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26 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27732578/a-renewed-model-of-pancreatic-cancer-evolution-based-on-genomic-rearrangement-patterns
#1
Faiyaz Notta, Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W Wilson, Ashton A Connor, Robert E Denroche, Sheng-Ben Liang, Andrew M K Brown, Jaeseung C Kim, Tao Wang, Jared T Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E Dick, Lawrence Heisler, Michael A Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G T Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M Petersen, Liran I Shlush, Lee Timms, Ming-Sound Tsao, Julie M Wilson, Christina K Yung, George Zogopoulos, John M S Bartlett, Ludmil B Alexandrov, Francisco X Real, Sean P Cleary, Michael H Roehrl, John D McPherson, Lincoln D Stein, Thomas J Hudson, Peter J Campbell, Steven Gallinger
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neoplasm (PanINs) lesions, makes two predictions: first, that pancreatic cancer develops through a particular sequence of genetic alterations (KRAS, followed by CDKN2A, then TP53 and SMAD4); and second, that the evolutionary trajectory of pancreatic cancer progression is gradual because each alteration is acquired independently...
October 12, 2016: Nature
https://www.readbyqxmd.com/read/27611616/invited-commentary-pasireotide-and-the-prevention-of-pancreatic-fistula-after-pancreatectomy-the-continued-search-for-harry-potter-s-liquid-luck
#2
Charles J Yeo
No abstract text is available yet for this article.
September 8, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27513157/no-need-for-routine-drainage-after-pancreatic-head-resection-the-dual-center-randomized-controlled-pandra-trial-isrctn04937707
#3
Helmut Witzigmann, Markus K Diener, Stefan Kienkötter, Inga Rossion, Thomas Bruckner, Bärbel Werner, Olaf Pridöhl, Olga Radulova-Mauersberger, Heike Lauer, Phillip Knebel, Alexis Ulrich, Oliver Strobel, Thilo Hackert, Markus W Büchler
OBJECTIVE: This dual-center, randomized, controlled, noninferiority trial aimed to prove that omission of drains does not increase reintervention rates after pancreatic surgery. BACKGROUND: There is considerable uncertainty regarding intra-abdominal drainage after pancreatoduodenectomy. METHODS: Patients undergoing pancreatic head resection with pancreaticojejunal anastomosis were randomized to intra-abdominal drainage versus no drainage. Primary endpoint was overall reintervention rate (relaparotomy or radiologic intervention)...
September 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27631774/neutrophil-to-lymphocyte-ratio-is-a-predictive-marker-for-invasive-malignancy-in-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#4
Georgios Gemenetzis, Fabio Bagante, James F Griffin, Neda Rezaee, Ammar A Javed, Lindsey L Manos, Anne M Lennon, Laura D Wood, Ralph H Hruban, Lei Zheng, Atif Zaheer, Elliot K Fishman, Nita Ahuja, John L Cameron, Matthew J Weiss, Jin He, Christopher L Wolfgang
OBJECTIVE: To evaluate the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values, and the presence of invasive carcinoma in patients with intraductal papillary mucinous neoplasm (IPMN). BACKGROUND: NLR and (PLR) are inflammatory markers that have been associated with overall survival in patients with invasive malignancies, including pancreatic cancer. METHODS: We retrospectively reviewed 272 patients who underwent surgical resection for histologically confirmed IPMN from January 1997 to July 2015...
September 14, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27663692/how-does-cholecystectomy-influence-recurrence-of-idiopathic-acute-pancreatitis
#5
Claire L Stevens, Saleh M Abbas, David A K Watters
BACKGROUND: Idiopathic acute pancreatitis is diagnosed in approximately 10-30 % of cases of acute pancreatitis. While there is evidence to suggest that the cause in many of these patients is microlithiasis, this fact has not been translated into a resource efficient treatment strategy that is proven to reduce recurrence rates. The aim of this study was to examine the value of prophylactic cholecystectomy following an episode of acute pancreatitis in patients with no history of alcohol abuse and no stones found on ultrasound...
