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vasculite geral

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32 papers 0 to 25 followers
https://www.readbyqxmd.com/read/28079513/high-dose-aspirin-for-kawasaki-disease-outdated-myth-or-effective-aid
#1
Gil Amarilyo, Yael Koren, Dafna Brik Simon, Maskit Bar-Meir, Hilla Bahat, Mona Hanna Helou, Amir Mendelson, Nofar Hezkelo, Gabriel Chodick, Yackov Berkun, Eli Eisenstein, Yonatan Butbul Aviel, Galia Barkai, Yoav Bolkier, Shai Padeh, Riva Brik, Phillip J Hashkes, Liora Harel, Yosef Uziel
OBJECTIVES: To compare the efficacy and safety of intravenous immunoglobulin (IVIG) plus high-dose aspirin (HDA) vs. IVIG plus low-dose aspirin (LDA) for the treatment of Kawasaki disease, with an emphasis on coronary artery outcomes. METHODS: This study was a retrospective, medical record review of paediatric patients with Kawasaki disease comparing 6 centres that routinely used HDA for initial treatment and 2 that used LDA in 2004-2013. Treatment response and adverse events were compared...
January 5, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27988436/a-scoping-review-of-the-use-of-non-biologic-disease-modifying-anti-rheumatic-drugs-in-the-management-of-large-vessel-vasculitis
#2
REVIEW
Durga Prasanna Misra, Aman Sharma, Tamilarasu Kadhiravan, Vir Singh Negi
Takayasu's arteritis (TA) and Giant cell arteritis (GCA) comprise the large vessel vasculitides (LVV). Patients with LVV are treated with disease-modifying anti-rheumatic drugs (DMARDs), both conventional (cDMARDs) and biologic (bDMARDs). We undertook a scoping review to assess the effectiveness of cDMARDs in TA and GCA. We could identify 11 studies in TA and 18 studies in GCA. There were only 3 randomized controlled trials on methotrexate, one on hydroxychloroquine and two on cyclosporine in GCA, the others being case series (including all studies on TA)...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27989761/anti-endothelial-cell-antibodies-in-vasculitis-a-systematic-review
#3
REVIEW
Paul Legendre, Alexis Régent, Mathilde Thiebault, Luc Mouthon
Anti-endothelial cell antibodies (AECAs) are those that can bind to endothelial cells (ECs) via variable region-specific interactions. The identification and quantification of AECAs varies depending on the technique used. The best approach would be to combine at least two different methods. Thus, AECA measurement cannot be considered a diagnostic tool, but the detection and titers of AECAs are associated with disease activity in various systemic vasculitis diseases. AECAs have been described in almost all primary systemic vasculitis diseases but also in many secondary vasculitis diseases, with the identification of various antigens...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27940595/the-association-of-vascular-risk-factors-with-visual-loss-in-giant-cell-arteritis
#4
Max Yates, Alex J MacGregor, Joanna Robson, Anthea Craven, Peter A Merkel, Raashid A Luqmani, Richard A Watts
OBJECTIVE: Blindness is a recognized complication of GCA; however, the frequency of and risk factors for this complication have not been firmly established. The aim of this study was to examine the incidence and determinants of blindness in patients with GCA, using a large international cohort. METHODS: The analysis was conducted among subjects recruited into the Diagnosis and Classification Criteria in Vasculitis Study. The study captures consecutive patients presenting to clinic-based physicians...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27931962/imaging-of-vasculitis-state-of-the-art
#5
REVIEW
Francesco Muratore, Nicolò Pipitone, Carlo Salvarani, Wolfgang A Schmidt
The increasing availability and improvement of imaging techniques are making a profound impact in the evaluation and management of patients with vasculitis, particularly for those with large vessel vasculitis, and will most likely play an ever more important role in the future. Deep, large vessels can be examined by CT or MRI, while ultrasound is the method of choice for the evaluation of superficial vessels (such as temporal, carotid, and axillary arteries). PET is very sensitive in detecting large vessel inflammation, but it does not delineate the vessel wall...
