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pediatric obesity and vitamin d

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32 papers 0 to 25 followers Pediatric obesity and vitamin D
Emanuele Miraglia del Giudice, Anna Grandone, Grazia Cirillo, Carlo Capristo, Pierluigi Marzuillo, Anna Di Sessa, Giuseppina Rosaria Umano, Laura Ruggiero, Laura Perrone
CONTEXT: Studies examining vitamin D levels in association with childhood obesity usually do not consider the effect of insulin on vitamin D-binding protein and do not calculate the unbound, bioavailable vitamin D. OBJECTIVE: This study aimed to evaluate in a group of children 1) the concentrations of both total 25-hydroxyvitamin D and bioavailable fraction, and 2) the potential role of insulin resistance in modulating the concentrations of bioavailable vitamin D...
October 2015: Journal of Clinical Endocrinology and Metabolism
G Cediel, C Corvalán, C Aguirre, D L de Romaña, R Uauy
BACKGROUND: Consistent data on the relation between vitamin D, body fat and insulin resistance (IR) in children are lacking. OBJECTIVES: (1) To evaluate the association between serum 25-Hydroxyvitamin D [25(OH)D] and key indicators of: adiposity (total and central), IR, and (2) to estimate serum 25(OH)D cut-offs that best reflect IR and total and central adiposity in children. SUBJECTS/METHODS: Prepubertal children (n=435, ~53% girls; ~age 7 years) from the Growth and Obesity Chilean Cohort Study were evaluated for potential associations between serum 25(OH)D and indicators of: (1) total adiposity (body mass index by age (BAZ), body fat (including three-component model)), central adiposity (waist circumference and trunk fatness); (2) IR (homeostasis model assessment of IR) and insulin sensitive (quantitative insulin sensitivity check index) using standardized multiple regression models with standardized coefficients and receiver operating characteristic curves...
January 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Elena Rodríguez-Rodríguez, Aránzazu Aparicio, Pedro Andrés, Rosa M Ortega
OBJECTIVE: Obesity has been associated with vitamin D deficiency and increased oxidative stress, which can lead to the dysregulation of adipokines and inflammation. The aim of the present work was to examine the association of vitamin D status [25(OH)D] on inflammatory related markers in overweight/obese children. SUBJECTS/METHODS: A total of 137 Spanish schoolchildren between 9 and 12 years of age (31.4% with overweight/obesity) were studied. Being overweight was defined as BMI≥85th percentile and obesity as BMI≥97th percentile using the reference tables of Hernández...
2014: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Debra R Keast, Kathleen M Hill Gallant, Ann M Albertson, Carolyn K Gugger, Norton M Holschuh
The aim of this study was to investigate associations of yogurt and dairy consumption with energy, macronutrient, calcium, and vitamin D intakes, and associations with indicators of overweight/obesity in U.S. children in the National Health and Nutrition Examination Survey (NHANES 2005-2008). Using 24-hour recall data, children 8-18 years of age were classified to dairy consumption groups of <1, 1 to <2, or 2+ dairy servings, and yogurt consumers were those who reported eating yogurt during at least one of two dietary intake interviews...
March 3, 2015: Nutrients
R M Campos, D C Masquio, F C Corgosinho, J P Carvalho-Ferreira, B D Netto, C Ackel-D'Elia, L Tock, S Tufik, M T de Mello, A R Damaso
OBJECTIVES: This study aimed to investigate the effect of vitamin D on cardiovascular risk in obese adolescents. METHODS: Thirty (16 females/14 males) post-puberty obese adolescents (15-19 years) were involved and measurements of inflammatory biomarkers, body composition, visceral fat, and vitamin D (serum and intake) were performed. The adolescents were submitted to a long-term interdisciplinary therapy with physical exercise, nutritional, psychological, and clinical interventions...
January 2015: Endocrine Regulations
Ronald Williams, Marsha Novick, Erik Lehman
PURPOSE: Our study sought to further delineate the prevalence of hypovitaminosis D and its relationship to comorbidities of childhood obesity. METHODS: We conducted a retrospective chart review from 155 obese children aged 5 to 19 years who attended the Penn State Children’s Hospital Pediatric Multidisciplinary Weight Loss Program from November 2009 through November 2010. We determined the incidence of hypovitaminosis D and examined its association with comorbidities including elevated blood pressure, diabetes, acanthosis nigricans, depression, hyperlipidemia, hyperinsulinemia, and abnormal liver function test results, as well as age, sex, and geographic location...
