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33 papers 25 to 100 followers
Douglas S Ross, Henry B Burch, David S Cooper, M Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A Rivkees, Mary Samuels, Julie Ann Sosa, Marius N Stan, Martin A Walter
BACKGROUND: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspecialty physicians and others providing care for patients with this condition. METHODS: The American Thyroid Association (ATA) previously cosponsored guidelines for the management of thyrotoxicosis that were published in 2011...
October 2016: Thyroid: Official Journal of the American Thyroid Association
Laura Maggino, Stefano Francesco Crinò, Laura Bernardoni, Giovanni Marchegiani, Giuseppe Malleo, Roberto Salvia, Armando Gabbrielli
No abstract text is available yet for this article.
2016: Endoscopy
J Gehrman, E Angenete, I Björholt, D Bock, J Rosenberg, E Haglind
BACKGROUND: Open surgery with resection and colostomy (Hartmann's procedure) has been the standard treatment for perforated diverticulitis with purulent peritonitis. In recent years laparoscopic lavage has emerged as an alternative, with potential benefits for patients with purulent peritonitis, Hinchey grade III. The aim of this study was to compare laparoscopic lavage and Hartmann's procedure with health economic evaluation within the framework of the DILALA (DIverticulitis - LAparoscopic LAvage versus resection (Hartmann's procedure) for acute diverticulitis with peritonitis) trial...
October 2016: British Journal of Surgery
Michael E Egger, Neal Bhutiani, Russell W Farmer, Arnold J Stromberg, Robert C G Martin, Amy R Quillo, Kelly M McMasters, Charles R Scoggins
BACKGROUND: Sentinel lymph node (SLN) biopsy for melanoma results in accurate nodal staging, which guides treatment decisions. Patients with a negative SLN biopsy in general have a favorable prognosis, but certain subsets are at increased risk for recurrence and death. This study aimed to identify risk factors predictive of prognosis in patients with a tumor-negative SLN biopsy for cutaneous melanoma. METHODS: In this post-hoc analysis of data from a multicenter prospective randomized trial, clinicopathologic data of patients with cutaneous melanoma ≥1...
May 2016: Surgery
Alban Zarzavadjian Le Bian, Manuela Cesaretti, Claude Smadja, Renato Costi
BACKGROUND: Total laparoscopic right colectomy (TLRC) is a demanding procedure requiring laparoscopic skills and expertise in surgical oncology. Identifying the correct plane of dissection may be difficult. A correct management of ileocecal and right colic vascular pedicles is pivotal to achieve an oncological resection and the adequate blood supply of ileal and colic stumps. METHODS: We describe a technique for TLRC with a duodenum-first approach. Using three ports, dividing the "duodenal window", ileocecal and right colic vascular pedicles, and the right ureter are easily identified...
June 2016: Surgical Oncology
Steven D Weisbord, Paul M Palevsky
No abstract text is available yet for this article.
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
A J M Rombouts, N Hugen, M A G Elferink, I D Nagtegaal, J H W de Wilt
BACKGROUND: Neoadjuvant chemoradiation therapy (CRT) has been widely implemented in the treatment of rectal cancer patients, but optimal timing of surgery after neoadjuvant therapy is unclear. The purpose of this study was to evaluate the effects of prolonged intervals between long-course CRT and surgery in rectal cancer patients. METHODS: Data on all rectal cancer patients diagnosed between 2006 and 2011 were retrieved from the population-based Netherlands Cancer Registry; the main outcome parameters were pathologic complete response (pCR) and overall survival (OS)...
October 2016: Annals of Surgical Oncology
Derek J Roberts, Chad G Ball, David V Feliciano, Ernest E Moore, Rao R Ivatury, Charles E Lucas, Timothy C Fabian, David A Zygun, Andrew W Kirkpatrick, Henry T Stelfox
OBJECTIVE: To review the history of the innovation of damage control (DC) for management of trauma patients. BACKGROUND: DC is an important development in trauma care that provides a valuable case study in surgical innovation. METHODS: We searched bibliographic databases (1950-2015), conference abstracts (2009-2013), Web sites, textbooks, and bibliographies for articles relating to trauma DC. The innovation of DC was then classified according to the Innovation, Development, Exploration, Assessment, and Long-term study model of surgical innovation...
June 17, 2016: Annals of Surgery
Lori-Ann Linkins
No abstract text is available yet for this article.
April 21, 2016: Blood
Ornela A Dervishaj
No abstract text is available yet for this article.
February 2016: Journal of the American College of Surgeons
Jeffrey E Gotts, Michael A Matthay
Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune dysfunction and catabolism. Much has been learnt about the pathogenesis of sepsis at the molecular, cell, and intact organ level...
