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vasculite geral

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23 papers 0 to 25 followers
Fatma Alibaz-Oner, Matthew J Koster, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Carlo Salvarani, Eric L Matteson, Kenneth J Warrington
OBJECTIVES: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis of medium-sized visceral vessels. However, cutaneous arteritis (CA) and gastrointestinal (GI) vasculitis are forms of single organ vasculitis having indistinguishable histopathological findings from PAN. The aim of this study was to evaluate and compare the clinical characteristics, treatment, and outcomes of patients with systemic PAN, CA and GI vasculitis. METHODS: Retrospective cohorts were assembled of patients with PAN, CA and GI vasculitis between 1980 and 2014...
August 26, 2016: Arthritis Care & Research
Maxime Rhéaume, Ryan Rebello, Christian Pagnoux, Simon Carette, Marie Clements-Baker, Violette Cohen-Hallaleh, David Doucette-Preville, B Stanley Jackson, Samih Salama Sargious Salama, George Ioannidis, Nader A Khalidi
OBJECTIVE To examine the diagnostic concordance between high-resolution magnetic resonance imaging (MRI) of the scalp arteries and temporal artery biopsy for the diagnosis of giant cell arteritis. METHODS Prospective cohort study of patients with suspected giant cell arteritis. Participants underwent high-field 3 Tesla MRI of the scalp arteries followed by temporal artery biopsy. Arterial wall thickness and enhancement on multiplanar postcontrast T1-weighted spin-echo images graded according to a published severity scheme (scale of 0 to 3)...
August 2, 2016: Arthritis & Rheumatology
Alice Sy, Nader Khalidi, Natasha Dehghan, Lillian Barra, Simon Carette, David Cuthbertson, Gary S Hoffman, Curry L Koening, Carol A Langford, Carol McAlear, Larry Moreland, Paul A Monach, Philip Seo, Ulrich Specks, Antoine Sreih, Steven R Ytterberg, Gert Van Assche, Peter A Merkel, Christian Pagnoux
BACKGROUND: Published small case series suggest that inflammatory bowel disease [IBD; Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than would be expected by chance. OBJECTIVES: To describe this association by an analysis of a large cohort of carefully studied patients and through a systematic literature review. METHODS: Patients with both IBD and vasculitis enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies, followed in Canadian Vasculitis research network (CanVasc) centers and/or in the University of Toronto's IBD clinic were included in this case series...
February 2016: Seminars in Arthritis and Rheumatism
Christian Dejaco, Christina Duftner, Frank Buttgereit, Eric L Matteson, Bhaskar Dasgupta
GCA and PMR are conditions of older persons that frequently overlap. The traditional concept of GCA has focused on cranial symptoms such as headache and visual disturbance, but extra-cranial manifestations such as constitutional symptoms, polymyalgia and limb claudication have also long been recognized. These symptoms may coincide with cranial GCA, occur as an independent clinical subset [large-vessel (LV) GCA] or overlap with PMR. Imaging studies have demonstrated that up to one-third of patients with PMR have subclinical LV inflammation at disease outset...
August 1, 2016: Rheumatology
Antoine Huart, Anne-Gaëlle Josse, Dominique Chauveau, Jean-Michel Korach, Farhad Heshmati, Eric Bauvin, Olivier Cointault, Nassim Kamar, David Ribes, Jacques Pourrat, Stanislas Faguer
The overall and renal outcomes of patients with Goodpasture syndrome (GS), a rare autoimmune disorder characterized by circulating anti-GBM antibodies and rapidly progressive glomerulonephritis and/or pulmonary hemorrhage, have mostly been reported in small-sized cohorts or by aggregating patients receiving a variety of therapies that include aggressive (i.e., combined plasma exchanges, corticosteroids, and cyclophosphamide) and less aggressive (i.e., either plasma exchanges or immunosuppressive drugs, or no treatment)...
September 2016: Journal of Autoimmunity
Rafael G Grau
An increasing number of therapeutic agents have been associated with a vasculitic syndrome. This usually involves small vessels, primarily capillaries, venules, and arterioles in leukocytoclastic vasculitis, small-vessel disease similar to an antineutrophil cytoplasmic antibody-related vasculitis, or mid-sized muscular arteries in a polyarteritis-like picture. Antineutrophil cytoplasmic antibodies are present in many cases of vasculitis regardless of the size of the vessel involved. Monoclonal antibodies used to treat many autoimmune disorders have become the most common agents associated with drug-induced vasculitis...
