collection
https://read.qxmd.com/read/24825341/advanced-glycation-glycoxidation-endproduct-carboxymethyl-lysine-and-incidence-of-coronary-heart-disease-and-stroke-in-older-adults
#21
JOURNAL ARTICLE
Jorge R Kizer, David Benkeser, Alice M Arnold, Joachim H Ix, Kenneth J Mukamal, Luc Djousse, Russell P Tracy, David S Siscovick, Bruce M Psaty, Susan J Zieman
BACKGROUND: Advanced glycation/glycoxidation endproducts (AGEs) accumulate in settings of increased oxidative stress--such as diabetes, chronic kidney disease and aging--where they promote vascular stiffness and atherogenesis, but the prospective association between AGEs and cardiovascular events in elders has not been previously examined. METHODS: To test the hypothesis that circulating levels of N(ɛ)-carboxymethyl-lysine (CML), a major AGE, increase the risk of incident coronary heart disease and stroke in older adults, we measured serum CML by immunoassay in 2111 individuals free of prevalent cardiovascular disease participating in a population-based study of U...
July 2014: Atherosclerosis
https://read.qxmd.com/read/24819922/anatomical-correlates-of-proprioceptive-impairments-following-acute-stroke-a-case-series
#22
JOURNAL ARTICLE
Jeffrey M Kenzie, Jennifer A Semrau, Sonja E Findlater, Troy M Herter, Michael D Hill, Stephen H Scott, Sean P Dukelow
BACKGROUND: Proprioception is the sensation of position and movement of our limbs and body in space. This sense is important for performing smooth coordinated movements and is impaired in approximately 50% of stroke survivors. In the present case series we wanted to determine how discrete stroke lesions to areas of the brain thought to be critical for somatosensation (thalamus, posterior limb of internal capsule, primary somatosensory cortex and posterior parietal cortex) would affect position sense and kinesthesia in the acute stages post-stroke...
July 15, 2014: Journal of the Neurological Sciences
https://read.qxmd.com/read/24816338/microstructural-abnormalities-in-white-matter-and-their-effect-on-depressive-symptoms-after-stroke
#23
JOURNAL ARTICLE
Fumihiko Yasuno, Akihiko Taguchi, Akihide Yamamoto, Katsufumi Kajimoto, Hiroaki Kazui, Atsuo Sekiyama, Kiwamu Matsuoka, Soichiro Kitamura, Kuniaki Kiuchi, Jun Kosaka, Toshifumi Kishimoto, Hidehiro Iida, Kazuyuki Nagatsuka
The aim of the study was to investigate the existence of microstructural abnormalities in the white matter of the brain in stroke patients, as well as the relationship between these microstructural abnormalities and changes in depressive symptoms over 6 months. Participants were 29 acute ischemic stroke patients and 37 healthy control subjects. Depressive symptoms were assessed in all subjects using the Hamilton Rating Scale for Depression and the Zung Self-rating Depression Scale. Whole brain voxel-based analysis was used to compare diffusion tensor imaging measures of Fractional Anisotropy (FA) between the groups...
July 30, 2014: Psychiatry Research
https://read.qxmd.com/read/24919838/interventional-management-of-acute-ischemic-stroke-a-systematic-review
#24
JOURNAL ARTICLE
J Scott Pannell, David R Santiago-Dieppa, Alexander A Khalessi
Historically, acute ischemic stroke (AIS) trials defined syndromes according to acute clinical presentation and post-ictus parenchymal imaging. With improvements in real-time arterial imaging, modern AIS treatment demands a structural approach based upon the level of cerebrovascular occlusion. The poor concordance of presenting National Institute of Health Stroke Scale (NIHSS) with vessel occlusion in recent trials bespeaks the need for an anatomic perspective. Specifically, patients with large-vessel occlusion (LVO) represent a distinct entity with a poorer prognosis than general AIS patients...