2016: BMJ: British Medical Journal
Andrew T Schlussel, Scott R Steele, Karim Alavi
BACKGROUND: Crohn's disease is a chronic inflammatory disorder, and the broad variability in phenotypic presentations makes the treatment of this disease a true multidisciplinary approach. We sought to review the current recommendations regarding the surgical management of Crohn's disease. DATA SOURCE: A Systematic literature review of surgical techniques was performed from 1979 through 2015. We evaluated 30 articles focusing on findings over the past 5 years. CONCLUSIONS: Crohn's is a complex disease with no surgical cure...
August 2016: American Journal of Surgery
C Atkinson, C M Penfold, A R Ness, R J Longman, S J Thomas, W Hollingworth, R Kandiyali, S D Leary, S J Lewis
BACKGROUND: Chewing gum may stimulate gastrointestinal motility, with beneficial effects on postoperative ileus suggested in small studies. The primary aim of this trial was to determine whether chewing gum reduces length of hospital stay (LOS) after colorectal resection. Secondary aims included examining bowel habit symptoms, complications and healthcare costs. METHODS: This clinical trial allocated patients randomly to standard postoperative care with or without chewing gum (sugar-free gum for at least 10 min, four times per day on days 1-5) in five UK hospitals...
July 2016: British Journal of Surgery
Devi Mukkai Krishnamurty, Paul E Wise
Distal resection margin (DRM) and circumferential resection margin (CRM) are two important considerations in rectal cancer management. Although guidelines recommend a 2 cm DRM, studies have shown that a shorter DRM is adequate, especially in patients receiving neoadjuvant chemoradiation. Standardization of total mesorectal excision has greatly improved quality of CRM. Although more patients are undergoing sphincter-saving procedures, abdominoperineal resection is indicated for very distal tumors, and pelvic exenteration is often necessary for tumors involving pelvic organs...
March 2016: Journal of Surgical Oncology
Robert P Jones, Graeme J Poston
No abstract text is available yet for this article.
February 2016: Annals of Surgical Oncology
Ali Irqam Malik, Richard L Nelson, Samson Tou
BACKGROUND: The perianal abscess is a common surgical problem. A third of perianal abscesses may manifest a fistula-in-ano which increases the risk of abscess recurrence requiring repeat surgical drainage. Treating the fistula at the same time as incision and drainage of the abscess may reduce the likelihood of recurrent abscess and the need for repeat surgery. However, this could affect sphincter function in some patients who may not have later developed a fistula-in-ano. OBJECTIVES: We aimed to review the available randomised controlled trial evidence comparing incision and drainage of perianal abscess with or without fistula treatment...
July 7, 2010: Cochrane Database of Systematic Reviews
Didier Musso, Duane J Gubler
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya...
July 2016: Clinical Microbiology Reviews
Daniel C Jupiter, Xiao Fang, Deepak Adhikari, Hemalkumar B Mehta, Taylor S Riall
OBJECTIVE: Our study aimed to estimate postoperative bleeding risk in older adults taking clopidogrel before gastrointestinal (GI) surgery, to aid surgeons in decisions regarding clopigogrel cessation. SUMMARY BACKGROUND DATA: Balancing risks of postoperative bleeding associated with continued clopidogrel use and those associated with cessation is difficult for GI surgeons. METHODS: Using 100% Texas Medicare Claims Data from 2006 to 2011, we identified patients undergoing emergent GI surgery...
April 5, 2016: Annals of Surgery
L Pearce, K Newton, S R Smith, P Barrow, J Smith, L Hancock, C C Kirwan, J Hill
INTRODUCTION: Management of perianal abscesses has remained largely unchanged for over 50 years. The evidence for postoperative wound packing is limited and may expose patients to painful procedures with no clinical benefit and at considerable increased cost. METHODS: Patients were recruited in 15 UK centres between December 2013 and October 2014. Outcome measures included number of dressing (pack) changes, healing, recurrence, return to work/normal function, postoperative fistula in ano and health utility scores (EQ-5D™)...
July 2016: British Journal of Surgery
Benjamin Y Tan, Geza Acs, Sophia K Apple, Sunil Badve, Ira J Bleiweiss, Edi Brogi, José P Calvo, David J Dabbs, Ian O Ellis, Vincenzo Eusebi, Gelareh Farshid, Stephen B Fox, Shu Ichihara, Sunil R Lakhani, Emad A Rakha, Jorge S Reis-Filho, Andrea L Richardson, Aysegul Sahin, Fernando C Schmitt, Stuart J Schnitt, Kalliopi P Siziopikou, Fernando A Soares, Gary M Tse, Anne Vincent-Salomon, Puay Hoon Tan
Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic...
January 2016: Histopathology
2016-04-11 08:48:22
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