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Telomere length and its relationship with lifestyle: ParuchMD

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By John Paruch Combined training in Internal Medicine-Psychiatry with holistic, evidence-based, preventive approach to implementation and promotion of wellness.
Tania-Marisa Freitas-Simoes, Emilio Ros, Aleix Sala-Vila
Identifying simple strategies to prevent or delay age-associated pathologies is a major public health concern. Attrition of telomeres, chromatin structures that help maintain genome stability, leads to cell death or senescence. Thus telomere length is a reliable hallmark of biological aging and the risk of developing age-related chronic diseases through common oxidation and inflammation mechanisms. Variability in telomere shortening that is independent of chronological age suggests that it is a modifiable factor, which may be explained in part by lifestyle variables such as smoking, adiposity, physical exercise, and diet...
April 2016: Metabolism: Clinical and Experimental
Dóra Révész, Yuri Milaneschi, Josine E Verhoeven, Brenda W J H Penninx
CONTEXT: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition. OBJECTIVE: We examined whether shorter baseline TL is associated with a worse metabolic profile and with less favorable trajectories of MetS components over a 6-year follow-up. DESIGN AND SETTING: PARTICIPANTS were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study with 6-year follow-up...
December 2014: Journal of Clinical Endocrinology and Metabolism
Line Rode, Børge G Nordestgaard, Maren Weischer, Stig E Bojesen
CONTEXT: Obesity is associated with short telomere length. The cause of this association is unknown. OBJECTIVE: We hypothesized that genetically increased body mass index (BMI) is associated with telomere length shortening and that low-grade inflammation might contribute through elevated C-reactive protein. SETTING AND DESIGN: We studied 45,069 individuals from the Copenhagen General Population Study with measurements of leukocyte telomere length, BMI, and C-reactive protein in a Mendelian randomization study...
September 2014: Journal of Clinical Endocrinology and Metabolism
J Huzen, L S M Wong, D J van Veldhuisen, N J Samani, A H Zwinderman, V Codd, R M Cawthon, G F J D Benus, I C C van der Horst, G Navis, S J L Bakker, R T Gansevoort, P E de Jong, H L Hillege, W H van Gilst, R A de Boer, P van der Harst
OBJECTIVES: Human age-dependent telomere attrition and telomere shortening are associated with several age-associated diseases and poorer overall survival. The aim of this study was to determine longitudinal leucocyte telomere length dynamics and identify factors associated with temporal changes in telomere length. DESIGN AND METHODS: Leucocyte telomere length was measured by quantitative polymerase chain reaction in 8074 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, an ongoing community-based prospective cohort study initiated in 1997...
February 2014: Journal of Internal Medicine
Dean Ornish, Jue Lin, June M Chan, Elissa Epel, Colleen Kemp, Gerdi Weidner, Ruth Marlin, Steven J Frenda, Mark Jesus M Magbanua, Jennifer Daubenmier, Ivette Estay, Nancy K Hills, Nita Chainani-Wu, Peter R Carroll, Elizabeth H Blackburn
BACKGROUND: Telomere shortness in human beings is a prognostic marker of ageing, disease, and premature morbidity. We previously found an association between 3 months of comprehensive lifestyle changes and increased telomerase activity in human immune-system cells. We followed up participants to investigate long-term effects. METHODS: This follow-up study compared ten men and 25 external controls who had biopsy-proven low-risk prostate cancer and had chosen to undergo active surveillance...
October 2013: Lancet Oncology
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