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Luteal Support in FET

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41 papers 0 to 25 followers Luteal phase support articles
Birgit Alsbjerg, Nikolaos P Polyzos, Helle Olesen Elbaek, Betina Boel Povlsen, Claus Yding Andersen, Peter Humaidan
The aim of this study was to evaluate the reproductive outcome in patients receiving frozen-thawed embryo transfer before and after doubling of the vaginal progesterone gel supplementation. The study was a retrospective study performed in The Fertility Clinic, Skive Regional Hospital, Denmark. A total of 346 infertility patients with oligoamenorrhoea undergoing frozen-thawed embryo transfer after priming with oestradiol and vaginal progesterone gel were included. The vaginal progesterone dose was changed from 90 mg (Crinone) once a day to twice a day and the reproductive outcome during the two periods was compared...
February 2013: Reproductive Biomedicine Online
Jacob Levron, Gil M Yerushalmi, Masha Brengauz, Itai Gat, Eldad Katorza
INTRODUCTION: There are two most popular protocols for Frozen Embryo Transfer: the natural and the E2&P4 replacement cycles. There is still a controversy whether one is superior over the other. PURPOSE: To compare the outcome in patient groups undergoing FET following these protocols. METHODS: About 1235 FET cycles were retrospectively analyzed during a period of 12 years. In 798 cycles (group A), the natural cycle protocol was used, and in 437 cycles (group B), the exogenous E2&P4 administration protocol was used...
July 2014: Gynecological Endocrinology
Matheus Roque, Marcello Valle, Fernando Guimarães, Marcos Sampaio, Selmo Geber
OBJECTIVE: To compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET (the "freeze-all" policy), with fresh ET performed only in cases without progesterone (P) elevation. DESIGN: Prospective, observational, cohort study. SETTING: Private IVF center. PATIENT(S): A total of 530 patients submitted to controlled ovarian stimulation (COS) with a gonadotropin-releasing hormone-antagonist protocol, and cleavage-stage, day-3 ET...
May 2015: Fertility and Sterility
Vivian Chi Yan Lee, Raymond Hang Wun Li, Joyce Chai, Tracy Wing Yee Yeung, William Shu Biu Yeung, Pak Chung Ho, Ernest Hung Yu Ng
OBJECTIVE: To assess the incidence of P elevation (PE) in natural cycles and evaluate its effect on frozen-thawed embryo transfer cycles performed in natural cycles (FET-NC). STUDY DESIGN: Retrospective analysis. SETTING: A tertiary assisted reproductive unit. PATIENT(S): Subfertile woman who did not conceive in their stimulated IVF cycle and underwent the first FET-NC cycle. INTERVENTION(S): Achieved serum samples were assayed for P concentrations from the day of LH surge up to 3 days before the surge...
May 2014: Fertility and Sterility
A van de Vijver, N P Polyzos, L Van Landuyt, S Mackens, D Stoop, M Camus, M De Vos, H Tournaye, C Blockeel
STUDY QUESTION: What is the impact on clinical pregnancy rates when vitrified cleavage stage Day 3 embryos, warmed and cultured overnight to Day 4, are transferred on the 3rd or 5th day of progesterone administration in an artificial cycle? SUMMARY ANSWER: Clinical pregnancy rates are similar when transferring a vitrified-warmed cleavage stage Day 3 embryo after overnight culture on the 3rd or 5th day of progesterone administration. WHAT IS KNOWN ALREADY: In artificially prepared cycles, progesterone supplementation is generally started 3 days before embryo transfer, although the optimal length of exposure to progesterone before frozen embryo transfer (FET) has not been established...
May 2016: Human Reproduction
Israel Ortega, Juan Antonio García Velasco
PURPOSE OF REVIEW: Currently, different modalities with regard to endometrial preparation for frozen-thawed embryo transfer (FTET) are used, the natural and artificial cycles being the most common approaches. This review is aimed to update the current knowledge about progesterone supplementation in both types of protocols. RECENT FINDINGS: Natural cycle-frozen-thawed embryo transfer (NC-FTET) is the favored option for women with normal ovulatory menstrual cycles and may be programmed following two different protocols: the 'true NC-FTET', associated with daily blood or urine luteinizing hormone measurements, and 'modified NC-FTET', triggering ovulation with human chorionic gonadotropin...
