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36 papers 25 to 100 followers
https://www.readbyqxmd.com/read/27840364/25-years-of-proton-pump-inhibitors-a-comprehensive-review
#1
REVIEW
Daniel S Strand, Daejin Kim, David A Peura
Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease...
November 14, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27604932/how-to-raise-a-genius-lessons-from-a-45-year-study-of-super-smart-children
#2
Tom Clynes
No abstract text is available yet for this article.
September 7, 2016: Nature
https://www.readbyqxmd.com/read/27790273/clinical-practice-guideline-of-acute-respiratory-distress-syndrome
#3
REVIEW
Young-Jae Cho, Jae Young Moon, Ein-Soon Shin, Je Hyeong Kim, Hoon Jung, So Young Park, Ho Cheol Kim, Yun Su Sim, Chin Kook Rhee, Jaemin Lim, Seok Jeong Lee, Won-Yeon Lee, Hyun Jeong Lee, Sang Hyun Kwak, Eun Kyeong Kang, Kyung Soo Chung, Won-Il Choi
There is no well-stated practical guideline for mechanically ventilated patients with or without acute respiratory distress syndrome (ARDS). We generate strong (1) and weak (2) grade of recommendations based on high (A), moderate (B) and low (C) grade in the quality of evidence. In patients with ARDS, we recommend low tidal volume ventilation (1A) and prone position if it is not contraindicated (1B) to reduce their mortality. However, we did not support high-frequency oscillatory ventilation (1B) and inhaled nitric oxide (1A) as a standard treatment...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27802794/unraveling-the-complexity-of-low-back-pain
#4
Peter O'Sullivan, Joao Paulo Caneiro, Mary O'Keeffe, Kieran O'Sullivan
Low back pain (LBP) is the leading cause of disability worldwide. Various approaches to diagnose and manage LBP have arisen, leading to an exponential increase in health care costs. Paradoxically, this trend has been associated with a concurrent increase in disability and chronicity. The health care system faces enormous challenges, with both the disability burden and financial impact relating to LBP escalating. Growing evidence suggests that current practice is discordant with contemporary evidence, and is in fact often exacerbating the problem...
November 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27637128/clinical-diagnosis-of-gout-without-joint-aspirate
#5
Joshua Steinberg
No abstract text is available yet for this article.
September 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27495202/diagnosis-and-management-of-tremor
#6
Elan D Louis
PURPOSE OF REVIEW: Tremor, which is a rhythmic oscillation of a body part, is among the most common involuntary movements. Rhythmic oscillations may manifest in a variety of ways; as a result, a rich clinical phenomenology surrounds tremor. For this reason, diagnosing tremor disorders can be particularly challenging. The aim of this article is to provide the reader with a straightforward approach to the diagnosis and management of patients with tremor. RECENT FINDINGS: Scientific understanding of the pathophysiologic basis of tremor disorders has grown considerably in recent years with the use of a broad range of neuroimaging approaches and rigorous, controlled postmortem studies...
August 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27729421/aspirin-for-primary-cardiovascular-risk-prevention-and-beyond-in-diabetes-mellitus
#7
Davide Capodanno, Dominick J Angiolillo
Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent cardiovascular events. However, the role of aspirin for primary prevention in patients with no overt cardiovascular disease is more controversial. In fact, in lower risk patients, the modest benefit in reducing serious vascular events can be offset by the increased risk of bleeding, including intracranial and gastrointestinal hemorrhage. Diabetes mellitus has been associated with a substantially increased risk of both first and recurrent atherothrombotic events, which makes aspirin therapy of potential value in these subjects...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27408698/mechanisms-of-low-back-pain-a-guide-for-diagnosis-and-therapy
#8
REVIEW
Massimo Allegri, Silvana Montella, Fabiana Salici, Adriana Valente, Maurizio Marchesini, Christian Compagnone, Marco Baciarello, Maria Elena Manferdini, Guido Fanelli
Chronic low back pain (CLBP) is a chronic pain syndrome in the lower back region, lasting for at least 3 months. CLBP represents the second leading cause of disability worldwide being a major welfare and economic problem. The prevalence of CLBP in adults has increased more than 100% in the last decade and continues to increase dramatically in the aging population, affecting both men and women in all ethnic groups, with a significant impact on functional capacity and occupational activities. It can also be influenced by psychological factors, such as stress, depression and/or anxiety...
