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44 papers 0 to 25 followers
https://www.readbyqxmd.com/read/29181841/epidural-therapy-for-the-treatment-of-severe-pre-eclampsia-in-non-labouring-women
#1
REVIEW
Amita Ray, Sujoy Ray
BACKGROUND: Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and reduced uteroplacental flow form the etiopathological basis of pre-eclampsia. There are several established therapies for pre-eclampsia including antihypertensives and anticonvulsants. Most of these therapies aim at controlling the blood pressure or preventing complications of elevated blood pressure, or both...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28938291/feasibility-and-safety-of-controlled-active-hypothermia-treatment-during-transport-in-neonates-with-hypoxic-ischemic-encephalopathy
#2
Eniko Szakmar, Kata Kovacs, Unoke Meder, Agnes Nagy, Andras Szell, Bojan Bundzsity, Zsolt Somogyvari, Attila J Szabo, Miklos Szabo, Agnes Jermendy
OBJECTIVES: To evaluate the feasibility and safety of controlled active hypothermia versus standard intensive care during neonatal transport in patients with hypoxic-ischemic encephalopathy. DESIGN: Cohort study with a historic control group. SETTING: All infants were transported by Neonatal Emergency & Transport Services to a Level-III neonatal ICU. PATIENTS: Two hundred fourteen term newborns with moderate-to-severe hypoxic-ischemic encephalopathy...
December 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28842403/use-of-a-smartphone-app-to-assess-neonatal-jaundice
#3
James A Taylor, James W Stout, Lilian de Greef, Mayank Goel, Shwetak Patel, Esther K Chung, Aruna Koduri, Shawn McMahon, Jane Dickerson, Elizabeth A Simpson, Eric C Larson
BACKGROUND: The assessment of jaundice in outpatient neonates is problematic. Visual assessment is inaccurate, and more exact methodologies are cumbersome and/or expensive. Our goal in this study was to assess the accuracy of a technology based on the analysis of digital images of newborns obtained using a smartphone application called BiliCam. METHODS: Paired BiliCam images and total serum bilirubin (TSB) levels were obtained in a diverse sample of newborns (<7 days old) at 7 sites across the United States...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28796992/abnormal-interhemispheric-synchrony-in-neonatal-hypoxic-ischemic-encephalopathy-a-retrospective-pilot-study
#4
Elise Leroy-Terquem, Anne Isabelle Vermersch, Pauline Dean, Ziad Assaf, Nathalie Boddaert, Alexandre Lapillonne, Jean-François Magny
BACKGROUND: Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown. OBJECTIVES: The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities. METHODS: We performed a single-center retrospective cohort study and enrolled 40 neonates with HIE who underwent hypothermia...
2017: Neonatology
https://www.readbyqxmd.com/read/28756088/protein-s100b-in-umbilical-cord-blood-as-a-potential-biomarker-of-hypoxic-ischemic-encephalopathy-in-asphyxiated-newborns
#5
Mehreen Zaigham, Fredrik Lundberg, Per Olofsson
BACKGROUND: Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating condition resulting from a sustained lack of oxygen during birth. The interest in identifying a relevant biomarker of HIE has thrown into limelight the role of protein S100B as a clinical diagnostic marker of hypoxic brain damage in neonates. AIMS: To evaluate the diagnostic value of protein S100B, measured in umbilical cord blood immediately after birth, as a useful biomarker in the diagnosis of HIE Sarnat stages II-III as well as a marker for long-term mortality and morbidity...
September 2017: Early Human Development
https://www.readbyqxmd.com/read/28556272/up-to-89-of-neonates-received-antibiotics-in-cross-sectional-indian-study-including-those-with-no-infections-and-unclear-diagnoses
#6
Camilla Hauge, Cecilia Stålsby Lundborg, Jagdish Mandaliya, Gaetano Marrone, Megha Sharma
AIM: There is a global lack of data on antibiotic prescribing for neonates. This study compared antibiotic prescribing practices in the neonatal intensive care units (NICUs) of two private-sector, tertiary-level hospitals. METHODS: A three-year, cross-sectional study was conducted from 2008 to 2011 in the NICUs of a teaching and nonteaching hospital in the Ujjain district of India. The data were analysed using methods recommended by the World Health Organization...
