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3 papers 0 to 25 followers
Rebecca Llewellyn-Bennett, Louise Bowman, Richard Bulbulia
BACKGROUND: Clinical trials typically have a relatively short follow-up period, and may both underestimate potential benefits of treatments investigated, and fail to detect hazards, which can take much longer to emerge. Prolonged follow-up of trial participants after the end of the scheduled trial period can provide important information on both efficacy and safety outcomes. This protocol describes a systematic review to qualitatively compare methods of post-trial follow-up used in large randomized controlled trials...
December 15, 2016: Systematic Reviews
Keith J Barrington
Staying abreast of the neonatal literature is an important task. Being aware of new information and knowing how to evaluate its reliability remain essential to be able to provide the most appropriate, evidence-based, therapy to our patients. This article discusses methods for being informed of, and critically reviewing, published research in order to fulfill these tasks without being overwhelmed by the number or complexity of publications.
December 2015: Seminars in Fetal & Neonatal Medicine
Lisa Askie, Martin Offringa
Systematic reviews and meta-analyses are at the top of the 'evidence hierarchy' when assessing the effectiveness of health interventions. As such, they are important sources of synthesized information for decision-makers including consumers, clinicians, funders, payers, regulators, and researchers. The main reasons for undertaking systematic reviews and meta-analyses are to minimize bias and to maximize data by collating all the relevant, available evidence on a particular topic. In order to correctly inform decision-makers, but not mislead them, a number of key methodological conditions need to be met when undertaking these types of analysis...
December 2015: Seminars in Fetal & Neonatal Medicine
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