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NICU Pulmonology

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3 papers 0 to 25 followers
https://www.readbyqxmd.com/read/26916176/effect-of-early-low-dose-hydrocortisone-on-survival-without-bronchopulmonary-dysplasia-in-extremely-preterm-infants-premiloc-a-double-blind-placebo-controlled-multicentre-randomised-trial
#1
RANDOMIZED CONTROLLED TRIAL
Olivier Baud, Laure Maury, Florence Lebail, Duksha Ramful, Fatima El Moussawi, Claire Nicaise, Véronique Zupan-Simunek, Anne Coursol, Alain Beuchée, Pascal Bolot, Pierre Andrini, Damir Mohamed, Corinne Alberti
BACKGROUND: Bronchopulmonary dysplasia, a major complication of extreme prematurity, has few treatment options. Postnatal steroid use is controversial, but low-dose hydrocortisone might prevent the harmful effects of inflammation on the developing lung. In this study, we aimed to assess whether low-dose hydrocortisone improved survival without bronchopulmonary dysplasia in extremely preterm infants. METHODS: In this double-blind, placebo-controlled, randomised trial done at 21 French tertiary-care neonatal intensive care units (NICUs), we randomly assigned (1:1), via a secure study website, extremely preterm infants inborn (born in a maternity ward at the same site as the NICU) at less than 28 weeks of gestation to receive either intravenous low-dose hydrocortisone or placebo during the first 10 postnatal days...
April 30, 2016: Lancet
https://www.readbyqxmd.com/read/27057767/continuous-positive-airway-pressure-versus-mechanical-ventilation-on-the-first-day-of-life-in-very-low-birth-weight-infants
#2
Dustin D Flannery, Elizabeth O'Donnell, Mike Kornhauser, Kevin Dysart, Jay Greenspan, Zubair H Aghai
Objective The objective of this study was to determine differences in the incidence of bronchopulmonary dysplasia (BPD) or death in very low-birth-weight (VLBW) infants managed successfully on continuous positive airway pressure (CPAP) versus mechanical ventilation on the first day of life (DOL). Study Design This is a retrospective analysis of the Alere neonatal database for infants born between January 2009 and December 2014, weighing ≤ 1,500 g. Baseline demographics, clinical characteristics, and outcomes were compared between the two groups...
August 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27025910/continuous-positive-airway-pressure-to-prevent-neonatal-lung-injury-how-did-we-get-here-and-how-do-we-improve
#3
Clyde J Wright, Richard A Polin, Haresh Kirpalani
No abstract text is available yet for this article.
June 2016: Journal of Pediatrics
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