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Acne

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30 papers 25 to 100 followers
https://www.readbyqxmd.com/read/28580338/exposure-to-visible-light-emitted-from-smartphones-and-tablets-increases-the-proliferation-of-staphylococcus-aureus-can-this-be-linked-to-acne
#1
M Taheri, M Darabyan, E Izadbakhsh, F Nouri, M Haghani, S A R Mortazavi, G Mortazavi, S M J Mortazavi, M Moradi
BACKGROUND: Due to rapid advances in modern technologies such as telecommunication technology, the world has witnessed an exponential growth in the use of digital handheld devices (e.g. smartphones and tablets). This drastic growth has resulted in increased global concerns about the safety of these devices. Smartphones, tablets, laptops, and other digital screens emit high levels of short-wavelength visible light (i.e. blue color region in the visible light spectrum). MATERIAL AND METHODS: At a dark environment, Staphylococcus aureus bacteria were exposed to the light emitted from common tablets/smartphones...
June 2017: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28585191/why-topical-retinoids-are-mainstay-of-therapy-for-acne
#2
REVIEW
James Leyden, Linda Stein-Gold, Jonathan Weiss
Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease...
September 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28627277/anti-acne-drugs-in-phase-1-and-2-clinical-trials
#3
REVIEW
Christos C Zouboulis, Clio Dessinioti, Fragkiski Tsatsou, Harald P M Gollnick
Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue...
July 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28658462/isotretinoin-and-timing-of-procedural-interventions-a-systematic-review-with-consensus-recommendations
#4
REVIEW
Leah K Spring, Andrew C Krakowski, Murad Alam, Ashish Bhatia, Jeremy Brauer, Joel Cohen, James Q Del Rosso, Lucia Diaz, Jeffrey Dover, Lawrence F Eichenfield, Geoffrey C Gurtner, C William Hanke, Marla N Jahnke, Kristen M Kelly, Shilpi Khetarpal, Megan A Kinney, Moise L Levy, James Leyden, Michael T Longaker, Girish S Munavalli, David M Ozog, Heidi Prather, Peter R Shumaker, Elizabeth Tanzi, Abel Torres, Mara Weinstein Velez, Abigail B Waldman, Albert C Yan, Andrea L Zaenglein
Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy...
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28261025/the-use-of-isotretinoin-in-low-doses-and-unconventional-treatment-regimens-in-different-types-of-acne-a-literature-review
#5
REVIEW
Jolanta D Torzecka, Bożena Dziankowska-Bartkowiak, Zofia Gerlicz-Kowalczuk, Anna Wozniacka
High effectiveness of isotretinoin treatment for severe types of acne resistant to antibiotics has been widely recognized. However, the recommended doses in conventional therapy, according to consensus of the Polish Dermatological Society, may cause serious adverse effects. Thus, research into less stressful, alternative treatment regimens with the use of low doses of isotretinoin has been carried out. The aim of the paper was to review the selected papers where authors present the results of their studies on different regimens with the use of isotretinoin in low doses in patients with acne, evaluate their efficacy, patient satisfaction, frequency of adverse effects, recurrences and also treatment costs...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28255924/oral-antibacterial-therapy-for-acne-vulgaris-an-evidence-based-review
#6
REVIEW
Amanda Bienenfeld, Arielle R Nagler, Seth J Orlow
BACKGROUND: To some degree, acne vulgaris affects nearly every individual worldwide. Oral antibiotic therapy is routinely prescribed for the treatment of moderate to severe inflammatory acne; however, long-term use of oral antibiotics for acne may have unintended consequences. OBJECTIVE: The aim of this study was to provide a systematic evaluation of the scientific evidence on the efficacy and appropriate use of oral antibiotics in the treatment of acne. METHODS: A systematic search of MEDLINE was conducted to identify randomized controlled clinical trials, systematic reviews, and meta-analyses evaluating the efficacy of oral antibiotics for acne...
