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39 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28556272/up-to-89-of-neonates-received-antibiotics-in-cross-sectional-indian-study-including-those-with-no-infections-and-unclear-diagnoses
#1
Camilla Hauge, Cecilia Stålsby Lundborg, Jagdish Mandaliya, Gaetano Marrone, Megha Sharma
AIM: There is a global lack of data on antibiotic prescribing for neonates. This study compared antibiotic prescribing practices in the neonatal intensive care units (NICUs) of two private sector, tertiary-level hospitals. METHODS: A three-year, cross-sectional study was conducted from 2008-2011 in the NICUs of a teaching and non-teaching hospital in the Ujjain district of India. The data were analysed using methods recommended by the World Health Organization. RESULTS: Of the 1,789 inpatients, 89% (1,399/1,572) in the non-teaching hospital and 71% (154/217) in the teaching hospital were prescribed antibiotics and 123 patients died...
May 26, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28532678/selective-intrauterine-growth-restriction-in-monochorionic-diamniotic-twin-pregnancies
#2
REVIEW
Mar Bennasar, Elisenda Eixarch, Josep Maria Martinez, Eduard Gratacós
Selective intrauterine growth restriction (sIUGR) affects 10-15% of all monochorionic pregnancies. Early severe forms are associated with intrauterine demise or neurological adverse outcome for both twins. The characteristics of umbilical artery (UA) Doppler in the IUGR fetus determine three clinical types: (I) normal UA Doppler and associated with good prognosis; (II) persistently absent/reverse UA end-diastolic flow and associated with early deterioration of the IUGR twin and very preterm delivery; (III) intermittently absent/reverse end-diastolic flow in the UA, and associated with unexpected fetal demise or neurological injury in one or both twins...
May 19, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28522033/placenta-directed-gene-therapy-for-fetal-growth-restriction
#3
REVIEW
Tara Krishnan, Anna L David
Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development...
May 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28142138/three-dimensional-imaging-based-web-application-for-predicting-tracheal-tube-depth-in-preterm-neonates
#4
Raksa Tupprasoot, Dean Langan, J Ciaran Hutchinson, Hannah Barrett, Michael R J Sury, Owen J Arthurs
BACKGROUND: Positioning a tracheal tube (TT) to the correct depth in preterm infants is challenging. Currently, there is no reliable single-predictor model for neonates applicable to the whole range of size or age. OBJECTIVE: In this study, we used post-mortem magnetic resonance imaging (PMMRI) of preterm infants to measure tracheal dimensions and to develop a clinical guide for TT positioning. METHODS: We measured tracheal length (TL) and tracheal diameter (TD) in a cohort of normal neonates and foetuses that underwent PMMRI (cause of death unexplained)...
2017: Neonatology
https://www.readbyqxmd.com/read/28051172/therapeutic-hypothermia-for-neonatal-encephalopathy-a-report-from-the-first-3-years-of-the-baby-cooling-registry-of-japan
#5
Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but is being applied to a wider range of neonates than originally envisaged. To examine the clinical use of therapeutic hypothermia, data collected during the first 3 years (2012-2014) of the Baby Cooling Registry of Japan were analysed. Of 485 cooled neonates, 96.5% were ≥36 weeks gestation and 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, and 96.7% required resuscitation for >10 min...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274163/biomarkers-for-predicting-spontaneous-preterm-birth-an-umbrella-systematic-review
#6
Francesca Lucaroni, Laura Morciano, Giuseppe Rizzo, Francesco D' Antonio, Ersilia Buonuomo, Leonardo Palombi, Domenico Arduini
OBJECTIVE: To identify all systematic reviews investigating the role of maternal and fetal biomarkers for predicting spontaneous preterm birth (SPTB). METHODS: Medline and Web of Sciences databases were searched electronically. Studies exploring the association between maternal biomarkers and spontaneous delivery were considered suitable for inclusion. A synthesis of the systematic reviews was performed with the umbrella methodology. Statistical measures of association (Odd ratio, OR, relative risk, RR) and predictive accuracy (sensitivity, specificity, positive and negative likelihood ratios were used to synthesize results of the included studies...
March 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28258656/a-novel-missense-mutation-q495k-of-slc26a3-gene-identified-in-a-chinese-child-with-congenital-chloride-losing-diarrhoea
#7
Hongmei Guo, Bi-Xia Zheng, Yu Jin
No abstract text is available yet for this article.
June 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28127794/admission-hypo-and-hyperthermia-are-associated-with-increased-mortality-and-morbidity-in-very-preterm-infants
#8
Julia Maletzki, Stephanie Adzikah, Christoph Rüegger, Dirk Bassler
No abstract text is available yet for this article.
