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甲状腺眼病

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https://www.readbyqxmd.com/read/26567024/pathogenesis-of-thyroid-eye-disease-review-and-update-on-molecular-mechanisms
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Jwu Jin Khong, Alan A McNab, Peter R Ebeling, Jamie E Craig, Dinesh Selva
Orbital changes in thyroid orbitopathy (TO) result from de novo adipogenesis, hyaluronan synthesis, interstitial oedema and enlargement of extraocular muscles. Cellular immunity, with predominantly CD4+ T cells expressing Th1 cytokines, and overexpression of macrophage-derived cytokines, perpetuate orbital inflammation. Orbital fibroblasts appear to be the major effector cells. Orbital fibroblasts express both thyrotropin receptor (TSHR) and insulin-like growth factor-1 receptor (IGF-1R) at higher levels than normal fibroblasts...
January 2016: British Journal of Ophthalmology
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