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Metabolic surgery

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25 papers 0 to 25 followers
Melania Manco, Antonella Mosca, Francesco De Peppo, Romina Caccamo, Renato Cutrera, Ugo Giordano, Cristiano De Stefanis, Anna Alisi, Ulrich Baumann, Gianfranco Silecchia, Valerio Nobili
OBJECTIVE: To determine whether bariatric surgery is effective for the treatment of nonalcoholic steatohepatitis (NASH) in adolescence, we compared the efficacy of laparoscopic sleeve gastrectomy (LSG) with that of lifestyle intervention (nonsurgical weight loss [NSWL]) for NASH reversal in obese adolescents. STUDY DESIGN: Obese (body mass index ≥ 35 kg/m(2)) adolescents (13-17 years of age) with biopsy-proven NAFLD underwent LSG, lifestyle intervention plus intragastric weight loss devices (IGWLD), or only NSWL...
September 30, 2016: Journal of Pediatrics
Guillaume de Lartigue, Charlene Diepenbroek
Vagal afferent neurons (VANs) play an important role in the control of food intake by signaling nutrient type and quantity to the brain. Recent findings are broadening our view of how VANs impact not only food intake but also energy homeostasis. This review focuses exclusively on studies of the vagus nerve from the past 2 years that highlight major new advancements in the field. We firstly discuss evidence that VANs can directly sense nutrients, and we consider new insights into mechanisms affecting sensing of gastric distension and signaling by gastrointestinal hormones ghrelin and GLP1...
September 1, 2016: Current Opinion in Pharmacology
Mary-Anne Aarts, Nardhana Sivapalan, Seyed-Ehsan Nikzad, Kristin Serodio, Sanjeev Sockalingam, Lesley Gotlib Conn
BACKGROUND: Failure to follow-up post-bariatric surgery has been associated with higher postoperative complications, lower percentage weight loss and poorer nutrition. OBJECTIVE: This study aimed to understand the patient follow-up experience in order to optimize follow-up care within a comprehensive bariatric surgery program. METHODS: Qualitative telephone interviews were conducted in patients who underwent surgery through a publically funded multidisciplinary bariatric surgery program in 2011, in Ontario, Canada...
September 7, 2016: Obesity Surgery
David Goitein, Nasser Sakran, Shlomi Rayman, Amir Szold, Orly Goitein, Asnat Raziel
BACKGROUND: Hiatal hernia (HH) is common in the bariatric population. Its presence imposes various degrees of difficulty in performing laparoscopic sleeve gastrectomy (LSG). Preoperative upper gastrointestinal evaluation consists of fluoroscopic and or endoscopic studies OBJECTIVES: To evaluate the efficacy of routine, preoperative barium swallow in identifying HH in patients undergoing LSG, and determine if such foreknowledge changes operative and immediate postoperative course regarding operative time, intraoperative adverse events, and length of hospital stay (LOS)...
August 5, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Lutgarda Bozzetto, Giuseppina Costabile, Delia Luongo, Daniele Naviglio, Valentina Cicala, Chiara Piantadosi, Lidia Patti, Paola Cipriano, Giovanni Annuzzi, Angela A Rivellese
AIMS/HYPOTHESIS: The aim of this work was to investigate hepatic lipid metabolic processes possibly involved in the reduction of liver fat content (LF) observed in patients with type 2 diabetes after an isoenergetic diet enriched in monounsaturated fatty acids (MUFAs). METHODS: This is an ancillary analysis of a published study. In a parallel-group design, 30 men and eight women, aged 35-70 years, with type 2 diabetes and whose blood glucose was controlled satisfactorily (HbA1c < 7...
September 20, 2016: Diabetologia
Weilin Liu, Dicky Struik, Vera J M Nies, Angelika Jurdzinski, Liesbeth Harkema, Alain de Bruin, Henkjan J Verkade, Michael Downes, Ronald M Evans, Tim van Zutphen, Johan W Jonker
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with obesity and type 2 diabetes. Currently, there is no approved pharmacological treatment for this disease, but improvement of insulin resistance using peroxisome proliferator-activated receptor-γ (PPARγ) agonists, such as thiazolidinediones (TZDs), has been shown to reduce steatosis and steatohepatitis effectively and to improve liver function in patients with obesity-related NAFLD. However, this approach is limited by adverse effects of TZDs...
