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Zika virus

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36 papers 0 to 25 followers
https://www.readbyqxmd.com/read/27214379/correction-characterization-of-lethal-zika-virus-infection-in-ag129-mice
#1
Matthew T Aliota, Elizabeth A Caine, Emma C Walker, Katrina E Larkin, Erwin Camacho, Jorge E Osorio
[This corrects the article DOI: 10.1371/journal.pntd.0004682.].
May 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27212660/zika-virus-targets-human-stat2-to-inhibit-type-i-interferon-signaling
#2
Alesha Grant, Sanket S Ponia, Shashank Tripathi, Vinod Balasubramaniam, Lisa Miorin, Marion Sourisseau, Megan C Schwarz, Mari Paz Sánchez-Seco, Matthew J Evans, Sonja M Best, Adolfo García-Sastre
The ongoing epidemic of Zika virus (ZIKV) illustrates the importance of flaviviruses as emerging human pathogens. All vector-borne flaviviruses studied thus far have to overcome type I interferon (IFN) to replicate and cause disease in vertebrates. The mechanism(s) by which ZIKV antagonizes IFN signaling is unknown. Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses examined could suppress IFN signaling, but through different mechanisms. ZIKV NS5 expression resulted in proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans, but not mice, which may explain the requirement for IFN deficiency to observe ZIKV-induced disease in mice...
June 8, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27102780/zika-virus-infection-during-pregnancy-and-microcephaly-occurrence-a-review-of-literature-and-brazilian-data
#3
Newton Sérgio De Carvalho, Beatriz Freitas De Carvalho, Cyllian Arias Fugaça, Bruna Dóris, Evellyn Silverio Biscaia
In November of 2015, the Ministry of Health of Brazil published an announcement confirming the relationship between Zika virus and the microcephaly outbreak in the Northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. The objectives of this study were to conduct a literature review about Zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. Zika virus is an arbovirus, whose main vector is the Aedes sp...
May 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27118575/zika-virus-associated-guillain-barr%C3%A3-syndrome-a-warning-for-critical-care-physicians
#4
Guillaume Thiery, Ruddy Valentino, Hossein Meddhaoui
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27126052/high-specificity-of-a-novel-zika-virus-elisa-in-european-patients-after-exposure-to-different-flaviviruses
#5
Daniela Huzly, Ingeborg Hanselmann, Jonas Schmidt-Chanasit, Marcus Panning
The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.
April 21, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27156023/wolbachia-blocks-currently-circulating-zika-virus-isolates-in-brazilian-aedes-aegypti-mosquitoes
#6
Heverton Leandro Carneiro Dutra, Marcele Neves Rocha, Fernando Braga Stehling Dias, Simone Brutman Mansur, Eric Pearce Caragata, Luciano Andrade Moreira
The recent association of Zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the Zika vector, Aedes aegypti mosquitoes. Wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. Here we report that Aedes aegypti harboring Wolbachia are highly resistant to infection with two currently circulating Zika virus isolates from the recent Brazilian epidemic. Wolbachia-harboring mosquitoes displayed lower viral prevalence and intensity and decreased disseminated infection and, critically, did not carry infectious virus in the saliva, suggesting that viral transmission was blocked...
June 8, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27050856/guillain-barr%C3%A3-syndrome-associated-with-the-zika-virus-outbreak-in-brazil
#7
Lucas Masiêro Araujo, Maria Lucia Brito Ferreira, Osvaldo Jm Nascimento
Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barré syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil...
March 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27115821/guillain-barr%C3%A3-syndrome-associated-with-zika-virus-infection
#8
Patrícia Brasil, Patricia Carvalho Sequeira, Andrea D'Avila Freitas, Heruza Einsfeld Zogbi, Guilherme Amaral Calvet, Rogerio Valls de Souza, André Machado Siqueira, Marcos Cesar Lima de Mendonca, Rita Maria Ribeiro Nogueira, Ana Maria Bispo de Filippis, Tom Solomon
No abstract text is available yet for this article.
