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Gianni Paulis, Davide Barletta, Paolo Turchi, Antonio Vitarelli, Giuseppe Dachille, Andrea Fabiani, Romano Gennaro
Peyronie's disease (PD) is a chronic disorder involving the tunica albuginea surrounding the corpora cavernosa of the penis. A conservative treatment is indicated in the first stage of disease. The aim of this study was to assess the therapeutic impact and possible side effects of treatment with pentoxifylline (PTX) in combination with other antioxidants in 307 patients with early-stage PD. Patients were subdivided into three groups: A, B, and C. Both groups, A and B, comprising of 206 patients, underwent treatment, whereas Group C was the control group (n=101)...
2016: Research and Reports in Urology
Bianjiang Liu, Quan Li, Gong Cheng, Ninghong Song, Min Gu, Zengjun Wang
BACKGROUND: To investigate the feasibility and safety of surgical treatment for Peyronie's disease (PD) by excising and repairing plaque using autologous tunica vaginalis of testis. METHODS: From March 2007 to December 2012, total 19 patients with PD underwent surgical treatment at our center. All patients had significant phallocampsis during erection. All patients complained of decreased sexual function. During the operation, the fibrotic plaque was excised and neurovascular bundle (NVB) was spared...
2016: BMC Urology
Taylor C Peak, Gregory C Mitchell, Faysal A Yafi, Wayne J Hellstrom
Peyronie's disease is a localized connective tissue disease characterized by an active, inflammatory phase and a stable, quiescent phase, with the eventual development of collagenous plaques within the tunica albuginea of the penis. Risk factors primarily associated with Peyronie's disease include Dupuytren's contracture, penile trauma, and family history. A variety of treatment strategies have been utilized, including oral and topical agents, electromotive drug administration, intralesional injections, extracorporeal shockwave therapy, penile traction, and surgery...
2015: Biologics: Targets & Therapy
Romano Gennaro, Davide Barletta, Gianni Paulis
OBJECTIVE: The significantly different effects of several conservative treatments for Peyronie's disease (PD) led us to conduct this study to evaluate the effectiveness of local treatment with injectable hyaluronic acid (HA) for patients with this disease. MATERIALS AND METHODS: The study included 83 PD patients who underwent treatment and 81 PD patients who did not (control group). The inclusion criteria were: penile plaque volume <1 cm(3); clinical characteristics and ultrasonographic appearance compatible with active inflammation; and penile curvature <45°...
October 2015: International Urology and Nephrology
Lucio Dell'Atti
INTRODUCTION: The aim of this study was to evaluate the combination of intralesional verapamil injection (IVI) therapy with and tadalafil in men affected by Peyronie's disease (PD). MATERIALS AND METHODS: In this study, 59 patients diagnosed with PD, were divided into three groups. Group A (GA) counted 23 patients treated with IVI; Group B (GB) treated 19 patients with tadalafil 5 mg once a day, and Group C (GC) treated 17 patients with IVI and tadalafil for 3 months...
July 2015: Urology Annals
Carrie A Stewart, Faysal A Yafi, Margaret Knoedler, Sree H Mandava, Ian R McCaslin, Premsant Sangkum, Suresh Sikka, Landon Trost, Wayne J G Hellstrom
PURPOSE: Collagenase clostridium histolyticum is the only FDA (Food and Drug Administration) approved treatment for Peyronie's disease. However, to our knowledge collagenase clostridium histolyticum has not been studied in men with ventral plaques. Given this limitation and the paucity of literature on ventral plaque outcomes, we compared the results of Peyronie's disease treatment in men with different plaque locations treated with intralesional interferon-α2b. MATERIALS AND METHODS: We retrospectively analyzed the records of men treated with intralesional interferon-α2b for Peyronie's disease at 1 institution from 2001 to 2014...
December 2015: Journal of Urology
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