December 2015: Current Rheumatology Reports
Aman Sharma, Aadhaar Dhooria, Ashish Aggarwal, Manish Rathi, Vinod Chandran
Vasculitides secondary to connective tissue diseases are classified under the category of 'vasculitis associated with systemic disease' in the revised International Chapel Hill Consensus Conference (CHCC) nomenclature. These secondary vasculitides may affect any of the small, medium or large vessels and usually portend a poor prognosis. Any organ system can be involved and the presentation would vary depending upon that involvement. Treatment depends upon the type and severity of presentation. In this review, we describe secondary vasculitis associated with rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, relapsing polychondritis, systemic sclerosis, Sjogren's syndrome and idiopathic inflammatory myositis, focusing mainly on recent advances in the past 3 years...
June 2016: Current Rheumatology Reports
Jérémie Dion, Nathalie Costedoat-Chalumeau, Damien Sène, Judith Cohen-Bittan, Gaëlle Leroux, Charlotte Dion, Camille Francès, Jean-Charles Piette
OBJECTIVE: Relapsing polychondritis is a rare condition characterized by recurrent inflammation of cartilaginous tissues and systemic manifestations. Data on this disease remain scarce. METHODS: Retrospective study of patients with relapsing polychondritis seen between 2000 and 2012 in a single center, to describe patient characteristics and disease evolution, identify prognostic factors and define different clinical phenotypes. RESULTS: We included 142 patients with chondritis types (86 women [61%]; mean age at first symptoms 43...
June 22, 2016: Arthritis & Rheumatology
Frank Buttgereit, Christian Dejaco, Eric L Matteson, Bhaskar Dasgupta
IMPORTANCE: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory disorders occurring in persons aged 50 years and older. Diagnostic and therapeutic approaches are heterogeneous in clinical practice. OBJECTIVE: To summarize current evidence regarding optimal methods for diagnosing and treating PMR and GCA. EVIDENCE REVIEW: MEDLINE, EMBASE, and Cochrane databases were searched from their inception dates to March 30, 2016...
June 14, 2016: JAMA: the Journal of the American Medical Association
Raffaele Serra, Lucia Butrico, Francesco Fugetto, Mariia Dmitrievna Chibireva, Alberto Malva, Giovanni De Caridi, Mafalda Massara, Andrea Barbetta, Marco Cannistrà, Stefano de Franciscis
BACKGROUND: Takayasu arteritis (TA) is a rare, systemic, inflammatory vasculitis of granulomatous nature, and still of unknown etiology. It mainly involves the aorta and its major branches and is more commonly seen in women of childbearing age and Asians. TA leads to stenosis, occlusion, or aneurysmal degeneration of large arteries, and its pathogenesis seems to be mainly due to an abnormal cell-mediated immunity, although other molecular and genetic abnormalities may contribute. The diagnosis and treatments lie on clinical and arteriographic findings...
August 2016: Annals of Vascular Surgery
Giuseppe Lopalco, Donato Rigante, Vincenzo Venerito, Giacomo Emmi, Maria Grazia Anelli, Giovanni Lapadula, Florenzo Iannone, Luca Cantarini
Inflammation mediated by cells of the immune system and necrosis are the most striking features observed at the histologic level in patients with vasculitides, clinical entities classified according to pathologic findings involving different organs, to etiology, or to size of vessels involved. Small vessel vasculitides (SVV) are a peculiar group of systemic disorders electively involving small intraparenchymal arteries, arterioles, capillaries, or venules and leading to different levels of vascular obstruction, tissue ischemia and risk of infarction; they can be divided into anti-neutrophil cytoplasmic antibody-associated vasculitides and immune complex vasculitides...
June 2016: Current Rheumatology Reports
Chih-Hung Kuo, Peter McCluskey, Clare L Fraser
No abstract text is available yet for this article.
May 5, 2016: New England Journal of Medicine
Y Ferfar, T Mirault, A C Desbois, C Comarmond, E Messas, L Savey, F Domont, P Cacoub, D Saadoun
Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP). Glucocorticosteroids are the mainstay of therapy in LVV. However, a significant proportion of patients have glucocorticoid dependance, serious side effects or refractory disease to steroids and other immunosuppressive treatments such as cyclophosphamide, azathioprine, mycophenolate mofetil and methotrexate. Recent advances in the understanding of the pathogenesis have resulted in the use of biological agents in patients with LVV...
June 2016: Autoimmunity Reviews
J Schmidt, A Smail, B Roche, P Gay, V Salle, H Pellet, P Duhaut
OBJECTIVE: To assess the incidence of infections leading to hospitalization, the mortality rate related to infections, and the determinants of these factors in patients with giant cell arteritis (GCA). METHODS: In total, 486 patients with GCA (75% women) were enrolled at the time of diagnosis. All patients fulfilled the American College of Rheumatology criteria for GCA. As controls, age- and sex-matched subjects were randomly selected from the general population and matched to patients at the time of diagnosis of GCA...