2016: F1000Research
https://www.readbyqxmd.com/read/27679682/international-consensus-icon-allergic-reactions-to-vaccines
#9
Stephen C Dreskin, Neal A Halsey, John M Kelso, Robert A Wood, Donna S Hummell, Kathryn M Edwards, Jean-Christoph Caubet, Renata J M Engler, Michael S Gold, Claude Ponvert, Pascal Demoly, Mario Sanchez-Borges, Antonella Muraro, James T Li, Menachem Rottem, Lanny J Rosenwasser
BACKGROUND: Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety of infectious diseases. However, allergic reactions to vaccines occur very rarely and can be life threatening. Given the large numbers of vaccines administered worldwide, there is a need for an international consensus regarding the evaluation and management of allergic reactions to vaccines. METHODS: Following a review of the literature, and with the active participation of representatives from the World Allergy Organization (WAO), the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma, and Immunology (AAAAI), and the American College of Allergy, Asthma, and Immunology (ACAAI), the final committee was formed with the purpose of having members who represented a wide-range of countries, had previously worked on vaccine safety, and included both allergist/immunologists as well as vaccinologists...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27301691/guideline-for-prescribing-opioids-for-chronic-pain
#10
Centers For Disease Control And Prevention Public Health Service U S Department Of Health And Human Services
Improving the way opioids are prescribed through clinical practice guidelines can ensure patients have access to safer, more effective chronic pain treatment while reducing the number of people who misuse, abuse, or overdose from these drugs. The Centers for Disease Control and Prevention (CDC) developed and published the Guideline for Prescribing Opioids for Chronic Pain to provide recommendations for the prescribing of opioid pain medication for patients 18 and older in primary care settings. Recommendations focus on the use of opioids in treating chronic pain (pain lasting longer than 3 months or past the time of normal tissue healing) outside of active cancer treatment, palliative care, and end-of-life care...
June 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27701664/the-quick-physical-exam
#11
Robert E Hirschtick
No abstract text is available yet for this article.
October 4, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26976277/crystalloid-fluid-therapy
#12
REVIEW
Sumeet Reddy, Laurence Weinberg, Paul Young
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.
March 15, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27017027/infant-colic
#13
Amy A Gelfand
This article reviews the evidence for an association between infant colic and migraine. Infant colic, or excessive crying in an otherwise healthy and well-fed infant, affects approximately 5%-19% of infants. Multiple case-control studies, a cross-sectional study, and a prospective cohort study have all found an association between infant colic and migraine. Although infant colic is often assumed to have a gastrointestinal cause, several treatment trials aimed at gastrointestinal etiologies have been negative...
February 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/27262256/pathophysiology-of-type-2-diabetes-the-evolution-of-our-understanding
#14
Stephen Brunton
This review article explores scientists' current understanding of type 2 diabetes as a complex disorder that involves not just the pancreas and insulin system but also the liver, kidneys, gut, muscle, fat cells, and even the brain. An appreciation of the complex pathophysiology of type 2 diabetes allows the primary care practitioner to best manage patients with this common and serious disorder.
April 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27238066/age-of-onset-duration-and-type-of-medication-therapy-for-attention-deficit-hyperactivity-disorder-and-substance-use-during-adolescence-a-multi-cohort-national-study
#15
Sean Esteban McCabe, Kara Dickinson, Brady T West, Timothy E Wilens
OBJECTIVE: To examine whether age of onset, duration, or type of medication therapy for attention-deficit/hyperactivity disorder (ADHD) is associated with substance use during adolescence. METHOD: Nationally representative samples of high school seniors were surveyed via self-administered questionnaires. The sample consisted of 40,358 individuals from 10 independent cohorts (2005-2014) and represented a population that was 52% female, 62% white, 10% African American, 14% Hispanic, and 14% other race/ethnicity...
