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Won Jae Huh, Robert J Coffey, Mary Kay Washington
Ménétrier's disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier's disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier's disease and the role of EGFR signaling in Ménétrier's disease...
January 2016: Journal of Pathology and Translational Medicine
Mark A Travis, Dean Sheppard
The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4(+) T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses...
2014: Annual Review of Immunology
Georgia Kaidonis, Mark C Gillies, Sotoodeh Abhary, Ebony Liu, Rohan W Essex, John H Chang, Bishwanath Pal, Sobha Sivaprasad, Maria Pefkianaki, Mark Daniell, Stewart Lake, Nikolai Petrovsky, Alex W Hewitt, Alicia Jenkins, Ecosse L Lamoureux, Jonathan M Gleadle, Jamie E Craig, Kathryn P Burdon
AIMS: This study aimed to investigate whether the single-nucleotide polymorphism (SNP) rs2910164 residing within microRNA-146a (miR-146a) is associated with diabetic microvascular complications diabetic nephropathy (DN), proliferative diabetic retinopathy (PDR) or diabetic macular oedema (DME) in either Caucasian patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. METHODS: Caucasian patients with T1DM (n = 733) or T2DM (n = 2215) were recruited from ophthalmology, renal and endocrine clinics in Australia and the UK...
August 2016: Acta Diabetologica
Gerrie-Cor M Herber-Gast, Hanneke van Essen, Wm Monique Verschuren, Coen DA Stehouwer, Ron T Gansevoort, Stephan Jl Bakker, Annemieke Mw Spijkerman
BACKGROUND: Although coffee consumption and tea consumption have been linked to diabetes, the relation with kidney function is less clear and is underresearched. OBJECTIVE: We investigated the prospective associations of coffee and tea consumption with estimated glomerular filtration rate (eGFR). DESIGN: We included 4722 participants aged 26-65 y from the Doetinchem Cohort Study who were examined every 5 y for 15 y. Coffee and tea consumption (in cups/d) were assessed at each round...
May 2016: American Journal of Clinical Nutrition
Leslie Sheu, Patricia S O'Sullivan, Eva M Aagaard, Darlene Tad-Y, Heather E Harrell, Jennifer R Kogan, James Nixon, Harry Hollander, Karen E Hauer
PURPOSE: Although residents trust interns to provide patient care, little is known about how trust forms. METHOD: Using a multi-institutional mixed-methods study design, the authors interviewed (March-September 2014) internal medicine (IM) residents in their second or third postgraduate year at a single institution to address how they develop trust in interns. Transcript analysis using grounded theory yielded a model for resident trust. Authors tested (January-March 2015) the model with residents from five IM programs using a two-section quantitative survey (38 items; 31 rated 0 = not at all to 100 = very much; 7 rated 0 = strongly disagree to 100 = strongly agree) to identify influences on how residents form trust...
March 15, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Cindy J Bednasz, Joshua R Sawyer, Anthony Martinez, Patrick G Rose, Samantha S Sithole, Holly R Hamilton, Farzia S Kaufman, Charles S Venuto, Qing Ma, Andrew Talal, Gene D Morse
Chronic hepatitis C virus (HCV) is a global epidemic, affecting approximately 150 million individuals throughout the world. The implications of HCV infection have been magnified in those who are infected with both HCV and the HIV as liver disease progression, liver failure and liver-related death are increased, particularly in those without well-controlled HIV disease. The development of direct-acting antiviral agents for HCV that allow shorter treatment periods with increased efficacy and decreased adverse events have greatly changed the outlook for HCV-infected individuals...
2015: Future Virology
David MacPhee, Erika Lunkenheimer, Nathaniel Riggs
Resilience can be defined as establishing equilibrium subsequent to disturbances to a system caused by significant adversity. When families experience adversity or transitions, multiple regulatory processes may be involved in establishing equilibrium, including adaptability, regulation of negative affect, and effective problem-solving skills. The authors' resilience-as-regulation perspective integrates insights about the regulation of individual development with processes that regulate family systems. This middle-range theory of family resilience focuses on regulatory processes across levels that are involved in adaptation: whole-family systems such as routines and sense of coherence; coregulation of dyads involving emotion regulation, structuring, and reciprocal influences between social partners; and individual self-regulation...
February 15, 2015: Family Relations
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