March 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/24054431/oral-propranolol-for-retinopathy-of-prematurity-risks-safety-concerns-and-perspectives
#9
RANDOMIZED CONTROLLED TRIAL
Luca Filippi, Giacomo Cavallaro, Paola Bagnoli, Massimo Dal Monte, Patrizio Fiorini, Gianpaolo Donzelli, Francesca Tinelli, Gabriella Araimo, Gloria Cristofori, Giancarlo la Marca, Maria Luisa Della Bona, Agostino La Torre, Pina Fortunato, Sandra Furlanetto, Silvia Osnaghi, Fabio Mosca
OBJECTIVE: To evaluate safety and efficacy of oral propranolol administration in preterm newborns affected by an early phase of retinopathy of prematurity (ROP). STUDY DESIGN: Fifty-two preterm newborns with Stage 2 ROP were randomized to receive oral propranolol (0.25 or 0.5 mg/kg/6 hours) added to standard treatment or standard treatment alone. To evaluate safety of the treatment, hemodynamic and respiratory variables were continuously monitored, and blood samples were collected weekly to check for renal, liver, and metabolic balance...
December 2013: Journal of Pediatrics
https://www.readbyqxmd.com/read/27986328/pathogenesis-of-nec-impact-of-an-altered-intestinal-microbiome
#10
REVIEW
Josef Neu, Mohan Pammi
Necrotizing enterocolitis (NEC), a disease most commonly seen in preterm infants, often presents without warning and is associated with very high mortality and morbidity. Progress in the prevention and treatment of NEC has been slow. In this article, we will discuss some of the reasons as to why this progress has been slow. We will describe some of the factors that appear to be highly associated and important components in the pathophysiology of NEC. We will discuss the intestinal microbial environment of the fetus as well as the preterm infant and how interaction of dysbiosis with an immature gastrointestinal tract combined with dietary factors play a role in the pathogenesis of NEC...
February 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/27767224/ethical-legal-and-social-implications-of-personalized-genomic-medicine-research-current-literature-and-suggestions-for-the-future
#11
Shawneequa L Callier, Rachel Abudu, Maxwell J Mehlman, Mendel E Singer, Duncan Neuhauser, Charlisse Caga-Anan, Georgia L Wiesner
PURPOSE: This review identifies the prominent topics in the literature pertaining to the ethical, legal, and social issues (ELSI) raised by research investigating personalized genomic medicine (PGM). METHODS: The abstracts of 953 articles extracted from scholarly databases and published during a 5-year period (2008-2012) were reviewed. A total of 299 articles met our research criteria and were organized thematically to assess the representation of ELSI issues for stakeholders, health specialties, journals, and empirical studies...
November 2016: Bioethics
https://www.readbyqxmd.com/read/27781295/3d-cohort-study-the-integrated-research-network-in-perinatology-of-quebec-and-eastern-ontario
#12
MULTICENTER STUDY
William D Fraser, Gabriel D Shapiro, François Audibert, Lise Dubois, Jean-Charles Pasquier, Pierre Julien, Anick Bérard, Gina Muckle, Jacquetta Trasler, Richard E Tremblay, Haim Abenhaim, Michel Welt, Marie-Josée Bédard, François Bissonnette, Emmanuel Bujold, Robert Gagnon, Jacques L Michaud, Isabelle Girard, Jean-Marie Moutquin, Isabelle Marc, Patricia Monnier, Jean R Séguin, Zhong-Cheng Luo
BACKGROUND: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. METHODS: Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment...
November 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27799323/diaphragmatic-activity-during-weaning-from-respiratory-support-in-preterm-infants
#13
Juliette V Kraaijenga, Cornelia G de Waal, Gerard J Hutten, Frans H de Jongh, Anton H van Kaam
OBJECTIVE: To determine if weaning from nasal continuous positive airway pressure (nCPAP) to lesser supportive low flow nasal cannula (LFNC) results in a change in electrical activity of the diaphragm in preterm infants. DESIGN: Prospective observational study. SETTING: Neonatal intensive care unit. PATIENTS: Stable preterm infants weaned from nCPAP to LFNC (1 L/min). MAIN OUTCOME MEASURES: Change in diaphragmatic activity, expressed as amplitude, peak and tonic activity, measured by transcutaneous electromyography (dEMG) from 30 min before (baseline) until 180 min after weaning...
July 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27604932/how-to-raise-a-genius-lessons-from-a-45-year-study-of-super-smart-children
#14
Tom Clynes
No abstract text is available yet for this article.
