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Glymphatic system

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8 papers 0 to 25 followers
By David Rhine MD FRCPC. Emergency medicine. Special interest in concussion management.
Andy R Eugene, Jolanta Masiak
Sleep is an important component of human life, yet many people do not understand the relationship between the brain and the process of sleeping. Sleep has been proven to improve memory recall, regulate metabolism, and reduce mental fatigue. A minimum of 7 hours of daily sleep seems to be necessary for proper cognitive and behavioral function. The emotional and mental handicaps associated with chronic sleep loss as well as the highly hazardous situations which can be contributed to the lack of sleep is a serious concern that people need to be aware of...
March 2015: MEDtube Science
Jenna M Tarasoff-Conway, Roxana O Carare, Ricardo S Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V Zlokovic, Blas Frangione, Kaj Blennow, Joël Ménard, Henrik Zetterberg, Thomas Wisniewski, Mony J de Leon
Accumulation of toxic protein aggregates-amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles-is the pathological hallmark of Alzheimer disease (AD). Aβ accumulation has been hypothesized to result from an imbalance between Aβ production and clearance; indeed, Aβ clearance seems to be impaired in both early and late forms of AD. To develop efficient strategies to slow down or halt AD, it is critical to understand how Aβ is cleared from the brain. Extracellular Aβ deposits can be removed from the brain by various clearance systems, most importantly, transport across the blood-brain barrier...
August 2015: Nature Reviews. Neurology
Alastair K Denniston, Pearse A Keane
No abstract text is available yet for this article.
June 2015: Investigative Ophthalmology & Visual Science
Aleksanteri Aspelund, Salli Antila, Steven T Proulx, Tine Veronica Karlsen, Sinem Karaman, Michael Detmar, Helge Wiig, Kari Alitalo
The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull...
June 29, 2015: Journal of Experimental Medicine
Nadia Aalling Jessen, Anne Sofie Finmann Munk, Iben Lundgaard, Maiken Nedergaard
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates  brain-wide distribution of several compounds, including glucose, lipids, amino acids, growth factors, and neuromodulators. Intriguingly, the glymphatic system function mainly during sleep and is largely disengaged during wakefulness...
December 2015: Neurochemical Research
Ferdinand K Hui
No abstract text is available yet for this article.
May 2015: World Neurosurgery
Benjamin A Plog, Matthew L Dashnaw, Emi Hitomi, Weiguo Peng, Yonghong Liao, Nanhong Lou, Rashid Deane, Maiken Nedergaard
The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics. Clinically relevant manipulation of glymphatic activity, including sleep deprivation and cisternotomy, suppressed or eliminated TBI-induced increases in serum S100β, GFAP, and neuron specific enolase...
January 14, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Andrew R Mendelsohn, James W Larrick
Decline of cognition and increasing risk of neurodegenerative diseases are major problems associated with aging in humans. Of particular importance is how the brain removes potentially toxic biomolecules that accumulate with normal neuronal function. Recently, a biomolecule clearance system using convective flow between the cerebrospinal fluid (CSF) and interstitial fluid (ISF) to remove toxic metabolites in the brain was described. Xie and colleagues now report that in mice the clearance activity of this so-called "glymphatic system" is strongly stimulated by sleep and is associated with an increase in interstitial volume, possibly by shrinkage of astroglial cells...
December 2013: Rejuvenation Research
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