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https://www.readbyqxmd.com/read/29605824/utility-of-serum-resistin-in-the-diagnosis-of-neonatal-sepsis-and-prediction-of-disease-severity-in-term-and-late-preterm-infants
#1
Ahmed Anwar Khattab, Muhammad Said El-Mekkawy, Mohamed Ahmed Helwa, Ehab Seif Omar
INTRODUCTION: Resistin is a proinflammatory hormone recently proposed as a sepsis biomarker. Our aim was to evaluate the diagnostic and prognostic values of this marker in neonatal sepsis. METHODS: This is a prospective observational study that includes 60 term and late preterm neonates with proven and possible sepsis besides 30 healthy controls. Resistin and other biomarkers, like C-reactive protein (CRP), were measured within 2 h of neonatal intensive care unit (NICU) admission...
March 31, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29615158/reduction-in-central-line-associated-bloodstream-infections-in-a-nicu-practical-lessons-for-its-achievement-and-sustainability
#2
Judith A Hawes, Kyong-Soon Lee
Central venous catheters are commonly used for the provision of parenteral nutrition and medications for critically ill neonates in the NICU. However, central line-associated bloodstream infections (CLABSIs) are a major complication associated with their use and remain an important cause of nosocomial sepsis in NICUs. Central line-associated bloodstream infection has shifted from being an expected routine complication of central line use to an adverse event now evaluated as a critical event with the goal of identifying root causes so future CLABSI events are prevented...
March 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29615159/antimicrobial-stewardship-in-neonates-challenges-and-opportunities
#3
Christopher McPherson, Caren Liviskie, Brandy Zeller, Miranda P Nelson, Jason G Newland
Neonatal infections result in significant morbidity and mortality. Antibiotics are vital for the treatment of infections but disrupt the neonatal microbiome, put the infant at risk for an adverse drug reaction, and may lead to the development of antibiotic resistance. Immediately after birth, clinicians must determine which infants require empiric antibiotics. Online risk stratification tools may provide a superior approach to decision trees. In infants who require empiric therapy for early-onset sepsis, ampicillin and an aminoglycoside with dosing based on recent pharmacokinetic studies represents the most appropriate first-line agents; third-generation cephalosporins should be reserved for patients with a high likelihood of Gram-negative meningitis...
March 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29611180/antimicrobial-lock-solutions-for-preventing-catheter-related-infections-in-haemodialysis
#4
REVIEW
Maria C Arechabala, Maria I Catoni, Juan Carlos Claro, Noelia P Rojas, Miriam E Rubio, Mario A Calvo, Luz M Letelier
BACKGROUND: Patients undergoing haemodialysis (HD) through a central venous catheter (CVC) are exposed to several risks, being a catheter-related infection (CRI) and a CVC lumen thrombosis among the most serious. Standard of care regarding CVCs includes their sealing with heparin lock solutions to prevent catheter lumen thrombosis. Other lock solutions to prevent CRI, such as antimicrobial lock solutions, have proven useful with antibiotics solutions, but not as yet for non-antibiotic antimicrobial solutions...
April 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29606026/strategies-for-preventing-early-onset-sepsis-and-for-managing-neonates-at-risk-wide-variability-across-six-western-countries
#5
Alberto Berardi, Cecilia Rossi, Caterina Spada, Giulia Vellani, Isotta Guidotti, Angela Lanzoni, Milena Azzalli, Irene Papa, Chiara Giugno, Laura Lucaccioni
OBJECTIVE: Group B streptococcus (GBS) early-onset sepsis (EOS) has declined after widespread intrapartum antibiotic prophylaxis. However, strategies for preventing EOS may differ across countries. The analysis of their strategies allows to compare the effectiveness of prevention in different countries and suggests opportunities for improvement. METHODS: We compared six western countries. Prevention strategies, incidence rates of EOS and approaches for managing neonates at-risk were analysed...
April 1, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29501938/the-strong-correlation-between-neonatal-early-onset-group-b-streptococcal-disease-and-necrotizing-enterocolitis
#6
Irene A Stafford, Eliza Rodrigue, Alexandra Berra, Wesley Adams, Asha J Heard, Joseph L Hagan, Shawn J Stafford
BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of newborn gastrointestinal emergencies, affecting 1-3 per 1000 live births. Although NEC has been linked to a microbial etiology, associations with maternal intrapartum and resultant newborn early-onset invasive Group B streptococcus (EO-GBS) have been weakly defined. OBJECTIVE: The study aim was to determine the relationship between EO-GBS and NEC. STUDY DESIGN: Data from 2008 to 2015 were collected from pediatric records with ICD diagnosis codes consistent with all stages of NEC, with the exception of neonatal EO-GBS data (only available 2011-2015)...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29476345/the-diagnostic-accuracy-of-presepsin-in-neonatal-sepsis-a-meta-analysis
#7
REVIEW
Ioannis Bellos, Georgia Fitrou, Vasilios Pergialiotis, Nikolaos Thomakos, Despina N Perrea, Georgios Daskalakis
There is growing evidence that presepsin is a promising biomarker in the diagnosis of sepsis in adults. The objective of our study is to investigate current evidence related to the diagnostic accuracy of presepsin in neonatal sepsis. To accomplish this, we searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017), and Google Scholar (2004-2017) databases. Eleven studies were included in the present meta-analysis, with a total number of 783 neonates...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28434651/neonatal-sepsis
#8
REVIEW
Andi L Shane, Pablo J Sánchez, Barbara J Stoll
Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of neonatal sepsis burden vary by setting. Differing estimates of disease burden have been reported from high-income countries compared with reports from low-income and middle-income countries. The clinical manifestations range from subclinical infection to severe manifestations of focal or systemic disease. The source of the pathogen might be attributed to an in-utero infection, acquisition from maternal flora, or postnatal acquisition from the hospital or community...
