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Depression: ParuchMD

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18 papers 25 to 100 followers
By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
Atul Gulati, Masood Ali, Mike Davies, Tim Quinnell, Ian Smith
BACKGROUND: Compliance with CPAP treatment for OSAS is not reliably predicted by the severity of symptoms or physiological variables. We examined a range of factors which could be measured before CPAP initiation to look for predictors of compliance. METHODS: This was a prospective cohort-study of CPAP treatment for OSAS, recording; socio-economic status, education, type D personality and clinician's prediction of compliance. RESULTS: We recruited 265 subjects, of whom 221 were still using CPAP at 6 months; median age 53 years, M: F, 3...
March 22, 2017: BMC Pulmonary Medicine
J J McGrath
No abstract text is available yet for this article.
March 2017: Acta Psychiatrica Scandinavica
Patricia A Ford, Karen Jaceldo-Siegl, Jerry W Lee, Serena Tonstad
Trans fatty acids in Western diets increase health risks, and have been associated with the risk of depression. We hypothesized that intakes of trans fatty acids (primarily from margarines and baked goods) were inversely associated with positive affect and positively associated with negative affect in a longitudinal study. Church attendees residing in North America completed a food frequency questionnaire in 2002-6 as part of the Adventist Health Study-2. A subset in which we excluded participants with established cardiovascular disease (n=8,771) completed the Positive and Negative Affect Schedule (PANAS) in 2006-7...
June 2016: Nutrition Research
Mark Olfson, Carlos Blanco, Steven C Marcus
Importance: Despite recent increased use of antidepressants in the United States, concerns persist that many adults with depression do not receive treatment, whereas others receive treatments that do not match their level of illness severity. Objective: To characterize the treatment of adult depression in the United States. Design, Setting, and Participants: Analysis of screen-positive depression, psychological distress, and depression treatment data from 46 417 responses to the Medical Expenditure Panel Surveys taken in US households by participants aged 18 years or older in 2012 and 2013...
October 1, 2016: JAMA Internal Medicine
Raghid Charara, Charbel El Bcheraoui, Hannah Kravitz, Satvinder S Dhingra, Ali H Mokdad
INTRODUCTION: Mental illness prevalence is increasing in USA. Understanding the relationship between functional status and mental health is crucial in optimizing psychiatric treatment. METHODS: We used 2000-2014 BRFSS data to examine the relationship between functional health and frequent mental distress in 51 states. RESULTS: East-South-Central US (14.88%) had the highest prevalence of frequent mental distress and West-North-Central (9.42%) the lowest...
August 2016: Preventive Medicine
Robin L Carhart-Harris, Mark Bolstridge, James Rucker, Camilla M J Day, David Erritzoe, Mendel Kaelen, Michael Bloomfield, James A Rickard, Ben Forbes, Amanda Feilding, David Taylor, Steve Pilling, Valerie H Curran, David J Nutt
BACKGROUND: Psilocybin is a serotonin receptor agonist that occurs naturally in some mushroom species. Recent studies have assessed the therapeutic potential of psilocybin for various conditions, including end-of-life anxiety, obsessive-compulsive disorder, and smoking and alcohol dependence, with promising preliminary results. Here, we aimed to investigate the feasibility, safety, and efficacy of psilocybin in patients with unipolar treatment-resistant depression. METHODS: In this open-label feasibility trial, 12 patients (six men, six women) with moderate-to-severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 mg and 25 mg, 7 days apart) in a supportive setting...
July 2016: Lancet Psychiatry
Kornanong Yuenyongchaiwat
BACKGROUND: Being overweight is associated not only with physical health problems, but also with risk of mental health problems. Increased physical activity (PA) has been recommended for the prevention of cardiovascular disease; however, little is known about the effect of walking on physical and mental health outcomes. OBJECTIVE: The purpose of the study was to explore the effectiveness of a pedometer-based PA intervention on physical and mental health states. METHOD: Thirty-five overweight participants with body mass index (BMI) ≥25 kg•m-2 were selected and assigned to a 12-week pedometer-based walking program (10,000 steps•d-1)...
June 16, 2016: Brazilian Journal of Physical Therapy
Larry Culpepper
Functional impairment is inherent to depression, but frequently these impairments are more resistant to treatment than the actual symptoms of depression. Unfortunately, a patient cannot truly overcome depression until these impairments are addressed. A number of validated instruments are available to help clinicians assess functional impairment and monitor it throughout treatment. Clinicians must work with patients to develop personalized short-term and long-term functional goals and determine whether pharmacologic, nonpharmacologic, or rehabilitative treatment is needed...
January 2016: Journal of Clinical Psychiatry
Robert M Carney, Brian C Steinmeyer, Kenneth E Freedland, Eugene H Rubin, Michael W Rich, William S Harris
OBJECTIVE: Depression is associated with low red blood cell (RBC) levels of 2 omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), suggesting that omega-3 supplements might improve depression. However, clinical trials have produced mixed results. The purpose of this secondary analysis of data from a randomized controlled trial was to determine whether baseline blood levels of omega-3, which are known to vary widely among individuals, predict depression outcomes...
February 2016: Journal of Clinical Psychiatry
Cristina Benatti, Joan M C Blom, Giovanna Rigillo, Silvia Alboni, Francesca Zizzi, Riccardo Torta, Nicoletta Brunello, Fabio Tascedda
Progression of major depression, a multifactorial disorder with a neuroinflammatory signature, seems to be associated with the disruption of body allostasis. High rates of comorbidity between depression and specific medical disorders, such as, stroke, chronic pain conditions, diabetes mellitus, and human immunodeficiency virus (HIV) infection, have been extensively reported. In this review, we discuss how these medical disorders may predispose an individual to develop depression by examining the impact of these disorders on some hallmarks of neuroinflammation known to be impaired in depressed patients: altered permeability of the blood brain barrier, immune cells infiltration, activated microglia, increased cytokines production, and the role of inflammasomes...
