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Prematurity

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2 papers 0 to 25 followers
https://www.readbyqxmd.com/read/22284156/vaginal-progesterone-in-women-with-an-asymptomatic-sonographic-short-cervix-in-the-midtrimester-decreases-preterm-delivery-and-neonatal-morbidity-a-systematic-review-and-metaanalysis-of-individual-patient-data
#1
REVIEW
Roberto Romero, Kypros Nicolaides, Agustin Conde-Agudelo, Ann Tabor, John M O'Brien, Elcin Cetingoz, Eduardo Da Fonseca, George W Creasy, Katharina Klein, Line Rode, Priya Soma-Pillay, Shalini Fusey, Cetin Cam, Zarko Alfirevic, Sonia S Hassan
OBJECTIVE: To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix (≤ 25 mm) in the midtrimester reduces the risk of preterm birth and improves neonatal morbidity and mortality. STUDY DESIGN: Individual patient data metaanalysis of randomized controlled trials. RESULTS: Five trials of high quality were included with a total of 775 women and 827 infants. Treatment with vaginal progesterone was associated with a significant reduction in the rate of preterm birth <33 weeks (relative risk [RR], 0...
February 2012: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26921136/vaginal-progesterone-prophylaxis-for-preterm-birth-the-opptimum-study-a-multicentre-randomised-double-blind-trial
#2
RANDOMIZED CONTROLLED TRIAL
Jane Elizabeth Norman, Neil Marlow, Claudia-Martina Messow, Andrew Shennan, Phillip R Bennett, Steven Thornton, Stephen C Robson, Alex McConnachie, Stavros Petrou, Neil J Sebire, Tina Lavender, Sonia Whyte, John Norrie
BACKGROUND: Progesterone administration has been shown to reduce the risk of preterm birth and neonatal morbidity in women at high risk, but there is uncertainty about longer term effects on the child. METHODS: We did a double-blind, randomised, placebo-controlled trial of vaginal progesterone, 200 mg daily taken from 22-24 to 34 weeks of gestation, on pregnancy and infant outcomes in women at risk of preterm birth (because of previous spontaneous birth at ≤34 weeks and 0 days of gestation, or a cervical length ≤25 mm, or because of a positive fetal fibronectin test combined with other clinical risk factors for preterm birth [any one of a history in a previous pregnancy of preterm birth, second trimester loss, preterm premature fetal membrane rupture, or a history of a cervical procedure to treat abnormal smears])...
May 21, 2016: Lancet
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