October 14, 2017: Lancet
https://www.readbyqxmd.com/read/28351429/corticosteroids-in-septic-shock-a-systematic-review-and-network-meta-analysis
#9
REVIEW
Ben Gibbison, José A López-López, Julian P T Higgins, Tom Miller, Gianni D Angelini, Stafford L Lightman, Djillali Annane
BACKGROUND: Multiple corticosteroids and treatment regimens have been used as adjuncts in the treatment of septic shock. Qualitative and quantitative differences exist at cellular and tissular levels between the different drugs and their patterns of delivery. The objective of this study was to elucidate any differences between the drugs and their treatment regimens regarding outcomes for corticosteroid use in adult patients with septic shock. METHODS: Network meta-analysis of the data used for the recently conducted Cochrane review was performed...
March 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29239828/evaluate-the-diagnosis-of-neonatal-sepsis-by-measuring-ils-a-systematic-review
#10
REVIEW
Hassan Boskabadi, Maryam Zakerihamidi
Neonatal sepsis is a dangerous and common disease among infants which is associated with high morbidity and mortality. Interleukins may be helpful for diagnosis of neonatal sepsis. Therefore, this study is conducted to investigate the role of interleukins in the diagnosis of neonatal sepsis. In this study, databases including PubMed, Cochrane Library, ISI and Google Scholar were searched up to 2016. Keywords were: Sepsis, neonatal, interleukins, prediction and diagnosis. Study inclusion criteria were: Articles about the relationship between the diagnosis of neonatal sepsis and interleukins; studies on babies; English and Persian articles and enough information from test results...
October 20, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29103346/efficacy-of-zinc-supplementation-for-neonatal-sepsis-a-systematic-review-and-meta-analysis
#11
Zhijun Tang, Zonghui Wei, Fei Wen, Yongdei Wu
BACKGROUND: Zinc supplementation has some potential in treating neonatal sepsis. We conduct a systematic review and meta-analysis to explore the efficacy of zinc supplementation for neonatal sepsis. METHODS: PubMed, Embase, Web of science, EBSCO, and Cochrane Library databases are systematically searched. Randomized controlled trials (RCTs) assessing the efficacy of zinc supplementation in neonatal sepsis are included. Two investigators independently search articles, extract the data, and assessed the quality of included studies...
December 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29097268/efficacy-and-safety-of-using-colistin-in-neonates
#12
EDITORIAL
Hao-Yuan Lee, Cheng-Hsun Chiu
No abstract text is available yet for this article.
December 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28916575/effects-of-probiotics-on-necrotizing-enterocolitis-sepsis-intraventricular-hemorrhage-mortality-length-of-hospital-stay-and-weight-gain-in-very-preterm-infants-a-meta-analysis
#13
REVIEW
Jing Sun, Gayatri Marwah, Matthew Westgarth, Nicholas Buys, David Ellwood, Peter H Gray
Probiotics are increasingly used as a supplement to prevent adverse health outcomes in preterm infants. We conducted a systematic review, meta-analysis, and subgroup analysis of findings from randomized controlled trials (RCTs) to assess the magnitude of the effect of the probiotics on health outcomes among very-low-birth-weight (VLBW) infants. Relevant articles from January 2003 to June 2017 were selected from a broad range of databases, including Medline, PubMed, Scopus, and Embase. Studies were included if they used an RCT design, involved a VLBW infant (birthweight <1500 g or gestational age <32 wk) population, included a probiotic intervention group, measured necrotizing enterocolitis (NEC) as a primary outcome, and measured sepsis, mortality, length of hospital stay, weight gain, and intraventricular hemorrhage (IVH) as additional outcomes...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28829405/probiotics-prevent-late-onset-sepsis-in-human-milk-fed-very-low-birth-weight-preterm-infants-systematic-review-and-meta-analysis
#14
REVIEW
Arianna Aceti, Luca Maggio, Isadora Beghetti, Davide Gori, Giovanni Barone, Maria Luisa Callegari, Maria Pia Fantini, Flavia Indrio, Fabio Meneghin, Lorenzo Morelli, Gianvincenzo Zuccotti, Luigi Corvaglia
Growing evidence supports the role of probiotics in reducing the risk of necrotizing enterocolitis, time to achieve full enteral feeding, and late-onset sepsis (LOS) in preterm infants. As reported for several neonatal clinical outcomes, recent data have suggested that nutrition might affect probiotics' efficacy. Nevertheless, the currently available literature does not explore the relationship between LOS prevention and type of feeding in preterm infants receiving probiotics. Thus, the aim of this systematic review and meta-analysis was to evaluate the effect of probiotics for LOS prevention in preterm infants according to type of feeding (exclusive human milk (HM) vs...