August 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28195079/update-on-etiopathogenesis-and-treatment-of-acne
#7
REVIEW
Yasmeen Jabeen Bhat, Insha Latief, Iffat Hassan
Acne, the most common skin disease, is a disorder of pilosebaceous units that affects adolescents mainly and adults occasionally. The pathogenesis is multifactorial. Besides genetic predisposition, other major factors include the action of androgens, pro-inflammatory lipids acting as ligands of peroxisome proliferator-activated receptors in the sebocytes, toll-like receptor-2 acting on keratinocytes, recognition of pathogen-associated molecular patterns, cytokines, chemokines, inflammasomes, neuroendocrine regulatory mechanisms, diet and other pro-inflammatory targets implicated in the activation of immune detection and response...
May 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28035217/the-possible-role-of-diet-in-the-pathogenesis-of-adult-female-acne
#8
REVIEW
Krystyna Romańska-Gocka, Magdalena Woźniak, Elżbieta Kaczmarek-Skamira, Barbara Zegarska
Acne in adults is a chronic, increasingly common disease, especially among women. It differs in pathogenesis and clinical presentation from adolescent acne. Acne in adults is associated with Western diet, defined as high consumption of milk, high glycemic load and high calorie intake. Metabolic signals of this diet result in a significant increase in insulin/insulin growth factor 1 serum level and consequently in the molecular interplay of mammalian target of rapamycin complex 1 kinase (mTORC1)/forkhead box protein 1 (FoxO1) mediated nutrient signaling, leading to increased proliferation of keratinocytes, increased lipogenesis and sebum production and finally to aggravation of acne...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27560161/comparison-of-vitamin-d-levels-in-patients-with-and-without-acne-a-case-control-study-combined-with-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Seul-Ki Lim, Jeong-Min Ha, Young-Ho Lee, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im
BACKGROUND: Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease; however, the association with vitamin D remains unclear. OBJECTIVES: We evaluated vitamin D levels in patients with acne to determine the effect of vitamin D supplementation. METHODS: This study included 80 patients with acne and 80 healthy controls...
2016: PloS One
https://www.readbyqxmd.com/read/27541148/optimizing-non-antibiotic-treatments-for-patients-with-acne-a-review
#10
REVIEW
Theresa N Canavan, Edward Chen, Boni E Elewski
Acne is a very common non-infectious skin condition that is frequently treated in dermatological practices. Because acne is often chronic and may persist for years, safe and effective long-term maintenance therapy is often required. Given the increasing frequency of antibiotic-resistant bacteria and the gravity of the consequences of this trend, it behooves dermatologists to maximize use of non-antimicrobial therapy when treating acne. In this review of the literature we present data regarding the efficacy and appropriate use of non-antimicrobial treatments for acne...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27376863/integrative-concepts-of-rosacea-pathophysiology-clinical-presentation-and-new-therapeutics
#11
REVIEW
Anna D Holmes, Martin Steinhoff
Rosacea is a chronic relapsing inflammatory skin disease with high prevalence worldwide. Recent research suggests that dysregulation of innate and adaptive immune pathways as well as neurovascular changes is present, with different degrees of importance in the various subtypes. Neither the aetiology, genetics nor pathophysiological basis of the vascular, inflammatory or fibrotic changes is well understood. The clinical spectrum comprises a huge variability from erythema (vasodilation) to papules/pustules (inflammatory infiltrate) to phymata (fibrosis, glandular hyperplasia) making it a valuable human disease model to understand the interplay between the neurovascular and immune systems as well as the progression from chronic inflammation to fibrosis in skin...
August 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/27363885/infectious-disease-practice-gaps-in-dermatology
#12
REVIEW
Shelby Hopp, Tyler L Quest, Karolyn A Wanat
The article highlights different educational and practice gaps in infectious diseases as they pertain to dermatology. These gaps include the use of antibiotics in relation to atopic dermatitis and acne vulgaris, treatment of skin and soft tissue infection, and diagnosis and treatment of onychomycosis. In addition, practice gaps related to use of imiquimod for molluscum contagiosum, risk of infections related to immunosuppressive medications and rates of vaccination, and the use of bedside diagnostics for diagnosing common infections were discussed...
July 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27185426/topical-minocycline-foam-for-moderate-to-severe-acne-vulgaris-phase-2-randomized-double-blind-vehicle-controlled-study-results
#13
RANDOMIZED CONTROLLED TRIAL
Avner Shemer, Joseph Shiri, Jacob Mashiah, Renata Farhi, Aditya K Gupta
No abstract text is available yet for this article.