August 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27813289/takayasu-arteritis-and-pregnancy-a-population-based-study-on-outcome-and-mother-child-related-concerns
#6
Birgir Gudbrandsson, Marianne Wallenius, Torhild Garen, Tore Henriksen, Øyvind Molberg, Øyvind Palm
OBJECTIVES: To assess pregnancy outcome in an unselected Takayasu arteritis (TAK) cohort, and identify pregnancy related concerns. METHODS: Consenting, female patients with TAK were predominantly recruited from a population based South-east Norway TAK cohort. Additional cases (n=8) were recruited at Oslo University Hospital. Data on the number of pregnancies, births and pregnancy outcome before and after disease onset were retrieved from medical charts, patient questionnaires and the Medical Birth Registry of Norway (MBRN)...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27886800/beh%C3%A3-et-s-disease-how-to-diagnose-and-treat-vascular-involvement
#7
REVIEW
Emire Seyahi
Behçet's disease is a multisystem disorder with unknown etiology and a unique geographic distribution. The disease is characterized by recurrent skin-mucosa lesions and sight-threatening panuveitis. Vascular involvement, which is more common and more severe among males, has also equally characteristic features such as affecting mostly veins, having a significant tendency for thrombosis, and running a relapsing course. Lower extremity vein thrombosis (LEVT) is the most frequent manifestation, followed by vena cava inferior thrombosis...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27799164/how-i-treat-cryoglobulinemia
#8
Eli Muchtar, Hila Magen, Morie A Gertz
Cryoglobulinemia is a distinct entity catheterized by the presence of cryoglobulins in the serum. Cryoglobulins differ in their composition, which has an impact on the clinical presentation and the underlying disease triggering cryoglobulin formation. Cryoglobulinemia is categorized into two main subgroups: Type I seen exclusively in clonal hematological diseases, and mixed cryoglobulinemia (type II/III) seen in HCV infection and systemic diseases such as B-cell lineage hematological malignancies and connective tissue disorders...
October 31, 2016: Blood
https://www.readbyqxmd.com/read/27755177/systemic-vasculitis-and-the-lung
#9
Rosaria Talarico, Simone Barsotti, Elena Elefante, Chiara Baldini, Chiara Tani, Marta Mosca
PURPOSE OF REVIEW: The purpose of this review is to provide a critical analysis of the recent literature on this topic, with particular focus on the most relevant studies published over the last year. RECENT FINDINGS: Many studies are published every year on the diagnosis, pathogenesis and treatment of pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). The main subjects covered by this article are the pathogenesis, diagnosis and clinical aspects of lung involvement in ANCA-associated vasculitis and non-ANCA-associated vasculitis...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27564269/the-clinical-spectrum-of-medium-sized-vessel-vasculitis
#10
Fatma Alibaz-Oner, Matthew J Koster, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Carlo Salvarani, Eric L Matteson, Kenneth J Warrington
OBJECTIVES: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis of medium-sized visceral vessels. However, cutaneous arteritis (CA) and gastrointestinal (GI) vasculitis are forms of single organ vasculitis having indistinguishable histopathological findings from PAN. The aim of this study was to evaluate and compare the clinical characteristics, treatment, and outcomes of patients with systemic PAN, CA and GI vasculitis. METHODS: Retrospective cohorts were assembled of patients with PAN, CA and GI vasculitis between 1980 and 2014...
August 26, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27483045/high-resolution-magnetic-resonance-imaging-of-scalp-arteries-for-the-diagnosis-of-giant-cell-arteritis-results-of-a-prospective-cohort-study
#11
Maxime Rhéaume, Ryan Rebello, Christian Pagnoux, Simon Carette, Marie Clements-Baker, Violette Cohen-Hallaleh, David Doucette-Preville, B Stanley Jackson, Samih Salama Sargious Salama, George Ioannidis, Nader A Khalidi
OBJECTIVE: To examine the concordance between high-resolution magnetic resonance imaging (MRI) of the scalp arteries and temporal artery biopsy for the diagnosis of giant cell arteritis (GCA). METHODS: We conducted a prospective cohort study of patients with suspected GCA. Participants underwent high-field 3T MRI of the scalp arteries followed by temporal artery biopsy. Arterial wall thickness and enhancement on multiplanar postcontrast T1-weighted spin-echo images were graded according to a published severity scale (range 0-3)...