August 2014: Current Treatment Options in Cardiovascular Medicine
https://read.qxmd.com/read/24768640/h%C3%A2-s-attenuates-cognitive-deficits-through-akt1-jnk3-signaling-pathway-in-ischemic-stroke
#25
JOURNAL ARTICLE
Xiangru Wen, Dashi Qi, Ying Sun, Xiaojing Huang, Fang Zhang, Jian Wu, Yanyan Fu, Kai Ma, Yang Du, Hongyan Dong, YongHai Liu, Hongzhi Liu, Yuanjian Song
Neuronal damage in the hippocampal formation which is more sensitive to ischemic stimulation and easily injured will cause severe learning and memory impairment. Therefore, inhibiting hippocampal neuron injuries is the main contributor for learning and memory impairment during cerebral ischemia. Hydrogen sulfide (H2S) is a new type of neurotransmitter that regulates the nervous, circulatory and immune systems as well as various adverse factors that can reduce cerebral vascular or brain parenchyma injury. During an ischemic stroke, H2S inhibits hippocampal neuronal damage, reducing learning and memory impairment...
August 1, 2014: Behavioural Brain Research
https://read.qxmd.com/read/24650791/genetic-variation-of-oxidative-phosphorylation-genes-in-stroke-and-alzheimer-s-disease
#26
JOURNAL ARTICLE
Alessandro Biffi, Mert R Sabuncu, Rahul S Desikan, Nick Schmansky, David H Salat, Jonathan Rosand, Christopher D Anderson
Previous research implicates alterations in oxidative phosphorylation (OXPHOS) in the development of Alzheimer's disease (AD). We sought to test whether genetic variants within OXPHOS genes increase the risk of AD. We first used gene-set enrichment analysis to identify associations, and then applied a previously replicated stroke genetic risk score to determine if OXPHOS genetic overlap exists between stroke and AD. Gene-set enrichment analysis identified associations between variation in OXPHOS genes and AD versus control status (p = 0...
August 2014: Neurobiology of Aging
https://read.qxmd.com/read/24769446/tramiprosate-protects-neurons-against-ischemic-stroke-by-disrupting-the-interaction-between-psd95-and-nnos
#27
JOURNAL ARTICLE
Shuangchan Wu, Yuan Yue, Hui Tian, Li Tao, Yuting Wang, Jin Xiang, Shi Wang, Hong Ding
Tramiprosate, a small aminosulphonate compound, is present in various species of red marine algae. In this study, we examined whether tramiprosate protects neurons and improves functional recovery following ischemic stroke in rats subjected to the intraluminal filament model of MCAO and further explored the underlying mechanisms. Tramiprosate dose-dependently reduced the infarct volume after MCAO, and the therapeutic time window of tramiprosate (50 mg/kg) for cerebral ischemia was at least 6 h. Moreover, functional assays and histochemical staining were performed...
August 2014: Neuropharmacology
https://read.qxmd.com/read/24054816/a-structured-training-programme-for-caregivers-of-inpatients-after-stroke-tracs-a-cluster-randomised-controlled-trial-and-cost-effectiveness-analysis
#28
RANDOMIZED CONTROLLED TRIAL
Anne Forster, Josie Dickerson, John Young, Anita Patel, Lalit Kalra, Jane Nixon, David Smithard, Martin Knapp, Ivana Holloway, Shamaila Anwar, Amanda Farrin
BACKGROUND: Most patients who have had a stroke are dependent on informal caregivers for activities of daily living. The TRACS trial investigated a training programme for caregivers (the London Stroke Carers Training Course, LSCTC) on physical and psychological outcomes, including cost-effectiveness, for patients and caregivers after a disabling stroke. METHODS: We undertook a pragmatic, multicentre, cluster randomised controlled trial with a parallel cost-effectiveness analysis...
December 21, 2013: Lancet
https://read.qxmd.com/read/24794351/stroke-risk-may-be-increased-after-shingles-episodes
#29
Jill Jin
No abstract text is available yet for this article.