December 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27224729/a-step-by-step-guide-to-laparoscopic-subtotal-fenestrating-cholecystectomy-a-damage-control-approach-to-the-difficult-gallbladder
#6
Sharmila Dissanaike
No abstract text is available yet for this article.
August 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/12365016/is-postoperative-adjuvant-chemotherapy-useful-for-gallbladder-carcinoma-a-phase-iii-multicenter-prospective-randomized-controlled-trial-in-patients-with-resected-pancreaticobiliary-carcinoma
#7
RANDOMIZED CONTROLLED TRIAL
Tadahiro Takada, Hodaka Amano, Hideki Yasuda, Yuji Nimura, Takashi Matsushiro, Hiroyuki Kato, Takukazu Nagakawa, Toshimichi Nakayama
BACKGROUND: To the authors' knowledge, the significance of postoperative adjuvant chemotherapy in pancreaticobiliary carcinoma has not yet been clarified. A randomized controlled study evaluated the effect of postoperative adjuvant therapy with mitomycin C (MMC) and 5-fluorouracil (5-FU) (MF arm) versus surgery alone (control arm) on survival and disease-free survival (DFS) for each specific disease comprising resected pancreaticobiliary carcinoma (pancreatic, gallbladder, bile duct, or ampulla of Vater carcinoma) separately...
October 15, 2002: Cancer
https://www.readbyqxmd.com/read/27244554/study-links-periodontal-disease-bacteria-to-pancreatic-cancer-risk
#8
Julie A Jacob
No abstract text is available yet for this article.
June 28, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27156933/gastric-cancer
#9
REVIEW
Eric Van Cutsem, Xavier Sagaert, Baki Topal, Karin Haustermans, Hans Prenen
Gastric cancer is one of the leading causes of cancer-related death worldwide. Many patients have inoperable disease at diagnosis or have recurrent disease after resection with curative intent. Gastric cancer is separated anatomically into true gastric adenocarcinomas and gastro-oesophageal-junction adenocarcinomas, and histologically into diffuse and intestinal types. Gastric cancer should be treated by teams of experts from different disciplines. Surgery is the only curative treatment. For locally advanced disease, adjuvant or neoadjuvant therapy is usually implemented in combination with surgery...
November 26, 2016: Lancet
https://www.readbyqxmd.com/read/27013365/advances-in-the-surgical-management-of-resectable-and-borderline-resectable-pancreas-cancer
#10
REVIEW
Beth A Helmink, Rebecca A Snyder, Kamran Idrees, Nipun B Merchant, Alexander A Parikh
Successful surgical resection offers the only chance for cure in patients with pancreatic cancer. However, pancreatic resection is feasible in less than 20% of the patients. In this review, the current state of surgical management of pancreatic cancer is discussed. The definition of resectability based on cross-sectional imaging and the technical aspects of surgery, including vascular resection and/or reconstruction, management of aberrant vascular anatomy and extent of lymphadenectomy, are appraised. Furthermore, common pancreatic resection-specific postoperative complications and their management are reviewed...
April 2016: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/17253565/primary-closure-versus-t-tube-drainage-after-open-common-bile-duct-exploration
#11
REVIEW
K S Gurusamy, K Samraj
BACKGROUND: Between 5% and 11% of people undergoing cholecystectomy have common bile duct stones. Open common bile duct exploration is an important operation when endoscopic retrograde cholangio-pancreatography fails or when expertise for laparoscopic common bile duct exploration is not available. The optimal method for performing open common bile duct exploration is unclear. OBJECTIVES: The aim is to assess the benefits and harms of primary closure versus routine T-tube drainage in open common bile duct exploration for common bile duct stones...