January 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26315859/vasculitis-in-patients-with-inflammatory-bowel-diseases-a-study-of-32-patients-and-systematic-review-of-the-literature
#12
REVIEW
Alice Sy, Nader Khalidi, Natasha Dehghan, Lillian Barra, Simon Carette, David Cuthbertson, Gary S Hoffman, Curry L Koening, Carol A Langford, Carol McAlear, Larry Moreland, Paul A Monach, Philip Seo, Ulrich Specks, Antoine Sreih, Steven R Ytterberg, Gert Van Assche, Peter A Merkel, Christian Pagnoux
BACKGROUND: Published small case series suggest that inflammatory bowel disease [IBD; Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than would be expected by chance. OBJECTIVES: To describe this association by an analysis of a large cohort of carefully studied patients and through a systematic literature review. METHODS: Patients with both IBD and vasculitis enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies, followed in Canadian Vasculitis research network (CanVasc) centers and/or in the University of Toronto's IBD clinic were included in this case series...
February 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27481272/the-spectrum-of-giant-cell-arteritis-and-polymyalgia-rheumatica-revisiting-the-concept-of-the-disease
#13
REVIEW
Christian Dejaco, Christina Duftner, Frank Buttgereit, Eric L Matteson, Bhaskar Dasgupta
GCA and PMR are conditions of older persons that frequently overlap. The traditional concept of GCA has focused on cranial symptoms such as headache and visual disturbance, but extra-cranial manifestations such as constitutional symptoms, polymyalgia and limb claudication have also long been recognized. These symptoms may coincide with cranial GCA, occur as an independent clinical subset [large-vessel (LV) GCA] or overlap with PMR. Imaging studies have demonstrated that up to one-third of patients with PMR have subclinical LV inflammation at disease outset...
August 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27267459/outcomes-of-patients-with-goodpasture-syndrome-a-nationwide-cohort-based-study-from-the-french-society-of-hemapheresis
#14
Antoine Huart, Anne-Gaëlle Josse, Dominique Chauveau, Jean-Michel Korach, Farhad Heshmati, Eric Bauvin, Olivier Cointault, Nassim Kamar, David Ribes, Jacques Pourrat, Stanislas Faguer
The overall and renal outcomes of patients with Goodpasture syndrome (GS), a rare autoimmune disorder characterized by circulating anti-GBM antibodies and rapidly progressive glomerulonephritis and/or pulmonary hemorrhage, have mostly been reported in small-sized cohorts or by aggregating patients receiving a variety of therapies that include aggressive (i.e., combined plasma exchanges, corticosteroids, and cyclophosphamide) and less aggressive (i.e., either plasma exchanges or immunosuppressive drugs, or no treatment)...
September 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/26503355/drug-induced-vasculitis-new-insights-and-a-changing-lineup-of-suspects
#15
REVIEW
Rafael G Grau
An increasing number of therapeutic agents have been associated with a vasculitic syndrome. This usually involves small vessels, primarily capillaries, venules, and arterioles in leukocytoclastic vasculitis, small-vessel disease similar to an antineutrophil cytoplasmic antibody-related vasculitis, or mid-sized muscular arteries in a polyarteritis-like picture. Antineutrophil cytoplasmic antibodies are present in many cases of vasculitis regardless of the size of the vessel involved. Monoclonal antibodies used to treat many autoimmune disorders have become the most common agents associated with drug-induced vasculitis...
