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Sven Cichon, Thomas W Mühleisen, Franziska A Degenhardt, Manuel Mattheisen, Xavier Miró, Jana Strohmaier, Michael Steffens, Christian Meesters, Stefan Herms, Moritz Weingarten, Lutz Priebe, Britta Haenisch, Michael Alexander, Jennifer Vollmer, René Breuer, Christine Schmäl, Peter Tessmann, Susanne Moebus, H-Erich Wichmann, Stefan Schreiber, Bertram Müller-Myhsok, Susanne Lucae, Stéphane Jamain, Marion Leboyer, Frank Bellivier, Bruno Etain, Chantal Henry, Jean-Pierre Kahn, Simon Heath, Marian Hamshere, Michael C O'Donovan, Michael J Owen, Nick Craddock, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andreas Reif, Johanna Sasse, Michael Bauer, Martin Hautzinger, Adam Wright, Philip B Mitchell, Peter R Schofield, Grant W Montgomery, Sarah E Medland, Scott D Gordon, Nicholas G Martin, Omar Gustafsson, Ole Andreassen, Srdjan Djurovic, Engilbert Sigurdsson, Stacy Steinberg, Hreinn Stefansson, Kari Stefansson, Lejla Kapur-Pojskic, Liliana Oruc, Fabio Rivas, Fermín Mayoral, Alexander Chuchalin, Gulja Babadjanova, Alexander S Tiganov, Galina Pantelejeva, Lilia I Abramova, Maria Grigoroiu-Serbanescu, Carmen C Diaconu, Piotr M Czerski, Joanna Hauser, Andreas Zimmer, Mark Lathrop, Thomas G Schulze, Thomas F Wienker, Johannes Schumacher, Wolfgang Maier, Peter Propping, Marcella Rietschel, Markus M Nöthen
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples...
March 11, 2011: American Journal of Human Genetics
Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T Schafer, Leah Boyer, Maria C Marchetto, John I Nurnberger, Joseph R Calabrese, Ketil J Ødegaard, Michael J McCarthy, Peter P Zandi, Martin Alda, Martin Alba, Caroline M Nievergelt, Shuangli Mi, Kristen J Brennand, John R Kelsoe, Fred H Gage, Jun Yao
Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide. Hence, it has been ranked by the World Health Organization as a top disorder of morbidity and lost productivity. Previous neuropathological studies have revealed a series of alterations in the brains of patients with bipolar disorder or animal models, such as reduced glial cell number in the prefrontal cortex of patients, upregulated activities of the protein kinase A and C pathways and changes in neurotransmission...
November 5, 2015: Nature
Harm J Gijsman, John R Geddes, Jennifer M Rendell, Willem A Nolen, Guy M Goodwin
OBJECTIVE: This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression. METHOD: The authors performed a systematic review and meta-analysis of randomized, controlled trials. They searched the Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials Register, incorporating results of searches of MEDLINE, EMBASE, CINAHL, PsycLIT, PSYNDEX, and LILACS...
September 2004: American Journal of Psychiatry
S N Ghaemi
No abstract text is available yet for this article.
March 2016: Acta Psychiatrica Scandinavica
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