J Huzen, L S M Wong, D J van Veldhuisen, N J Samani, A H Zwinderman, V Codd, R M Cawthon, G F J D Benus, I C C van der Horst, G Navis, S J L Bakker, R T Gansevoort, P E de Jong, H L Hillege, W H van Gilst, R A de Boer, P van der Harst
OBJECTIVES: Human age-dependent telomere attrition and telomere shortening are associated with several age-associated diseases and poorer overall survival. The aim of this study was to determine longitudinal leucocyte telomere length dynamics and identify factors associated with temporal changes in telomere length. DESIGN AND METHODS: Leucocyte telomere length was measured by quantitative polymerase chain reaction in 8074 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, an ongoing community-based prospective cohort study initiated in 1997...
February 2014: Journal of Internal Medicine