December 2015: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27097818/connective-tissue-disorder-associated-vasculitis
#16
REVIEW
Aman Sharma, Aadhaar Dhooria, Ashish Aggarwal, Manish Rathi, Vinod Chandran
Vasculitides secondary to connective tissue diseases are classified under the category of 'vasculitis associated with systemic disease' in the revised International Chapel Hill Consensus Conference (CHCC) nomenclature. These secondary vasculitides may affect any of the small, medium or large vessels and usually portend a poor prognosis. Any organ system can be involved and the presentation would vary depending upon that involvement. Treatment depends upon the type and severity of presentation. In this review, we describe secondary vasculitis associated with rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, relapsing polychondritis, systemic sclerosis, Sjogren's syndrome and idiopathic inflammatory myositis, focusing mainly on recent advances in the past 3 years...
June 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27331771/relapsing-polychondritis-can-be-characterized-by-three-different-clinical-phenotypes-analysis-of-a-recent-series-of-142-patients
#17
Jérémie Dion, Nathalie Costedoat-Chalumeau, Damien Sène, Judith Cohen-Bittan, Gaëlle Leroux, Charlotte Dion, Camille Francès, Jean-Charles Piette
OBJECTIVE: Relapsing polychondritis (RP) is a rare condition characterized by recurrent inflammation of cartilaginous tissue and systemic manifestations. Data on this disease remain scarce. This study was undertaken to describe patient characteristics and disease evolution, identify prognostic factors, and define different clinical phenotypes of RP. METHODS: We performed a retrospective study of 142 patients with RP who were seen between 2000 and 2012 in a single center...
December 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27299619/polymyalgia-rheumatica-and-giant-cell-arteritis-a-systematic-review
#18
REVIEW
Frank Buttgereit, Christian Dejaco, Eric L Matteson, Bhaskar Dasgupta
IMPORTANCE: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are related inflammatory disorders occurring in persons aged 50 years and older. Diagnostic and therapeutic approaches are heterogeneous in clinical practice. OBJECTIVE: To summarize current evidence regarding optimal methods for diagnosing and treating PMR and GCA. EVIDENCE REVIEW: MEDLINE, EMBASE, and Cochrane databases were searched from their inception dates to March 30, 2016...
June 14, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27238990/updates-in-pathophysiology-diagnosis-and-management-of-takayasu-arteritis
#19
REVIEW
Raffaele Serra, Lucia Butrico, Francesco Fugetto, Mariia Dmitrievna Chibireva, Alberto Malva, Giovanni De Caridi, Mafalda Massara, Andrea Barbetta, Marco Cannistrà, Stefano de Franciscis
BACKGROUND: Takayasu arteritis (TA) is a rare, systemic, inflammatory vasculitis of granulomatous nature, and still of unknown etiology. It mainly involves the aorta and its major branches and is more commonly seen in women of childbearing age and Asians. TA leads to stenosis, occlusion, or aneurysmal degeneration of large arteries, and its pathogenesis seems to be mainly due to an abnormal cell-mediated immunity, although other molecular and genetic abnormalities may contribute. The diagnosis and treatments lie on clinical and arteriographic findings...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27118389/management-of-small-vessel-vasculitides
#20
REVIEW
Giuseppe Lopalco, Donato Rigante, Vincenzo Venerito, Giacomo Emmi, Maria Grazia Anelli, Giovanni Lapadula, Florenzo Iannone, Luca Cantarini
Inflammation mediated by cells of the immune system and necrosis are the most striking features observed at the histologic level in patients with vasculitides, clinical entities classified according to pathologic findings involving different organs, to etiology, or to size of vessels involved. Small vessel vasculitides (SVV) are a peculiar group of systemic disorders electively involving small intraparenchymal arteries, arterioles, capillaries, or venules and leading to different levels of vascular obstruction, tissue ischemia and risk of infarction; they can be divided into anti-neutrophil cytoplasmic antibody-associated vasculitides and immune complex vasculitides...
June 2016: Current Rheumatology Reports
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