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NEC

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57 papers 0 to 25 followers
https://www.readbyqxmd.com/read/29570713/maternal-fetal-and-perinatal-factors-associated-with-necrotizing-enterocolitis-in-sweden-a-national-case-control-study
#1
Margareta Ahle, Peder Drott, Anders Elfvin, Roland E Andersson
OBJECTIVE: To analyze associations of maternal, fetal, gestational, and perinatal factors with necrotizing enterocolitis in a matched case-control study based on routinely collected, nationwide register data. STUDY DESIGN: All infants born in 1987 through 2009 with a diagnosis of necrotizing enterocolitis in any of the Swedish national health care registers were identified. For each case up to 6 controls, matched for birth year and gestational age, were selected...
2018: PloS One
https://www.readbyqxmd.com/read/29576179/revisiting-the-use-of-probiotics-in-premature-infants-for-the-prevention-of-nec
#2
Emily Heikamp
No abstract text is available yet for this article.
April 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29618272/does-fortification-of-pasteurized-donor-human-milk-increase-the-incidence-of-necrotizing-enterocolitis-among-preterm-neonates-a-randomized-controlled-trial
#3
Bethou Adhisivam, Dilesh Kohat, Vasanthan Tanigasalam, Vishnu Bhat, Nishad Plakkal, C Palanivel
OBJECTIVE: To compare the effect of fortified pasteurized donor human milk (PDHM) versus unfortified PDHM on the incidence of necrotizing enterocolitis (NEC) and immediate outcome among preterm neonates. METHODS: This randomized controlled trial (RCT) conducted in a tertiary care teaching hospital, south India included 80 healthy preterm neonates randomized to two groups (Group A and B). Neonates in Group A and B were fed with fortified PDHM and unfortified PDHM respectively...
April 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29402455/routine-supplementation-of-lactobacillus-rhamnosus-gg-and-risk-of-necrotizing-enterocolitis-in-very-low-birth-weight-infants
#4
Andrea F Kane, Anisha D Bhatia, Patricia W Denning, Andi L Shane, Ravi Mangal Patel
OBJECTIVE: To evaluate if routine supplementation of Lactobacillus rhamnosus GG ATCC 53103 (LGG) is associated with a decreased risk of necrotizing enterocolitis in very low birth weight (VLBW) infants. STUDY DESIGN: Retrospective observational cohort study of VLBW (<1500 g) infants at a single center from 2008 to 2016. LGG supplementation with Culturelle at a dose of 2.5 to 5 × 109 CFU/day began in 2014. We used multivariable logistic regression to evaluate the association between LGG supplementation and necrotizing enterocolitis (modified Bell stage IIA or greater), after adjusting for potential confounders...
February 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29566974/donor-human-milk-and-risk-of-surgical-necrotizing-enterocolitis-a-meta-analysis
#5
Marco Silano, Gregorio Paolo Milani, Giovanni Fattore, Carlo Agostoni
BACKGROUND & AIM: The prevention of necrotizing enterocolitis (NEC) is a primary goal in the care of preterm and low birth-weight infants. Donor-banked milk (DM)-feeding has been reported to have a protective effect towards NEC with respect to formula-feeding. All the meta-analysis published so far, have been focused on the protective effect of DM on the overall risk of NEC, none of them focused on the risk of the most severe cases on NEC only, that are those requiring surgery. We conducted a meta-analysis of available evidences on the risk of developing surgical cases of NEC in DM-fed preterm and/or low birth weight infants with respect to those formula-fed...
