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BPD

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27 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28304322/endothelin-1-as-a-predictor-marker-for-bronchopulmonary-dysplasia-in-preterm-neonates-with-respiratory-distress-syndrome
#1
M S El Shemi, S T Amer, S M Khafagy, M T Hamza, A M A Youssef
OBJECTIVE: We aimed to investigate if endothelin 1 concentration at day 3 postnatal age could be used as a predictive marker for development of bronchopulmonary dysplasia in preterm neonates with respiratory distress syndrome. METHODS: This prospective observational study was done on 69 preterm neonates with gestational ages between 28 and 34 weeks and diagnosed as having respiratory distress syndrome. Serum concentrations of endothelin 1 was measured for all patients at day 3 of life and they were divided into BPD and No-BPD groups according to whether they developed bronchopulmonary dysplasia or not...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28165675/intratracheal-administration-of-budesonide-surfactant-in-prevention-of-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants-a-systematic-review-and-meta-analysis
#2
REVIEW
Rohini Venkataraman, Majeeda Kamaluddeen, Shabih U Hasan, Helen Lee Robertson, Abhay Lodha
Despite the near universal adaptation of gentle mechanical ventilation, surfactant use and non-invasive respiratory support, bronchopulmonary dysplasia (BPD) remains one of the most common respiratory morbidities in very low birth weight (VLBW) infants. Thus, the objective of this review was to evaluate the efficacy of intra-tracheal administration of budesonide-surfactant mixture in preventing bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. MEDLINE, EMBASE, and PubMed were searched for randomized clinical trials in which intra-tracheal administration of budesonide-surfactant was used to prevent BPD in infants...
February 6, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28141913/systemic-corticosteroid-regimens-for-prevention-of-bronchopulmonary-dysplasia-in-preterm-infants
#3
REVIEW
Wes Onland, Anne Pmc De Jaegere, Martin Offringa, Anton van Kaam
BACKGROUND: Cochrane systematic reviews show that systemic postnatal corticosteroids reduce the risk of bronchopulmonary dysplasia (BPD) in preterm infants. However, corticosteroids have also been associated with an increased risk of neurodevelopmental impairment. It is unknown whether these beneficial and adverse effects are modulated by differences in corticosteroid treatment regimens. OBJECTIVES: To assess the effects of different corticosteroid treatment regimens on mortality, pulmonary morbidity, and neurodevelopmental outcome in very low birth weight (VLBW) infants...
January 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27908652/antibiotic-exposure-and-risk-for-death-or-bronchopulmonary-dysplasia-in-very-low-birth-weight-infants
#4
Joseph B Cantey, Landon W Huffman, Abirami Subramanian, Anderson S Marshall, A Rebecca Ballard, Cassandra Lefevre, Malvika Sagar, Jessica E Pruszynski, Lea H Mallett
We assessed the association between antibiotic exposure in the first 2 weeks of life and development of bronchopulmonary dysplasia in a cohort of very low birth weight infants. After controlling for the severity of illness, each additional day of antibiotic therapy was associated with both an increased risk for and severity of bronchopulmonary dysplasia.
February 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28067830/bronchopulmonary-dysplasia-chronic-lung-disease-of-infancy-and-long-term-pulmonary-outcomes
#5
REVIEW
Lauren M Davidson, Sara K Berkelhamer
Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in reducing rates of BPD. Lack of progress may in part be attributed to the limited therapeutic options available for prevention and treatment of BPD. Several lung-protective strategies have been shown to reduce risks, including use of non-invasive support, as well as early extubation and volume ventilation when intubation is required...
January 6, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27893721/biomarkers-associated-with-bronchopulmonary-dysplasia-mortality-in-premature-infants
#6
Jessica Balena-Borneman, Namasivayam Ambalavanan, Hemant K Tiwari, Russell L Griffin, Brian Halloran, David Askenazi
BACKGROUND: Bronchopulmonary dysplasia (BPD) portends lifelong organ impairment and death. Our ability to predict BPD in first days of life is limited, but could be enhanced using novel biomarkers. METHODS: Using an available clinical and urine biomarker database obtained from a prospective 113 infant cohort (birth weight ≤1,200 g and/or gestational age ≤31 wk), we evaluated the independent association of 14 urine biomarkers with BPD/mortality. RESULTS: Two of the 14 urine biomarkers were independently associated with BPD/mortality after controlling for gestational age (GA), small for gestational age (SGA), and intubation status...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28052185/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-very-low-birth-weight-preterm-neonates
#7
REVIEW
Vibhuti S Shah, Arne Ohlsson, Henry L Halliday, Michael Dunn
BACKGROUND: Chronic lung disease (CLD) remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short- and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28045472/inhaled-nitric-oxide-for-respiratory-failure-in-preterm-infants
#8
REVIEW
Keith J Barrington, Neil Finer, Thomas Pennaforte
BACKGROUND: Inhaled nitric oxide (iNO) is effective in term infants with hypoxic respiratory failure. The pathophysiology of respiratory failure and the potential risks of iNO differ substantially in preterm infants, necessitating specific study in this population. OBJECTIVES: To determine effects of treatment with inhaled nitric oxide (iNO) on death, bronchopulmonary dysplasia (BPD), intraventricular haemorrhage (IVH) or other serious brain injury and on adverse long-term neurodevelopmental outcomes in preterm newborn infants with hypoxic respiratory failure...