April 2, 2016: Lancet
https://www.readbyqxmd.com/read/27013429/zika-virus-in-the-americas-early-epidemiological-and-genetic-findings
#9
Nuno Rodrigues Faria, Raimunda do Socorro da Silva Azevedo, Moritz U G Kraemer, Renato Souza, Mariana Sequetin Cunha, Sarah C Hill, Julien Thézé, Michael B Bonsall, Thomas A Bowden, Ilona Rissanen, Iray Maria Rocco, Juliana Silva Nogueira, Adriana Yurika Maeda, Fernanda Giseli da Silva Vasami, Fernando Luiz de Lima Macedo, Akemi Suzuki, Sueli Guerreiro Rodrigues, Ana Cecilia Ribeiro Cruz, Bruno Tardeli Nunes, Daniele Barbosa de Almeida Medeiros, Daniela Sueli Guerreiro Rodrigues, Alice Louize Nunes Queiroz, Eliana Vieira Pinto da Silva, Daniele Freitas Henriques, Elisabeth Salbe Travassos da Rosa, Consuelo Silva de Oliveira, Livia Caricio Martins, Helena Baldez Vasconcelos, Livia Medeiros Neves Casseb, Darlene de Brito Simith, Jane P Messina, Leandro Abade, José Lourenço, Luiz Carlos Junior Alcantara, Maricélia Maia de Lima, Marta Giovanetti, Simon I Hay, Rodrigo Santos de Oliveira, Poliana da Silva Lemos, Layanna Freitas de Oliveira, Clayton Pereira Silva de Lima, Sandro Patroca da Silva, Janaina Mota de Vasconcelos, Luciano Franco, Jedson Ferreira Cardoso, João Lídio da Silva Gonçalves Vianez-Júnior, Daiana Mir, Gonzalo Bello, Edson Delatorre, Kamran Khan, Marisa Creatore, Giovanini Evelim Coelho, Wanderson Kleber de Oliveira, Robert Tesh, Oliver G Pybus, Marcio R T Nunes, Pedro F C Vasconcelos
Brazil has experienced an unprecedented epidemic of Zika virus (ZIKV), with ~30,000 cases reported to date. ZIKV was first detected in Brazil in May 2015, and cases of microcephaly potentially associated with ZIKV infection were identified in November 2015. We performed next-generation sequencing to generate seven Brazilian ZIKV genomes sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. Results of phylogenetic and molecular clock analyses show a single introduction of ZIKV into the Americas, which we estimated to have occurred between May and December 2013, more than 12 months before the detection of ZIKV in Brazil...
April 15, 2016: Science
https://www.readbyqxmd.com/read/27019049/zika-virus-and-autoimmunity-from-microcephaly-to-guillain-barr%C3%A3-syndrome-and-beyond
#10
REVIEW
Guglielmo Lucchese, Darja Kanduc
Zika virus (ZIKV) infection during pregnancy may be linked to fetal neurological complications that include brain damage and microcephaly. How the viral infection relates to fetal brain malformations is unknown. This study analyzes ZIKV polyprotein for peptide sharing with human proteins that, when altered, associate with microcephaly and brain calcifications. Results highlight a vast viral versus human peptide commonality that, in particular, involves centriolar and centrosomal components canonically cataloged as microcephaly proteins, i...
August 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27022155/characterization-of-a-novel-murine-model-to-study-zika-virus
#11
Shannan L Rossi, Robert B Tesh, Sasha R Azar, Antonio E Muruato, Kathryn A Hanley, Albert J Auguste, Rose M Langsjoen, Slobodan Paessler, Nikos Vasilakis, Scott C Weaver
The mosquito-borne Zika virus (ZIKV) is responsible for an explosive ongoing outbreak of febrile illness across the Americas. ZIKV was previously thought to cause only a mild, flu-like illness, but during the current outbreak, an association with Guillain-Barré syndrome and microcephaly in neonates has been detected. A previous study showed that ZIKV requires murine adaptation to generate reproducible murine disease. In our study, a low-passage Cambodian isolate caused disease and mortality in mice lacking the interferon (IFN) alpha receptor (A129 mice) in an age-dependent manner, but not in similarly aged immunocompetent mice...