January 24, 2007: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27139061/pancreatic-cyst-disease-a-review
#12
REVIEW
Alexander Stark, Timothy R Donahue, Howard A Reber, O Joe Hines
IMPORTANCE: Cystic lesions of the pancreas are common and increasingly detected in the primary care setting. Some patients have a low risk for developing a malignancy and others have a high risk and need further testing and interventions. OBSERVATIONS: Pancreatic cysts may be intraductal mucinous neoplasms, mucinous cystic neoplasms, serous cystadenomas, solid pseudopapillary neoplasms, cystic variations of pancreatic neuroendocrine tumors, pancreatic ductal adenocarcinomas, or 1 of several types of nonneoplastic cysts...
May 3, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27093365/pd-1-blockade-with-pembrolizumab-in-advanced-merkel-cell-carcinoma
#13
MULTICENTER STUDY
Paul T Nghiem, Shailender Bhatia, Evan J Lipson, Ragini R Kudchadkar, Natalie J Miller, Lakshmanan Annamalai, Sneha Berry, Elliot K Chartash, Adil Daud, Steven P Fling, Philip A Friedlander, Harriet M Kluger, Holbrook E Kohrt, Lisa Lundgren, Kim Margolin, Alan Mitchell, Thomas Olencki, Drew M Pardoll, Sunil A Reddy, Erica M Shantha, William H Sharfman, Elad Sharon, Lynn R Shemanski, Michi M Shinohara, Joel C Sunshine, Janis M Taube, John A Thompson, Steven M Townson, Jennifer H Yearley, Suzanne L Topalian, Martin A Cheever
BACKGROUND: Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma often responds to chemotherapy, but responses are transient. Blocking the programmed death 1 (PD-1) immune inhibitory pathway is of interest, because these tumors often express PD-L1, and MCPyV-specific T cells express PD-1. METHODS: In this multicenter, phase 2, noncontrolled study, we assigned adults with advanced Merkel-cell carcinoma who had received no previous systemic therapy to receive pembrolizumab (anti-PD-1) at a dose of 2 mg per kilogram of body weight every 3 weeks...
June 30, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/26822397/gastrectomy-plus-chemotherapy-versus-chemotherapy-alone-for-advanced-gastric-cancer-with-a-single-non-curable-factor-regatta-a-phase-3-randomised-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Kazumasa Fujitani, Han-Kwang Yang, Junki Mizusawa, Young-Woo Kim, Masanori Terashima, Sang-Uk Han, Yoshiaki Iwasaki, Woo Jin Hyung, Akinori Takagane, Do Joong Park, Takaki Yoshikawa, Seokyung Hahn, Kenichi Nakamura, Cho Hyun Park, Yukinori Kurokawa, Yung-Jue Bang, Byung Joo Park, Mitsuru Sasako, Toshimasa Tsujinaka
BACKGROUND: Chemotherapy is the standard of care for incurable advanced gastric cancer. Whether the addition of gastrectomy to chemotherapy improves survival for patients with advanced gastric cancer with a single non-curable factor remains controversial. We aimed to investigate the superiority of gastrectomy followed by chemotherapy versus chemotherapy alone with respect to overall survival in these patients. METHODS: We did an open-label, randomised, phase 3 trial at 44 centres or hospitals in Japan, South Korea, and Singapore...
March 2016: Lancet Oncology
https://www.readbyqxmd.com/read/26813914/a-review-and-update-of-treatment-options-and-controversies-in-the-management-of-hepatocellular-carcinoma
#15
Mashaal Dhir, Alyson A Melin, Jeffrey Douaiher, Chi Lin, Weining Ken Zhen, Shahid M Hussain, Jean-Francois H Geschwind, Maria B Majella Doyle, Ghassan K Abou-Alfa, Chandrakanth Are
OBJECTIVE: To review the current management, outline recent advances and address controversies in the management of hepatocellular carcinoma (HCC). SUMMARY OF BACKGROUND DATA: The treatment of HCC is multidisciplinary involving hepatologists, surgeons, medical oncologists, radiation oncologists, radiologists, interventional radiologists, and other disciplines. Each of these disciplines brings its unique perspective and differing opinions that add to controversies in the management of HCC...