February 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Jinbo Han, Erwei Li, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng, Yiguo Wang
Abnormal accumulation of triglycerides in the liver, caused in part by increased de novo lipogenesis, results in non-alcoholic fatty liver disease and insulin resistance. Sterol regulatory element-binding protein 1 (SREBP1), an important transcriptional regulator of lipogenesis, is synthesized as an inactive precursor that binds to the endoplasmic reticulum (ER). In response to insulin signalling, SREBP1 is transported from the ER to the Golgi in a COPII-dependent manner, processed by proteases in the Golgi, and then shuttled to the nucleus to induce lipogenic gene expression; however, the mechanisms underlying enhanced SREBP1 activity in insulin-resistant obesity and diabetes remain unclear...
August 13, 2015: Nature
Vanessa M Oddo, Lauren Hersch Nicholas, Sara N Bleich, Jessica C Jones-Smith
BACKGROUND: The recent economic recession represents an opportunity to test whether decreases in economic resources may have deleterious consequences on childhood overweight/obesity risk. METHODS: We investigated the association between indicators of changing macroeconomic conditions from 2008 to 2012 and overweight/obesity risk among school-aged children in California (n=1 741 712) using longitudinal anthropometric measurements. Multivariate regression, with individual and county fixed effects, was used to examine the effects of annual county-level unemployment and foreclosure rates on risk of child overweight/obesity, overall and among subgroups (race/ethnicity, sex, county-level median household income and county-level urban/rural status)...
September 2016: Journal of Epidemiology and Community Health
Jing Li, Jun Song, Yekaterina Y Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E Starr, Ji Tae Kim, Jennifer W Harris, Frederique B Yiannikouris, Wendy S Katz, Peter M Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M Higashi, Tianyan Gao, Andrew J Morris, Lisa A Cassis, Teresa W-M Fan, Heidi L Weiss, Paul R Dobner, Olle Melander, Jianhang Jia, B Mark Evers
Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually and are among the most prevalent and challenging conditions confronting the medical profession. Neurotensin (NT; also known as NTS), a 13-amino-acid peptide predominantly localized in specialized enteroendocrine cells of the small intestine and released by fat ingestion, facilitates fatty acid translocation in rat intestine, and stimulates the growth of various cancers...
May 11, 2016: Nature
A L João, F Reis, R Fernandes
Incretins are gastrointestinal-derived hormones released in response to a meal playing a key role in the regulation of postprandial secretion of insulin (incretin effect) and glucagon by the pancreas. Both incretins, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1), have several other actions by peripheral and central mechanisms. GLP-1 regulates body weight by inhibiting appetite and delaying gastric, emptying actions that are dependent on central nervous system GLP-1 receptor activation...
July 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Phillip Kemp Bohan, John Yonge, Christopher Connelly, Justin J Watson, Erica Friedman, George Fielding
No abstract text is available yet for this article.
April 2016: American Surgeon
G Craig Wood, Tooraj Mirshahi, Christopher D Still, Annemarie G Hirsch
No abstract text is available yet for this article.
August 1, 2016: JAMA Surgery
Paola Aceto, Carlo Lai, Valter Perilli, Teresa Sacco, Cristina Modesti, Marco Raffaelli, Liliana Sollazzi
BACKGROUND: Previous studies performed in non-obese patients undergoing elective surgery have revealed that psychological factors may affect postoperative analgesic requirements. The aim of this observational prospective study was to investigate the extent to which psychopathological dimensions, including anxiety, depression and alexithymia, may influence postoperative pain intensity and analgesics consumption using patient-controlled analgesia (PCA) in patients undergoing bariatric surgery...