June 1, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27033547/the-3-8-%C3%A3-resolution-cryo-em-structure-of-zika-virus
#12
Devika Sirohi, Zhenguo Chen, Lei Sun, Thomas Klose, Theodore C Pierson, Michael G Rossmann, Richard J Kuhn
The recent rapid spread of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome have generated worldwide concern. Zika virus is a flavivirus like the dengue, yellow fever, and West Nile viruses. We present the 3.8 angstrom resolution structure of mature Zika virus, determined by cryo-electron microscopy (cryo-EM). The structure of Zika virus is similar to other known flavivirus structures, except for the ~10 amino acids that surround the Asn(154) glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell...
April 22, 2016: Science
https://www.readbyqxmd.com/read/27032927/characterizing-the-zika-virus-genome-a-bioinformatics-study
#13
Ashesh Nandy, Sumanta Dey, Subhash C Basak, Dorota Bielinska-Waz, Piotr Waz
BACKGROUND: The recent epidemic of Zika virus infections in South and Latin America have raised serious concern on its ramifications for the population in the Americas and spread of the virus worldwide. The Zika virus disease is a relatively new phenomenon for which sufficient and comprehensive data and investigative reports have not been available to date. OBJECTIVE: To carry out a bioinformatics study of the available Zika virus genomic sequences to characterize the virus...
2016: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/27036749/microcephaly-and-zika-virus
#14
EDITORIAL
Consuelo Silva de Oliveira, Pedro Fernando da Costa Vasconcelos
No abstract text is available yet for this article.
March 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27029595/zika-virus
#15
REVIEW
Didier Musso, Duane J Gubler
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya...
July 2016: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/26956448/zika-virus-outbreak-a-perfect-storm
#16
Jing-Wen Ai, Ying Zhang, Wenhong Zhang
No abstract text is available yet for this article.
2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/26941134/first-complete-genome-sequence-of-zika-virus-flaviviridae-flavivirus-from-an-autochthonous-transmission-in-brazil
#17
Mariana Sequetin Cunha, Danillo Lucas Alves Esposito, Iray Maria Rocco, Adriana Yurika Maeda, Fernanda Gisele Silva Vasami, Juliana Silva Nogueira, Renato Pereira de Souza, Akemi Suzuki, Marcelo Addas-Carvalho, Maria de Lourdes Barjas-Castro, Mariângela Ribeiro Resende, Raquel Silveira Bello Stucchi, Ilka de Fátima Santana Ferreira Boin, Gizelda Katz, Rodrigo Nogueira Angerami, Benedito Antonio Lopes da Fonseca
We report here the genome sequence of Zika virus, strain ZikaSPH2015, containing all structural and nonstructural proteins flanked by the 5' and 3' untranslated region. It was isolated in São Paulo state, Brazil, in 2015, from a patient who received a blood transfusion from an asymptomatic donor at the time of donation.
2016: Genome Announcements
https://www.readbyqxmd.com/read/26923117/zika-virus-and-neurological-disease-approaches-to-the-unknown
#18
Tom Solomon, Matthew Baylis, David Brown
No abstract text is available yet for this article.
April 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/26925496/the-zika-outbreak-of-the-21st-century
#19
Christopher Chang, Kristina Ortiz, Aftab Ansari, M Eric Gershwin
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels. This virus was first identified in 1947, when it was isolated from a sentinel rhesus monkey placed by British scientists working at the Yellow Fever Research Laboratory located in the Zika forest area of Uganda, hence its name, and is transmitted primarily by the mosquito vector, Aedes aegypti. The fact that the rhesus macaque is an Asian species being placed in an African forest brings to mind the possibility of rapid adaptation of the virus from an African to Asian species, an issue that has not been considered...
April 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/26932976/study-links-zika-virus-to-guillain-barr%C3%A3-syndrome
#20
COMMENT
Jacqui Wise
No abstract text is available yet for this article.
March 1, 2016: BMJ: British Medical Journal
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