September 8, 2016: Nature
https://www.readbyqxmd.com/read/27799322/hyperglycaemia-in-infants-with-hypoxic-ischaemic-encephalopathy-is-associated-with-improved-outcomes-after-therapeutic-hypothermia-a-post-hoc-analysis-of-the-coolcap-study
#15
Sudeepta K Basu, Jason L Salemi, Alistair J Gunn, Jeffrey R Kaiser
OBJECTIVE: To investigate whether glycaemic profile is associated with multiorgan dysfunction and with response to hypothermia after perinatal hypoxic-ischaemic encephalopathy (HIE). DESIGN: Post hoc analysis of the CoolCap Study. SETTING: 25 perinatal centres in UK, USA and New Zealand during 1999-2002. PATIENTS: 194/234 (83%) infants of ≥36 weeks' gestation with moderate-to-severe HIE enrolled in the CoolCap Study with documented plasma glucose levels and follow-up outcome...
July 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27729791/melatonin-in-the-management-of-perinatal-hypoxic-ischemic-encephalopathy-light-at-the-end-of-the-tunnel
#16
Mohamed A Hendaus, Fatima A Jomha, Ahmed H Alhammadi
Perinatal hypoxic-ischemic encephalopathy (HIE) affects one to three per 1,000 live full-term births and can lead to severe and permanent neuropsychological sequelae, such as cerebral palsy, epilepsy, mental retardation, and visual motor or visual perceptive dysfunction. Melatonin has begun to be contemplated as a good choice in order to diminish the neurological sequelae from hypoxic-ischemic brain injury. Melatonin emerges as a very interesting medication, because of its capacity to cross all physiological barriers extending to subcellular compartments and its safety and effectiveness...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27609825/the-bilirubin-binding-panel-a-henderson-hasselbalch-approach-to-neonatal-hyperbilirubinemia
#17
REVIEW
Charles E Ahlfors
Poor plasma bilirubin binding increases the risk of bilirubin neurotoxicity in newborns with hyperbilirubinemia. New laboratory tests may soon make it possible to obtain a complete bilirubin binding panel when evaluating these babies. The 3 measured components of the panel are the plasma total bilirubin concentration (BTotal), which is currently used to guide clinical care; the bilirubin binding capacity (BBC); and the concentration of non-albumin bound or free bilirubin (BFree). The fourth component is the bilirubin-albumin equilibrium dissociation constant, KD, which is calculated from BTotal, BBC, and BFree The bilirubin binding panel is comparable to the panel of components used in the Henderson-Hasselbalch approach to acid-base assessment...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27172918/long-term-outcomes-of-pulmonary-hypertension-in-preterm-infants-with-bronchopulmonary-dysplasia
#18
Hye Won Kwon, Han-Suk Kim, Hyo Soon An, Bo Sang Kwon, Gi Beom Kim, Seung Han Shin, Ee-Kyung Kim, Eun Jung Bae, Chung Il Noh, Jung-Hwan Choi
BACKGROUND: The long-term cardiovascular outcomes of pulmonary hypertension (PH) in preterm infants with bronchopulmonary dysplasia (BPD) are uncertain. OBJECTIVES: The purpose of this study was to assess outcomes of PH in prematurely born children diagnosed with moderate to severe BPD. METHODS: We retrospectively reviewed the medical records of patients born before 32 weeks of gestation and diagnosed with moderate to severe BPD from June 2004 to April 2008...
2016: Neonatology
https://www.readbyqxmd.com/read/27540721/pulse-oximetry-could-significantly-enhance-the-early-detection-of-critical-congenital-heart-disease-in-neonatal-intensive-care-units
#19
COMPARATIVE STUDY
Xiao-Jing Hu, Qu-Ming Zhao, Xiao-Jing Ma, Wei-Li Yan, Xiao-Ling Ge, Bing Jia, Fang Liu, Lin Wu, Ming Ye, Guo-Ying Huang
AIM: Limited data have been available regarding critical congenital heart disease (CHD) screening in neonatal intensive care unit (NICUs). This study evaluated the feasibility of screening for CHD by adding pulse oximetry (POX) to clinical evaluation in a NICU in Shanghai, China. METHODS: We screened 4128 eligible consecutive NICU admissions using POX plus clinical evaluation. Infants with positive screening results were then evaluated with echocardiography. Those with negative screening results were put under observation, and they also underwent echocardiography if their oxygen saturation fell below 95% on room air during hospitalisation...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27405769/octreotide-in-a-critically-ill-extremely-preterm-infant-with-perforated-necrotizing-enterocolitis
#20
Silvia Martini, Arianna Aceti, Mario Lima, Michela Maffi, Giacomo Faldella, Luigi Corvaglia
Necrotizing enterocolitis (NEC) is the most severe gastrointestinal complication of prematurity. Surgery, either peritoneal drainage placement or laparotomy with resection of the intestinal necrotic tracts, is the definitive treatment of perforated NEC; however, when clinical conditions contraindicate surgical approaches, little is known about medical treatments adjuvant or alternative to surgery. Octreotide is a synthetic somatostatin analog that inhibits pancreatic secretion and leads to splanchnic vasoconstriction...
August 2016: Pediatrics
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