Luiza Moore, Alex Cagan, Tim H H Coorens, Matthew D C Neville, Rashesh Sanghvi, Mathijs A Sanders, Thomas R W Oliver, Daniel Leongamornlert, Peter Ellis, Ayesha Noorani, Thomas J Mitchell, Timothy M Butler, Yvette Hooks, Anne Y Warren, Mette Jorgensen, Kevin J Dawson, Andrew Menzies, Laura O'Neill, Calli Latimer, Mabel Teng, Ruben van Boxtel, Christine A Iacobuzio-Donahue, Inigo Martincorena, Rakesh Heer, Peter J Campbell, Rebecca C Fitzgerald, Michael R Stratton, Raheleh Rahbari
Over the course of an individual's lifetime, normal human cells accumulate mutations1 . Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two ubiquitous mutational signatures, SBS1 and SBS5/40, accounted for the majority of acquired mutations in most cell types, but their absolute and relative contributions varied substantially. SBS18, which potentially reflects oxidative damage2 , and several additional signatures attributed to exogenous and endogenous exposures contributed mutations to subsets of cell types...
September 2021: Nature