread-of-infection-review-of-the-literature
#2
REVIEW
Ingrid Jullian-Desayes, Caroline Landelle, Marie-Reine Mallaret, Christian Brun-Buisson, Frédéric Barbut
BACKGROUND: Clostridium difficile infection (CDI) can be transmitted from patient to patient by the hands of health care workers (HCWs); however, the relative importance of this route in the spread of C difficile in the hospital is currently unknown. Our aim was to review studies examining HCWs' hand carriage and its potential role in CDI transmission. METHODS: First, English-speaking references addressing HCWs' hand sampling obtained from the PubMed database were reviewed...
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28078087/clostridium-difficile-infection-in-cystic-fibrosis-an-uncommon-but-life-threatening-complication
#3
Francesco Piccolo, Anna Sze Tai, Hooi Ee, Siobhain Mulrennan, Scott Bell, Gerard Ryan
Adults with cystic fibrosis (CF) have significant rates of asymptomatic Clostridium difficile carriage and are frequently exposed to risk factors for C. difficile infection (CDI). Despite this, the rate of reported CDI in CF is low. We describe three cases of near fatal CDI in adults with CF and review the literature regarding presentation, management, and recurrence prevention. Early recognition is important as the clinical presentation may be atypical and the illness can be severe and even life-threatening...
January 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28115504/lack-of-adherence-to-shea-idsa-treatment-guidelines-for-clostridium-difficile-infection-is-associated-with-increased-mortality
#4
I Patel, M Wungjiranirun, T Theethira, J Villafuerte-Galvez, N Castillo, M Akbari, C D Alonso, D A Leffler, C P Kelly
OBJECTIVES: The objective of this study was to determine our institution's compliance with 2010 Society for Healthcare Epidemiology of America and IDSA Clostridium difficile infection (CDI) treatment guidelines and their respective outcomes. METHODS: We collected clinical parameters, laboratory values, antibiotic therapy and clinical outcomes from the electronic medical records for all patients hospitalized at our institution with a diagnosis of CDI from December 2012 to November 2013...
February 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28166328/comparative-effectiveness-of-vancomycin-and-metronidazole-for-the-prevention-of-recurrence-and-death-in-patients-with-clostridium-difficile-infection
#5
Vanessa W Stevens, Richard E Nelson, Elyse M Schwab-Daugherty, Karim Khader, Makoto M Jones, Kevin A Brown, Tom Greene, Lindsay D Croft, Melinda Neuhauser, Peter Glassman, Matthew Bidwell Goetz, Matthew H Samore, Michael A Rubin
Importance: Metronidazole hydrochloride has historically been considered first-line therapy for patients with mild to moderate Clostridium difficile infection (CDI) but is inferior to vancomycin hydrochloride for clinical cure. The choice of therapy may likewise have substantial consequences on other downstream outcomes, such as recurrence and mortality, although these secondary outcomes have been less studied. Objective: To evaluate the risk of recurrence and all-cause 30-day mortality among patients receiving metronidazole or vancomycin for the treatment of mild to moderate and severe CDI...
February 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28172613/transmissibility-of-clostridium-difficile-without-contact-isolation-results-from-a-prospective-observational-study-with-451-patients
#6
Andreas F Widmer, Reno Frei, Stefan Erb, Anne Stranden, Ed J Kuijper, Cornelis W Knetsch, Sarah Tschudin-Sutter
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28192108/timely-use-of-probiotics-in-hospitalized-adults-prevents-clostridium-difficile-infection-a-systematic-review-with-meta-regression-analysis
#7
Nicole T Shen, Anna Maw, Lyubov L Tmanova, Alejandro Pino, Kayley Ancy, Carl V Crawford, Matthew S Simon, Arthur T Evans
BACKGROUND & AIMS: Systematic reviews have provided evidence for the efficacy of probiotics in preventing Clostridium difficile infection (CDI), but guidelines do not recommend probiotic use for prevention of CDI. We performed an updated systematic review to help guide clinical practice. METHODS: We searched MEDLINE, EMBASE, International Journal of Probiotics and Prebiotics, and The Cochrane Library databases for randomized controlled trials evaluating use of probiotics and CDI in hospitalized adults taking antibiotics...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28169013/cost-analysis-of-an-outbreak-of-clostridium-difficile-infection-ribotype-027-in-a-dutch-tertiary-care-centre
#8
Y H van Beurden, M K Bomers, S D van der Werff, E A P M Pompe, S Spiering, C M J E Vandenbroucke-Grauls, C J J Mulder
BACKGROUND: The economic impact of Clostridium difficile infection (CDI) on the healthcare system is significant. From May 2013 to May 2014, an outbreak of C. difficile ribotype 027 occurred in a Dutch tertiary care hospital, involving 72 patients. The primary aim of this study was to provide insight into the financial burden that this CDI outbreak brought upon this hospital. METHODS: A retrospective analysis was performed to estimate the costs of a one-year-long C...
December 30, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28077203/clostridium-difficile-infection-in-older-adults-systematic-review-of-efforts-to-reduce-occurrence-and-improve-outcomes
#9
Leisa L Marshall, Samuel Peasah, Gregg A Stevens
OBJECTIVE: Provide a systematic review of the primary literature on efforts to reduce Clostridium difficile infection (CDI) occurrence and improve outcomes in older adults. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION: PubMed and CINAHL databases were searched for research studies using search terms CDI, CDI prevention, reduction, control, management, geriatric, elderly, adults 65 years of age and older. The MeSH categories Aged and Aged, 80 and older, were used...
