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Epilepsy co-morbidities

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65 papers 0 to 25 followers
Mark R Keezer, Sanjay M Sisodiya, Josemir W Sander
The burden of comorbidity in people with epilepsy is high. Several diseases, including depression, anxiety, dementia, migraine, heart disease, peptic ulcers, and arthritis are up to eight times more common in people with epilepsy than in the general population. Several mechanisms explain how epilepsy and comorbidities are associated, including shared risk factors and bidirectional relations. There is a pressing need for new and validated screening instruments and guidelines to help with the early detection and treatment of comorbid conditions...
January 2016: Lancet Neurology
Kenneth Alper, Kelly A Schwartz, Russell L Kolts, Arif Khan
BACKGROUND: Clinical trial data provide an approach to the investigation of the effects of psychopharmacological agents, and psychiatric disorders themselves, on seizure threshold. METHODS: We accessed public domain data from Food and Drug Administration (FDA) Phase II and III clinical trials as Summary Basis of Approval (SBA) reports that noted seizure incidence in trials of psychotropic drugs approved in the United States between 1985 and 2004, involving a total of 75,873 patients...
August 15, 2007: Biological Psychiatry
Mike P Kerr, Seth Mensah, Frank Besag, Bertrand de Toffol, Alan Ettinger, Kousuke Kanemoto, Andres Kanner, Steven Kemp, Ennapadum Krishnamoorthy, W Curt LaFrance, Marco Mula, Bettina Schmitz, Ludgers Tebartz van Elst, Julian Trollor, Sarah J Wilson
In order to address the major impact on quality of life and epilepsy management caused by associated neuropsychiatric conditions, an international consensus group of epileptologists met with the aim of developing clear evidence-based and practice-based statements to provide guidance on the management of these conditions. Using a Delphi process, this group prioritized a list of key management areas. These included: depression, anxiety, psychotic disorders, nonepileptic seizures, cognitive dysfunction, antiepileptic drug (AED)-related neurobehavioral disorders, suicidality, disorders in children and adolescents, disorders in children with intellectual disability, and epilepsy surgery...
November 2011: Epilepsia
Udaya Seneviratne, Deepa Rajendran, Maria Brusco, Thanh G Phan
The accuracy of visual diagnosis of seizures based on semiologic features among different health care professionals is largely unknown. We evaluated the ability of health care professionals to correctly diagnose epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES) from a random selection of 10 ES and 10 PNES videos. The 20 videos (without accompanying electroencephalography) were shown only once, in a random mix to different groups of health care professionals. These individuals, blinded to the diagnosis, were asked to classify the seizure as ES or PNES...
April 2012: Epilepsia
Barbara Mostacci, Francesca Bisulli, Lara Alvisi, Laura Licchetta, Agostino Baruzzi, Paolo Tinuper
Psychogenic nonepileptic seizures (PNES) are highly prevalent in selected populations, with a strong impact in terms of morbidity and social cost. The gold standard for PNES diagnosis is video/EEG recording of a typical attack. However this technique is costly and not always available. In addition, many patients are treated with antiepileptic drugs for several years before undergoing video/EEG recording. The diagnosis is further complicated by concomitant epileptic seizures in some patients with PNES. Therefore, a good knowledge of PNES semiology is important for early screening of patients for video/EEG recording and for correct interpretation of the examination...
October 2011: Epilepsy & Behavior: E&B
Rick Hendrickson, Alexandra Popescu, Ronak Dixit, Gena Ghearing, Anto Bagic
Psychogenic nonepileptic spells (PNES) are frequently challenging to differentiate from epileptic seizures. The experience of panic attack symptoms during an event may assist in distinguishing PNES from seizures secondary to epilepsy. A retrospective analysis of 354 patients diagnosed with PNES (N=224) or with epilepsy (N=130) investigated the thirteen Diagnostic and Statistical Manual-IV-Text Revision panic attack criteria endorsed by the two groups. We found a statistically higher mean number of symptoms reported by patients with PNES compared with those with epilepsy...
August 2014: Epilepsy & Behavior: E&B
Francesco Brigo, Stanley C Igwe, Harald Ausserer, Raffaele Nardone, Frediano Tezzon, Luigi Giuseppe Bongiovanni, Michele Tinazzi, Eugen Trinka
Several different terms have been used to describe "psychogenic nonepileptic seizures" (PNES) in the literature. In this study, we evaluated the most common English terms used to describe PNES on Google and in PubMed using multiple search terms ( and The information prevalence of the five terms most frequently used to refer to PNES in PubMed were: psychogenic non(-)epileptic seizure(s), followed by pseudo(-)seizure(s), non(-)epileptic seizure(s), psychogenic seizure(s), and non(-)epileptic event(s)...
March 2015: Epilepsia
Brien J Smith
Psychogenic nonepileptic seizures (PNES) are events commonly encountered by primary care physicians, neurologists, pediatricians, and emergency medicine physicians in their practices, yet there continues to be significant variability in the way they are evaluated, diagnosed, and treated. Lack of understanding this condition and limited data on long-term outcome from current treatment paradigms have resulted in an environment with iatrogenic injury, morbidity, and significant costs to the patient and healthcare system...
March 2014: Epilepsy Currents
Barbara A Dworetzky
No abstract text is available yet for this article.
November 2015: Epilepsy Currents
William Diprose, Frederick Sundram, David B Menkes
OBJECTIVES: Psychogenic nonepileptic seizures (PNESs) are closely linked with psychological distress, but their etiology is not well-understood. We reviewed psychiatric comorbidity in PNESs and epileptic seizures (ESs) with an aim to assist understanding, diagnosis, and management of PNESs. METHODS: A search of Web of Science, MEDLINE (PubMed), PsycINFO, and Scopus identified 32 relevant studies on the prevalence of psychiatric comorbidity in PNESs. We used meta-analysis to compare psychiatric comorbidity between PNESs and ESs...
