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Bronchopulmonary dysplasia

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https://www.readbyqxmd.com/read/27843119/potential-nutrients-for-preventing-or-treating-bronchopulmonary-dysplasia
#1
REVIEW
Liya Ma, Ping Zhou, Josef Neu, Hung-Chih Lin
Bronchopulmonary dysplasia (BPD) is a frequent complication occurring in extremely preterm infants. Despite recent advances in newborn medicine, the incidence of BPD does not appear to have changed markedly, and specific treatments and prevention strategies are still lacking. Nutrition plays an important role in normal lung development and maturation. Malnutrition may delay somatic growth and new alveoli development, thus aggravating pulmonary injury involved in the pathogenesis of BPD. However, few nutrients have been investigated for their potential to mitigate the pathogenesis of BPD...
September 15, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27852668/less-invasive-surfactant-administration-versus-intubation-for-surfactant-delivery-in-preterm-infants-with-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#2
Jose C Aldana-Aguirre, Merlin Pinto, Robin M Featherstone, Manoj Kumar
CONTEXT: In spontaneously breathing preterm infants with respiratory distress syndrome (RDS) receiving nasal continuous positive airway pressure, a method of less invasive surfactant administration (LISA) using a thin catheter has been described as an alternative to endotracheal intubation for surfactant delivery to reduce lung injury. OBJECTIVE: A systematic review of randomised controlled trials (RCTs) comparing LISA with the standard method of surfactant delivery for clinical outcomes...
November 15, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27893721/biomarkers-associated-with-bronchopulmonary-dysplasia-mortality-in-premature-infants
#3
Jessica Balena-Borneman, Namasivayam Ambalavanan, Hemant K Tiwari, Russell L Griffin, Brian Halloran, David Askenazi
BACKGROUND: Bronchopulmonary dysplasia (BPD) portends lifelong organ impairment and death. Our ability to predict BPD in first days of life is limited, but could be enhance using novel biomarkers. METHODS: Using an available clinical and urine biomarker database obtained from a prospective 113 infant cohort (birth weight ≤1200 g and/or gestational age ≤31 weeks), we evaluated the independent association of 14 urine biomarkers with BPD/mortality. RESULTS: Two of the 14 urine biomarkers were independently associated with BPD/mortality after controlling for gestational age (GA), small for gestational age (SGA), and intubation status...
November 28, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27908648/interdisciplinary-care-of-children-with-severe-bronchopulmonary-dysplasia
#4
Steven H Abman, Joseph M Collaco, Edward G Shepherd, Martin Keszler, Milenka Cuevas-Guaman, Stephen E Welty, William E Truog, Sharon A McGrath-Morrow, Paul E Moore, Lawrence M Rhein, Haresh Kirpalani, Huayan Zhang, Linda L Gratny, Susan K Lynch, Jennifer Curtiss, Barbara S Stonestreet, Robin L McKinney, Kevin C Dysart, Jason Gien, Christopher D Baker, Pamela K Donohue, Eric Austin, Candice Fike, Leif D Nelin
No abstract text is available yet for this article.
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27908652/antibiotic-exposure-and-risk-for-death-or-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants
#5
Joseph B Cantey, Landon W Huffman, Abirami Subramanian, Anderson S Marshall, A Rebecca Ballard, Cassandra Lefevre, Malvika Sagar, Jessica E Pruszynski, Lea H Mallett
We assessed the association between antibiotic exposure in the first 2 weeks of life and development of bronchopulmonary dysplasia in a cohort of very low birth weight infants. After controlling for the severity of illness, each additional day of antibiotic therapy was associated with both an increased risk for and severity of bronchopulmonary dysplasia.
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27914140/comparison-of-the-mortality-and-in-hospital-outcomes-of-preterm-infants-treated-with-ibuprofen-for-patent-ductus-arteriosus-with-or-without-clinical-symptoms-attributable-to-the-patent-ductus-arteriosus-at-the-time-of-ibuprofen-treatment
#6
Hani Yoo, Jin A Lee, Sohee Oh, Young Hwa Jung, Jin A Sohn, Seung Han Shin, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim
The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory difficulty) attributable to hemodynamically-significant patent ductus arteriosus (hsPDA) at the time of first ibuprofen treatment. In total, 91 infants born from April 2010 to March 2015 were included. Fourteen infants (15...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27918385/neurally-adjusted-ventilatory-assist-in-preterm-infants-with-established-or-evolving-bronchopulmonary-dysplasia-on-high-intensity-mechanical-ventilatory-support-a-single-center-experience
#7
Young Hwa Jung, Han-Suk Kim, Juyoung Lee, Seung Han Shin, Ee-Kyung Kim, Jung-Hwan Choi
OBJECTIVES: The aim of the present study was to report possible improvements in ventilator variables associated with a transition from synchronized intermittent mandatory ventilation to neurally adjusted ventilatory assist in preterm infants with bronchopulmonary dysplasia who required a high level of mechanical ventilatory support in a single center. DESIGN: Retrospective study. SETTING: Neonatal ICU. PATIENTS: Twenty-nine preterm infants with a median gestational age of 25...