May 7, 2014: JAMA
https://read.qxmd.com/read/24481585/neuroprotection-of-posttreatment-with-risperidone-an-atypical-antipsychotic-drug-in-rat-and-gerbil-models-of-ischemic-stroke-and-the-maintenance-of-antioxidants-in-a-gerbil-model-of-ischemic-stroke
#30
JOURNAL ARTICLE
Bing Chun Yan, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Ok Kyu Park, Jae-Chul Lee, Ki-Yeon Yoo, Jung Hoon Choi, Choong Hyun Lee, In Koo Hwang, Jeong Ho Park, Song Her, Jin Su Kim, Hyung-Cheul Shin, Jun Hwi Cho, Young-Myeong Kim, Seung-Hae Kwon, Moo-Ho Won
Risperidone, an atypical antipsychotic drug, has been discovered to have some beneficial effects beyond its original effectiveness. The present study examines the neuroprotective effects of risperidone against ischemic damage in the rat and gerbil induced by transient focal and global cerebral ischemia, respectively. The results showed that pre- and posttreatment with 4 mg/kg risperidone significantly protected against neuronal death from ischemic injury. Many NeuN-immunoreactive neurons and a few F-J B-positive cells were found in the rat cerebral cortex and gerbil hippocampal CA1 region (CA1) in the risperidone-treated ischemia groups compared with those in the vehicle-treated ischemia group...
June 2014: Journal of Neuroscience Research
https://read.qxmd.com/read/24428837/circulating-mirna-profiles-provide-a-biomarker-for-severity-of-stroke-outcomes-associated-with-age-and-sex-in-a-rat-model
#31
JOURNAL ARTICLE
Amutha Selvamani, Madison H Williams, Rajesh C Miranda, Farida Sohrabji
Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex on miRNA expression following ischaemic stroke in an animal model. Adult (6 month) and middle-aged (11-12 months) female and male rats were subject to MCAo (middle cerebral artery occlusion) using ET-1 (endothelin-1). Circulating miRNAs were analysed in blood samples at 2 and 5 days post-stroke, and brain miRNAs were analysed at 5 days post-stroke...
July 2014: Clinical Science (1979-)
https://read.qxmd.com/read/24582641/brain-volumes-and-risk-of-cardiovascular-events-and-mortality-the-smart-mr-study
#32
JOURNAL ARTICLE
Pieternella H van der Veen, Majon Muller, Koen L Vincken, Willem P T M Mali, Yolanda van der Graaf, Mirjam I Geerlings
Brain atrophy is a strong predictor for cognitive decline and dementia, and these are, in turn, associated with increased mortality in the general population. Patients with cardiovascular disease have more brain atrophy and a higher morbidity and mortality. We investigated if brain volumes on magnetic resonance imaging were associated with the risk of cardiovascular events and mortality in patients with manifest arterial disease (n = 1215; mean age 58 years). Automated brain segmentation was used to quantify intracranial volume, and volumes of total brain, sulcal cerebrospinal fluid, and ventricles...
July 2014: Neurobiology of Aging
https://read.qxmd.com/read/24529500/age-specific-transcriptional-response-to-stroke
#33
JOURNAL ARTICLE
Matthias W Sieber, Madlen Guenther, Nadine Jaenisch, Daniela Albrecht-Eckardt, Matthias Kohl, Otto W Witte, Christiane Frahm
Increased age is a major risk factor for stroke incidence and post-ischemic mortality. To develop age-adjusted therapeutic interventions, a clear understanding of the complexity of age-related post-ischemic mechanisms is essential. Transient occlusion of the middle cerebral artery--a model that closely resembles human stroke--was used to induce cerebral infarction in mice of 4 different ages (2, 9, 15, 24 months). By using Illumina cDNA microarrays and quantitative PCR we detected a distinct age-dependent response to stroke involving 350 differentially expressed genes...
July 2014: Neurobiology of Aging
https://read.qxmd.com/read/24081287/risk-benefit-profile-of-long-term-dual-versus-single-antiplatelet-therapy-among-patients-with-ischemic-stroke-a-systematic-review-and-meta-analysis
#34
REVIEW
Meng Lee, Jeffrey L Saver, Keun-Sik Hong, Neal M Rao, Yi-Ling Wu, Bruce Ovbiagele
BACKGROUND: Dual-antiplatelet regimens for prevention of recurrent stroke promote antithrombotic effects but may increase the risk for hemorrhage. PURPOSE: To qualitatively and quantitatively examine the risk for recurrent stroke and intracranial hemorrhage (ICH) linked to long-term dual- and single-antiplatelet therapy among patients with ischemic stroke and transient ischemic attack. DATA SOURCES: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials through March 2013 without language restrictions...