June 2016: Annals of Surgery
https://www.readbyqxmd.com/read/26791838/meta-analysis-of-drain-amylase-content-on-postoperative-day-1-as-a-predictor-of-pancreatic-fistula-following-pancreatic-resection
#16
REVIEW
M C Giglio, D R C Spalding, A Giakoustidis, A Zarzavadjian Le Bian, L R Jiao, N A Habib, M Pai
BACKGROUND: Drain amylase content in the days immediately after major pancreatic resection has been investigated previously as a predictor of postoperative pancreatic fistula (POPF). Its accuracy, however, has not been determined conclusively. The purpose of this study was to evaluate the accuracy of drain amylase content on the first day after major pancreatic resection in predicting the occurrence of POPF. METHODS: A literature search of the MEDLINE, Embase and Scopus(®) databases to 13 May 2015 was performed to identify studies evaluating the accuracy of drain amylase values on day 1 after surgery in predicting the occurrence of POPF...
March 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/26649591/how-much-should-we-pay-to-minimize-pancreatic-leak-the-cost-effectiveness-of-pasireotide-in-pancreatic-resection-retracted
#17
Daniel E Abbott, Jeffrey M Sutton, Peter L Jernigan, Alex Chang, Patrick Frye, Shimul A Shah, Daniel P Schauer, Mark H Eckman, Syed A Ahmad, Jeffrey J Sussman
INTRODUCTION: Pasireotide was recently shown to decrease leak rates after pancreatic resection, though the significant cost of the drug may be prohibitive. We conducted a cost-effectiveness analysis to determine whether prophylactic pasireotide possesses a reasonable cost profile by improving outcomes. METHODS: A cost-effectiveness model was constructed to compare pasireotide administration after pancreatic resection versus usual care, populated by probabilities of clinical outcomes from a recent randomized trial and hospital costs (2013 US$) from a university pancreatic disease center...
November 26, 2015: Annals of Surgery
https://www.readbyqxmd.com/read/26363649/multidisciplinary-management-of-locally-advanced-pancreatic-ductal-adenocarcinoma
#18
REVIEW
Farzad Alemi, Adnan Alseidi, W Scott Helton, Flavio G Rocha
No abstract text is available yet for this article.
September 2015: Current Problems in Surgery
https://www.readbyqxmd.com/read/26258316/resection-margin-and-survival-in-2368-patients-undergoing-hepatic-resection-for-metastatic-colorectal-cancer-surgical-technique-or-biologic-surrogate
#19
Eran Sadot, Bas Groot Koerkamp, Julie N Leal, Jinru Shia, Mithat Gonen, Peter J Allen, Ronald P DeMatteo, T Peter Kingham, Nancy Kemeny, Leslie H Blumgart, William R Jarnagin, Michael I DʼAngelica
OBJECTIVES: The impact of margin width on overall survival (OS) in the context of other prognostic factors after resection for colorectal liver metastases is unclear. We evaluated the relationship between resection margin and OS utilizing high-resolution histologic distance measurements. METHODS: A single-institution prospectively maintained database was queried for all patients who underwent an initial complete resection of colorectal liver metastases between 1992 and 2012...
September 2015: Annals of Surgery
https://www.readbyqxmd.com/read/26158612/minimally-invasive-versus-open-pancreaticoduodenectomy-for-cancer-practice-patterns-and-short-term-outcomes-among-7061-patients
#20
COMPARATIVE STUDY
Mohamed Abdelgadir Adam, Kingshuk Choudhury, Michaela A Dinan, Shelby D Reed, Randall P Scheri, Dan G Blazer, Sanziana A Roman, Julie A Sosa
OBJECTIVES: To describe national practice patterns regarding utilization of minimally invasive pancreaticoduodenectomy (MIPD) and compare short-term outcomes with those following open pancreaticoduodenectomy for cancer. BACKGROUND: There is increasing interest in use of MIPD; however, published data are limited to single institutional experiences. METHODS: Adult patients undergoing pancreaticoduodenectomy were identified from the National Cancer Database, 2010-2011...
August 2015: Annals of Surgery
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