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Epilepsy pharmacology

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Dieter Schmidt
Epilepsy is a serious brain disease with seizures as the main symptom, which can be successfully treated with antiepileptic drugs (AEDs). AEDs are usually started as soon as the epilepsy diagnosis has been established. About 80% of adults with new-onset epilepsy will achieve lasting seizure remission on AEDs. However, 20% continue to have seizures despite treatment (drug-resistant epilepsy). AEDs can be safely discontinued after several years of seizure remission during early treatment. Remarkably, 60% of all treated patients remain in remission off AEDs, making epilepsy one of the best treatable among chronic brain diseases...
May 2016: Neurologic Clinics
Dieter Schmidt, Steven C Schachter
Epilepsy is a serious, potentially life shortening brain disorder, the symptoms of which can be successfully treated in most patients with one or more antiepileptic drug. About two in three adults with new onset epilepsy will achieve lasting seizure remission on or off these drugs, although around half will experience mild to moderately severe adverse effects. Patients with epilepsy, especially the 20-30% whose seizures are not fully controlled with available drugs (drug resistant epilepsy), have a significantly increased risk of death, as well as psychiatric and somatic comorbidities, and adverse effects from antiepileptic drugs...
February 28, 2014: BMJ: British Medical Journal
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