2016: CNS & Neurological Disorders Drug Targets
Monika B Raniti, Nicholas B Allen, Orli Schwartz, Joanna M Waloszek, Michelle L Byrne, Michael J Woods, Bei Bei, Christian L Nicholas, John Trinder
This study explored whether short sleep duration and sleep quality mediate the relationship between age and depressive symptoms. For comparison, we also explored whether depressive symptoms mediate the relationship between age and short sleep duration and sleep quality. The sample comprised 741 adolescents (63.5% female, mean age 15.78 years, range 11.92-19.67 years) in grades 7-12 from 11 secondary schools in metropolitan Melbourne, Australia. Students completed the Pittsburgh Sleep Quality Index (PSQI) and Center for Epidemiologic Studies Depression Scale (CES-D)...
May 2017: Behavioral Sleep Medicine
Kerry Gibson, Claire Cartwright, John Read
While men's experiences of depression and help seeking are known to be shaped by gender, there is little research which examines their experience of using antidepressants to treat this. This study is based on in-depth, narrative-style interviews with 20 New Zealand men who had used antidepressants. The analysis identified a number of areas of conflict in the men's accounts of using this medication. Conflict centered on the way taking antidepressants was seen as undermining personal control while also allowing users to take charge of their problems; facilitating general functioning while undermining sexual functioning; relieving emotional distress while undermining emotional vitality; and the tension participants felt between making autonomous judgments about the value of antidepressants and relying on the "expertise" of others...
January 2018: American Journal of Men's Health
George G Kirov, Laura Owen, Hazel Ballard, Adele Leighton, Kara Hannigan, Danielle Llewellyn, Valentina Escott-Price, Maria Atkins
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective acute treatment for severe depression, but widely held concerns about memory problems may limit its use. AIMS: To find out whether repeated or maintenance courses of ECT cause cumulative cognitive deterioration. METHOD: Analysis of the results of 10 years of cognitive performance data collection from patients who have received ECT. The 199 patients had a total of 498 assessments, undertaken after a mean of 15...
March 2016: British Journal of Psychiatry: the Journal of Mental Science
Damien Ridge, Renata Kokanovic, Alex Broom, Susan Kirkpatrick, Claire Anderson, Claire Tanner
Discontents surrounding depression are many, and include concerns about a creeping appropriation of everyday kinds of misery; divergent opinions on the diagnostic category(ies); and debates about causes and appropriate treatments. The somewhat mixed fortunes of antidepressants - including concerns about their efficacy, overuse and impacts on personhood - have contributed to a moral ambivalence around antidepressant use for people with mental health issues. Given this, we set out to critically examine how antidepressant users engage in the moral underpinnings of their use, especially how they ascribe legitimacy (or otherwise) to this usage...
December 2015: Social Science & Medicine
J Verduijn, Y Milaneschi, R A Schoevers, A M van Hemert, A T F Beekman, B W J H Penninx
Meta-analyses support the involvement of different pathophysiological mechanisms (inflammation, hypothalamic-pituitary (HPA)-axis, neurotrophic growth and vitamin D) in major depressive disorder (MDD). However, it remains unknown whether dysregulations in these mechanisms are more pronounced when MDD progresses toward multiple episodes and/or chronicity. We hypothesized that four central pathophysiological mechanisms of MDD are not only involved in etiology, but also associated with clinical disease progression...
September 29, 2015: Translational Psychiatry
M Belvederi Murri, M Amore, M Menchetti, G Toni, F Neviani, M Cerri, M B L Rocchi, D Zocchi, L Bagnoli, E Tam, A Buffa, S Ferrara, M Neri, G S Alexopoulos, S Zanetidou
BACKGROUND: Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. AIMS: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. METHOD: Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone...
September 2015: British Journal of Psychiatry: the Journal of Mental Science
Mats Hallgren, Martin Kraepelien, Agneta Öjehagen, Nils Lindefors, Zangin Zeebari, Viktor Kaldo, Yvonne Forsell
BACKGROUND: Depression is common and tends to be recurrent. Alternative treatments are needed that are non-stigmatising, accessible and can be prescribed by general medical practitioners. AIMS: To compare the effectiveness of three interventions for depression: physical exercise, internet-based cognitive-behavioural therapy (ICBT) and treatment as usual (TAU). A secondary aim was to assess changes in self-rated work capacity. METHOD: A total of 946 patients diagnosed with mild to moderate depression were recruited through primary healthcare centres across Sweden and randomly assigned to one of three 12-week interventions (trail registry: KCTR study ID: KT20110063)...
September 2015: British Journal of Psychiatry: the Journal of Mental Science
Megumi Ida, Itsurou Ida, Naoki Wada, Makoto Sohmiya, Masayuki Tazawa, Kenji Shirakura
BACKGROUND: The efficacy of physical exercise as an augmentation to pharmacotherapy with antidepressants for depressive patients has been documented. However, to clarify the effectiveness of exercise in the treatment of depression, it is necessary to distinguish the effect of the exercise itself from the effect of group dynamics. Furthermore, an objective measurement for estimation of the effect is needed. Previous reports adopted a series of group exercises as the exercise intervention and mainly psychometric instruments for the measurement of effectiveness...
2013: BioPsychoSocial Medicine
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