March 2016: Epilepsy & Behavior: E&B
M Ayman Haykal, Brien Smith
The diagnosis of psychogenic nonepileptic seizures (PNES) is usually made in the seizure monitoring unit (SMU; also commonly named the epilepsy monitoring unit) after PNES are recorded on video-EEG. The diagnosis should be discussed with the patient thoroughly. The discussion should focus on how the diagnosis was reached and that the diagnosis is real and treatable. When the diagnosis is communicated well, some patients may improve significantly without further interventions. Next, a psychiatric evaluation should be completed, ideally before discharge from the SMU...
September 2015: Current Treatment Options in Neurology
Hannah Wiseman, Markus Reuber
PURPOSE: There has been a rapid increase in the rate of publications about psychogenic nonepileptic seizures (PNES). This review summarises insights from the 50 most important original articles about PNES published since 2011 and describes the advances made in the understanding of PNES over the last 3 years. METHOD: We carried out a systematic literature search of all English language publications about PNES published between October 2011 and October 2014 on Scopus, Ovid Medline and Web of Knowledge, and inspected all abstracts...
July 2015: Seizure: the Journal of the British Epilepsy Association
Barbara A Dworetzky
No abstract text is available yet for this article.
March 2015: Epilepsy Currents
Richard J Brown, Markus Reuber
Psychogenic non-epileptic seizures (PNES) are common in neurological settings and often associated with considerable distress and disability. The psychological mechanisms underlying PNES are poorly understood and there is a lack of well-established, evidence-based treatments. This paper advances our understanding of PNES by providing a comprehensive systematic review of the evidence pertaining to the main theoretical models of this phenomenon. Methodological quality appraisal and effect size calculation were conducted on one hundred forty empirical studies on the following aspects of PNES: life adversity, dissociation, anxiety, suggestibility, attentional dysfunction, family/relationship problems, insecure attachment, defence mechanisms, somatization/conversion, coping, emotion regulation, alexithymia, emotional processing, symptom modelling, learning and expectancy...
April 2016: Clinical Psychology Review
Jagan A Pillai, Sheryl R Haut
Seizure and EEG characteristics of patients with epilepsy and concomitant psychogenic non-epileptic seizures (PNES) were compared to age and sex matched controls with epilepsy alone in a retrospective case control study. 39 patients with clearly documented epileptic and non-epileptic events were compared to 78 age and sex matched controls, sequentially admitted for video-EEG monitoring with documentation of epilepsy alone. Frontal seizures were higher in prevalence in patients with PNES who had concomitant epilepsy (P<0...
January 2012: Seizure: the Journal of the British Epilepsy Association
A Gross, O Devinsky, L E Westbrook, A H Wharton, K Alper
Physicians are often reluctant to use psychotropic medications in epilepsy patients with psychiatric disorders because of concern over the potential risk for lowering seizure threshold. This study assesses retrospectively the impact of psychotropic medications on seizure frequency in 57 patients seen consecutively at an epilepsy center. During psychotropic drug therapy, seizure frequency decreased in 33% of patients, was unchanged in 44%, and increased in 23%. Mean seizure frequency was not statistically different between pre-treatment and treatment periods (t = 0...
2000: Journal of Neuropsychiatry and Clinical Neurosciences
Gislaine Baroni, Vitoria Piccinini, William Alves Martins, Luciano de Paola, Eliseu Paglioli, Regina Margis, André Palmini
PURPOSE: Epileptic seizures (ES) have many mimickers, perhaps the most relevant being psychogenic nonepileptic seizures (PNES). The picture is even more challenging when PNES are associated with ES in a given patient. The aim of this research paper was to delineate the demographic, epileptological and psychiatric profile of that specific population. METHODS: A systematic review was carried out from 2000 to 2015 for articles in English, French, Italian, Spanish and Portuguese in PUBMED and EMBASE...
April 2016: Seizure: the Journal of the British Epilepsy Association
L E M Breuer, P Boon, J W M Bergmans, W H Mess, R M H Besseling, A de Louw, A G Tijhuis, S Zinger, A Bernas, D C W Klooster, A P Aldenkamp
A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused on the identification of risk factors and characterization of aberrant cognitive trajectories in epilepsy. Evidence is found that the cognitive trajectory of patients with epilepsy over time differs from processes of cognitive ageing in healthy people, especially in adulthood-onset epilepsy...
May 2016: Neuroscience and Biobehavioral Reviews
Andres M Kanner
The treatment of epileptic seizure disorders is not restricted to the achievement of seizure-freedom, but must also include the management of comorbid medical, neurological, psychiatric and cognitive comorbidities. Psychiatric and neurological comorbidities are relatively common and often co-exist in people with epilepsy (PWE). For example, depression and anxiety disorders are the most common psychiatric comorbidities in PWE, and they are particularly common in PWE who also have a neurological comorbidity, such as migraine, stroke, traumatic brain injury or dementia...
February 2016: Nature Reviews. Neurology
Becky Jones, Markus Reuber, Paul Norman
Psychogenic nonepileptic seizures (PNES) often have a debilitating effect on patients' lives. Patients, family members, and clinicians have yet to fully understand the mechanisms and treatment of this disorder. Although reviews exist about epileptic seizures, there have been no systematic reviews of studies focusing on the impact of PNES. This review considers research on factors associated with the health-related quality of life (HRQoL) of patients with PNES. Searches of Medline, PsycINFO, CINAHL, and Cochrane Library were conducted...
February 2016: Epilepsia
2016-04-26 03:57:47
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