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By Fatih Kelesoglu ...
Uma Chandrasekaran, Woelsung Yi, Sanjay Gupta, Chien-Huan Weng, Eugenia Giannopoulou, Yurii Chinenov, Rolf Jessberger, Casey T Weaver, Govind Bhagat, Alessandra B Pernis
OBJECTIVE: Treg cells need to acquire an effector phenotype to function in settings of inflammation. Whether effector Treg cells can limit disease severity in lupus is unknown. Interferon regulatory factor 4 (IRF-4) is an essential controller of effector Treg cells and regulates their ability to express interleukin-10 (IL-10). In non-Treg cells, IRF-4 activity is modulated by interactions with DEF-6 and its homolog switch-associated protein 70 (SWAP-70). Although mice lacking both DEF-6 and SWAP-70 (double-knockout [DKO] mice) develop lupus, they display normal survival, suggesting that in DKO mice, Treg cells can moderate disease development...
June 2016: Arthritis & Rheumatology
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