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gestational diabetes

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24 papers 0 to 25 followers Management of gestational diabetes
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January 2016: Diabetes Care
Emily Bain, Morven Crane, Joanna Tieu, Shanshan Han, Caroline A Crowther, Philippa Middleton
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their babies in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions. OBJECTIVES: To assess the effects of combined diet and exercise interventions for preventing GDM and associated adverse health consequences for women and their babies...
2015: Cochrane Database of Systematic Reviews
Ewelina Rogozińska, Monica Chamillard, Graham A Hitman, Khalid S Khan, Shakila Thangaratinam
INTRODUCTION: The rise in gestational diabetes (GDM), defined as first onset or diagnosis of diabetes in pregnancy, is a global problem. GDM is often associated with unhealthy diet and is a major contributor to adverse outcomes maternal and fetal outcomes. Manipulation of nutrition has the potential to prevent GDM. METHODS: We assessed the effects of nutritional manipulation in pregnancy on GDM and relevant maternal and fetal outcomes by a systematic review of the literature...
2015: PloS One
Elizabeth Buschur, Florence Brown, Jennifer Wyckoff
Insulin has been the mainstay of treatment of diabetes during pregnancy for decades. Although glyburide and metformin are classified as category B during pregnancy, recent research has suggested that these oral agents alone or in conjunction with insulin may be safe for the treatment of gestational diabetes (GDM). This paper summarizes the data on the use of glyburide and metformin for treatment of GDM.
February 2015: Current Diabetes Reports
David Simmons
The number of women with gestational diabetes mellitus (GDM: diabetes first diagnosed in pregnancy) continues to grow, as do the associated risks of antenatal and postnatal complications and the chance of future diabetes and obesity in both mother and offspring. Recent randomised controlled trials have demonstrated clear benefits for intensive management of GDM using lifestyle modification, self blood glucose monitoring, close clinical supervision and, where glycaemia remains inadequately controlled, insulin therapy...
January 2015: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Katrien Benhalima, Roland Devlieger, André Van Assche
Gestational diabetes (GDM) is a frequent medical condition during pregnancy. It is associated with an increased risk of complications for both the mother and the baby during pregnancy and post partum. The International Association of Diabetes and Pregnancy Study Groups (IADPSG) has proposed a new screening strategy for overt diabetes in pregnancy and screening for GDM. However, there is still a lack of international uniformity in the approach to the screening and diagnosis of GDM. Controversies include universal versus selective screening, the optimal time for screening, appropriate tests and cutoff values, and whether testing should be conducted in one or two steps...
April 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Jamie Klein, Ron Charach, Eyal Sheiner
INTRODUCTION: Gestational diabetes mellitus (GDM), defined as glucose intolerance with first recognition or onset during pregnancy, is steadily rising in prevalence. GDM affects ∼ 3 - 5% of pregnancies in the US and is associated with significant adverse perinatal and maternal outcomes. Diagnosing and treating GDM early in pregnancy is of utmost importance as it can prevent poor outcomes such as macrosomia, shoulder dystocia and obstetric complications. AREAS COVERED: This review describes the importance of treating GDM and the various available interventions for glycemic control in women with GDM, including the latest evidence regarding pharmacological treatments and specifically anti-hyperglycemic agents...
February 2015: Expert Opinion on Pharmacotherapy
Luciana Verçoza Viana, Jorge Luiz Gross, Mirela Jobim Azevedo
OBJECTIVE: Diet is the cornerstone treatment of patients with gestational diabetes mellitus (GDM), but its role in maternal and newborn outcomes has been scarcely studied. The purpose of this study was to analyze the efficacy of dietary interventions on maternal or newborn outcomes in patients with GDM. RESEARCH DESIGN AND METHODS: A systematic review and meta-analysis of randomized clinical trials (RCTs) of dietary intervention in GDM or pregnancy with hyperglycemia was performed...
December 2014: Diabetes Care
Rachel J Ryu, Karen E Hays, Mary F Hebert
Oral hypoglycemic agents such as glyburide (second-generation sulfonylurea) and metformin (biguanide) are attractive alternatives to insulin due to lower cost, ease of administration, and better patient adherence. The majority of evidence from retrospective and prospective studies suggests comparable efficacy and safety of oral hypoglycemic agents such as glyburide and metformin as compared to insulin when used in the treatment of women with gestational diabetes mellitus (GDM). Glyburide and metformin have altered pharmacokinetics during pregnancy and both agents cross the placenta...
December 2014: Seminars in Perinatology
Penglong Chen, Shuxiang Wang, Jianying Ji, Aiping Ge, Chunlai Chen, Yanfei Zhu, Ni Xie, Yi Wang
Gestational diabetes mellitus (GDM) is considered to be a typical condition of glucose intolerance in which a woman previously undiagnosed with diabetes exhibits high levels of blood glucose during the third trimester of pregnancy. It can hence be defined as any degree of intolerance to glucose with its first recognition only during the pregnancy. Approximately 7 % of all cases of pregnancy are found to be variedly complicated with GDM and this result in more than 200,000 cases annually. In US only, GDM has been found to complicate about 7-14 % cases annually, and the trend seems to have increased by 35-100 % in the recent years...
