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Michelle E van der Laan, Marcus T R Roofthooft, Marian W A Fries, Rolf M F Berger, Trijntje E Schat, Anne G J F van Zoonen, Jozien C Tanis, Arend F Bos, Elisabeth M W Kooi
BACKGROUND: Patent ductus arteriosus (PDA) is common in preterm infants and is associated with significant morbidity. To determine whether the PDA is hemodynamically significant (HSDA), several echocardiographic parameters have been suggested, including retrograde diastolic blood flow in the descending aorta (Dao). OBJECTIVE: To assess the impact of an HSDA, including retrograde diastolic flow in the Dao, on regional tissue oxygen saturation (rSO2) and extraction measured by near-infrared spectroscopy (NIRS)...
2016: Neonatology
Petra M A Lemmers, Manon J N L Benders, Rita D'Ascenzo, Jorine Zethof, Thomas Alderliesten, Karina J Kersbergen, Ivana Isgum, Linda S de Vries, Floris Groenendaal, Frank van Bel
BACKGROUND AND OBJECTIVES: A hemodynamically significant patent ductus arteriosus (PDA) can compromise perfusion and oxygenation of the preterm brain. Reports suggest that PDA is associated with increased mortality and morbidity. We hypothesize that long-standing low cerebral oxygenation due to PDA might affect brain volume at term equivalent age. METHODS: Observational study in 140 infants investigating the relationship between near-infrared spectroscopy-monitored cerebral oxygen saturation (rSco2) and MRI-assessed regional brain volume and maturation of the posterior limb of the internal capsule at term-equivalent age in 3 groups: those whose PDA closed with indomethacin, those who needed additional surgical closure, and matched controls...
April 2016: Pediatrics
Rocky Tsang, Lara S Shekerdemian
No abstract text is available yet for this article.
April 2016: Pediatrics
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