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By Ahmed Abdo I like medicine
Stefano Ballestri, Fabio Nascimbeni, Dante Romagnoli, Enrica Baldelli, Giovanni Targher, Amedeo Lonardo
The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC)) that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D...
2016: International Journal of Molecular Sciences
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