August 2015: Current Opinion in Obstetrics & Gynecology
Daniel Shapiro, Robert Boostanfar, Kaylen Silverberg, Elena Hesina Yanushpolsky
ART has evolved over time and frozen-thawed embryo transfer (FET) is now a frequently performed, successful option. During the last decade, cryopreservation techniques have received considerable interest, whereas interest in the priming and preparation of the endometrium prior to and after embryo transfer was more limited. The available evidence for the rationale and timing of progesterone supplementation as well as an understanding of the differences among progesterone formulations with respect to efficacy, optimum use, and patient preference is worth examining...
December 2014: Reproductive Biomedicine Online
Robert F Casper, Elena H Yanushpolsky
With significant improvements in cryopreservation technology (vitrification) the number of frozen ET IVF cycles is increasing and may soon surpass in numbers and success rates those of fresh stimulated IVF cycles. Increasing numbers of elective single ETs are also resulting in more frozen embryos (blastocysts) available for subsequent frozen ET cycles. Optimal endometrial preparation and identification of the receptive window for ET in frozen ET cycles thus assumes utmost importance for insuring the best frozen ET outcomes...
April 2016: Fertility and Sterility
Raoul Orvieto, Noa Feldman, Daniel Lantsberg, Daphna Manela, Eran Zilberberg, Jigal Haas
PURPOSE: Several replacement protocols for frozen-thawed ET (FET) exist, with no advantage of one protocol over the others. In the present study, we aim to evaluate the outcome of natural cycle FET with modified luteal support. METHODS: All consecutive patients undergoing natural or artificial hormone replacement (AHR) day-2/3 FET cycles between May 2012 and June 2015 in our IVF unit were evaluated. While AHR FET cycles were consistent, those undergoing natural cycle FET received progesterone luteal support, and from June 2014, patients received two additional injections, one of recombinant hCG and the other of GnRH-agonist, on day of transfer and 4 days later, respectively (modified luteal support)...
May 2016: Journal of Assisted Reproduction and Genetics
Robab Davar, Maryam Farid Mojtahedi, Sepideh Miraj
BACKGROUND: There is no doubt that luteal phase support is essential to enhance the reproductive outcome in IVF cycles. In addition to progesterone and human chorionic gonadotropin, several studies have described GnRH agonists as luteal phase support to improve implantation rate, pregnancy rate and live birth rate, whereas other studies showed dissimilar conclusions. All of these studies have been done in fresh IVF cycles. OBJECTIVE: To determine whether an additional GnRH agonist administered at the time of implantation for luteal phase support in frozen-thawed embryo transfer (FET) improves the embryo developmental potential...
August 2015: Iranian Journal of Reproductive Medicine
Jigal Haas, Daniel Lantsberg, Noa Feldman, Daphna Manela, Ronit Machtinger, Shir Dar, Jaron Rabinovici, Raoul Orvieto
With the recent trend toward single embryo transfer (ET), cryopreservation of extraneous embryos is becoming increasingly prevalent. Several replacement protocols for frozen-thawed ET (FET) exist, with no advantage of one protocol over the others. All consecutive patients undergoing natural cycle Day-3 FET cycles between May 2012 and March 2015 in our IVF unit were evaluated. While following spontaneous ovulation, all patients received progesterone luteal support. Since June 2014, patients underwent the same aforementioned natural cycle FET cycles, with two additional injections, one of recombinant hCG (250 mcg) and the other of GnRH-agonist (triptorelin 0...
2015: Gynecological Endocrinology
Yang Wang, Yaqiong He, Xiaoming Zhao, Xiaowei Ji, Yan Hong, Yuan Wang, Qinling Zhu, Bin Xu, Yun Sun
UNLABELLED: To compare Crinone vaginal progesterone gel with intramuscularly injected progesterone for luteal phase support in progesterone-supplemented frozen-thawed embryo transfer (FET) cycles, a randomized prospective study of patients qualified for FET was conducted between September 2010 and January 2013 at a hospital in Shanghai, China. From the day of transformation into secretory phase endometrium (day 0), Crinone vaginal gel (90 mg/d) was administered to patients in the Gel Group, while progesterone (40 mg/d) was injected intramuscularly in patients in the Inj Group (n = 750 per group)...
2015: PloS One
Phoebe H Leonard, Alexis N Hokenstad, Zaraq Khan, Jani R Jensen, Elizabeth A Stewart, Charles C Coddington
OBJECTIVE: To evaluate pregnancy rates based on the route of progesterone replacement in frozen embryo transfer (FET) cycles. STUDY DESIGN: A randomized controlled trial and retrospective analysis. In the randomized group 76 FET cycles were randomized. In the retrospective group 508 FET cycles were reviewed. Intramuscular (IM) proges-erone in oil 100 mg daily or oral micronized progesterone prior to transfer followed by compounded vaginal proges-erone 200 mg 3 times daily (OV)...