January 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27456511/oxygen-targeting-in-extremely-low-birth-weight-infants
#9
James J Cummings, Richard A Polin
The use of supplemental oxygen plays a vital role in the care of the critically ill preterm infant, but the unrestricted use of oxygen can lead to unintended harms, such as chronic lung disease and retinopathy of prematurity. An overly restricted use of supplemental oxygen may have adverse effects as well. Ideally, continuous monitoring of tissue and cellular oxygen delivery would allow clinicians to better titrate the use of supplemental oxygen, but such monitoring is not currently feasible in the clinical setting...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/27461202/systemic-corticosteroids-for-the-prevention-of-bronchopulmonary-dysplasia-picking-the-right-drug-for-the-right-baby
#10
Sara E Rostas, Christopher McPherson
Bronchopulmonary dysplasia is a morbidity of prematurity with implications into adulthood on respiratory and neurologic health. Multiple risk factors contribute to the development of bronchopulmonary dysplasia leading to examination of various strategies of prevention. Systemic corticosteroids are one prevention strategy with a large body of data, creating an ongoing controversy regarding the risks and benefits of therapy. Careful consideration of the available data along with the clinical characteristics of the individual infant is required before using this powerful therapy...
2016: Neonatal Network: NN
https://www.readbyqxmd.com/read/27315509/prophylactic-nasal-continuous-positive-airway-pressure-for-preventing-morbidity-and-mortality-in-very-preterm-infants
#11
REVIEW
Prema Subramaniam, Jacqueline J Ho, Peter G Davis
BACKGROUND: Cohort studies have suggested that nasal continuous positive airways pressure (CPAP) starting in the immediate postnatal period before the onset of respiratory disease (prophylactic CPAP) may be beneficial in reducing the need for intubation and intermittent positive pressure ventilation (IPPV) and in preventing bronchopulmonary dysplasia (BPD) in preterm or low birth weight infants. OBJECTIVES: To determine if prophylactic nasal CPAP started soon after birth regardless of respiratory status in the very preterm or very low birth weight infant reduces the use of IPPV and the incidence of bronchopulmonary dysplasia (BPD) without adverse effects...
June 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27062476/how-useful-and-feasible-are-early-biochemical-markers-of-bronchopulmonary-dysplasia
#12
EDITORIAL
Manuel Sanchez Luna
No abstract text is available yet for this article.
May 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27059072/early-inhaled-steroid-use-in-extremely-low-birthweight-infants-a-randomised-controlled-trial
#13
Tomohiko Nakamura, Naohiro Yonemoto, Masahiro Nakayama, Shinya Hirano, Hirofumi Aotani, Satoshi Kusuda, Masanori Fujimura, Masanori Tamura
OBJECTIVE: We hypothesised that a prophylactic inhaled steroid would prevent the progression of bronchopulmonary dysplasia (BPD) in extremely low birthweight infants (ELBWIs). DESIGN: This study was a multicentre, randomised, double-blinded, placebo-controlled trial. SETTING: This investigation was conducted in 12 level III neonatal intensive care units (NICUs). PATIENTS: A total of 211 ELBWIs requiring ventilator support were enrolled...
April 8, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26044104/inhalation-or-instillation-of-steroids-for-the-prevention-of-bronchopulmonary-dysplasia
#14
REVIEW
Dirk Bassler
Survival of extremely preterm infants has increased over recent years, but bronchopulmonary dysplasia (BPD) remains a major cause of morbidity. In the USA, BPD is the most common chronic respiratory disorder of infancy and affects the pulmonary and overall health of 10,000 preterm infants annually. Preclinical and clinical studies suggest a crucial role for lung inflammation and host immune response in the pathogenesis of BPD. Inflammation may result from, amongst others, chorioamnionitis, postnatal infection, ventilation, and the administration of oxygen...