March 10, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29501938/the-strong-correlation-between-neonatal-early-onset-group-b-streptococcal-disease-and-necrotizing-enterocolitis
#6
Irene A Stafford, Eliza Rodrigue, Alexandra Berra, Wesley Adams, Asha J Heard, Joseph L Hagan, Shawn J Stafford
BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of newborn gastrointestinal emergencies, affecting 1-3 per 1000 live births. Although NEC has been linked to a microbial etiology, associations with maternal intrapartum and resultant newborn early-onset invasive Group B streptococcus (EO-GBS) have been weakly defined. OBJECTIVE: The study aim was to determine the relationship between EO-GBS and NEC. STUDY DESIGN: Data from 2008 to 2015 were collected from pediatric records with ICD diagnosis codes consistent with all stages of NEC, with the exception of neonatal EO-GBS data (only available 2011-2015)...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28096129/current-knowledge-of-necrotizing-enterocolitis-in-preterm-infants-and-the-impact-of-different-types-of-enteral-nutrition-products
#7
REVIEW
Jocelyn Shulhan, Bryan Dicken, Lisa Hartling, Bodil Mk Larsen
Preterm infants are extremely vulnerable to a range of morbidities and mortality. Underdeveloped cardiac, respiratory, gastrointestinal, and immune systems in the preterm period increase the risk of necrotizing enterocolitis (NEC), a serious disease of the gut. NEC affects 5-12% of very-low birth-weight infants, leads to surgery in 20-40% of cases, and is fatal in 25-50% of cases. There are multiple factors that may contribute to NEC, but the exact cause is not yet fully understood. Severe cases can result in intestinal resection or death, and the health care costs average >$300,000/infant when surgical management is required...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28514886/physiological-effects-of-prebiotics-and-its-role-in-prevention-of-necrotizing-enterocolitis-in-preterm-neonates
#8
Bhawan Deep Garg, Haribalakrishna Balasubramanian, Nandkishor S Kabra
Necrotizing enterocolitis (NEC) is one of the most serious gastrointestinal emergencies in very low birth weight (VLBW) preterm neonates, affecting 7-14% of these neonates. Due to the seriousness of the disease, prevention of NEC is the most important goal. Current evidence from systematic review and meta-analysis revealed that probiotics are the most promising intervention in reduction of the incidence of NEC in VLBW neonates. As per the evidence, prebiotics modulate the composition of human intestine microflora to the benefit of the host by suppression of colonization of harmful microorganism and/or the stimulation of bifidobacterial growth, decreased stool viscosity, reduced gastrointestinal transit time, and better feed tolerance...
May 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28513631/paediatrics-are-human-milk-oligosaccharides-the-magic-bullet-for-necrotizing-enterocolitis
#9
Michael S Caplan
No abstract text is available yet for this article.
July 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28914455/using-probiotics-to-prevent-necrotising-enterocolitis
#10
EDITORIAL
Thomas R Abrahamsson
No abstract text is available yet for this article.
November 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28833564/why-haven-t-the-documented-benefits-of-probiotics-on-preterm-babies-led-to-their-wider-acceptance-and-use
#11
EDITORIAL
Constantin R Popescu, Leah T Stiemsma, Pascal M Lavoie
No abstract text is available yet for this article.
November 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28949953/effects-of-probiotics-on-experimental-necrotizing-enterocolitis-a-systematic-review-and-meta-analysis
#12
REVIEW
Gayatri Athalye-Jape, Shripada Rao, Sanjay Patole
BackgroundMeta-analyses of randomized controlled trials (RCTs) suggest that probiotics decrease the risk of necrotizing enterocolitis (NEC) in preterm infants. Many animal RCTs have evaluated probiotics for preventing NEC. We systematically reviewed the literature on this topic.MethodsThe protocol for systematic review of animal intervention studies (SYRCLE) was followed. Medline, Embase, ISI Web of Science, e-abstracts from the Pediatric Academic Society meetings, and other neonatal conferences were searched in December 2015 and August 2016...
January 2018: Pediatric Research
https://www.readbyqxmd.com/read/29281615/vitamin-d-ameliorates-neonatal-necrotizing-enterocolitis-via-suppressing-tlr4-in-a-murine-model
#13
Yongyan Shi, Tianjing Liu, Xinyi Zhao, Li Yao, Ana Hou, Jianhua Fu, Xindong Xue
BackgroundThe toll-like receptor 4 (TLR4) has been reported to play an important role in necrotizing enterocolitis (NEC). As an established regulator of TLR4, vitamin D has been demonstrated to be intestinal-protective. This study aims at finding out whether the vitamin D/vitamin D receptor (VDR) pathway ameliorates NEC by regulating TLR4.MethodsSerum 25-hydrovitamin D (25(OH)D) was tested and compared in 15 preterm infants with NEC, 12 preterm infants without known complications and 20 healthy term infants...
January 24, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29255185/standardized-feeding-and-probiotic-supplementation-for-reducing-necrotizing-enterocolitis-in-preterm-infants-in-a-resource-limited-set-up
#14
Saurabh Patel, Mayur Chaudhari, Sandeep Kadam, Shripada Rao, Sanjay Patole
BACKGROUND/OBJECTIVES: Necrotizing enterocolitis (NEC ≥ Stage II) is associated with high mortality and morbidity in preterm infants. To assess if introduction of standardized feeding regimen (SFR) and routine probiotic supplementation (RPS) was associated with reduced incidence of NEC in preterm infants in our nursery in a resource limited set up. SUBJECTS/METHODS: This was a retrospective cohort study assessing the incidence of NEC ≥ Stage II before (Epoch 1: N = 144) vs...