September 1, 2016: Physiology & Behavior
Olivier F Noel, Christopher D Still, George Argyropoulos, Michael Edwards, Glenn S Gerhard
Overweight and obesity represent major risk factors for diabetes and related metabolic diseases. Obesity is associated with a chronic and progressive inflammatory response leading to the development of insulin resistance and type 2 diabetes (T2D) mellitus, although the precise mechanism mediating this inflammatory process remains poorly understood. The most effective intervention for the treatment of obesity, bariatric surgery, leads to glucose normalization and remission of T2D. Recent work in both clinical studies and animal models supports bile acids (BAs) as key mediators of these effects...
2016: Journal of Obesity
Luca Montesi, Marwan El Ghoch, Lucia Brodosi, Simona Calugi, Giulio Marchesini, Riccardo Dalle Grave
The long-term weight management of obesity remains a very difficult task, associated with a high risk of failure and weight regain. However, many people report that they have successfully managed weight loss maintenance in the long term. Several factors have been associated with better weight loss maintenance in long-term observational and randomized studies. A few pertain to the behavioral area (eg, high levels of physical activity, eating a low-calorie, low-fat diet; frequent self-monitoring of weight), a few to the cognitive component (eg, reduced disinhibition, satisfaction with results achieved, confidence in being able to lose weight without professional help), and a few to personality traits (eg, low novelty seeking) and patient-therapist interaction...
2016: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Gregory C Miller, Andrew S Reid, Ian S Brown
Sleeve gastrectomy specimens are increasingly common surgical specimens received for examination following bariatric surgery for weight loss. The spectrum of pathological changes seen in these cases is not well documented. Retrospective examination was undertaken of 1463 consecutive sleeve gastrectomy specimens received at Envoi Specialist Pathologists. Most cases showed no pathological changes (80.2%). The most common changes seen were non-specific, non-Helicobacter associated chronic gastritis (7.2%), Helicobacter associated gastritis (6...
April 2016: Pathology
G Yorulmaz, M Cilekar, U Bilge, E Akcan, A Akalin
OBJECTIVES: Our aim was to examine changes in insulin resistance, Carotid Intima-Media Thickness (CIMT), in morbid obese patients without any known associated chronic diseases who underwent sleeve gastrectomy. MATERIALS AND METHODS: The subjects of this study were patients with minimum BMI of 40, who did not have any known chronic diseases. Sleeve gastrectomy was performed and perioperative control endoscopy was performed. The following values were measured before the operation and after follow-up period after the operation: Fasting blood glucose and insulin, lipid profile, BMI, liver function tests, right and left CIMT...
May 2016: Nigerian Journal of Clinical Practice
Federico Moser, Mariana Marconetto, Verónica Gorodner, Germán Viscido, Noel Piazzoni, Pablo Maldonado, Eugenia Loretani Rodriguez, Lucio Obeide
BACKGROUND: It is commonly believed that eating habits, specially the sweet eating habit, can predict results after bariatric surgery; for this reason, it is considered one of the selection criteria when deciding the surgical technique. However, there is not enough evidence of its impact on the results after sleeve gastrectomy (SG). OBJECTIVE: To evaluate the relationship between the sweet eating habit and weight loss after SG. DESIGN: Cross-sectional retrospective study...
April 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Jia Zheng, Xinhua Xiao, Qian Zhang, Miao Yu, Jianping Xu, Cuijuan Qi, Tong Wang
Substantial evidence indicated that catch-up growth could increase the susceptibility to obesity, insulin resistance, and type 2 diabetes mellitus in adulthood. However, investigations into the "programming" effects of catch-up growth on gut microbiota in the offspring are limited. C57/BL6 mice were fed on either low protein (LP) or normal chow (NC) diet throughout gestation and lactation. Then, the offspring were randomly weaned to either NC or high fat (HF) diet until 32 weeks of age, generating four experimental groups: NC-NC, NC-HF, LP-NC, and LP-HF...
April 2016: MicrobiologyOpen
Henriette Frikke-Schmidt, Randy J Seeley
No abstract text is available yet for this article.
March 2016: Obesity
2016-02-14 14:17:41
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