October 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28532678/selective-intrauterine-growth-restriction-in-monochorionic-diamniotic-twin-pregnancies
#7
REVIEW
Mar Bennasar, Elisenda Eixarch, Josep Maria Martinez, Eduard Gratacós
Selective intrauterine growth restriction (sIUGR) affects 10-15% of all monochorionic pregnancies. Early severe forms are associated with intrauterine demise or neurological adverse outcome for both twins. The characteristics of umbilical artery (UA) Doppler in the IUGR fetus determine three clinical types: (I) normal UA Doppler and associated with good prognosis; (II) persistently absent/reverse UA end-diastolic flow and associated with early deterioration of the IUGR twin and very preterm delivery; (III) intermittently absent/reverse end-diastolic flow in the UA, and associated with unexpected fetal demise or neurological injury in one or both twins...
December 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28522033/placenta-directed-gene-therapy-for-fetal-growth-restriction
#8
REVIEW
Tara Krishnan, Anna L David
Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development...
May 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28142138/three-dimensional-imaging-based-web-application-for-predicting-tracheal-tube-depth-in-preterm-neonates
#9
Raksa Tupprasoot, Dean Langan, J Ciaran Hutchinson, Hannah Barrett, Michael R J Sury, Owen J Arthurs
BACKGROUND: Positioning a tracheal tube (TT) to the correct depth in preterm infants is challenging. Currently, there is no reliable single-predictor model for neonates applicable to the whole range of size or age. OBJECTIVE: In this study, we used post-mortem magnetic resonance imaging (PMMRI) of preterm infants to measure tracheal dimensions and to develop a clinical guide for TT positioning. METHODS: We measured tracheal length (TL) and tracheal diameter (TD) in a cohort of normal neonates and foetuses that underwent PMMRI (cause of death unexplained)...
2017: Neonatology
https://www.readbyqxmd.com/read/28051172/therapeutic-hypothermia-for-neonatal-encephalopathy-a-report-from-the-first-3-years-of-the-baby-cooling-registry-of-japan
#10
Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but is being applied to a wider range of neonates than originally envisaged. To examine the clinical use of therapeutic hypothermia, data collected during the first 3 years (2012-2014) of the Baby Cooling Registry of Japan were analysed. Of 485 cooled neonates, 96.5% were ≥36 weeks gestation and 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, and 96.7% required resuscitation for >10 min...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274163/biomarkers-for-predicting-spontaneous-preterm-birth-an-umbrella-systematic-review
#11
Francesca Lucaroni, Laura Morciano, Giuseppe Rizzo, Francesco D' Antonio, Ersilia Buonuomo, Leonardo Palombi, Domenico Arduini
OBJECTIVE: To identify all systematic reviews investigating the role of maternal and fetal biomarkers for predicting spontaneous preterm birth (SPTB). METHODS: Medline and Web of Sciences databases were searched electronically. Studies exploring the association between maternal biomarkers and spontaneous delivery were considered suitable for inclusion. A synthesis of the systematic reviews was performed with the umbrella methodology. Statistical measures of association (Odd ratio, OR, relative risk, RR) and predictive accuracy (sensitivity, specificity, positive and negative likelihood ratios were used to synthesize results of the included studies...
March 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28258656/a-novel-missense-mutation-q495k-of-slc26a3-gene-identified-in-a-chinese-child-with-congenital-chloride-losing-diarrhoea
#12
Hongmei Guo, Bi-Xia Zheng, Yu Jin
No abstract text is available yet for this article.
June 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28127794/admission-hypo-and-hyperthermia-are-associated-with-increased-mortality-and-morbidity-in-very-preterm-infants
#13
Julia Maletzki, Stephanie Adzikah, Christoph Rüegger, Dirk Bassler
No abstract text is available yet for this article.
March 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/24054431/oral-propranolol-for-retinopathy-of-prematurity-risks-safety-concerns-and-perspectives
#14
RANDOMIZED CONTROLLED TRIAL
Luca Filippi, Giacomo Cavallaro, Paola Bagnoli, Massimo Dal Monte, Patrizio Fiorini, Gianpaolo Donzelli, Francesca Tinelli, Gabriella Araimo, Gloria Cristofori, Giancarlo la Marca, Maria Luisa Della Bona, Agostino La Torre, Pina Fortunato, Sandra Furlanetto, Silvia Osnaghi, Fabio Mosca
OBJECTIVE: To evaluate safety and efficacy of oral propranolol administration in preterm newborns affected by an early phase of retinopathy of prematurity (ROP). STUDY DESIGN: Fifty-two preterm newborns with Stage 2 ROP were randomized to receive oral propranolol (0.25 or 0.5 mg/kg/6 hours) added to standard treatment or standard treatment alone. To evaluate safety of the treatment, hemodynamic and respiratory variables were continuously monitored, and blood samples were collected weekly to check for renal, liver, and metabolic balance...