January 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28011611/fecal-fixation-fecal-microbiota-transplantation-for-clostridium-difficile-infection
#10
EDITORIAL
Stuart Johnson, Dale N Gerding
No abstract text is available yet for this article.
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27917075/management-of-clostridium-difficile-infection
#11
Layth S Al-Jashaami, Herbert L DuPont
Since the discovery of Clostridium difficile infection (CDI) in the 1970s, there has been an increase in the incidence, severity, and recurrence rate of the disease. We reviewed the recent CDI literature in PubMed published before February 28, 2016 that focused on advances in therapy. Despite a large number of studies describing methods for diagnosing the disease, there is currently no definitive test that identifies this infection with certainty, which complicates therapy. Recommended therapy for CDI includes oral metronidazole for mild cases and oral vancomycin or fidaxomicin for moderate to severe cases, each given for 10 to 14 days...
October 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27601193/-a-scoring-system-for-prescribing-fidaxomicin-in-clostridium-diff%C3%A3-cile-infection
#12
María Jesús Vivancos-Gallego, M Ángeles Jiménez-López, Francesca Gioia, Dione Ibañez-Segura, José Romero-Vivas, Javier Cobo
Recurrences of Clostridium difficile infections lead to hospital readmissions and high costs, in addition to the suffering and frustration for the patients. Fidaxomicin has recently been introduced as a new antibiotic that has been shown to significantly reduce the recurrence of this infection. Despite this superiority, its high cost has led to very restrictive policies in its use, as such that many institutions only use it in patients with multiple recurrences. While waiting for new predictive clinical tools, we propose the development of scoring systems that allow the more high-risk patients to be treated earlier...
September 3, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27621508/risk-factors-for-recurrent-clostridium-difficile-infections-and-strategies-to-decrease-readmissions-in-a-community-hospital
#13
EDITORIAL
Darrin Majors, Patrick Ellis
BACKGROUND: Currently there are no universally accepted approaches for the prevention of recurrent Clostridium difficile infections (CDI) following the initial infection. Several studies have identified common risk factors for the emergence of recurrent CDI. Identifying patients at high risk for recurrent CDI through the assessment of risk factors at initial diagnosis could enable health care providers to optimize available treatment options. A vancomycin hydrochloride-tapered regimen may be an effective treatment option for the prevention of recurrent CDI following the initial infection...
November 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/27460910/european-society-of-clinical-microbiology-and-infectious-diseases-update-of-the-diagnostic-guidance-document-for-clostridium-difficile-infection
#14
M J T Crobach, T Planche, C Eckert, F Barbut, E M Terveer, O M Dekkers, M H Wilcox, E J Kuijper
In 2009 the first European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guideline for diagnosing Clostridium difficile infection (CDI) was launched. Since then newer tests for diagnosing CDI have become available, especially nucleic acid amplification tests. The main objectives of this update of the guidance document are to summarize the currently available evidence concerning laboratory diagnosis of CDI and to formulate and revise recommendations to optimize CDI testing. This update is essential to improve the diagnosis of CDI and to improve uniformity in CDI diagnosis for surveillance purposes among Europe...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27462827/optimizing-the-diagnostic-testing-of-clostridium-difficile-infection
#15
Emilio Bouza, Luis Alcalá, Elena Reigadas
INTRODUCTION: Clostridium difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and is associated with a considerable health and cost burden. However, there is still not a clear consensus on the best laboratory diagnosis approach and a wide variation of testing methods and strategies can be encountered. AREAS COVERED: We aim to review the most practical aspects of CDI diagnosis providing our own view on how to optimize CDI diagnosis. Expert commentary: Laboratory diagnosis in search of C...
September 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27470257/a-comparison-of-current-guidelines-of-five-international-societies-on-clostridium-difficile-infection-management
#16
REVIEW
Csaba Fehér, Josep Mensa
Clostridium difficile infection (CDI) is increasingly recognized as an emerging healthcare problem of elevated importance. Prevention and treatment strategies are constantly evolving along with the apperance of new scientific evidence and novel treatment methods, which is well-reflected in the differences among consecutive international guidelines. In this article, we summarize and compare current guidelines of five international medical societies on CDI management, and discuss some of the controversial and currently unresolved aspects which should be addressed by future research...
September 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27501856/can-we-improve-the-therapy-of-clostridium-difficile-infection-in-elderly-patients
#17
Katarina Bielakova, Emmanuela Fernandova, Hana Matejovska-Kubesova, Pavel Weber, Dana Prudius, Josef Bednar
BACKGROUND: Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. METHODS: In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013...
August 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27515721/clostridium-difficile-infection-in-special-high-risk-populations
#18
REVIEW
Alberto Cózar-Llistó, Antonio Ramos-Martinez, Javier Cobo
Antibiotic use continues to be the most important risk factor for the development of Clostridium difficile infection (CDI) through disruption of the indigenous microbiota of the colon. This factor, together with environmental contamination, makes hospital and other healthcare facilities the perfect breeding ground for the infection. Several groups of patients are exposed to the hospital environment and, at the same time, affected by conditions that can make CDI more prevalent, more severe or make it present a different clinical picture...
September 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27437421/evaluating-the-effectiveness-of-an-antimicrobial-stewardship-intervention-on-reducing-the-incidence-rate-of-healthcare-associated-clostridium-difficile-infection
#19
Giulio Didiodato, Leslie Mcarthur
No abstract text is available yet for this article.
December 2015: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27365386/editorial-commentary-where-to-place-the-new-treatments-for-clostridium-difficile-infection
#20
EDITORIAL
Oliver A Cornely, Maria J G T Vehreschild
No abstract text is available yet for this article.
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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