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Wellness Biomarkers & Genes: ParuchMD

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11 papers 0 to 25 followers Relevant biological and genetic markers of health and well-being. ##ParuchMD
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
Raj Chetty, Michael Stepner, Sarah Abraham, Shelby Lin, Benjamin Scuderi, Nicholas Turner, Augustin Bergeron, David Cutler
IMPORTANCE: The relationship between income and life expectancy is well established but remains poorly understood. OBJECTIVES: To measure the level, time trend, and geographic variability in the association between income and life expectancy and to identify factors related to small area variation. DESIGN AND SETTING: Income data for the US population were obtained from 1.4 billion deidentified tax records between 1999 and 2014. Mortality data were obtained from Social Security Administration death records...
April 26, 2016: JAMA: the Journal of the American Medical Association
Pia Leandersson, Grigorios Kalapotharakos, Emir Henic, Henrik Borgfeldt, Max Petzold, Gunilla Høyer-Hansen, Christer Borgfeldt
BACKGROUND/AIM: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II. PATIENTS AND METHODS: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) were analyzed in 350 patients with adnexal lesions. RESULTS: The levels of suPAR(II-III), HE4, CA125 were all higher in EOC II than in EOC I, borderline and benign ovarian tumors...
March 2016: Anticancer Research
Christy A Olson, Nancy A Hamilton, Virend K Somers
Sleep contributes importantly to energy homeostasis, and may impact hormones regulating appetite, such as leptin, an adipocyte-derived hormone. There is increasing evidence that sleep duration, and reduced rapid eye movement sleep, are linked to obesity. Leptin has central neural effects beyond modulation of appetite alone. As sleep is not a unifrom process, interactions between leptin and sleep stages including rapid eye movement sleep may play a role in the relationship between sleep and obesity. This study examined the relationship between serum leptin and rapid eye movement sleep in a sample of healthy adults...
August 2016: Journal of Sleep Research
Luminita Animarie Vida Simiti, Irina Todor, Mirela Anca Stoia, Cerasela Mihaela Goidescu, Florin Petru Anton, Anca Daniela Farcas
BACKGROUND AND AIM: The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD...
2016: Clujul Medical (1957)
Orhan Ünal Zorba, Hakkı Uzun, Görkem Akça, Selim Yazar
Because various criteria are used to define metabolic syndrome (MetS), this study examines the most relevant definition for patients with benign prostatic enlargement (BPE). Most studies regarding the link between MetS and BPE/lower urinary tract symptoms (LUTS) have used the National Cholesterol Education Program Adult Treatment Panel III criteria for diagnosis, while a few have used criteria from the International Diabetes Federation and/or American Heart Association. Patients with LUTS due to BPE are classified as having MetS or not by the aforementioned three definitions...
March 18, 2016: American Journal of Men's Health
T Dimitroulas, A Sandoo, J Hodson, J Smith, K M Douglas, G D Kitas
OBJECTIVES: The aim of our study was to determine whether asymmetric dimethylarginine (ADMA) levels are associated with homocysteine (Hcy) and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) gene variants in patients with rheumatoid arthritis (RA). METHOD: Serum ADMA and Hcy levels were measured in 201 RA individuals [155 (77.1%) females, median age 67 years (interquartile range 59-73)]. The MTHFR C677T polymorphism was assessed by using the LightCyclerTM System...
July 2016: Scandinavian Journal of Rheumatology
Nancy L Sin, Jennifer E Graham-Engeland, Anthony D Ong, David M Almeida
OBJECTIVE: Inflammation increases the risk of chronic diseases, but the links between emotional responses to daily events and inflammation are unknown. We examined individual differences in affective reactivity to daily stressors (i.e., changes in positive and negative affect in response to stressors) as predictors of inflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP). METHODS: A cross-sectional sample of 872 adults from the National Study of Daily Experiences (substudy of Midlife in the United States II) reported daily stressors and affect during telephone interviews for 8 days...
December 2015: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Ikuhiko Shibuya, Shinichiro Nagamitsu, Hisayoshi Okamura, Shuichi Ozono, Hiromi Chiba, Takashi Ohya, Yushiro Yamashita, Toyojiro Matsuishi
BACKGROUND: Cortisol awakening response (CAR) as an indicator of psychological stress and related physical and psychiatric diseases has attracted growing attention from researchers. Although CAR changes have been investigated extensively in children with behavioral and psychiatric disorders, the association between CAR and conventional psychometric scales for healthy children has not been reported. The aim of this study was to investigate the association between salivary CAR and subscales of Profiles of Mood States (POMS), a self-assessment questionnaire widely used to evaluate the temporal emotional states of healthy children...
2014: BioPsychoSocial Medicine
Wen-Hsuan Lan, Albert C Yang, Jen-Ping Hwang, Chen-Jee Hong, Ying-Jay Liou, Heng-Liang Yeh, Mu-En Liu, Shih-Jen Tsai
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression. The present work aimed to investigate the effect of MTHFR C677T polymorphism on the presence of depression and loneliness in cognitively normal male subjects. A total of 323 cognitively normal male subjects were included in this study (mean age=80.6; SD=5.3). Depression was assessed by the Geriatric Depression Scale-Short Form (GDS-SF) and loneliness by UCLA loneliness scales...
July 11, 2012: Neuroscience Letters
Odette L J Peerbooms, Jim van Os, Marjan Drukker, Gunter Kenis, Loes Hoogveld, Marc de Hert, Philippe Delespaul, Ruud van Winkel, Bart P F Rutten
Past analyses examining the relationship between genetic variation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have provided mixed and largely inconclusive findings. MTHFR is involved in the one-carbon metabolic pathway which is essential for DNA biosynthesis and the epigenetic process of DNA methylation. We conducted a meta-analysis of all published case-control studies investigating associations between two common MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T (sample size 29,502) and A1298C (sample size 7934), and the major psychiatric disorders (i) schizophrenia (SZ), (ii) bipolar disorder (BPD), and (iii) unipolar depressive disorder (UDD)...
November 2011: Brain, Behavior, and Immunity
Sereina Bodenmann, Thomas Rusterholz, Roland Dürr, Claudia Stoll, Valérie Bachmann, Eva Geissler, Karin Jaggi-Schwarz, Hans-Peter Landolt
Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Val allele homozygotes exhibit higher COMT activity and lower dopaminergic signaling in prefrontal cortex than Met/Met homozygotes...
September 2, 2009: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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