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osteosarcoma and lncRna

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3 papers 0 to 25 followers
Li Min, Song Hong, Hong Duan, Yong Zhou, Wenli Zhang, Yi Luo, Rui Shi, Chongqi Tu
BACKGROUND: Antidifferentiation noncoding RNA (ANCR), a newly identified long noncoding RNA (lncRNA), plays a critical role for stem cells to maintain undifferentiated cell state. However, the functions of ANCR in human cancers have not been reported. This study is designed to explore the role of ANCR in osteosarcoma. METHODS: Lentivirus-mediated (shRNA) was applied to silence ANCR in the human osteosarcoma cell lines U2OS and Saos-2. Cell viability was measured by MTT assay...
March 2016: Cancer Biotherapy & Radiopharmaceuticals
Yan Zhang, Tao Wang, Hua-Qiao Huang, Wei Li, Xiao-Ling Cheng, Jing Yang
PURPOSE: Long non-coding RNAs (lncRNAs) have been shown to play a crucial role in the development as well as the prognosis of various human cancers, particularly in human metastasis associated lung adenocarcinoma transcript-1 (MALAT-1), which has been shown to be upregulated in some tumors. However, the role of MALAT-1 in cervical cancer (CC) is yet to be elucidated. This study aimed to establish a correlation between MALAT-1 and its role in CC progression and prognosis. METHODS: The expression of MALAT-1 was examined in tissue samples of 30 CC patients and was compared with the adjacent non-cancerous tissues...
November 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Xianyi Cai, Yunlu Liu, Wen Yang, Yun Xia, Cao Yang, Shuhua Yang, Xianzhe Liu
Recent studies have revealed that long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in the development of several solid tumors. However, the function of MALAT1 in the tumorigenesis of osteosarcoma remains unknown. In the present study, levels of MALAT1 in human osteosarcoma cell lines and tissues were detected by quantitative real-time polymerase chain reaction (RT-PCR). The roles of MALAT1 in osteosarcoma were investigated by using in vitro and in vivo assays...
June 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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