December 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27918754/interventions-to-improve-rates-of-successful-extubation-in-preterm-infants-a-systematic-review-and-meta-analysis
#8
Kristin N Ferguson, Calum T Roberts, Brett J Manley, Peter G Davis
Importance: Clinicians aim to extubate preterm infants as early as possible, to minimize the risks of mechanical ventilation. Extubation is often unsuccessful owing to lung disease or inadequate respiratory drive. Objective: To conduct a systematic review and meta-analysis of interventions to improve rates of successful extubation in preterm infants. Data Sources: Searches were undertaken in PubMed and The Cochrane Library. Study Selection: The review was conducted using the methods of the Cochrane Collaboration and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
December 5, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27919118/preeclampsia-and-the-risk-of-bronchopulmonary-dysplasia-in-preterm-infants-less-than-32-weeks-gestation
#9
Nancy Soliman, Kathleen Chaput, Belal Alshaikh, Kamran Yusuf
Objective Angiogenesis is essential for normal lung development. The objective of our study was to test the hypothesis that preeclampsia, an antiangiogenic state, is a risk factor for bronchopulmonary dysplasia (BPD). Design Prospective cohort study of infants less than 32 weeks' gestation born to mothers with preeclampsia between January 2007 and June 2010 at a single tertiary care center. Their BPD outcome was compared with infants born to the next two normotensive mothers with a ± 1 week gestational age difference...
December 5, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27814345/pro-inflammatory-immune-responses-in-leukocytes-of-premature-infants-exposed-to-maternal-chorioamnionitis-or-funisitis
#10
Courtney M Jackson, Casey B Wells, Meredith E Tabangin, Jareen Meinzen-Derr, Alan H Jobe, Claire A Chougnet
BACKGROUND: Acute chorioamnionitis contributes to premature birth, and is associated with post-birth complications. How chorioamnionitis impacts neonate's developing immune system has not been well defined. METHODS: Blood from extremely preterm infants (=28 weeks gestation) was drawn at the 1(st), 2(nd), and 4(th) week of life. Blood was either left unstimulated or stimulated for 4 hours with PMA/ionomycin. mRNA expression of transcription factors in unstimulated cells (RORC, TBET, GATA3, FOXP3) and inflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, and IL-6) in unstimulated and stimulated cells were analyzed...
November 4, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27792267/very-low-birth-weight-bronchopulmonary-dysplasia-survivors-had-similar-cardiac-outcomes-to-controls-at-6-14-years-of-age
#11
Piia Suursalmi, Anneli Eerola, Tuija Poutanen, Päivi Korhonen, Tarja Kopeli, Outi Tammela
AIM: This study evaluated cardiac function and its associations with lung function and neonatal pulmonary morbidity in very low birth weight (VLBW) children, with and without severe radiographic bronchopulmonary dysplasia (radBPD), at school age. METHODS: We examined 18 VLBW children with radBPD, 17 VLBW children without radBPD and 18 healthy term-born children using conventional echocardiography, tissue Doppler imaging, speckle tracking echocardiography and real-time three-dimensional echocardiography at 6-14 years of age...
October 28, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27760764/bnp-troponin-i-and-ykl-40-as-screening-markers-in-extremely-preterm-infants-at-risk-for-pulmonary-hypertension-associated-with-bronchopulmonary-dysplasia
#12
Kai König, Katelyn J Guy, Claudia A Nold-Petry, Charles P Barfield, Geraldine Walsh, Sandra M Drew, Alex Veldman, Marcel F Nold, Dan M Casalaz
Bronchopulmonary dysplasia (BPD) is often complicated by pulmonary hypertension (PH). We investigated three biomarkers potentially suitable as screening markers for extremely preterm infants at risk of BPD-associated PH. In this prospective observational cohort study conducted in a tertiary neonatal intensive care unit, 83 preterm infants with BPD born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP), troponin I, and YKL-40...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27770256/cell-based-therapies-for-neonatal-lung-disease
#13
Megan O'Reilly, Bernard Thébaud
Preterm birth occurs in approximately 11 % of all births worldwide. Advances in perinatal care have enabled the survival of preterm infants born as early as 23-24 weeks of gestation. However, many are affected by bronchopulmonary dysplasia (BPD)-a common respiratory complication of preterm birth, which has life-long consequences for lung health. Currently, there is no specific treatment for BPD. Recent advances in stem cell research have opened new therapeutic avenues for prevention/repair of lung damage...
October 22, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27742123/the-relationship-of-nosocomial-infection-reduction-to-changes-in-neonatal-intensive-care-unit-rates-of-bronchopulmonary-dysplasia
#14
Wannasiri Lapcharoensap, Peiyi Kan, Richard J Powers, Gary M Shaw, David K Stevenson, Jeffrey B Gould, David D Wirtschafter, Henry C Lee
OBJECTIVE: To examine whether recent reductions in rates of nosocomial infection have contributed to changes in rates of bronchopulmonary dysplasia (BPD) in a population-based cohort. STUDY DESIGN: This was a retrospective, population-based cohort study that used the California Perinatal Quality Care Collaborative database from 2006 to 2013. Eligible infants included those less than 30 weeks' gestational age and less than 1500 g who survived to 3 days of life. Primary variables of interest were rates of nosocomial infections and BPD...
