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benzo withdrawal

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15 papers 0 to 25 followers Articles about withdrawal from benzodiazepines
Jonathan Brett, Bridin Murnion
There are well-recognised harms from long-term use of benzodiazepines. These include dependency, cognitive decline and falls. It is important to prevent and recognise benzodiazepine dependence. A thorough risk assessment guides optimal management and the necessity for referral. The management of dependence involves either gradual benzodiazepine withdrawal or maintenance treatment. Prescribing interventions, substitution, psychotherapies and pharmacotherapies can all contribute. Unless the patient is elderly, it is helpful to switch to a long-acting benzodiazepine in both withdrawal and maintenance therapy...
October 2015: Australian Prescriber
Katrin Janhsen, Patrik Roser, Knut Hoffmann
BACKGROUND: Benzodiazepine abuse and dependence have been recognized and widely discussed for more than 40 years. With more than 230 million daily doses prescribed in Germany per year, the burden of reimbursement on the statutory health insurance carriers is high, albeit with a slight decline from year to year. At present, about 50% of all prescriptions in Germany are issued privately, even for patients who have statutory health insurance. METHODS: We selectively review the literature on the epidemiology and treatment of benzodiazepine dependence and abuse in Germany...
January 5, 2015: Deutsches Ärzteblatt International
Allison M Paquin, Kristin Zimmerman, James L Rudolph
INTRODUCTION: Benzodiazepines (BZD) are potentially inappropriate for older adults, yet their use persists. Patients and providers may hesitate to discontinue BZDs due to concerns for withdrawal or relapse. We reviewed the literature for BZD reduction protocols to examine common elements, safety and efficacy. A framework is proposed for clinicians to address BZD reduction challenges. AREAS COVERED: Following a systematic literature review, this analysis included 28 studies of older out-patients tapering chronic BZDs...
July 2014: Expert Opinion on Drug Safety
Priya Gopalan, Jody B Glance, Pierre N Azzam
Substance use disorders during pregnancy pose serious risks for both the mother and the fetus, demanding careful monitoring by the patient's medical providers. Sedative-hypnotic use, in particular, is common but remains poorly studied. Management of withdrawal from chronic benzodiazepine use during pregnancy presents unique challenges to the treating physician. We present two pregnant patients with dependence on sedative-hypnotic agents, outline principles of benzodiazepine withdrawal, and suggest guidelines for detoxification during pregnancy...
April 2014: Archives of Women's Mental Health
Jeffrey A Gudin, Shanthi Mogali, Jermaine D Jones, Sandra D Comer
The concurrent use of opioids, benzodiazepines (BZDs), and/or alcohol poses a formidable challenge for clinicians who manage chronic pain. While the escalating use of opioid analgesics for the treatment of chronic pain and the concomitant rise in opioid-related abuse and misuse are widely recognized trends, the contribution of combination use of BZDs, alcohol, and/or other sedative agents to opioid-related morbidity and mortality is underappreciated, even when these agents are used appropriately. Patients with chronic pain who use opioid analgesics along with BZDs and/or alcohol are at higher risk for fatal/nonfatal overdose and have more aberrant behaviors...
July 2013: Postgraduate Medicine
Fabio Lugoboni, Gianluca Quaglio
No abstract text is available yet for this article.
February 2014: British Journal of Clinical Pharmacology
Sean David Hood, Amanda Norman, Dana Adelle Hince, Jan Krzysztof Melichar, Gary Kenneth Hulse
Globally benzodiazepines remain one of the most prescribed medication groups, especially in the primary care setting. With such high levels of prescribing it is not surprising that benzodiazepine dependence is common, cutting across all socioeconomic levels. Despite recognition of the potential for the development of iatrogenic dependence and the lack of any effective treatment, benzodiazepines continue to be widely prescribed in general practice. Conventional dependence management, benzodiazepine tapering, is commonly a protracted process over several weeks or months...
