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Giuseppe Rubini, Artor Niccoli-Asabella, Cristina Ferrari, Vito Racanelli, Nicola Maggialetti, Francesco Dammacco
Multiple myeloma (MM) is the second most common hematological malignancy. Although it can affect different organs, the bone compartment stands out both in terms of prevalence and clinical impact. Despite the striking advances in MM therapy, bone disease can remarkably affect the patient's quality of life. The occurrence and extension of bone marrow and extra-medullary involvement should be carefully assessed to confirm the diagnosis, to locate and whenever possible prevent dreadful complications such as pathological fractures and spinal cord compression, and to establish suitable therapeutic measures...
May 2016: Critical Reviews in Oncology/hematology
Eli Muchtar, Morie A Gertz, Hila Magen
Carfilzomib, a second-generation proteasome inhibitor, has been increasingly used in relapsed/refractory multiple myeloma (MM) since its approval by the American food and drug administration (FDA) in the summer of 2012. The drug is active as a single agent and in combination with other antimyeloma agents. As a result of its efficacy and safety in the relapsed/refractory setting, carfilzomib is being evaluated in patients with newly diagnosed MM as well as in high-risk smoldering MM. This review will give a comprehensive summary of the drug, including its mechanism of action, the evaluated doses and schedules as well as a summary of the main clinical trials in the relapsed/refractory and newly diagnosed settings...
June 2016: European Journal of Haematology
Guy Pratt, Matthew Jenner, Roger Owen, John A Snowden, John Ashcroft, Kwee Yong, Sylvia Feyler, Gareth Morgan, Jamie Cavenagh, Gordon Cook, Eric Low, Simon Stern, Judith Behrens, Faith Davies, Jennifer Bird
No abstract text is available yet for this article.
October 2014: British Journal of Haematology
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