June 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27252338/efficacy-and-relapse-rates-of-different-isotretinoin-dosages-in-treating-acne-vulgaris-systemic-review
#14
REVIEW
Tyng Hwey Tan, Rachel Hallett, Paul Devakar Yesudian
No abstract text is available yet for this article.
June 1, 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27255624/is-less-more-with-isotretinoin-and-acne
#15
Gurkirti Brar, Parbeer Grewal, Christina Korownyk
No abstract text is available yet for this article.
May 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27272079/two-randomized-double-blind-split-face-studies-to-compare-the-irritation-potential-of-two-topical-acne-fixed-combinations-over-a-21-day-treatment-period
#16
RANDOMIZED CONTROLLED TRIAL
Neal Bhatia, Varsha Bhatt, Gina Martin, Radhakrishnan Pillai
Topical therapy of acne vulgaris (acne) is very common, however cutaneous tolerability can influence patient adherence, and concerns about skin irritation have lead to a number of comparative split-face studies. Advances in formulation technology have provided new fixed combinations with lower concentrations of potentially irritating ingredients without compromising efficacy. These developments now afford the opportunity to formulate fixed combinations with higher concentrations of active ingredients that may provide the greater efficacy needed in more severe disease with good tolerability...
June 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27275326/fractional-carbon-dioxide-laser-in-treatment-of-acne-scars
#17
Andrej Petrov, Vesna Pljakovska
BACKGROUND: Scars appear as a result of skin damage during the process of the skin healing. There are two types of acne scars, depending on whether there is a loss or accumulation of collagen: atrophic and hypertrophic. In 80-90% it comes to scars with loss of collagen compared to smaller number of hypertrophic scars and keloids. AIM: The aim of the study was to determine efficiency and safety of fractional carbon dioxide laser in the treatment of acne scars. MATERIAL AND METHODS: The study was carried out in Acibadem Sistina Clinical Hospital, Skopje at the Department of Dermatovenerology, with a total of 40 patients treated with fractional carbon dioxide laser (Lutronic eCO2)...
March 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27015783/when-acne-is-not-acne
#18
REVIEW
James Q Del Rosso, Nanette Silverberg, Joshua A Zeichner
Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as multiple small epidermal cysts or deep milia, multiple osteoma cutis, multiple small adnexal neoplasms, and follicular and/or infections characterized by multiple small papules and/or pustules such as gram-positive folliculitis, gram-negative folliculitis, Malassezia folliculitis, keratosis pilaris, and flat warts. This can lead to an erroneous diagnosis and improper management...
April 2016: Dermatologic Clinics
https://www.readbyqxmd.com/read/27038134/interventions-for-acne-scars
#19
REVIEW
Rania Abdel Hay, Khalid Shalaby, Hesham Zaher, Vanessa Hafez, Ching-Chi Chi, Sandra Dimitri, Ashraf F Nabhan, Alison M Layton
BACKGROUND: Acne scarring is a frequent complication of acne and resulting scars may negatively impact on an affected person's psychosocial and physical well-being. Although a wide range of interventions have been proposed, there is a lack of high-quality evidence on treatments for acne scars to better inform patients and their healthcare providers about the most effective and safe methods of managing this condition. This review aimed to examine treatments for atrophic and hypertrophic acne scars, but we have concentrated on facial atrophic scarring...
April 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27128240/acne-scar-treatment-a-multimodality-approach-tailored-to-scar-type
#20
REVIEW
Lisa A Zaleski-Larsen, Sabrina G Fabi, Timothy McGraw, Mark Taylor
BACKGROUND: Acne scarring can be classified into atrophic icepick, boxcar, and rolling scars in addition to keloidal and hypertrophic scars. Additionally, these scars can be erythematous, hyperpigmented, and/or hypopigmented. Each scar type has a different structural cause warranting a customized approach. Many cosmetic options exist to address these changes individually, but little literature exists about the safety and efficacy of combining such procedures and devices. METHODS: A Medline search was performed on combination treatments because it relates to facial acne scarring, and results are summarized...
May 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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