October 1, 2013: Annals of Internal Medicine
https://read.qxmd.com/read/23147454/the-plan-score-a-bedside-prediction-rule-for-death-and-severe-disability-following-acute-ischemic-stroke
#35
MULTICENTER STUDY
Martin J O'Donnell, Jiming Fang, Cami D'Uva, Gustavo Saposnik, Linda Gould, Emer McGrath, Moira K Kapral
BACKGROUND: We sought to develop and validate a simple clinical prediction rule for death and severe disability after acute ischemic stroke that can be used by general clinicians at the time of hospital admission. METHODS: We analyzed data from a registry of 9847 patients (4943 in the derivation cohort and 4904 in the validation cohort) hospitalized with acute ischemic stroke and included in the Registry of the Canadian Stroke Network (July 1, 2003, to March 31, 2008; 11 regional stroke centers in Ontario, Canada)...
November 12, 2012: Archives of Internal Medicine
https://read.qxmd.com/read/23642343/targeted-use-of-heparin-heparinoids-or-low-molecular-weight-heparin-to-improve-outcome-after-acute-ischaemic-stroke-an-individual-patient-data-meta-analysis-of-randomised-controlled-trials
#36
JOURNAL ARTICLE
William N Whiteley, Harold P Adams, Philip M W Bath, Eivind Berge, Per Morten Sandset, Martin Dennis, Gordon D Murray, Ka-Sing Lawrence Wong, Peter A G Sandercock
BACKGROUND: Many international guidelines on the prevention of venous thromboembolism recommend targeting heparin treatment at patients with stroke who have a high risk of venous thrombotic events or a low risk of haemorrhagic events. We sought to identify reliable methods to target anticoagulant treatment and so improve the chance of avoiding death or dependence after stroke. METHODS: We obtained individual patient data from the five largest randomised controlled trials in acute ischaemic stroke that compared heparins (unfractionated heparin, heparinoids, or low-molecular-weight heparin) with aspirin or placebo...
June 2013: Lancet Neurology
https://read.qxmd.com/read/23780953/the-soar-stroke-score-predicts-inpatient-and-7-day-mortality-in-acute-stroke
#37
JOURNAL ARTICLE
Chun Shing Kwok, John F Potter, Genevieve Dalton, Abraham George, Anthony K Metcalf, Joseph Ngeh, Anne Nicolson, Peter Owusu-Agyei, Raj Shekhar, Kevin Walsh, Elizabeth A Warburton, Phyo Kyaw Myint
BACKGROUND AND PURPOSE: An accurate prognosis is useful for patients, family, and service providers after acute stroke. METHODS: We validated the Stroke subtype, Oxfordshire Community Stroke Project Classification, Age, and prestroke Rankin stroke score in predicting inpatient and 7-day mortality using data from 8 National Health Service hospital trusts in the Anglia Stroke and Heart Clinical Network between September 2008 and April 2011. RESULTS: A total of 3547 stroke patients (ischemic, 92%) were included...
July 2013: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/22302109/ct-ct-angiography-and-mri-findings-predict-recurrent-stroke-after-transient-ischemic-attack-and-minor-stroke-results-of-the-prospective-catch-study
#38
COMPARATIVE STUDY
Shelagh B Coutts, Jayesh Modi, Shiel K Patel, Andrew M Demchuk, Mayank Goyal, Michael D Hill
BACKGROUND AND PURPOSE: Transient ischemic attack and minor stroke portend a substantial risk of recurrent stroke. MRI can identify patients at high risk for a recurrent stroke. However, MRI is not commonly available as an emergency. If similarly clinically predictive, a CT/CT angiographic (CTA) imaging strategy would be more widely applicable. METHODS: Five hundred ten patients with consecutive transient ischemic attack and minor stroke underwent CT/CTA and subsequent MRI...
