Govindaiah Vinukonda, Preeti Dohare, Arslan Arshad, Muhammad T Zia, Sanjeet Panda, Ritesh Korumilli, Robert Kayton, Vincent C Hascall, Mark E Lauer, Praveen Ballabh
Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of the white matter. Hyaluronan (HA) inhibits OPC maturation and complexes with the heavy chain (HC) of glycoprotein inter-α-inhibitor to form pathological HA (HC-HA complex), which exacerbates inflammation. Therefore, we hypothesized that IVH would result in accumulation of HA, and that either degradation of HA by hyaluronidase treatment or elimination of HCs from pathological HA by HA oligosaccharide administration would restore OPC maturation, myelination, and neurological function in survivors with IVH...
January 20, 2016: Journal of Neuroscience