February 2014: British Journal of Clinical Pharmacology
Malcolm Lader
The benzodiazepines (BZDs) are anxiolytics, hypnotics, anticonvulsants, muscle-relaxants and induce anaesthesia. Adverse effects comprise sedation subjectively and cognitive and psychomotor impairment objectively. Complex skills such as driving can be compromised. Paradoxical excitement can have forensic implications. Long term use beyond the licensed durations is common but both efficacy and adverse effects associated with this have been poorly documented. Withdrawal and dependence have excited particular concern, and even polemic...
February 2014: British Journal of Clinical Pharmacology
Panagiotis Oulis, George Konstantakopoulos
INTRODUCTION: Both alcohol and benzodiazepine dependence (AD, BD) are severe and chronic conditions with devastating physical and mental health effects. The relative scarcity and controversial evidential status of available pharmacological interventions for the treatment of patients' acute withdrawal syndrome and/or relapse prevention call for the clinical investigation of novel safe and efficacious agents. AREAS COVERED: We review published studies of pregabalin as monotherapy in the treatment of AD and BD in more than 450 patients...
July 2012: Expert Opinion on Investigational Drugs
N Authier, D Balayssac, M Sautereau, A Zangarelli, P Courty, A A Somogyi, B Vennat, P-M Llorca, A Eschalier
Benzodiazepines are potentially addictive drugs: psychological and physical dependence can develop within a few weeks or years of regular or repeated use. The socioeconomic costs of the present high level of long-term benzodiazepine use are considerable. These consequences could be minimised if prescriptions for long-term benzodiazepines were decreased. However, many physicians continue to prescribe benzodiazepines and patients wishing to withdraw receive little advice or support. Particular care should be taken in prescribing benzodiazepines for vulnerable patients such as elderly persons, pregnant women, children, alcohol- or drug-dependent patients and patients with comorbid psychiatric disorders...
November 2009: Annales Pharmaceutiques Françaises
Malcolm Lader
No abstract text is available yet for this article.
January 2009: Addiction
Malcolm Lader, Andre Tylee, John Donoghue
The use of benzodiazepine anxiolytics and hypnotics continues to excite controversy. Views differ from expert to expert and from country to country as to the extent of the problem, or even whether long-term benzodiazepine use actually constitutes a problem. The adverse effects of these drugs have been extensively documented and their effectiveness is being increasingly questioned. Discontinuation is usually beneficial as it is followed by improved psychomotor and cognitive functioning, particularly in the elderly...
2009: CNS Drugs
Jannette M Parr, David J Kavanagh, Lareina Cahill, Geoffrey Mitchell, Ross McD Young
AIMS: To assess the effectiveness of current treatment approaches to assist benzodiazepine discontinuation. METHODS: A systematic review of approaches to benzodiazepine discontinuation in general practice and out-patient settings was undertaken. Routine care was compared with three treatment approaches: brief interventions, gradual dose reduction (GDR) and psychological interventions. GDR was compared with GDR plus psychological interventions or substitutive pharmacotherapies...
January 2009: Addiction
Richard C Oude Voshaar, Jaap E Couvée, Anton J L M van Balkom, Paul G H Mulder, Frans G Zitman
BACKGROUND: The prevalence of benzodiazepine consumption in European countries remains at 2-3% of the general population despite the well-documented disadvantages of long-term use. AIMS: To review systematically the success rates of different benzodiazepine discontinuation strategies. METHOD: Meta-analysis of comparable intervention studies. RESULTS: Twenty-nine articles met inclusion criteria. Two groups of interventions were identified; minimal intervention (e...
September 2006: British Journal of Psychiatry: the Journal of Mental Science
Heather Ashton
PURPOSE OF REVIEW: Despite repeated recommendations to limit benzodiazepines to short-term use (2-4 weeks), doctors worldwide are still prescribing them for months or years. This over-prescribing has resulted in large populations of long-term users who have become dependent on benzodiazepines and has also led to leakage of benzodiazepines into the illicit drug market. This review outlines the risks of long-term benzodiazepine use, gives guidelines on the management of benzodiazepine withdrawal and suggests ways in which dependence can be prevented...
May 2005: Current Opinion in Psychiatry
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