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Miriam Brazzelli, Moira Cruickshank, Mary Kilonzo, Irfan Ahmed, Fiona Stewart, Paul McNamee, Andy Elders, Cynthia Fraser, Alison Avenell, Craig Ramsay
BACKGROUND: Gallstone disease is a common gastrointestinal disorder in industrialised countries. Although symptoms can be severe, some people can be symptom free for many years after the original attack. Surgery is the current treatment of choice, but evidence suggests that observation is also feasible and safe. We reviewed the evidence on cholecystectomy versus observation for uncomplicated symptomatic gallstones and conducted a cost-effectiveness analysis. METHODS: We searched six electronic databases (last search April 2014)...
March 2015: Surgical Endoscopy
V Sallinen, E A Akl, J J You, A Agarwal, S Shoucair, P O Vandvik, T Agoritsas, D Heels-Ansdell, G H Guyatt, K A O Tikkinen
BACKGROUND: For more than a century, appendicectomy has been the treatment of choice for appendicitis. Recent trials have challenged this view. This study assessed the benefits and harms of antibiotic therapy compared with appendicectomy in patients with non-perforated appendicitis. METHODS: A comprehensive search was conducted for randomized trials comparing antibiotic therapy with appendicectomy in patients with non-perforated appendicitis. Key outcomes were analysed using random-effects meta-analysis, and the quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach...
March 17, 2016: British Journal of Surgery
Takashi Igarashi, Shuichi Ito, Mayumi Sako, Akihiko Saitoh, Hiroshi Hataya, Masashi Mizuguchi, Tsuneo Morishima, Kenji Ohnishi, Naohisa Kawamura, Hirotsugu Kitayama, Akira Ashida, Shinya Kaname, Hiromichi Taneichi, Julian Tang, Makoto Ohnishi
No abstract text is available yet for this article.
August 2014: Clinical and Experimental Nephrology
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