August 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28992392/norepinephrine-infusion-improves-haemodynamics-in-the-preterm-infants-during-septic-shock
#15
M Y Rizk, A Lapointe, F Lefebvre, K J Barrington
AIM: This study evaluated the clinical and haemodynamic effects of norepinephrine infusion in preterm infants. METHODS: The effects of norepinephrine therapy for refractory hypotension were evaluated in preterm infants between April 2009 and April 2011 at the neonatal intensive care unit of Sainte-Justine Hospital, Montreal, Quebec. Changes in haemodynamics and clinical parameters were analysed eight hours before and eight hours after the start of norepinephrine infusion, and eight hours after its cessation...
March 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/28827065/timing-of-sepsis-is-an-important-risk-factor-for-white-matter-abnormality-in-extremely-premature-infants-with-sepsis
#16
Ju Sun Heo, Ee-Kyung Kim, Young Hun Choi, Seung Han Shin, Jin A Sohn, Jung-Eun Cheon, Han-Suk Kim
BACKGROUND: Systemic infection is a major upstream mechanism for white matter abnormality (WMA). Our aim was to evaluate the risk factors for moderate-to-severe WMA in extremely premature infants (gestational age < 28 weeks) with neonatal sepsis. METHODS: Extremely premature infants with culture-proven sepsis between 2006 and 2015 in a tertiary neonatal intensive care unit were classified as having none-to-mild or moderate-to-severe WMA based on WM scores of brain magnetic resonance imaging at the term-equivalent age...
February 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28982710/identification-of-extremely-premature-infants-at-low-risk-for-early-onset-sepsis
#17
MULTICENTER STUDY
Karen M Puopolo, Sagori Mukhopadhyay, Nellie I Hansen, C Michael Cotten, Barbara J Stoll, Pablo J Sanchez, Edward F Bell, Abhik Das, Angelita M Hensman, Krisa P Van Meurs, Myra H Wyckoff
BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS: Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by isolation of pathogenic species from blood or cerebrospinal fluid culture at ≤72 hours age...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28634222/the-role-of-procalcitonin-in-diagnosis-of-sepsis-and-antibiotic-stewardship-opportunities-and-challenges
#18
Angela W S Fung, Daniel Beriault, Eleftherios P Diamandis, Carey-Ann D Burnham, Todd Dorman, Mark Downing, Joshua Hayden, Bradley J Langford
No abstract text is available yet for this article.
September 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28642139/clinical-characteristics-and-epidemiology-of-sepsis-in-the-neonatal-intensive-care-unit-in-the-era-of-multi-drug-resistant-organisms-a-retrospective-review
#19
Dawood Yusef, Tala Shalakhti, Samah Awad, Hana'a Algharaibeh, Wasim Khasawneh
BACKGROUND: Sepsis in the neonatal intensive care unit (NICU) remains one of the most significant causes of morbidity and mortality, especially for preterm newborns. Multi-drug resistant organisms (MDROs) are emerging as important pathogens that cause neonatal sepsis in NICU. Therefore, studying the epidemiology, clinical features, and outcome caused by MDROs vs. non-MDROs, and identifying risk factors that may predispose patients to sepsis by MDROs are important. METHODS: Episodes of blood culture-proven sepsis (age: 0-90 days) in the NICU at our institution from January 2012 to December 2015 were retrospectively reviewed...
February 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28667188/c-reactive-protein-in-healthy-term-newborns-during-the-first-48-hours-of-life
#20
Serafina Perrone, Federica Lotti, Mariangela Longini, Annalisa Rossetti, Ilaria Bindi, Francesco Bazzini, Elisa Belvisi, Pasquale Sarnacchiaro, Carlo Scapellato, Giuseppe Buonocore
BACKGROUND: Early-onset neonatal sepsis (EOS) is a serious and potentially life-threatening disease in newborns. C reactive protein (CRP) is the most used laboratory biomarker for the detection of EOS. Little is known about normal reference values of CRP during the perinatal period as several factors are able to influence it. OBJECTIVES: To identify an appropriate range of CRP values in healthy term newborns during the first 48 hours of life. DESIGN: CRP determination was performed in 859 term newborns at 12, 24 and 48 hours of life...
March 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
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