October 11, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27711043/right-ventricular-performance-using-myocardial-deformation-imaging-in-infants-with-bronchopulmonary-dysplasia
#15
U Haque, C Stiver, B K Rivera, B Richards, N Ma, C L Cua, C V Smith, C H Backes
OBJECTIVE: Right ventricular (RV) performance among infants with bronchopulmonary dysplasia (BPD) remains poorly understood. We tested the hypothesis that myocardial deformation imaging (MDI) strain and strain rate would allow for differentiation between infants with severe and milder forms of BPD, independent of tissue Doppler imaging (TDI) and superior to conventional echocardiographic measurements. STUDY DESIGN: Infants with various severities of BPD (11 with none or mild, 13 with moderate and 10 with severe) underwent conventional echocardiography, TDI and MDI assessments at >36 weeks of corrected gestational age...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27711256/the-effect-of-gender-on-mesenchymal-stem-cell-msc-efficacy-in-neonatal-hyperoxia-induced-lung-injury
#16
Ibrahim Sammour, Santhosh Somashekar, Jian Huang, Sunil Batlahally, Matthew Breton, Krystalenia Valasaki, Aisha Khan, Shu Wu, Karen C Young
BACKGROUND: Mesenchymal stem cells (MSC) improve alveolar and vascular structures in experimental models of bronchopulmonary dysplasia (BPD). Female MSC secrete more anti-inflammatory and pro-angiogenic factors as compared to male MSC. Whether the therapeutic efficacy of MSC in attenuating lung injury in an experimental model of BPD is influenced by the sex of the donor MSC or recipient is unknown. Here we tested the hypothesis that female MSC would have greater lung regenerative properties than male MSC in experimental BPD and this benefit would be more evident in males...
2016: PloS One
https://www.readbyqxmd.com/read/27735931/inhaled-hydrofluoalkane-beclomethasone-dipropionate-in-bronchopulmonary-dysplasia-a-double-blind-randomized-controlled-pilot-study
#17
A Kugelman, M Peniakov, S Zangen, Y Shiff, A Riskin, A Iofe, I Shoris, D Bader, S Arnon
OBJECTIVE: The efficacy of inhaled steroids in spontaneously breathing infants with established bronchopulmonary dysplasia (BPD) is debatable. The inhaled steroid hydrofluoalkane-beclomethasone dipropionate (QVAR) is unique in its small particle size that results in higher lung deposition. Our objective was to determine if inhaled QVAR could decrease respiratory rehospitalizations of infants with established BPD. STUDY DESIGN: Double-blind, randomized placebo-controlled, multicenter pilot study...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27425012/cell-therapy-for-bronchopulmonary-dysplasia-promises-and-perils
#18
Marius Alexander Möbius, Bernard Thébaud
Despite great achievements in neonatal and perinatal medicine over the past decades, the immature lung remains the most critical organ to care for after premature birth. As a consequence, bronchopulmonary dysplasia (BPD) remains the most common complication of extreme prematurity. BPD impairs normal development and may cause lifelong morbidities. At present, there is no effective treatment for BPD - including preventing premature birth. Recent insights into the biology of stem and progenitor cells have ignited the hope of protecting the immature lung, and even regenerating an already damaged lung by using exogenous stem- or progenitor cells as therapeutics...
June 18, 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/27442157/impact-of-pulmonary-hypertension-on-neurodevelopmental-outcome-in-preterm-infants-with-bronchopulmonary-dysplasia-a-cohort-study
#19
H Nakanishi, A Uchiyama, S Kusuda
OBJECTIVES: To evaluate the impact of pulmonary hypertension (PH) on long-term growth and neurodevelopmental outcomes of extremely preterm infants with bronchopulmonary dysplasia (BPD). STUDY DESIGN: A single-center retrospective cohort of preterm infants born at <28 weeks gestational age from 2000 to 2011 was evaluated at 3 years of age. Growth and neurodevelopmental outcomes were compared among 3 groups: non-BPD, BPD without PH and BPD with PH. BPD was defined according to oxygen demand at 36 weeks postmenstrual age...
October 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27458992/pulmonary-mri-of-neonates-in-the-intensive-care-unit-using-3d-ultrashort-echo-time-and-a-small-footprint-mri-system
#20
Andrew D Hahn, Nara S Higano, Laura L Walkup, Robert P Thomen, Xuefeng Cao, Stephanie L Merhar, Jean A Tkach, Jason C Woods, Sean B Fain
PURPOSE: To determine the feasibility of pulmonary magnetic resonance imaging (MRI) of neonatal lung structures enabled by combining two novel technologies: first, a 3D radial ultrashort echo time (UTE) pulse sequence capable of high spatial resolution full-chest imaging in nonsedated quiet-breathing neonates; and second, a unique, small-footprint 1.5T MRI scanner design adapted for neonatal imaging and installed within the neonatal intensive care unit (NICU). MATERIALS AND METHODS: Ten patients underwent MRI within the NICU, in accordance with an approved Institutional Review Board protocol...
July 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
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