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6 papers 25 to 100 followers Breast Cancer Surgery
Hannah Headon, Umar Wazir, Abdul Kasem, Kefah Mokbel
Traditionally, stage IV metastatic breast cancer has been treated with systemic therapy and/or radiotherapy in order to decrease cancer-associated symptoms, maintain quality of life and control disease burden. Previous research suggests that surgical treatment of the primary tumour may prolong survival, as well achieve local control of disease. Using the PubMed and Ovid SP databases, a literature review and meta-analysis was performed in order to assess whether surgical resection of the primary tumour in metastatic breast cancer prolongs survival...
May 2016: Molecular and Clinical Oncology
Lynn C Hartmann, Noralane M Lindor
No abstract text is available yet for this article.
February 4, 2016: New England Journal of Medicine
Anees B Chagpar, Brigid K Killelea, Theodore N Tsangaris, Meghan Butler, Karen Stavris, Fangyong Li, Xiaopan Yao, Veerle Bossuyt, Malini Harigopal, Donald R Lannin, Lajos Pusztai, Nina R Horowitz
BACKGROUND: Routine resection of cavity shave margins (additional tissue circumferentially around the cavity left by partial mastectomy) may reduce the rates of positive margins (margins positive for tumor) and reexcision among patients undergoing partial mastectomy for breast cancer. METHODS: In this randomized, controlled trial, we assigned, in a 1:1 ratio, 235 patients with breast cancer of stage 0 to III who were undergoing partial mastectomy, with or without resection of selective margins, to have further cavity shave margins resected (shave group) or not to have further cavity shave margins resected (no-shave group)...
August 6, 2015: New England Journal of Medicine
C Bonneau, D Hequet, J P Estevez, N Pouget, R Rouzier
AIM: The objective of this study was to determine the effects of axillary lymph node dissection (ALND) versus sentinel lymph node biopsy alone (SLNB) on the survival of patients with 3 or more metastatic lymph nodes (MLN) in invasive breast cancer. METHODS: Data of 9521 patients with invasive T1-2M0 breast carcinoma and initial treatment with SLNB completed or not by ALND and 3 or more MLN were extracted from the SEER database. Univariate and multivariate analyses were performed...
August 2015: European Journal of Surgical Oncology
Yun Fu, Debra Chung, Minh-An Cao, Sophia Apple, Helena Chang
BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial reported that axillary lymph node dissection (ALND) did not change the recurrence and overall survival (OS) rates in patients with lumpectomy and one to two positive nodes detected by sentinel lymph node biopsy (SLNB). The aim of this study was to determine whether patients with mastectomy and pathological N1 disease found by SLNB could forego ALND. MATERIALS AND METHODS: This is a retrospective study of 214 patients diagnosed with primary invasive breast cancer who were treated by mastectomy and lymph node staging surgery (SLNB or ALND) at the Revlon/UCLA Breast Center between January 2002 and December 2010...
December 2014: Annals of Surgical Oncology
Armando E Giuliano, Kelly K Hunt, Karla V Ballman, Peter D Beitsch, Pat W Whitworth, Peter W Blumencranz, A Marilyn Leitch, Sukamal Saha, Linda M McCall, Monica Morrow
CONTEXT: Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival. OBJECTIVE: To determine the effects of complete axillary lymph node dissection (ALND) on survival of patients with sentinel lymph node (SLN) metastasis of breast cancer. DESIGN, SETTING, AND PATIENTS: The American College of Surgeons Oncology Group Z0011 trial, a phase 3 noninferiority trial conducted at 115 sites and enrolling patients from May 1999 to December 2004...
February 9, 2011: JAMA: the Journal of the American Medical Association
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