March 2015: Journal of Reproductive Medicine
Elena H Yanushpolsky
It has been well demonstrated that luteal phase physiology is disrupted in in vitro fertilization (IVF) cycles conducted with either gonadotropin-releasing hormone (GnRH) agonists or antagonists, and that supplementation of the luteal phase with either exogenous progesterone or human chorionic gonadotropin (hCG) is necessary to optimize IVF cycle outcomes. Though both progesterone and hCG supplementation resulted in comparable pregnancy rates, hCG supplementation was associated with increased risk for ovarian hyperstimulation syndrome (OHSS)...
March 2015: Seminars in Reproductive Medicine
Peter Humaidan, Lawrence Engmann, Claudio Benadiva
The challenges in attaining an adequate luteal phase after GnRH agonist (GnRHa) trigger to induce final oocyte maturation have resulted in different approaches focused on rescuing the luteal phase insufficiency so that a fresh transfer can be carried out without jeopardizing IVF outcomes. Over the years, two different concepts have emerged: intensive luteal support with aggressive exogenous administration of E2 and P; and low-dose hCG rescue in the form of a small dose of hCG either on the day of oocyte retrieva or on the day of GnRHa trigger (the so called "dual trigger")...
April 2015: Fertility and Sterility
Matthew T Connell, Jennifer M Szatkowski, Nancy Terry, Alan H DeCherney, Anthony M Propst, Micah J Hill
OBJECTIVE: To summarize the available published randomized controlled trial data regarding timing of P supplementation during the luteal phase of patients undergoing assisted reproductive technology (ART). DESIGN: A systematic review. SETTING: Not applicable. PATIENT(S): Undergoing IVF. INTERVENTION(S): Different starting times of P for luteal support. MAIN OUTCOME MEASURE(S): Clinical pregnancy (PR) and live birth rates...
April 2015: Fertility and Sterility
Rui Yang, Hongbin Chi, Lixue Chen, Rong Li, Ping Liu, Jie Qiao
OBJECTIVE: To determine whether luteal support of dydrogesterone may enhance the outcome of frozen-thawed embryo transfer (FET) in natural cycles by comparing the FET outcomes of different luteal support methods. METHODS: A total of 2 248 natural FET cycles with an endometrial thickness of 8-12 mm and type A on ovulation day, from January 2011 to March 2013 were chosen. Oral dydrogesterone (n = 1 967) or intramuscular progesterone (n = 281) was used for luteal support...
November 11, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Richard Russell, Charles Kingsland, Zarko Alfirevic, Rafet Gazvani
Luteal support is considered as an essential component of IVF treatment following ovarian stimulation and embryo transfer. Several studies have consistently demonstrated a benefit of luteal support compared with no treatment and whilst a number of preparations are available, no product has been demonstrated as superior. There is an emerging body of evidence which suggests that extension of luteal support beyond biochemical pregnancy does not confer a benefit in terms of successful pregnancy outcome. We performed two surveys separated by 5 years of practice evolution, with the latter reporting on the use of luteal support in all IVF clinics in the UK...
March 2015: Human Fertility: Journal of the British Fertility Society
Chung-Hoon Kim, You-Jeong Lee, Kyung-Hee Lee, Su-Kyung Kwon, Sung-Hoon Kim, Hee-Dong Chae, Byung-Moon Kang
OBJECTIVE: To evaluate the effect of progesterone supplementation during the luteal phase on pregnancy outcome in natural frozen-thawed embyo transfer (FTET) cycles. METHODS: In this retrospective cohort study, 228 consecutive patients who underwent FTET cycles between January 2009 and September 2012 were included. One hundred forty-five patients received luteal progesterone support (P group) but 83 patients did not receive any progesterone supplementation during luteal phase (control group)...
July 2014: Obstetrics & Gynecology Science
Jemma Evans, Natalie J Hannan, Tracey A Edgell, Beverley J Vollenhoven, Peter J Lutjen, Tiki Osianlis, Lois A Salamonsen, Luk J F Rombauts
BACKGROUND: Improvements in vitrification now make frozen embryo transfers (FETs) a viable alternative to fresh embryo transfer, with reports from observational studies and randomized controlled trials suggesting that: (i) the endometrium in stimulated cycles is not optimally prepared for implantation; (ii) pregnancy rates are increased following FET and (iii) perinatal outcomes are less affected after FET. METHODS: This review integrates and discusses the available clinical and scientific evidence supporting embryo transfer in a natural cycle...
November 2014: Human Reproduction Update
2016-03-23 21:38:19
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