2015: Neonatology
https://www.readbyqxmd.com/read/26593079/impact-of-nutrition-on-bronchopulmonary-dysplasia
#15
REVIEW
Brenda B Poindexter, Camilia R Martin
Bronchopulmonary dysplasia (BPD) remains a common morbidity of prematurity. Although the pathogenesis of BPD is recognized to be both multifactorial and complex, the role of nutrition in the pathophysiology of BPD is typically limited to management after a diagnosis has been made. Infants born small for gestational age and those who experience postnatal growth failure are more likely to have BPD. Therapies for lung disease, such as fluid restriction, diuretics, and corticosteroids, can negatively impact postnatal growth...
December 2015: Clinics in Perinatology
https://www.readbyqxmd.com/read/26593077/evidence-based-pharmacologic-therapies-for-prevention-of-bronchopulmonary-dysplasia-application-of-the-grading-of-recommendations-assessment-development-and-evaluation-methodology
#16
REVIEW
Erik A Jensen, Elizabeth E Foglia, Barbara Schmidt
Bronchopulmonary dysplasia (BPD) is the most common chronic complication of extreme preterm birth. The authors applied the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to pharmacologic therapies found to prevent BPD. Caffeine and vitamin A are the only medications shown in high-quality studies to prevent BPD without the risk of clinically important adverse effects. Dexamethasone is effective for the prevention of BPD; but for many infants, the increased risks of hypertrophic cardiomyopathy, gastrointestinal perforation, and cerebral palsy outweigh this benefit...
December 2015: Clinics in Perinatology
https://www.readbyqxmd.com/read/26593076/biomarkers-early-diagnosis-and-clinical-predictors-of-bronchopulmonary-dysplasia
#17
REVIEW
Charitharth Vivek Lal, Namasivayam Ambalavanan
The pathogenesis of bronchopulmonary dysplasia (BPD) is multifactorial, and the clinical phenotype of BPD is extremely variable. Several clinical and laboratory biomarkers have been proposed for the early identification of infants at higher risk of BPD and for determination of prognosis of infants with a diagnosis of BPD. The authors review available literature on prediction tools and biomarkers of BPD, using clinical variables and biomarkers based on imaging, lung function measures, and measurements of various analytes in different body fluids that have been determined to be associated with BPD either in a targeted manner or by unbiased omic profiling...
December 2015: Clinics in Perinatology
https://www.readbyqxmd.com/read/25010224/a-systematic-review-of-randomized-controlled-trials-for-the-prevention-of-bronchopulmonary-dysplasia-in-infants
#18
REVIEW
K S Beam, S Aliaga, S K Ahlfeld, M Cohen-Wolkowiez, P B Smith, M M Laughon
OBJECTIVE: Bronchopulmonary dysplasia (BPD) is the most common cause of pulmonary morbidity in premature infants and is associated with life-long morbidities. Developing drugs for the prevention of BPD would improve public health. We sought to determine characteristics of favorable randomized controlled trials (RCTs) of drugs for BPD prevention. STUDY DESIGN: We searched MEDLINE and EMBASE from 1992 to 2014 using the MeSH terms 'BPD' and 'respiratory distress syndrome, newborn'...
September 2014: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/25278176/azithromycin-and-other-macrolides-for-prevention-of-bronchopulmonary-dysplasia-a-systematic-review-and-meta-analysis
#19
REVIEW
Vrinda Nair, Prakash Loganathan, Amuchou Singh Soraisham
BACKGROUND AND OBJECTIVE: Ureaplasma spp. infection has been associated with bronchopulmonary dysplasia (BPD) in preterm infants. Macrolides have been used for the treatment of Ureaplasma spp. infection, with an intention to prevent BPD. The objective of this meta-analysis is to evaluate the use of macrolides in the prevention of BPD in preterm infants. METHODS: We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials, abstracts of the major pediatric society meetings and bibliographies of retrieved articles...
2014: Neonatology
https://www.readbyqxmd.com/read/26621048/does-breastmilk-influence-the-development-of-bronchopulmonary-dysplasia
#20
MULTICENTER STUDY
Juliane Spiegler, Michael Preuß, Corinna Gebauer, Meike Bendiks, Egbert Herting, Wolfgang Göpel
OBJECTIVE: To assess whether breastmilk feeding is associated with a reduced risk of bronchopulmonary dysplasia (BPD). Secondary outcome measures analyzed were retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). STUDY DESIGN: In an ongoing multicenter cohort study, the data of 1433 very low birth weight infants born before 32 weeks of gestation and discharged in 2013 were analyzed. We compared growth and neonatal complications of infants who received breastmilk exclusively (N = 223) with those who received formula feedings exclusively (N = 239)...
February 2016: Journal of Pediatrics
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