2014: Permanente Journal
Roberto Ercole Rusconi, Valentina De Cosmi, Ghilardi Gianluca, Claudia Giavoli, Carlo Agostoni
Vitamin D (25OHD) deficiency is reported in obese children. Low 25OHD levels are associated with dyslipidemia and increased risk of cardiovascular complication in adulthood. Within an observational study, 120 obese subjects in pediatric age were enrolled: 59 had 25OHD <20 ng/ml (group A) while 61 had 25OHD >20 ng/ml (group B). Group A versus Group B showed elevated total cholesterol (TC), p = 0.017, low-density lipoprotein cholesterol (LDL-C), p = 0.045, and parathormone (PTH), p = 0.008. Apolipoprotein B (ApoB) showed a similar trend, p = 0...
March 2015: International Journal of Food Sciences and Nutrition
Siân M Robinson, Sarah R Crozier, Nicholas C Harvey, Benjamin D Barton, Catherine M Law, Keith M Godfrey, Cyrus Cooper, Hazel M Inskip
BACKGROUND: Early life may be a "critical period" when appetite and regulation of energy balance are programmed, with lifelong consequences for obesity risk. Insight into the potential impact of modifying early-life risk factors on later obesity can be gained by evaluating their combined effects. OBJECTIVE: The objective was to examine the relation between the number of early-life risk factors and obesity outcomes among children in a prospective birth cohort (Southampton Women's Survey)...
February 2015: American Journal of Clinical Nutrition
Cynthia K Colapinto, Melissa Rossiter, Mohammad K A Khan, Sara F L Kirk, Paul J Veugelers
OBJECTIVE: Vitamin D intake in childhood is primarily for the prevention of rickets. Inconsistent evidence has associated adequate blood concentrations with a decreased risk of certain health conditions. Further, obese individuals may have lower vitamin D status. The estimated average requirement (EAR) for children recently doubled to 400 IU/day. Our aim was to examine dietary intake of vitamin D in different body mass index (BMI) categories, in addition to assessing determinants. METHODS: Data from two provincial surveys of grade 5 children, including a food frequency questionnaire and measured BMI, were used...
November 2014: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
B Pyrżak, E Witkowska-Sędek, M Krajewska, U Demkow, A M Kucharska
Numerous studies highlighted the link between vitamin D deficiency and cardiovascular, autoimmune, metabolic diseases, and obesity. However, a clear role of vitamin D in these disorders is still unknown. Vitamin D deficiency in children can be a potential risk factor for developing diseases at a later age. Early prevention and vitamin D supplementation should become a public health priority. This review highlights the clinical implications of vitamin D deficiency in adults and children with obesity.
2015: Advances in Experimental Medicine and Biology
Sonsoles Gutiérrez Medina, Teresa Gavela-Pérez, María Nieves Domínguez-Garrido, Elisa Gutiérrez-Moreno, Adela Rovira, Carmen Garcés, Leandro Soriano-Guillén
BACKGROUND: Puberty can affect vitamin D levels. OBJECTIVES: The goal of this study was to analyze the relation between vitamin D deficiency and puberty in obese Spanish children, along with the possible interrelation between vitamin D status and degree of insulin resistance. METHODS: A cross-sectional study was carried out, in which clinical and biochemical data were gathered from 120 obese and 50 normal weight children between January 2011 and January 2013...
January 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
Hua-qi Zhang, Jian-hua Teng, Ying Li, Xiao-xia Li, Yong-han He, Xuan He, Chang-hao Sun
OBJECTIVE: The aim of this study was to evaluate serum 25-hydroxyvitamin D [25(OH)D] level and its association with adiposity, inflammation, and oxidative stress in schoolchildren. METHODS: A total of 1488 schoolchildren ages 7 to 11 y were recruited in Harbin, China (latitude: 44°04'N-46°40'N) in May. Serum 25(OH)D, which is an indicator of vitamin D status, was determined. Anthropometric data were collected following general physical examinations. Serum lipids, glucose metabolism indices, inflammatory molecules, and oxidative stress markers were determined...
September 2014: Nutrition
Nalini N E Radhakishun, Mariska van Vliet, Dennis C W Poland, Olivier Weijer, Jos H Beijnen, Dees P M Brandjes, Michaela Diamant, Ines A von Rosenstiel
BACKGROUND: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with vitamin D insufficiency/deficiency. METHODS: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (<50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later...