December 2013: Journal of Pediatrics
https://www.readbyqxmd.com/read/27986328/pathogenesis-of-nec-impact-of-an-altered-intestinal-microbiome
#15
REVIEW
Josef Neu, Mohan Pammi
Necrotizing enterocolitis (NEC), a disease most commonly seen in preterm infants, often presents without warning and is associated with very high mortality and morbidity. Progress in the prevention and treatment of NEC has been slow. In this article, we will discuss some of the reasons as to why this progress has been slow. We will describe some of the factors that appear to be highly associated and important components in the pathophysiology of NEC. We will discuss the intestinal microbial environment of the fetus as well as the preterm infant and how interaction of dysbiosis with an immature gastrointestinal tract combined with dietary factors play a role in the pathogenesis of NEC...
February 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/27767224/ethical-legal-and-social-implications-of-personalized-genomic-medicine-research-current-literature-and-suggestions-for-the-future
#16
Shawneequa L Callier, Rachel Abudu, Maxwell J Mehlman, Mendel E Singer, Duncan Neuhauser, Charlisse Caga-Anan, Georgia L Wiesner
PURPOSE: This review identifies the prominent topics in the literature pertaining to the ethical, legal, and social issues (ELSI) raised by research investigating personalized genomic medicine (PGM). METHODS: The abstracts of 953 articles extracted from scholarly databases and published during a 5-year period (2008-2012) were reviewed. A total of 299 articles met our research criteria and were organized thematically to assess the representation of ELSI issues for stakeholders, health specialties, journals, and empirical studies...
November 2016: Bioethics
https://www.readbyqxmd.com/read/27781295/3d-cohort-study-the-integrated-research-network-in-perinatology-of-quebec-and-eastern-ontario
#17
MULTICENTER STUDY
William D Fraser, Gabriel D Shapiro, François Audibert, Lise Dubois, Jean-Charles Pasquier, Pierre Julien, Anick Bérard, Gina Muckle, Jacquetta Trasler, Richard E Tremblay, Haim Abenhaim, Michel Welt, Marie-Josée Bédard, François Bissonnette, Emmanuel Bujold, Robert Gagnon, Jacques L Michaud, Isabelle Girard, Jean-Marie Moutquin, Isabelle Marc, Patricia Monnier, Jean R Séguin, Zhong-Cheng Luo
BACKGROUND: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. METHODS: Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment...
November 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27799323/diaphragmatic-activity-during-weaning-from-respiratory-support-in-preterm-infants
#18
Juliette V Kraaijenga, Cornelia G de Waal, Gerard J Hutten, Frans H de Jongh, Anton H van Kaam
OBJECTIVE: To determine if weaning from nasal continuous positive airway pressure (nCPAP) to lesser supportive low flow nasal cannula (LFNC) results in a change in electrical activity of the diaphragm in preterm infants. DESIGN: Prospective observational study. SETTING: Neonatal intensive care unit. PATIENTS: Stable preterm infants weaned from nCPAP to LFNC (1 L/min). MAIN OUTCOME MEASURES: Change in diaphragmatic activity, expressed as amplitude, peak and tonic activity, measured by transcutaneous electromyography (dEMG) from 30 min before (baseline) until 180 min after weaning...
July 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27604932/how-to-raise-a-genius-lessons-from-a-45-year-study-of-super-smart-children
#19
Tom Clynes
No abstract text is available yet for this article.
September 8, 2016: Nature
https://www.readbyqxmd.com/read/27799322/hyperglycaemia-in-infants-with-hypoxic-ischaemic-encephalopathy-is-associated-with-improved-outcomes-after-therapeutic-hypothermia-a-post-hoc-analysis-of-the-coolcap-study
#20
RANDOMIZED CONTROLLED TRIAL
Sudeepta K Basu, Jason L Salemi, Alistair J Gunn, Jeffrey R Kaiser
OBJECTIVE: To investigate whether glycaemic profile is associated with multiorgan dysfunction and with response to hypothermia after perinatal hypoxic-ischaemic encephalopathy (HIE). DESIGN: Post hoc analysis of the CoolCap Study. SETTING: 25 perinatal centres in UK, USA and New Zealand during 1999-2002. PATIENTS: 194/234 (83%) infants of ≥36 weeks' gestation with moderate-to-severe HIE enrolled in the CoolCap Study with documented plasma glucose levels and follow-up outcome...
July 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
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