March 2015: Cell Biochemistry and Biophysics
Jan Skupień, Katarzyna Cyganek, Maciej T Małecki
PURPOSE OF REVIEW: We review the recent changes in diagnostic criteria of gestational diabetes mellitus (GDM), describe problems with maintaining and monitoring adequate blood glucose, especially in type 1 diabetes, and provide a brief overview of the currently approved glucose-lowering therapies in pregnancy. RECENT FINDINGS: After the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, the definition of GDM was revised under the auspices of the International Association of Diabetes and Pregnancy Study Groups...
December 2014: Current Opinion in Obstetrics & Gynecology
Liran Hiersch, Yariv Yogev
Gestational diabetes mellitus (GDM) complicates 3-15% of pregnancies depending upon the geographic location and ethnic groups, and its incidence is estimated to increase even further due to the increasing rates of obesity in the general population and the trend towards advanced maternal age in pregnancy. GDM is associated with adverse pregnancy outcome such as an increased rate of fetal macrosomia, neonatal metabolic disturbances, and maternal injuries. It has been shown that there is an inverse relation between maternal glycemic control and the risk of complications...
February 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Louise K K Weile, James G Kahn, Elliot Marseille, Dorte M Jensen, Peter Damm, Nicolai Lohse
Gestational diabetes mellitus (GDM) is an increasing cause of morbidity in women and their offspring. Screening and intervention can reduce perinatal and most likely also long-term diabetes consequences. There have been many economic studies, but not recently systematically compared. We conducted a systematic search and abstraction of cost-effectiveness and cost-utility studies from 2002 to 2014. We standardized all findings to 2014 US dollars. We found that cost-effectiveness ratios varied widely. Most variation was found to be due to differences in geographic setting, diagnostic criteria and intervention approaches, and outcomes (e...
February 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Lisa Chasan-Taber
While lifestyle interventions involving exercise and a healthy diet in high-risk adults have been found to reduce progression to type 2 diabetes by >50%, little attention has been given to the potential benefits of such strategies in women with a history of gestational diabetes mellitus (GDM). We conducted a literature search of PubMed for English language studies of randomized controlled trials of lifestyle interventions among women with a history of GDM. In total, nine studies were identified which fulfilled the eligibility criteria...
January 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Nalinee Poolsup, Naeti Suksomboon, Muhammad Amin
OBJECTIVE: To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care. METHODS: A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any form of therapeutic intervention in comparison to usual antenatal care. A literature search was conducted using electronic databases together with a hand search of relevant journals and conference proceedings...
2014: PloS One
Helen L Barrett, Marloes Dekker Nitert, Louise S Conwell, Leonie K Callaway
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a range of adverse pregnancy outcomes for mother and infant. The prevention of GDM using lifestyle interventions has proven difficult. The gut microbiome (the composite of bacteria present in the intestines) influences host inflammatory pathways, glucose and lipid metabolism and, in other settings, alteration of the gut microbiome has been shown to impact on these host responses. Probiotics are one way of altering the gut microbiome but little is known about their use in influencing the metabolic environment of pregnancy...
2014: Cochrane Database of Systematic Reviews
Helaine Thomaz de Lima, Eliane Lopes Rosado, Paulo Augusto Ribeiro Neves, Raphaela Corrêa Monteiro Machado, Larissa Mello de Oliveira, Cláudia Saunders
INTRODUCTION: Several methods of dietetic counseling can be used in the nutritional therapy in gestational diabetes mellitus (GDM). The main methods are the traditional method (TM) and the carbohydrate counting (CCM). OBJECTIVE: Presenting a systematic review of the literature on the impact of nutritional therapy in GDM, through TM and CCM, evaluating the results for maternal and child health. METHODS: We searched databases PubMed, Scopus, Web of Science, Lilacs and CAPES Digital Bank of Thesis...
November 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Teri L Hernandez, Molly A Anderson, Catherine Chartier-Logan, Jacob E Friedman, Linda A Barbour
Elucidating the optimal macronutrient composition for dietary management of gestational diabetes mellitus has enormous potential to improve perinatal outcomes. Diet therapy may result in significant cost savings if effective in deterring the need for expensive medical management within this growing population. In only 6 randomized controlled trials in 250 women, data suggest that a diet higher in complex carbohydrate and fiber, low in simple sugar, and lower in saturated fat may be effective in blunting postprandial hyperglycemia, preventing worsened insulin resistance and excess fetal growth...
December 2013: Clinical Obstetrics and Gynecology
Kristin Castorino, Lois Jovanovič
Women with gestational diabetes mellitus require a continuum of care before, during, and after pregnancy for optimal management of hyperglycemia. Postpartum education and lifestyle modification should begin during pregnancy, and should continue during the postpartum period. Women should receive education on the long-term risk of type 2 diabetes mellitus, and should be encouraged to breastfeed, engage in regular physical activity, and select a highly effective contraceptive method in preparation for subsequent pregnancy...
December 2013: Clinical Obstetrics and Gynecology
Erica K Berggren, Kim A Boggess
In gestational diabetes (GDM), achieving euglycemia through treatment decreases the risk of adverse outcomes associated with hyperglycemia. Treatment starts with diet and nutritional counseling; however, up to 50% of women will require pharmacologic therapy to meet glucose goals. Although insulin remains the only Federal Drug Administration-approved agent to treat GDM, oral hypoglycemic agents are an attractive and increasingly common alternative. Research suggests that glyburide and metformin can each effectively manage hyperglycemia in pregnancy...
December 2013: Clinical Obstetrics and Gynecology
2016-04-07 21:14:54
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