2014: Hormone Research in Pædiatrics
Nicole S Nader, Roxana Aguirre Castaneda, James Wallace, Ravinder Singh, Amy Weaver, Seema Kumar
BACKGROUND/AIMS: To determine the effect of vitamin D3 supplementation on 25-hydroxyvitamin D [25(OH)D], lipid profile and markers of insulin resistance in obese adolescents. METHODS: In this double-blind, randomized, placebo-controlled trial, 58 obese adolescents (n = 58; 12-18 years of age) received either vitamin D3 (2,000 IU/day) or placebo for 12 weeks. Total 25(OH)D, fasting plasma glucose, insulin and lipid profile were measured at baseline and following supplementation...
2014: Hormone Research in Pædiatrics
Arnold H Slyper, Laurissa Kashmer, Wei-Min Huang, Yochai Re'em
OBJECTIVES: The aim of this study is to identify factors accounting for the variation in 25-hydroxyvitamin D levels in a pediatric obese population. PATIENTS AND METHODS: One hundred and forty-nine obese children and adolescents (BMI ≥95th percentile) were evaluated in a pediatric endocrine office. Acanthosis nigricans (AN) skin lesions were rated on a 4-point scale. RESULTS: The 25-hydroxyvitamin D levels were significantly different between those without AN and those with any severity of AN (p=<0...
November 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
S Bellone, S Esposito, E Giglione, G Genoni, C Fiorito, A Petri, G Bona, F Prodam
BACKGROUND: Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. AIM: Aim of our study was to evaluate vitamin D status in children living in Northern Italy. METHODS: We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal and pubertal. We considered vitamin D levels >20 ng/ml as normal, but also measured percentage of children with vitamin D levels higher than a cutoff of 30 ng/ml...
September 2014: Journal of Endocrinological Investigation
Catherine A Peterson, Anthony M Belenchia
Obesity and vitamin D deficiency represent two of the most wide-spread health concerns in the United States, especially among children. There is a well-established inverse relationship between vitamin D status and obesity; however, it is unknown as to whether vitamin D deficiency contributes to, or is a consequence of obesity. Based on available research, the positive effects of correcting hypovitaminosis D in obesity seem to be primarily related to its action on glycemic control.
January 2014: Missouri Medicine
Ozgur Pirgon, Ferhat Cekmez, Huseyin Bilgin, Esra Eren, Bumin Dundar
AIM: The aim of this study was to investigate the relationships between 25-hydroxy-vitamin D (25(OH)D) and insulin resistance in obese adolescents with non-alcoholic fatty liver disease (NAFLD). PATIENTS AND METHODS: Eighty-seven obese adolescents (45 girls and 42 boys, mean age: 12.7 ± 1.3 years, mean body mass index standard deviation score (BMI-SDS): 2.1 ± 0.3) and 30 lean subjects (15 girls and 15 boys, mean age: 12.3 ± 1.45 years, mean BMI-SDS: 0.5 ± 0...
July 2013: Obesity Research & Clinical Practice
C Banzato, C Maffeis, E Maines, P Cavarzere, R Gaudino, C Fava, P Minuz, A Boner, F Antoniazzi
In adults, low levels of vitamin D are associated with hypertension. The aim of this study was to evaluate the relationship between 24-h blood pressure (BP) patterns and vitamin D levels in obese children. We recorded anthropometric parameters, took blood samples for 25-hydroxivitamin D measurements and monitored ambulatory BP (ABP) in 32 obese children (male/female: 21/11, age 7-16 years). Subjects in the lower tertiles had higher homeostasis model assessment of insulin resistance, nighttime systolic and diastolic ABP, nighttime systolic and diastolic ABP load, 24-h ABP index and nighttime systolic and diastolic ABP index than those in the higher tertile...
June 2014: Journal of Human Hypertension
Cenk Aypak, Ozlem Türedi, Adnan Yüce
UNLABELLED: Low serum 25-hydroxyvitamin D3 (25(OH)D) levels have been associated with insulin resistance and cardiovascular diseases. The influences of gender, puberty and adiposity on vitamin D status and the relationship between 25(OH)D and cardiometabolic risk factors in obese and non-obese children were studied. A retrospective analysis was carried out on 168 Turkish children during late winter. Age, gender, puberty, body mass index (BMI), 25(OH)D levels and cardiometabolic risk factors including lipid profiles, high-sensitivity C-reactive protein and insulin resistance index calculated by homeostasis model assessment (HOMA-IR) were evaluated...
March 2014: European Journal of Pediatrics
2016-04-12 19:24:02
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