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Antibiotic choice

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7 papers 0 to 25 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
Itzhak Brook
Anaerobes are the most predominant components of the normal human skin and mucous membranes bacterial flora, and are a frequent cause of endogenous bacterial infections. Anaerobic infections can occur in all body locations: the central nervous system, oral cavity, head and neck, chest, abdomen, pelvis, skin, and soft tissues. Treatment of anaerobic infection is complicated by their slow growth in culture, by their polymicrobial nature and by their growing resistance to antimicrobials. Antimicrobial therapy is frequently the only form of therapy needed, whereas in others it is an important adjunct to drainage and surgery...
January 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Charles M Cotten
PURPOSE OF REVIEW: Antibiotics have not only saved lives and improved outcomes, but they also influence the evolving microbiome. This review summarizes reports on neonatal infections and variation in antibiotic utilization, discusses the emergence of resistant organisms, and presents data from human neonates and animal models demonstrating the impact of antibiotics on the microbiome, and how microbiome alterations impact health. The importance of antibiotic stewardship is also discussed...
April 2016: Current Opinion in Pediatrics
Gilselena Kerbauy, Ana C P Vivan, Glenda C Simões, Ane S Simionato, Marsileni Pelisson, Eliana C Vespero, Silvia F Costa, Celia G T de J Andrade, Daiane M Barbieri, João C P Mello, Alexandre T Morey, Lucy M Yamauchi, Sueli F Yamada-Ogatta, Admilton G de Oliveira, Galdino Andrade
Multidrug-resistant organisms (MDRO) are a great problem in hospitals, where thousands of people are infected daily, with the occurrence of high mortality rates, especially in infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-producing Kpn). The challenge is to find new compounds that can control KPC producing-Kpn infections. The aim of this study was to evaluate the antibiotic activity of the F3d fraction produced by the Pseudomonas aeruginosa LV strain against clinical isolates of KPC-producing Kpn...
2016: Current Pharmaceutical Biotechnology
Adriana Osińska, Monika Harnisz, Ewa Korzeniewska
Fluoroquinolones (FQs) are fully synthetic broad-spectrum antibacterial agents that are becoming increasingly popular in the treatment of clinical and veterinary infections. Being excreted during treatment, mostly as active compounds, their biological action is not limited to the therapeutic site, but it is moved further as resistance selection pressure into the environment. Water environment is an ideal medium for the aggregation and dissemination of antibiotics, antibiotic-resistant bacteria (ARB), and antibiotic resistance genes (ARGs), which can pose a serious threat to human health...
June 2016: Environmental Science and Pollution Research International
Sunil Vijay, Gaurav Dalela
AIM: To find out the prevalence of Lower Respiratory Tract Infection (LRTI) such as bacterial, fungal, mycobacterial infections etc. in patients with productive cough of duration less than 15 days and to rule out the patients having previous history of tuberculosis or having treatment of tuberculosis. MATERIALS AND METHODS: Outdoor and Indoor patients of Department of Medicine and Chest & TB, SRG hospital and Jhalawar Medical College, Jhalawar were included...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Dalila Gargouri, Asma Ouakaa-Kchaou, Asma Kochlef, Héla Elloumi, Norsaf Bibani, Dorra Trad, Mohamed Zili, Jamel Kharrat
BACKGROUND: Biliary obstruction together with bacterial colonization of the bile duct may lead to development of acute cholangitis. The reported incidence of infectious complications may reach up to 10%. Nevertheless, no antibiotic prophylaxis is administered routinely, prior to endoscopic therapeutic procedures. AIM: To investigate the presence and degree of biliary bacterial colonization during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary obstruction...
October 2015: La Tunisie Médicale
Ezzeldin A Saleh, Darrell R Schroeder, Andrew C Hanson, Ritu Banerjee
Antibiotics are commonly prescribed in pediatric outpatient settings; however, efforts to decrease inappropriate use have largely focused on inpatients. We obtained baseline metrics to identify conditions that may benefit from establishment of outpatient antimicrobial stewardship interventions (ASP). We evaluated rates and appropriateness of antibiotic prescribing for children with acute otitis media (AOM), community acquired pneumonia (CAP), and skin and soft tissue infections (SSTI) in ambulatory settings within a large healthcare system in the US Midwest...
January 10, 2015: Clinical Research in Infectious Diseases
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