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By Alessandro Franciscon doctor
F Güçlü Pinarli, Aynur Oguz, Karadeniz Ceyda, Leyla Memiş, Poyraz Aylar
Pleuropulmonary blastoma is a rare and aggressive primary intrathoracic neoplasm of children. T'he prognosis is extremely poor with frequent metastasis to the brain and bone. A 4-year-old boy successfully treated with multimodal therapy despite unfavorable prognostic factors is presented. The authors support the use of aggressive treatment of pleuropulmonary blastoma with surgery, chemotherapy, and radiotherapy.
January 2005: Pediatric Hematology and Oncology
Julio C Barredo, Meenakshi Devidas, Stephen J Lauer, Amy Billett, Maryanne Marymont, Jeanette Pullen, Bruce Camitta, Naomi Winick, William Carroll, A Kim Ritchey
PURPOSE: Prognosis and outcome of children with isolated CNS relapse of acute lymphoblastic leukemia (ALL) has depended on duration of first complete remission (CR1). This study intensified systemic therapy by delaying CNS radiation for 12 months and tailored CNS radiation by CR1 duration. PATIENTS AND METHODS: Seventy-six children with first isolated CNS relapse of ALL were treated with systemic chemotherapy that effectively penetrates into the CSF and intrathecal chemotherapy for 12 months...
July 1, 2006: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Edward Allan R Sison, Lewis B Silverman
No abstract text is available yet for this article.
December 5, 2014: Hematology—the Education Program of the American Society of Hematology
Navin R Pinto, Mark A Applebaum, Samuel L Volchenboum, Katherine K Matthay, Wendy B London, Peter F Ambros, Akira Nakagawara, Frank Berthold, Gudrun Schleiermacher, Julie R Park, Dominique Valteau-Couanet, Andrew D J Pearson, Susan L Cohn
Risk-based treatment approaches for neuroblastoma have been ongoing for decades. However, the criteria used to define risk in various institutional and cooperative groups were disparate, limiting the ability to compare clinical trial results. To mitigate this problem and enhance collaborative research, homogenous pretreatment patient cohorts have been defined by the International Neuroblastoma Risk Group classification system. During the past 30 years, increasingly intensive, multimodality approaches have been developed to treat patients who are classified as high risk, whereas patients with low- or intermediate-risk neuroblastoma have received reduced therapy...
September 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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