June 2016: Arthritis & Rheumatology
Hélène Vallet, Pascal Seve, Lucie Biard, Jean Baptiste Fraison, Philip Bielefeld, Laurent Perard, Boris Bienvenu, Sébastien Abad, Aude Rigolet, Alban Deroux, Damien Sene, Antoinette Perlat, Isabelle Marie, Elodie Feurer, Eric Hachulla, Olivier Fain, Gaëlle Clavel, Sophie Riviere, Pierre-Alban Bouche, Julie Gueudry, Gregory Pugnet, Phuc Le Hoang, Matthieu Resche Rigon, Patrice Cacoub, Bahram Bodaghi, David Saadoun
OBJECTIVE: To analyze the factors associated with response to anti-tumor necrosis factor (anti-TNF) treatment and compare the efficacy and safety of infliximab (IFX) and adalimumab (ADA) in patients with refractory noninfectious uveitis. METHODS: This was a multicenter observational study of 160 patients (39% men and 61% women; median age 31 years [interquartile range 21-42]) with uveitis that had been refractory to other therapies, who were treated with anti-TNF (IFX 5 mg/kg at weeks 0, 2, 6, and then every 5-6 weeks [n = 98] or ADA 40 mg every 2 weeks [n = 62])...
June 2016: Arthritis & Rheumatology
Marcella Prete, Francesco Indiveri, Federico Perosa
The vasculitides form a heterogeneous group of systemic diseases that differ in etiology, histological patterns, and, consequently, clinical significance and prognosis but are traceable to the same pathological event, namely, vessel wall inflammation. The clinical heterogeneity among these diseases, together with yet unknown pathogenetic mechanisms for many of them, creates difficulties in the early diagnosis and correct management of affected patients. Therefore, several groups of investigators have elaborated nomenclatures to set some order in the definition and grouping of the vasculitides...
February 2016: Autoimmunity Reviews
Franco Dammacco, Vito Racanelli, Sabino Russi, Domenico Sansonno
Cryoglobulinemic vasculitis (CV) is a small-to-medium-vessel vasculitis that appears in 10-15 % of patients chronically infected with hepatitis C virus (HCV). The classic symptom triad of CV, purpura/asthenia/arthralgia, is accompanied by clinical features that include glomerulonephritis, neuropathy, interstitial pneumonitis, and cardiomyopathy, ranging in their severity from mild to life threatening. The risk of developing non-Hodgkin lymphoma is also higher. The cumulative 10-year survival rate of CV patients is significantly lower than in the age- and sex-matched general population, with death typically caused by nephropathy, malignancies, liver involvement, and severe infections...
August 2016: Clinical and Experimental Medicine
Peter M Villiger, Sabine Adler, Stefan Kuchen, Felix Wermelinger, Diana Dan, Veronika Fiege, Lukas Bütikofer, Michael Seitz, Stephan Reichenbach
BACKGROUND: Giant cell arteritis is an immune-mediated disease of medium and large-sized arteries that affects mostly people older than 50 years of age. Treatment with glucocorticoids is the gold-standard and prevents severe vascular complications but is associated with substantial morbidity and mortality. Tocilizumab, a humanised monoclonal antibody against the interleukin-6 receptor, has been associated with rapid induction and maintenance of remission in patients with giant cell arteritis...
May 7, 2016: Lancet
Armando De Virgilio, Antonio Greco, Giuseppe Magliulo, Andrea Gallo, Giovanni Ruoppolo, Michela Conte, Salvatore Martellucci, Marco de Vincentiis
Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis predominantly targeting medium-sized arteries. PAN is a rare form of vasculitis, and the precise frequency of this disease is difficult to determine. The major environmental factor associated with PAN is HBV infection. The pathogenesis of "idiopathic PAN" remains enigmatic, although the clinical responses to immunosuppressive therapy support the concept that immunological mechanisms play an active pathogenic role. The spectrum of disease ranges from involving a single organ to polyvisceral failure...
June 2016: Autoimmunity Reviews
Lucia Longo, Antonio Greco, Andrea Rea, Vincenza Rita Lo Vasco, Armando De Virgilio, Marco De Vincentiis
Relapsing polychondritis (RP) is a rare connective tissue disease in which recurrent bouts of inflammation, involve the cartilage of the ears, nose, larynx, tracheobronchial tree and cardiovascular system. RP is generally observed in the fourth and fifth decades of life and occurs with equal frequency in both sexes. The cause of RP is still unknown. It is considered an immune-mediated disease, as there is an overlap between well documented RP with other rheumatic and autoimmune diseases. There is a significant association of RP with the antigen HLA-DR4...
June 2016: Autoimmunity Reviews
2016-02-20 06:11:09
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