February 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29275816/probiotics-and-necrotizing-enterocolitis
#15
Ravi Mangal Patel, Mark A Underwood
In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC. We also summarize findings from several recent meta-analyses and report a new cumulative meta-analysis of probiotic trials. Finally, we review data from cohorts routinely using commercially available probiotics...
February 2018: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29275810/necrotizing-enterocolitis-pathophysiology-from-a-historical-context
#16
David Hackam, Michael Caplan
Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born weighing less than 1500g, though recent investigations have provided novel insights into the pathogenesis of this complex disease. The disease has been a major cause of morbidity and mortality in neonatal intensive care units worldwide for many years, and our current understanding reflects exceptional observations made decades ago. In this review, we will describe NEC from a historical context and summarize seminal findings that underscore the importance of enteral feeding, the gut microbiota, and intestinal inflammation in this complex pathophysiology...
February 2018: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29275814/changing-the-paradigm-of-defining-detecting-and-diagnosing-nec-perspectives-on-bell-s-stages-and-biomarkers-for-nec
#17
Sheila M Gephart, Phillip V Gordon, Alexander H Penn, Katherine E Gregory, Jonathan R Swanson, Akhil Maheshwari, Karl Sylvester
Better means to diagnose and define necrotizing enterocolitis are needed to guide clinical practice and research. Adequacy of Bell's staging system for clinical practice and clarity of cases used in NEC clinical datasets has been a topic of controversy for some time. This article provides reasons why a better global definition for NEC is needed and offers a simple alternative bedside definition for preterm NEC called the "Two out of Three" rule. Some argue that biomarkers may fill knowledge gaps and provide greater precision in defining relevant features of a clinical disease like NEC...
February 2018: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29176013/transfusion-associated-necrotizing-enterocolitis-in-preterm-infants-an-updated-meta-analysis-of-observational-data
#18
Parvesh Garg, Rachel Pinotti, C Vivek Lal, Ariel A Salas
BACKGROUND: The number of observational studies that report an association between packed red blood cell (PRBC) transfusions and necrotizing enterocolitis (NEC) has increased. The primary objective of this study was to evaluate the association between PRBC transfusions and NEC in observational studies. METHODS: Medline, Embase and Cochrane Library databases as well as the Pediatrics Academic Societies abstract archives were systematically searched to identify observational studies that investigated the association between PRBC transfusions and NEC...
November 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29276042/intestinal-tight-junctions-are-severely-altered-in-nec-preterm-neonates
#19
Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz
BACKGROUND & AIMS: Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants. It is well established that the gut barrier is severely damaged in NEC patients, nonetheless an in depth investigation of modifications at the transcriptional and translational levels of tight junction genes and proteins during NEC are still missing. The aim of this study was to investigate changes in the expression of tight junctions and other associated proteins during NEC and determine their correlation to the disease severity...
December 7, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29270303/nec-zero-recommendations-from-scoping-review-of-evidence-to-prevent-and-foster-timely-recognition-of-necrotizing-enterocolitis
#20
REVIEW
Sheila M Gephart, Corrine Hanson, Christine M Wetzel, Michelle Fleiner, Erin Umberger, Laura Martin, Suma Rao, Amit Agrawal, Terri Marin, Khaver Kirmani, Megan Quinn, Jenny Quinn, Katherine M Dudding, Tanya Clay, Jason Sauberan, Yael Eskenazi, Caroline Porter, Amy L Msowoya, Christina Wyles, Melissa Avenado-Ruiz, Shayla Vo, Kristina M Reber, Jennifer Duchon
Background: Although decades have focused on unraveling its etiology, necrotizing enterocolitis (NEC) remains a chief threat to the health of premature infants. Both modifiable and non-modifiable risk factors contribute to varying rates of disease across neonatal intensive care units (NICUs). Purpose: The purpose of this paper is to present a scoping review with two new meta-analyses, clinical recommendations, and implementation strategies to prevent and foster timely recognition of NEC...
2017: Maternal Health, Neonatology and Perinatology
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