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brayden papers

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B Zane Horowitz, Kenneth Bizovi, Raymond Moreno
No abstract text is available yet for this article.
June 2002: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Vincent Roolvink, Borja Ibáñez, Jan Paul Ottervanger, Gonzalo Pizarro, Niels van Royen, Alonso Mateos, Jan-Henk E Dambrink, Noemi Escalera, Erik Lipsic, Agustín Albarran, Antonio Fernández-Ortiz, Francisco Fernández-Avilés, Javier Goicolea, Javier Botas, Wouter Remkes, Victoria Hernandez-Jaras, Elvin Kedhi, José L Zamorano, Felipe Navarro, Fernando Alfonso, Alberto García-Lledó, Joaquin Alonso, Maarten van Leeuwen, Robin Nijveldt, Sonja Postma, Evelien Kolkman, Marcel Gosselink, Bart de Smet, Saman Rasoul, Jan J Piek, Valentin Fuster, Arnoud W J van 't Hof
BACKGROUND: The impact of intravenous (IV) beta-blockers before primary percutaneous coronary intervention (PPCI) on infarct size and clinical outcomes is not well established. OBJECTIVES: This study sought to conduct the first double-blind, placebo-controlled international multicenter study testing the effect of early IV beta-blockers before PPCI in a general ST-segment elevation myocardial infarction (STEMI) population. METHODS: STEMI patients presenting <12 h from symptom onset in Killip class I to II without atrioventricular block were randomized 1:1 to IV metoprolol (2 × 5-mg bolus) or matched placebo before PPCI...
June 14, 2016: Journal of the American College of Cardiology
Robert C Brunham, Sami L Gottlieb, Jorma Paavonen
New England Journal of Medicine, Volume 372, Issue 21, Page 2039-2048, May 2015.
May 21, 2015: New England Journal of Medicine
Jonathan Rosenson, Carter Clements, Barry Simon, Jules Vieaux, Sarah Graffman, Farnaz Vahidnia, Bitou Cisse, Joseph Lam, Harrison Alter
BACKGROUND: Acute alcohol withdrawal syndrome (AAWS) is encountered in patients presenting acutely to the Emergency Department (ED) and often requires pharmacologic management. OBJECTIVE: We investigated whether a single dose of intravenous (i.v.) phenobarbital combined with a standardized lorazepam-based alcohol withdrawal protocol decreases intensive care unit (ICU) admission in ED patients with acute alcohol withdrawal. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study...
March 2013: Journal of Emergency Medicine
LeShaundra Cordier Scott, Sarah Lewis
No abstract text is available yet for this article.
April 19, 2016: JAMA: the Journal of the American Medical Association
Joshua J Fenton, Anthony F Jerant, Klea D Bertakis, Peter Franks
BACKGROUND: Patient satisfaction is a widely used health care quality metric. However, the relationship between patient satisfaction and health care utilization, expenditures, and outcomes remains ill defined. METHODS: We conducted a prospective cohort study of adult respondents (N = 51,946) to the 2000 through 2007 national Medical Expenditure Panel Survey, including 2 years of panel data for each patient and mortality follow-up data through December 31, 2006, for the 2000 through 2005 subsample (n = 36,428)...
March 12, 2012: Archives of Internal Medicine
Deborah Dowell, Tamara M Haegerich, Roger Chou
IMPORTANCE: Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious risks, including opioid use disorder and overdose. OBJECTIVE: To provide recommendations about opioid prescribing for primary care clinicians treating adult patients with chronic pain outside of active cancer treatment, palliative care, and end-of-life care. PROCESS: The Centers for Disease Control and Prevention (CDC) updated a 2014 systematic review on effectiveness and risks of opioids and conducted a supplemental review on benefits and harms, values and preferences, and costs...