April 2012: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/23381943/ischemic-stroke-is-associated-with-the-abo-locus-the-euroclot-study
#39
JOURNAL ARTICLE
Frances M K Williams, Angela M Carter, Pirro G Hysi, Gabriela Surdulescu, Dylan Hodgkiss, Nicole Soranzo, Matthew Traylor, Steve Bevan, Martin Dichgans, Peter M W Rothwell, Cathie Sudlow, Martin Farrall, Kaisa Silander, Mari Kaunisto, Peter Wagner, Olli Saarela, Kari Kuulasmaa, Jarmo Virtamo, Veikko Salomaa, Philippe Amouyel, Dominique Arveiler, Jean Ferrieres, Per-Gunnar Wiklund, M Arfan Ikram, Albert Hofman, Giorgio B Boncoraglio, Eugenio A Parati, Anna Helgadottir, Solveig Gretarsdottir, Unnur Thorsteinsdottir, Gudmar Thorleifsson, Kari Stefansson, Sudha Seshadri, Anita DeStefano, Andreas Gschwendtner, Bruce Psaty, Will Longstreth, Braxton D Mitchell, Yu-Ching Cheng, Robert Clarke, Marco Ferrario, Joshua C Bis, Christopher Levi, John Attia, Elizabeth G Holliday, Rodney J Scott, Myriam Fornage, Pankaj Sharma, Karen L Furie, Jonathan Rosand, Mike Nalls, James Meschia, Thomas H Mosely, Alun Evans, Aarno Palotie, Hugh S Markus, Peter J Grant, Tim D Spector
OBJECTIVE: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype. METHODS: Common genetic variants identified through genome-wide association studies of coagulation factors and fibrin structure/function in healthy twins (n = 2,100, Stage 1) were examined in ischemic stroke (n = 4,200 cases) using 2 independent samples of European ancestry (Stage 2)...
January 2013: Annals of Neurology
https://read.qxmd.com/read/23041239/genetic-risk-factors-for-ischaemic-stroke-and-its-subtypes-the-metastroke-collaboration-a-meta-analysis-of-genome-wide-association-studies
#40
JOURNAL ARTICLE
Matthew Traylor, Martin Farrall, Elizabeth G Holliday, Cathie Sudlow, Jemma C Hopewell, Yu-Ching Cheng, Myriam Fornage, M Arfan Ikram, Rainer Malik, Steve Bevan, Unnur Thorsteinsdottir, Mike A Nalls, Wt Longstreth, Kerri L Wiggins, Sunaina Yadav, Eugenio A Parati, Anita L Destefano, Bradford B Worrall, Steven J Kittner, Muhammad Saleem Khan, Alex P Reiner, Anna Helgadottir, Sefanja Achterberg, Israel Fernandez-Cadenas, Sherine Abboud, Reinhold Schmidt, Matthew Walters, Wei-Min Chen, E Bernd Ringelstein, Martin O'Donnell, Weang Kee Ho, Joanna Pera, Robin Lemmens, Bo Norrving, Peter Higgins, Marianne Benn, Michele Sale, Gregor Kuhlenbäumer, Alexander S F Doney, Astrid M Vicente, Hossein Delavaran, Ale Algra, Gail Davies, Sofia A Oliveira, Colin N A Palmer, Ian Deary, Helena Schmidt, Massimo Pandolfo, Joan Montaner, Cara Carty, Paul I W de Bakker, Konstantinos Kostulas, Jose M Ferro, Natalie R van Zuydam, Einar Valdimarsson, Børge G Nordestgaard, Arne Lindgren, Vincent Thijs, Agnieszka Slowik, Danish Saleheen, Guillaume Paré, Klaus Berger, Gudmar Thorleifsson, Albert Hofman, Thomas H Mosley, Braxton D Mitchell, Karen Furie, Robert Clarke, Christopher Levi, Sudha Seshadri, Andreas Gschwendtner, Giorgio B Boncoraglio, Pankaj Sharma, Joshua C Bis, Solveig Gretarsdottir, Bruce M Psaty, Peter M Rothwell, Jonathan Rosand, James F Meschia, Kari Stefansson, Martin Dichgans, Hugh S Markus
BACKGROUND: Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes. METHODS: We meta-analysed data from 15 ischaemic stroke cohorts with a total of 12 389 individuals with ischaemic stroke and 62 004 controls, all of European ancestry...
November 2012: Lancet Neurology
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