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Cancer & Cognition

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2 papers 0 to 25 followers
R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Chemotherapeutic drugs for cancer treatment are, of necessity, cytotoxic. Unintended damage to normal central nervous system neuronal structure or function might lead to deleterious adverse effects on cognitive function, a mild form of which is reported by some cancer survivors. Understanding the physiologic connection between cancer chemotherapy and the reported cognitive dysfunction, could help inform choice of drugs, treatment regimens and new drug development...
June 2011: Journal of Clinical Pharmacy and Therapeutics
R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Cancer chemotherapy-associated cognitive impairments (termed 'chemo-fog' or 'chemo-brain'), particularly in memory, have been self-reported or identified in cancer survivors previously treated with chemotherapy. Although a variety of deficits have been detected, a consistent theme is a detriment in visuospatial working memory. The parietal cortex, a major site of storage of such memory, is implicated in chemotherapy-induced damage. However, if the findings of two recent publications are combined, the (pre)frontal cortex might be an equally viable target...
August 2013: Journal of Clinical Pharmacy and Therapeutics
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