April 19, 2016: JAMA: the Journal of the American Medical Association
Stavros V Konstantinides, Stefano Barco, Mareike Lankeit, Guy Meyer
Pulmonary embolism (PE) remains a major contributor to global disease burden. Risk-adapted treatment and follow-up contributes to a favorable outcome. Age-adjusted cutoff levels increase D-dimer specificity and may decrease overuse of imaging procedures and overdiagnosis of PE. Primary systemic fibrinolysis has an unfavorable risk-benefit ratio in intermediate-risk PE; catheter-directed techniques are an option for patients with hemodynamic decompensation and high bleeding risk. New oral anticoagulant agents are effective and safe alternatives to standard anticoagulation regimens...
March 1, 2016: Journal of the American College of Cardiology
Mervyn Singer, Clifford S Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annane, Michael Bauer, Rinaldo Bellomo, Gordon R Bernard, Jean-Daniel Chiche, Craig M Coopersmith, Richard S Hotchkiss, Mitchell M Levy, John C Marshall, Greg S Martin, Steven M Opal, Gordon D Rubenfeld, Tom van der Poll, Jean-Louis Vincent, Derek C Angus
IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE: To evaluate and, as needed, update definitions for sepsis and septic shock. PROCESS: A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine...
February 23, 2016: JAMA: the Journal of the American Medical Association
Eugene R Viscusi, Andrew C Barrett, Craig Paterson, William P Forbes
BACKGROUND AND OBJECTIVES: In patients with chronic noncancer pain, subcutaneous methylnaltrexone for opioid-induced constipation (OIC) was examined in a randomized controlled trial (RCT) followed by an open-label extension (OLE). This study examined the reproducibility of RCT findings by analyzing data from placebo-treated patients who crossed over to methylnaltrexone. METHODS: Adults with less than 3 weekly rescue-free bowel movements (RFBMs), taking 50 mg or more of an oral morphine equivalent per day, were randomized to receive methylnaltrexone 12 mg or placebo for 4 weeks, followed by open-label methylnaltrexone 12 mg as needed for 8 weeks...
January 2016: Regional Anesthesia and Pain Medicine
Patrick Mismetti, Silvy Laporte, Olivier Pellerin, Pierre-Vladimir Ennezat, Francis Couturaud, Antoine Elias, Nicolas Falvo, Nicolas Meneveau, Isabelle Quere, Pierre-Marie Roy, Olivier Sanchez, Jeannot Schmidt, Christophe Seinturier, Marie-Antoinette Sevestre, Jean-Paul Beregi, Bernard Tardy, Philippe Lacroix, Emilie Presles, Alain Leizorovicz, Hervé Decousus, Fabrice-Guy Barral, Guy Meyer
IMPORTANCE: Although retrievable inferior vena cava filters are frequently used in addition to anticoagulation in patients with acute venous thromboembolism, their benefit-risk ratio is unclear. OBJECTIVE: To evaluate the efficacy and safety of retrievable vena cava filters plus anticoagulation vs anticoagulation alone for preventing pulmonary embolism recurrence in patients presenting with acute pulmonary embolism and a high risk of recurrence. DESIGN, SETTING, AND PARTICIPANTS: Randomized, open-label, blinded end point trial (PREPIC2) with 6-month follow-up conducted from August 2006 to January 2013...
April 28, 2015: JAMA: the Journal of the American Medical Association
S J Lustik, A K Chhibber, J W Kolano, I A Hilmi, L C Henson, M C Morris, O Bronsther
Progesterone and estradiol are metabolized in the liver and are elevated in patients with cirrhosis. Progesterone stimulates ventilation by activating progesterone receptors in the central nervous system; estradiol may facilitate progesterone's actions by increasing progesterone receptors. This study evaluated whether progesterone and estradiol contribute to the respiratory alkalosis common in cirrhotic patients. Arterial blood gases and progesterone and estradiol levels were obtained in 50 patients with cirrhosis...
January 1997: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
J H Kim, H A Gallis
No abstract text is available yet for this article.
August 1989: American Journal of Medicine
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