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warfarin & gemfibrozil

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3 papers 0 to 25 followers warfarin & gemfibrozil
https://www.readbyqxmd.com/read/20103024/fibrate-statin-initiation-in-warfarin-users-and-gastrointestinal-bleeding-risk
#1
Hedi Schelleman, Warren B Bilker, Colleen M Brensinger, Fei Wan, Yu-Xiao Yang, Sean Hennessy
PURPOSE: To evaluate whether initiation of a fibrate or statin increases the risk of hospitalization for gastrointestinal bleeding in warfarin users. METHODS: We used Medicaid claims data (1999-2003) to perform an observational case-control study nested within person-time exposed to warfarin in those > or =18 years (n=353,489). Gastrointestinal bleeding cases were matched to 50 controls based on index date and state. RESULTS: Chronic warfarin users had an increased odds ratio of gastrointestinal bleeding upon initiation of gemfibrozil (1...
February 2010: American Journal of Medicine
https://www.readbyqxmd.com/read/19476425/interaction-between-gemfibrozil-and-warfarin-case-report-and-review-of-the-literature
#2
REVIEW
Dave L Dixon, Virginia G Williams
Possible procoagulant effects can occur when lipid-lowering fibric acid derivatives, such as gemfibrozil and fenofibrate, are taken concomitantly with warfarin. Although there are several detailed reports of fenofibrate potentiating the anticoagulant effects of warfarin, few case reports have been published regarding an interaction between gemfibrozil and warfarin. We describe a 62-year-old man who was taking warfarin for paroxysmal atrial fibrillation and came to the anticoagulation clinic for a routine follow-up...
June 2009: Pharmacotherapy
https://www.readbyqxmd.com/read/9726762/gemfibrozil-warfarin-drug-interaction-resulting-in-profound-hypoprothrombinemia
#3
J P Rindone, H C Keng
The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil. Despite a warning by the manufacturer, only one report of this interaction has been published in the literature. This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.
August 1998: Chest
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