June 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/26926406/diabetes-mellitus-screening-and-diagnosis
#16
Karly Pippitt, Marlana Li, Holly E Gurgle
Diabetes mellitus is one of the most common diagnoses made by family physicians. Uncontrolled diabetes can lead to blindness, limb amputation, kidney failure, and vascular and heart disease. Screening patients before signs and symptoms develop leads to earlier diagnosis and treatment, but may not reduce rates of end-organ damage. Randomized trials show that screening for type 2 diabetes does not reduce mortality after 10 years, although some data suggest mortality benefits after 23 to 30 years. Lifestyle and pharmacologic interventions decrease progression to diabetes in patients with impaired fasting glucose or impaired glucose tolerance...
January 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27250216/ventricular-arrhythmias-and-sudden-cardiac-death-in-adults-with-congenital-heart-disease
#17
Paul Khairy
Remarkable gains in survival have led to an unprecedented number of adults with congenital heart disease. Arrhythmias collectively comprise the most common complication encountered. Recognising the unique issues and challenges involved in managing arrhythmias in adults with congenital heart disease and the consequential decisions surrounding sudden death prevention, expert societies have proposed evidence-based recommendations. On the whole, acute ventricular arrhythmias are managed according to general cardiology guidelines, while taking into consideration congenital heart disease-specific issues, such as positioning of patches or paddles according to location of the heart...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27247281/migraine-and-risk-of-cardiovascular-disease-in-women-prospective-cohort-study
#18
Tobias Kurth, Anke C Winter, A Heather Eliassen, Rimma Dushkes, Kenneth J Mukamal, Eric B Rimm, Walter C Willett, JoAnn E Manson, Kathryn M Rexrode
OBJECTIVE:  To evaluate the association between migraine and incident cardiovascular disease and cardiovascular mortality in women. DESIGN:  Prospective cohort study among Nurses' Health Study II participants, with follow-up from 1989 and through June 2011. SETTING:  Cohort of female nurses in United States. PARTICIPANTS:  115 541 women aged 25-42 years at baseline and free of angina and cardiovascular disease...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26202799/chest-pain-syndromes-are-associated-with-high-rates-of-recidivism-and-costs-in-young-united-states-veterans
#19
Basmah Safdar, James Dziura, Harini Bathulapalli, Douglas L Leslie, Melissa Skanderson, Cynthia Brandt, Sally G Haskell
BACKGROUND: Recurrent chest pain is common in patients with and without coronary artery disease. The prevalence and burden of these symptoms on healthcare is unknown. OBJECTIVES: To compare chest pain return visits (recidivism) in patients with unexplained chest pain (UCP) against reference group of patients with coronary artery disease (CAD) and estimate the annual cost of recurrent chest pain. METHODS: In a retrospective cohort study, a Veteran Affairs (VA) administrative and clinical database of Veterans who were deployed to or served in support of the wars in Iraq or Afghanistan was queried for first disease specific ICD-9 code to form two cohorts (UCP or CAD)...
2015: BMC Family Practice
https://www.readbyqxmd.com/read/26386541/attention-deficit-hyperactivity-disorder
#20
REVIEW
Anita Thapar, Miriam Cooper
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a prevalence of 1·4-3·0%. It is more common in boys than girls. Comorbidity with childhood-onset neurodevelopmental disorders and psychiatric disorders is substantial. ADHD is highly heritable and multifactorial; multiple genes and non-inherited factors contribute to the disorder. Prenatal and perinatal factors have been implicated as risks, but definite causes remain unknown. Most guidelines recommend a stepwise approach to treatment, beginning with non-drug interventions and then moving to pharmacological treatment in those most severely affected...
March 19, 2016: Lancet
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